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Q52915

- CYA2_RHIME

UniProt

Q52915 - CYA2_RHIME

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Protein

Adenylate cyclase 2

Gene

cya2

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Binds 1 magnesium ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi162 – 1621MagnesiumBy similarity
Metal bindingi206 – 2061MagnesiumBy similarity

GO - Molecular functioni

  1. adenylate cyclase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-1507-MONOMER.
SMEL266834:GJF6-1216-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase 2 (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase 2
Adenylyl cyclase 2
Gene namesi
Name:cya2
Ordered Locus Names:R01190
ORF Names:SMc00621
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Adenylate cyclase 2PRO_0000195745Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266834.SMc00621.

Structurei

3D structure databases

ProteinModelPortaliQ52915.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini157 – 286130Guanylate cyclasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the adenylyl cyclase class-3 family.Curated
Contains 1 guanylate cyclase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2114.
HOGENOMiHOG000295398.
KOiK01768.
OMAiRYHRPVE.
OrthoDBiEOG6NSGCV.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 1 hit.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q52915-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRWRFSTLEI ILLLLVVAGS GMAYAWVVYG GGGLIGATYA LFMCMPILAF
60 70 80 90 100
ERHIIFRRLY RRIHGSPTPA FLLSSLAVYF IFVNVGYAAA GLLLHVAGVM
110 120 130 140 150
RESRTDAMLP SLNVLVYALA TSGPIIFVLR VRELLGRDVF LSLLTGRYRK
160 170 180 190 200
PVQEERVFLF IDLAGSTSLA ERFGDLRMQE YLGKLFAAMA DPVLRYGGSI
210 220 230 240 250
DDYVGDAAVI TWPYDRAVAD AACIRCVFDI LEQIEADAHR WQKDYGEVPR
260 270 280 290 300
LRAALHGGTI VAAEIGVDKH KITYFGDTVN TTARLEGLCR TLNRQVLISA
310 320 330 340 350
DLLRRLRPPV FVRAEDLGEH EVKGRGQKLA VLSLTAGSLS GDGATEPAGE
360
TVRSPAAEAF TSL
Length:363
Mass (Da):39,902
Last modified:May 30, 2000 - v2
Checksum:i486A0B0C43378E37
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti179 – 1791Q → H in CAA56916. (PubMed:7750735)Curated
Sequence conflicti302 – 3021L → R in CAA56916. (PubMed:7750735)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80991 Genomic DNA. Translation: CAA56916.1.
AL591688 Genomic DNA. Translation: CAC45769.1.
PIRiS60684.
RefSeqiNP_385296.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC45769; CAC45769; SMc00621.
GeneIDi1232834.
KEGGisme:SMc00621.
PATRICi23631681. VBISinMel96828_2601.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80991 Genomic DNA. Translation: CAA56916.1 .
AL591688 Genomic DNA. Translation: CAC45769.1 .
PIRi S60684.
RefSeqi NP_385296.1. NC_003047.1.

3D structure databases

ProteinModelPortali Q52915.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266834.SMc00621.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC45769 ; CAC45769 ; SMc00621 .
GeneIDi 1232834.
KEGGi sme:SMc00621.
PATRICi 23631681. VBISinMel96828_2601.

Phylogenomic databases

eggNOGi COG2114.
HOGENOMi HOG000295398.
KOi K01768.
OMAi RYHRPVE.
OrthoDBi EOG6NSGCV.

Enzyme and pathway databases

BioCyci RETL1328306-WGS:GSTH-1507-MONOMER.
SMEL266834:GJF6-1216-MONOMER.

Family and domain databases

Gene3Di 3.30.70.1230. 1 hit.
InterProi IPR001054. A/G_cyclase.
IPR029787. Nucleotide_cyclase.
[Graphical view ]
Pfami PF00211. Guanylate_cyc. 1 hit.
[Graphical view ]
SMARTi SM00044. CYCc. 1 hit.
[Graphical view ]
SUPFAMi SSF55073. SSF55073. 1 hit.
PROSITEi PS50125. GUANYLATE_CYCLASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the second adenylate cyclase gene (cya2) from Rhizobium meliloti F34: sequence similarity to eukaryotic cyclases."
    Archdeacon J., Talty J., Boesten B., Danchin A., O'Gara F.
    FEMS Microbiol. Lett. 128:177-184(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: F34.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiCYA2_RHIME
AccessioniPrimary (citable) accession number: Q52915
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: October 29, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3