Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q52KE7

- CCNL1_MOUSE

UniProt

Q52KE7 - CCNL1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cyclin-L1

Gene

Ccnl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs). Inhibited by the CDK-specific inhibitor p21 (By similarity).By similarity

GO - Biological processi

  1. regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. RNA processing Source: InterPro
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-L1
Short name:
Cyclin-L
Alternative name(s):
Cyclin Ania-6a
Gene namesi
Name:Ccnl1
Synonyms:Ania6a, Ccn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1922664. Ccnl1.

Subcellular locationi

Isoform 1 : Nucleus speckle
Note: More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nuclear speck Source: Ensembl
  3. transcription elongation factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Cyclin-L1PRO_0000080481Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei331 – 3311PhosphothreonineBy similarity
Modified residuei341 – 3411PhosphoserineBy similarity
Modified residuei344 – 3441PhosphoserineBy similarity
Modified residuei358 – 3581Phosphoserine1 Publication
Modified residuei361 – 3611Phosphoserine1 Publication
Modified residuei451 – 4511PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ52KE7.
PaxDbiQ52KE7.
PRIDEiQ52KE7.

PTM databases

PhosphoSiteiQ52KE7.

Expressioni

Gene expression databases

BgeeiQ52KE7.
CleanExiMM_CCNL1.
ExpressionAtlasiQ52KE7. baseline and differential.
GenevestigatoriQ52KE7.

Interactioni

Subunit structurei

Interacts with POLR2A via its hyperphosphorylated C-terminal domain (CTD), CDK11A, CDK11B, CDK12, CDK13 and SFRS2.1 Publication

Protein-protein interaction databases

IntActiQ52KE7. 1 interaction.
MINTiMINT-4131139.

Structurei

3D structure databases

ProteinModelPortaliQ52KE7.
SMRiQ52KE7. Positions 70-299.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 196103Cyclin-like 1Add
BLAST
Regioni209 – 29385Cyclin-like 2Add
BLAST
Regioni396 – 43843RSAdd
BLAST

Domaini

Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions (By similarity).By similarity

Sequence similaritiesi

Belongs to the cyclin family. Cyclin L subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5333.
GeneTreeiENSGT00760000119191.
HOGENOMiHOG000231292.
HOVERGENiHBG056044.
InParanoidiQ52KE7.
OMAiFERSHKG.
OrthoDBiEOG7K9K34.
PhylomeDBiQ52KE7.
TreeFamiTF101011.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR015429. Cyclin_C/H/T/L.
IPR017060. Cyclin_L.
IPR015431. Cyclin_L1_chr.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10026. PTHR10026. 1 hit.
PTHR10026:SF64. PTHR10026:SF64. 1 hit.
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF036580. Cyclin_L. 1 hit.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q52KE7-1) [UniParc]FASTAAdd to Basket

Also known as: Cyclin L alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASGPHPTST AAAAAAAAAS ASSAAPSAGG SSSGTTTTTT TTTGGILIGD
60 70 80 90 100
RLYSEVSLTI DHSLIPEERL SPTPSMQDGL DLPSETDLRI LGCELIQAAG
110 120 130 140 150
ILLRLPQVAM ATGQVLFHRF FYSKSFVKHS FEIVAMACIN LASKIEEAPR
160 170 180 190 200
RIRDVINVFH HLRQLRGKRT PSPLILDQNY INTKNQVIKA ERRVLKELGF
210 220 230 240 250
CVHVKHPHKI IVMYLQVLEC ERNQTLVQTA WNYMNDSLRT NVFVRFQPET
260 270 280 290 300
IACACIYLAA RALQIPLPTR PHWFLLFGTT EEEIQEICIE TLRLYTRKKP
310 320 330 340 350
NYELLEKEVE KRKVALQEAK LKAKGLNLDG TPALSTLGGF SPASKPSSPR
360 370 380 390 400
EVKAEEKSPV SINVKTVKKE PEDRQQASKS PYNGVRKDSK RSRTSRSASR
410 420 430 440 450
SRSRTRSRSR SHSPRRHYNN RRSRSGTYSS RSRSRSRSHS ESPRRHHNHG
460 470 480 490 500
SPHLKAKHTR EDLKSSNRHG HKRKKSRSRS QSKTRDHSDV TKKHRHERGH
510 520 530
HRDRRERSRS FERSHKGKHH GGSRSGHGRH RR

Note: Found in the nucleus, with a speckled pattern of expression.

Length:532
Mass (Da):60,133
Last modified:May 24, 2005 - v1
Checksum:iECBE41C070D0CA18
GO
Isoform 2 (identifier: Q52KE7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-252: IIVMYLQVLE...FVRFQPETIA → VSCKVQTLQF...SFLLDVDICF
     253-532: Missing.

Note: Found both in the nucleus and cytoplasm.

