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Q52KE7

- CCNL1_MOUSE

UniProt

Q52KE7 - CCNL1_MOUSE

Protein

Cyclin-L1

Gene

Ccnl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs). Inhibited by the CDK-specific inhibitor p21 By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. RNA processing Source: InterPro
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-L1
    Short name:
    Cyclin-L
    Alternative name(s):
    Cyclin Ania-6a
    Gene namesi
    Name:Ccnl1
    Synonyms:Ania6a, Ccn1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1922664. Ccnl1.

    Subcellular locationi

    Isoform 1 : Nucleus speckle
    Note: More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nuclear speck Source: UniProtKB-SubCell
    3. transcription elongation factor complex Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 532532Cyclin-L1PRO_0000080481Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei331 – 3311PhosphothreonineBy similarity
    Modified residuei341 – 3411PhosphoserineBy similarity
    Modified residuei344 – 3441PhosphoserineBy similarity
    Modified residuei358 – 3581Phosphoserine1 Publication
    Modified residuei361 – 3611Phosphoserine1 Publication
    Modified residuei451 – 4511PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ52KE7.
    PaxDbiQ52KE7.
    PRIDEiQ52KE7.

    PTM databases

    PhosphoSiteiQ52KE7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ52KE7.
    BgeeiQ52KE7.
    CleanExiMM_CCNL1.
    GenevestigatoriQ52KE7.

    Interactioni

    Subunit structurei

    Interacts with POLR2A via its hyperphosphorylated C-terminal domain (CTD), CDK11A, CDK11B, CDK12, CDK13 and SFRS2.1 Publication

    Protein-protein interaction databases

    IntActiQ52KE7. 1 interaction.
    MINTiMINT-4131139.

    Structurei

    3D structure databases

    ProteinModelPortaliQ52KE7.
    SMRiQ52KE7. Positions 70-299.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 196103Cyclin-like 1Add
    BLAST
    Regioni209 – 29385Cyclin-like 2Add
    BLAST
    Regioni396 – 43843RSAdd
    BLAST

    Domaini

    Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions (By similarity).By similarity

    Sequence similaritiesi

    Belongs to the cyclin family. Cyclin L subfamily.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5333.
    GeneTreeiENSGT00690000101911.
    HOGENOMiHOG000231292.
    HOVERGENiHBG056044.
    InParanoidiQ52KE7.
    OMAiFERSHKG.
    OrthoDBiEOG7K9K34.
    PhylomeDBiQ52KE7.
    TreeFamiTF101011.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    InterProiIPR013763. Cyclin-like.
    IPR015429. Cyclin_C/H/T/L.
    IPR017060. Cyclin_L.
    IPR015431. Cyclin_L1_chr.
    IPR006671. Cyclin_N.
    [Graphical view]
    PANTHERiPTHR10026. PTHR10026. 1 hit.
    PTHR10026:SF64. PTHR10026:SF64. 1 hit.
    PfamiPF00134. Cyclin_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036580. Cyclin_L. 1 hit.
    SMARTiSM00385. CYCLIN. 2 hits.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q52KE7-1) [UniParc]FASTAAdd to Basket

    Also known as: Cyclin L alpha

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASGPHPTST AAAAAAAAAS ASSAAPSAGG SSSGTTTTTT TTTGGILIGD    50
    RLYSEVSLTI DHSLIPEERL SPTPSMQDGL DLPSETDLRI LGCELIQAAG 100
    ILLRLPQVAM ATGQVLFHRF FYSKSFVKHS FEIVAMACIN LASKIEEAPR 150
    RIRDVINVFH HLRQLRGKRT PSPLILDQNY INTKNQVIKA ERRVLKELGF 200
    CVHVKHPHKI IVMYLQVLEC ERNQTLVQTA WNYMNDSLRT NVFVRFQPET 250
    IACACIYLAA RALQIPLPTR PHWFLLFGTT EEEIQEICIE TLRLYTRKKP 300
    NYELLEKEVE KRKVALQEAK LKAKGLNLDG TPALSTLGGF SPASKPSSPR 350
    EVKAEEKSPV SINVKTVKKE PEDRQQASKS PYNGVRKDSK RSRTSRSASR 400
    SRSRTRSRSR SHSPRRHYNN RRSRSGTYSS RSRSRSRSHS ESPRRHHNHG 450
    SPHLKAKHTR EDLKSSNRHG HKRKKSRSRS QSKTRDHSDV TKKHRHERGH 500
    HRDRRERSRS FERSHKGKHH GGSRSGHGRH RR 532

    Note: Found in the nucleus, with a speckled pattern of expression.

    Length:532
    Mass (Da):60,133
    Last modified:May 24, 2005 - v1
    Checksum:iECBE41C070D0CA18
    GO
    Isoform 2 (identifier: Q52KE7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         210-252: IIVMYLQVLE...FVRFQPETIA → VSCKVQTLQF...SFLLDVDICF
         253-532: Missing.

