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Q52915

- CYA2_RHIME

UniProt

Q52915 - CYA2_RHIME

Protein

Adenylate cyclase 2

Gene

cya2

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.

    Catalytic activityi

    ATP = 3',5'-cyclic AMP + diphosphate.

    Cofactori

    Binds 1 magnesium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi162 – 1621MagnesiumBy similarity
    Metal bindingi206 – 2061MagnesiumBy similarity

    GO - Molecular functioni

    1. adenylate cyclase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    cAMP biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-1507-MONOMER.
    SMEL266834:GJF6-1216-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate cyclase 2 (EC:4.6.1.1)
    Alternative name(s):
    ATP pyrophosphate-lyase 2
    Adenylyl cyclase 2
    Gene namesi
    Name:cya2
    Ordered Locus Names:R01190
    ORF Names:SMc00621
    OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
    Taxonomic identifieri266834 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001976: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 363363Adenylate cyclase 2PRO_0000195745Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266834.SMc00621.

    Structurei

    3D structure databases

    ProteinModelPortaliQ52915.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini157 – 286130Guanylate cyclasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-3 family.Curated
    Contains 1 guanylate cyclase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2114.
    HOGENOMiHOG000295398.
    KOiK01768.
    OMAiRYHRPVE.
    OrthoDBiEOG6NSGCV.

    Family and domain databases

    Gene3Di3.30.70.1230. 1 hit.
    InterProiIPR001054. A/G_cyclase.
    [Graphical view]
    PfamiPF00211. Guanylate_cyc. 1 hit.
    [Graphical view]
    SMARTiSM00044. CYCc. 1 hit.
    [Graphical view]
    SUPFAMiSSF55073. SSF55073. 1 hit.
    PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q52915-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRWRFSTLEI ILLLLVVAGS GMAYAWVVYG GGGLIGATYA LFMCMPILAF    50
    ERHIIFRRLY RRIHGSPTPA FLLSSLAVYF IFVNVGYAAA GLLLHVAGVM 100
    RESRTDAMLP SLNVLVYALA TSGPIIFVLR VRELLGRDVF LSLLTGRYRK 150
    PVQEERVFLF IDLAGSTSLA ERFGDLRMQE YLGKLFAAMA DPVLRYGGSI 200
    DDYVGDAAVI TWPYDRAVAD AACIRCVFDI LEQIEADAHR WQKDYGEVPR 250
    LRAALHGGTI VAAEIGVDKH KITYFGDTVN TTARLEGLCR TLNRQVLISA 300
    DLLRRLRPPV FVRAEDLGEH EVKGRGQKLA VLSLTAGSLS GDGATEPAGE 350
    TVRSPAAEAF TSL 363
    Length:363
    Mass (Da):39,902
    Last modified:May 30, 2000 - v2
    Checksum:i486A0B0C43378E37
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti179 – 1791Q → H in CAA56916. (PubMed:7750735)Curated
    Sequence conflicti302 – 3021L → R in CAA56916. (PubMed:7750735)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80991 Genomic DNA. Translation: CAA56916.1.
    AL591688 Genomic DNA. Translation: CAC45769.1.
    PIRiS60684.
    RefSeqiNP_385296.1. NC_003047.1.

    Genome annotation databases

    EnsemblBacteriaiCAC45769; CAC45769; SMc00621.
    GeneIDi1232834.
    KEGGisme:SMc00621.
    PATRICi23631681. VBISinMel96828_2601.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80991 Genomic DNA. Translation: CAA56916.1 .
    AL591688 Genomic DNA. Translation: CAC45769.1 .
    PIRi S60684.
    RefSeqi NP_385296.1. NC_003047.1.

    3D structure databases

    ProteinModelPortali Q52915.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266834.SMc00621.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC45769 ; CAC45769 ; SMc00621 .
    GeneIDi 1232834.
    KEGGi sme:SMc00621.
    PATRICi 23631681. VBISinMel96828_2601.

    Phylogenomic databases

    eggNOGi COG2114.
    HOGENOMi HOG000295398.
    KOi K01768.
    OMAi RYHRPVE.
    OrthoDBi EOG6NSGCV.

    Enzyme and pathway databases

    BioCyci RETL1328306-WGS:GSTH-1507-MONOMER.
    SMEL266834:GJF6-1216-MONOMER.

    Family and domain databases

    Gene3Di 3.30.70.1230. 1 hit.
    InterProi IPR001054. A/G_cyclase.
    [Graphical view ]
    Pfami PF00211. Guanylate_cyc. 1 hit.
    [Graphical view ]
    SMARTi SM00044. CYCc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55073. SSF55073. 1 hit.
    PROSITEi PS50125. GUANYLATE_CYCLASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the second adenylate cyclase gene (cya2) from Rhizobium meliloti F34: sequence similarity to eukaryotic cyclases."
      Archdeacon J., Talty J., Boesten B., Danchin A., O'Gara F.
      FEMS Microbiol. Lett. 128:177-184(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: F34.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.

    Entry informationi

    Entry nameiCYA2_RHIME
    AccessioniPrimary (citable) accession number: Q52915
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3