Show »
Length:252
Mass (Da):27,441
Checksum:i9643A9CC56E56E2B
GO

Sequence cautioni

The sequence AAD43568.1 differs from that shown. Reason: Frameshift at positions 29 and 51. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 942CE → WQ in AAL75565. (PubMed:11683997)Curated
Sequence conflicti147 – 1471E → G in BAB27744. (PubMed:16141072)Curated
Sequence conflicti283 – 2831E → G in BAB27744. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei210 – 25243IIVMY…PETIA → VSCKVQTLQFVSIRAFSEIL NSVWRVKLTGVFKSFLLDVD ICF in isoform 2. 1 PublicationVSP_016126Add
BLAST
Alternative sequencei253 – 532280Missing in isoform 2. 1 PublicationVSP_016127Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159159 mRNA. Translation: AAD43568.1. Frameshift.
AF467251 mRNA. Translation: AAL75565.1.
AK051380 mRNA. Translation: BAC34619.1.
AK011629 mRNA. Translation: BAB27744.3.
BC094383 mRNA. Translation: AAH94383.1.
CCDSiCCDS17390.1. [Q52KE7-1]
RefSeqiNP_064321.2. NM_019937.3. [Q52KE7-1]
UniGeneiMm.175612.

Genome annotation databases

EnsembliENSMUST00000029416; ENSMUSP00000029416; ENSMUSG00000027829. [Q52KE7-1]
GeneIDi56706.
KEGGimmu:56706.
UCSCiuc008pku.1. mouse. [Q52KE7-1]
uc008pkx.1. mouse. [Q52KE7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159159 mRNA. Translation: AAD43568.1 . Frameshift.
AF467251 mRNA. Translation: AAL75565.1 .
AK051380 mRNA. Translation: BAC34619.1 .
AK011629 mRNA. Translation: BAB27744.3 .
BC094383 mRNA. Translation: AAH94383.1 .
CCDSi CCDS17390.1. [Q52KE7-1 ]
RefSeqi NP_064321.2. NM_019937.3. [Q52KE7-1 ]
UniGenei Mm.175612.

3D structure databases

ProteinModelPortali Q52KE7.
SMRi Q52KE7. Positions 70-299.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q52KE7. 1 interaction.
MINTi MINT-4131139.

PTM databases

PhosphoSitei Q52KE7.

Proteomic databases

MaxQBi Q52KE7.
PaxDbi Q52KE7.
PRIDEi Q52KE7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029416 ; ENSMUSP00000029416 ; ENSMUSG00000027829 . [Q52KE7-1 ]
GeneIDi 56706.
KEGGi mmu:56706.
UCSCi uc008pku.1. mouse. [Q52KE7-1 ]
uc008pkx.1. mouse. [Q52KE7-2 ]

Organism-specific databases

CTDi 57018.
MGIi MGI:1922664. Ccnl1.

Phylogenomic databases

eggNOGi COG5333.
GeneTreei ENSGT00760000119191.
HOGENOMi HOG000231292.
HOVERGENi HBG056044.
InParanoidi Q52KE7.
OMAi FERSHKG.
OrthoDBi EOG7K9K34.
PhylomeDBi Q52KE7.
TreeFami TF101011.

Miscellaneous databases

NextBioi 313159.
PROi Q52KE7.
SOURCEi Search...

Gene expression databases

Bgeei Q52KE7.
CleanExi MM_CCNL1.
ExpressionAtlasi Q52KE7. baseline and differential.
Genevestigatori Q52KE7.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
InterProi IPR013763. Cyclin-like.
IPR015429. Cyclin_C/H/T/L.
IPR017060. Cyclin_L.
IPR015431. Cyclin_L1_chr.
IPR006671. Cyclin_N.
[Graphical view ]
PANTHERi PTHR10026. PTHR10026. 1 hit.
PTHR10026:SF64. PTHR10026:SF64. 1 hit.
Pfami PF00134. Cyclin_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF036580. Cyclin_L. 1 hit.
SMARTi SM00385. CYCLIN. 2 hits.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin."
    Berke J.D., Sgambato V., Zhu P.-P., Lavoie B., Vincent M., Krause M., Hyman S.E.
    Neuron 32:277-287(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
    Strain: BALB/c and C57BL/6.
    Tissue: Testis.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-309 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Embryo and Spinal ganglion.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Eye.
  4. "CDK13/CDC2L5 interacts with L-type cyclins and regulates alternative splicing."
    Chen H.H., Wong Y.H., Geneviere A.M., Fann M.J.
    Biochem. Biophys. Res. Commun. 354:735-740(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CDK13.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-358 AND SER-361, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCCNL1_MOUSE
AccessioniPrimary (citable) accession number: Q52KE7
Secondary accession number(s): Q8BQ75
, Q8R5H9, Q922K0, Q9CSZ3, Q9WV44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3