    Note: Found both in the nucleus and cytoplasm.

    Show »
    Length:252
    Mass (Da):27,441
    Checksum:i9643A9CC56E56E2B
    GO

    Sequence cautioni

    The sequence AAD43568.1 differs from that shown. Reason: Frameshift at positions 29 and 51.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti93 – 942CE → WQ in AAL75565. (PubMed:11683997)Curated
    Sequence conflicti147 – 1471E → G in BAB27744. (PubMed:16141072)Curated
    Sequence conflicti283 – 2831E → G in BAB27744. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei210 – 25243IIVMY…PETIA → VSCKVQTLQFVSIRAFSEIL NSVWRVKLTGVFKSFLLDVD ICF in isoform 2. 1 PublicationVSP_016126Add
    BLAST
    Alternative sequencei253 – 532280Missing in isoform 2. 1 PublicationVSP_016127Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF159159 mRNA. Translation: AAD43568.1. Frameshift.
    AF467251 mRNA. Translation: AAL75565.1.
    AK051380 mRNA. Translation: BAC34619.1.
    AK011629 mRNA. Translation: BAB27744.3.
    BC094383 mRNA. Translation: AAH94383.1.
    CCDSiCCDS17390.1. [Q52KE7-1]
    RefSeqiNP_064321.2. NM_019937.3. [Q52KE7-1]
    UniGeneiMm.175612.

    Genome annotation databases

    EnsembliENSMUST00000029416; ENSMUSP00000029416; ENSMUSG00000027829. [Q52KE7-1]
    GeneIDi56706.
    KEGGimmu:56706.
    UCSCiuc008pku.1. mouse. [Q52KE7-1]
    uc008pkx.1. mouse. [Q52KE7-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF159159 mRNA. Translation: AAD43568.1 . Frameshift.
    AF467251 mRNA. Translation: AAL75565.1 .
    AK051380 mRNA. Translation: BAC34619.1 .
    AK011629 mRNA. Translation: BAB27744.3 .
    BC094383 mRNA. Translation: AAH94383.1 .
    CCDSi CCDS17390.1. [Q52KE7-1 ]
    RefSeqi NP_064321.2. NM_019937.3. [Q52KE7-1 ]
    UniGenei Mm.175612.

    3D structure databases

    ProteinModelPortali Q52KE7.
    SMRi Q52KE7. Positions 70-299.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q52KE7. 1 interaction.
    MINTi MINT-4131139.

    PTM databases

    PhosphoSitei Q52KE7.

    Proteomic databases

    MaxQBi Q52KE7.
    PaxDbi Q52KE7.
    PRIDEi Q52KE7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029416 ; ENSMUSP00000029416 ; ENSMUSG00000027829 . [Q52KE7-1 ]
    GeneIDi 56706.
    KEGGi mmu:56706.
    UCSCi uc008pku.1. mouse. [Q52KE7-1 ]
    uc008pkx.1. mouse. [Q52KE7-2 ]

    Organism-specific databases

    CTDi 57018.
    MGIi MGI:1922664. Ccnl1.

    Phylogenomic databases

    eggNOGi COG5333.
    GeneTreei ENSGT00690000101911.
    HOGENOMi HOG000231292.
    HOVERGENi HBG056044.
    InParanoidi Q52KE7.
    OMAi FERSHKG.
    OrthoDBi EOG7K9K34.
    PhylomeDBi Q52KE7.
    TreeFami TF101011.

    Miscellaneous databases

    NextBioi 313159.
    PROi Q52KE7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q52KE7.
    Bgeei Q52KE7.
    CleanExi MM_CCNL1.
    Genevestigatori Q52KE7.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    InterProi IPR013763. Cyclin-like.
    IPR015429. Cyclin_C/H/T/L.
    IPR017060. Cyclin_L.
    IPR015431. Cyclin_L1_chr.
    IPR006671. Cyclin_N.
    [Graphical view ]
    PANTHERi PTHR10026. PTHR10026. 1 hit.
    PTHR10026:SF64. PTHR10026:SF64. 1 hit.
    Pfami PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036580. Cyclin_L. 1 hit.
    SMARTi SM00385. CYCLIN. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin."
      Berke J.D., Sgambato V., Zhu P.-P., Lavoie B., Vincent M., Krause M., Hyman S.E.
      Neuron 32:277-287(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
      Strain: BALB/c and C57BL/6.
      Tissue: Testis.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-309 (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Embryo and Spinal ganglion.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Eye.
    4. "CDK13/CDC2L5 interacts with L-type cyclins and regulates alternative splicing."
      Chen H.H., Wong Y.H., Geneviere A.M., Fann M.J.
      Biochem. Biophys. Res. Commun. 354:735-740(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CDK13.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-358 AND SER-361, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiCCNL1_MOUSE
    AccessioniPrimary (citable) accession number: Q52KE7
    Secondary accession number(s): Q8BQ75
    , Q8R5H9, Q922K0, Q9CSZ3, Q9WV44
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3