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Q52915 (CYA2_RHIME) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenylate cyclase 2

EC=4.6.1.1
Alternative name(s):
ATP pyrophosphate-lyase 2
Adenylyl cyclase 2
Gene names
Name:cya2
Ordered Locus Names:R01190
ORF Names:SMc00621
OrganismRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) [Complete proteome] [HAMAP]
Taxonomic identifier266834 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.

Catalytic activity

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Sequence similarities

Belongs to the adenylyl cyclase class-3 family.

Contains 1 guanylate cyclase domain.

Ontologies

Keywords
   Biological processcAMP biosynthesis
   LigandATP-binding
Magnesium
Metal-binding
Nucleotide-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processintracellular signal transduction

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

adenylate cyclase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363Adenylate cyclase 2
PRO_0000195745

Regions

Domain157 – 286130Guanylate cyclase

Sites

Metal binding1621Magnesium By similarity
Metal binding2061Magnesium By similarity

Experimental info

Sequence conflict1791Q → H in CAA56916. Ref.1
Sequence conflict3021L → R in CAA56916. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q52915 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: 486A0B0C43378E37

FASTA36339,902
        10         20         30         40         50         60 
MRWRFSTLEI ILLLLVVAGS GMAYAWVVYG GGGLIGATYA LFMCMPILAF ERHIIFRRLY 

        70         80         90        100        110        120 
RRIHGSPTPA FLLSSLAVYF IFVNVGYAAA GLLLHVAGVM RESRTDAMLP SLNVLVYALA 

       130        140        150        160        170        180 
TSGPIIFVLR VRELLGRDVF LSLLTGRYRK PVQEERVFLF IDLAGSTSLA ERFGDLRMQE 

       190        200        210        220        230        240 
YLGKLFAAMA DPVLRYGGSI DDYVGDAAVI TWPYDRAVAD AACIRCVFDI LEQIEADAHR 

       250        260        270        280        290        300 
WQKDYGEVPR LRAALHGGTI VAAEIGVDKH KITYFGDTVN TTARLEGLCR TLNRQVLISA 

       310        320        330        340        350        360 
DLLRRLRPPV FVRAEDLGEH EVKGRGQKLA VLSLTAGSLS GDGATEPAGE TVRSPAAEAF 


TSL 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of the second adenylate cyclase gene (cya2) from Rhizobium meliloti F34: sequence similarity to eukaryotic cyclases."
Archdeacon J., Talty J., Boesten B., Danchin A., O'Gara F.
FEMS Microbiol. Lett. 128:177-184(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: F34.
[2]"Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021."
Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J., Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S., Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D. expand/collapse author list , Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F.
Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1021.
[3]"The composite genome of the legume symbiont Sinorhizobium meliloti."
Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F., Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G., Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P., Cowie A. expand/collapse author list , Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S., Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I., Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S., Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C., Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R., Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H., Wong K., Yeh K.-C., Batut J.
Science 293:668-672(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1021.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X80991 Genomic DNA. Translation: CAA56916.1.
AL591688 Genomic DNA. Translation: CAC45769.1.
PIRS60684.
RefSeqNP_385296.1. NC_003047.1.

3D structure databases

ProteinModelPortalQ52915.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266834.SMc00621.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC45769; CAC45769; SMc00621.
GeneID1232834.
KEGGsme:SMc00621.
PATRIC23631681. VBISinMel96828_2601.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2114.
HOGENOMHOG000295398.
KOK01768.
OMARYHRPVE.
OrthoDBEOG6NSGCV.

Enzyme and pathway databases

BioCycRETL1328306-WGS:GSTH-1507-MONOMER.
SMEL266834:GJF6-1216-MONOMER.

Family and domain databases

Gene3D3.30.70.1230. 1 hit.
InterProIPR001054. A/G_cyclase.
[Graphical view]
PfamPF00211. Guanylate_cyc. 1 hit.
[Graphical view]
SMARTSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMSSF55073. SSF55073. 1 hit.
PROSITEPS50125. GUANYLATE_CYCLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYA2_RHIME
AccessionPrimary (citable) accession number: Q52915
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: July 9, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families