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Q52I78

- NAMPT_PIG

UniProt

Q52I78 - NAMPT_PIG

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Protein
Nicotinamide phosphoribosyltransferase
Gene
NAMPT, PBEF1
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function By similarity.

Catalytic activityi

Nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei196 – 1961Diphosphate By similarity
Binding sitei219 – 2191Nicotinamide ribonucleotide By similarity
Binding sitei247 – 2471Diphosphate By similarity
Binding sitei311 – 3111Diphosphate By similarity
Binding sitei384 – 3841Nicotinamide ribonucleotide; via amide nitrogen By similarity
Binding sitei392 – 3921Nicotinamide ribonucleotide By similarity

GO - Molecular functioni

  1. nicotinamide phosphoribosyltransferase activity Source: UniProtKB-EC
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Glycosyltransferase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

ReactomeiREACT_212440. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
REACT_221141. Nicotinamide salvaging.
UniPathwayiUPA00253; UER00890.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinamide phosphoribosyltransferase (EC:2.4.2.12)
Short name:
NAmPRTase
Short name:
Nampt
Alternative name(s):
Pre-B-cell colony-enhancing factor 1 homolog
Short name:
PBEF
Visfatin
Gene namesi
Name:NAMPT
Synonyms:PBEF1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 9

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity. Secreted By similarity
Note: Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular space Source: UniProtKB-KW
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Nicotinamide phosphoribosyltransferase
PRO_0000205865Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ52I78.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000016366.

Structurei

3D structure databases

ProteinModelPortaliQ52I78.
SMRiQ52I78. Positions 8-483.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni311 – 3133Nicotinamide ribonucleotide binding By similarity
Regioni353 – 3542Nicotinamide ribonucleotide binding By similarity

Sequence similaritiesi

Belongs to the NAPRTase family.

Phylogenomic databases

eggNOGiCOG1488.
GeneTreeiENSGT00390000006647.
HOGENOMiHOG000216546.
HOVERGENiHBG000336.
KOiK03462.
OMAiKKFPITE.
OrthoDBiEOG7PGDQH.
TreeFamiTF333530.

Family and domain databases

InterProiIPR007229. Nic_PRibTrfase-Fam.
IPR016471. Nicotinamide_PRibTrfase.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PTHR11098:SF2. PTHR11098:SF2. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF005943. NMPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.

Sequencei

Sequence statusi: Complete.

Q52I78-1 [UniParc]FASTAAdd to Basket

« Hide

MNAAAEAEFN ILLATDSYKV THYKQYPPNT SKVYSYFECR EKKTENSKIR    50
KVKYEETVFY GLQYILNKYL KGKVVTKEKI QEAKEVYKEH FQDDVFNEKG 100
WNYILEKYDG HLPIEVKAVP EGSVIPRGNV LFTVENTDPE CYWLTNWIET 150
ILVQSWYPIT VATNSREQKK ILAKYLLETS GNLDGLEYKL HDFGYRGVSS 200
QETAGIGASA HLVNFKGTDT VAGIALIKKY YGTKDPVPGY SVPAAEHSTI 250
TAWGKDHEKD AFEHIVTQFS SVPVSVVSDS YDIYNACEKI WGEDLRHLIV 300
SRSTEAPLII RPDSGNPLDT VLKVLDILGK KFPVTENSKG YKLLPPYLRV 350
IQGDGVDINT LQEIVEGMKQ KKWSIENIAF GSGGALLQKL TRDLLNCSFK 400
CSYVVTNGLG INVFKDPVAD PNKRSKKGRL SLHRTPGGNF VTLEEGKGDL 450
EEYGHDLLHT VFKNGKVTKS YSFDEVRKNA QLNIELEAAP H 491
Length:491
Mass (Da):55,374
Last modified:January 24, 2006 - v2
Checksum:iEC9CF05026B4793E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ020218 mRNA. Translation: AAY89036.1.
DQ001974 mRNA. Translation: AAY18209.2.
RefSeqiNP_001026963.1. NM_001031793.2.
XP_005667778.1. XM_005667721.1.
UniGeneiSsc.22083.

Genome annotation databases

EnsembliENSSSCT00000016815; ENSSSCP00000016366; ENSSSCG00000015435.
GeneIDi595123.
KEGGissc:595123.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ020218 mRNA. Translation: AAY89036.1 .
DQ001974 mRNA. Translation: AAY18209.2 .
RefSeqi NP_001026963.1. NM_001031793.2.
XP_005667778.1. XM_005667721.1.
UniGenei Ssc.22083.

3D structure databases

ProteinModelPortali Q52I78.
SMRi Q52I78. Positions 8-483.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000016366.

Proteomic databases

PRIDEi Q52I78.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000016815 ; ENSSSCP00000016366 ; ENSSSCG00000015435 .
GeneIDi 595123.
KEGGi ssc:595123.

Organism-specific databases

CTDi 10135.

Phylogenomic databases

eggNOGi COG1488.
GeneTreei ENSGT00390000006647.
HOGENOMi HOG000216546.
HOVERGENi HBG000336.
KOi K03462.
OMAi KKFPITE.
OrthoDBi EOG7PGDQH.
TreeFami TF333530.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00890 .
Reactomei REACT_212440. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
REACT_221141. Nicotinamide salvaging.

Family and domain databases

InterProi IPR007229. Nic_PRibTrfase-Fam.
IPR016471. Nicotinamide_PRibTrfase.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
PTHR11098:SF2. PTHR11098:SF2. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF005943. NMPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of porcine visfatin."
    Liu B.-H., Ding S.-T.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Chen H., Yang Z.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiNAMPT_PIG
AccessioniPrimary (citable) accession number: Q52I78
Secondary accession number(s): Q3I6K8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: January 24, 2006
Last modified: September 3, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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