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Protein

Adenylate cyclase 2

Gene

cya2

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi162 – 1621MagnesiumBy similarity
Metal bindingi206 – 2061MagnesiumBy similarity

GO - Molecular functioni

  1. adenylate cyclase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-1507-MONOMER.
SMEL266834:GJF6-1216-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase 2 (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase 2
Adenylyl cyclase 2
Gene namesi
Name:cya2
Ordered Locus Names:R01190
ORF Names:SMc00621
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Adenylate cyclase 2PRO_0000195745Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266834.SMc00621.

Structurei

3D structure databases

ProteinModelPortaliQ52915.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini157 – 286130Guanylate cyclasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the adenylyl cyclase class-3 family.Curated
Contains 1 guanylate cyclase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2114.
HOGENOMiHOG000295398.
KOiK01768.
OMAiRYHRPVE.
OrthoDBiEOG6NSGCV.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 1 hit.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q52915-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRWRFSTLEI ILLLLVVAGS GMAYAWVVYG GGGLIGATYA LFMCMPILAF
60 70 80 90 100
ERHIIFRRLY RRIHGSPTPA FLLSSLAVYF IFVNVGYAAA GLLLHVAGVM
110 120 130 140 150
RESRTDAMLP SLNVLVYALA TSGPIIFVLR VRELLGRDVF LSLLTGRYRK
160 170 180 190 200
PVQEERVFLF IDLAGSTSLA ERFGDLRMQE YLGKLFAAMA DPVLRYGGSI
210 220 230 240 250
DDYVGDAAVI TWPYDRAVAD AACIRCVFDI LEQIEADAHR WQKDYGEVPR
260 270 280 290 300
LRAALHGGTI VAAEIGVDKH KITYFGDTVN TTARLEGLCR TLNRQVLISA
310 320 330 340 350
DLLRRLRPPV FVRAEDLGEH EVKGRGQKLA VLSLTAGSLS GDGATEPAGE
360
TVRSPAAEAF TSL
Length:363
Mass (Da):39,902
Last modified:May 30, 2000 - v2
Checksum:i486A0B0C43378E37
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti179 – 1791Q → H in CAA56916 (PubMed:7750735).Curated
Sequence conflicti302 – 3021L → R in CAA56916 (PubMed:7750735).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80991 Genomic DNA. Translation: CAA56916.1.
AL591688 Genomic DNA. Translation: CAC45769.1.
PIRiS60684.
RefSeqiNP_385296.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC45769; CAC45769; SMc00621.
GeneIDi1232834.
KEGGisme:SMc00621.
PATRICi23631681. VBISinMel96828_2601.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80991 Genomic DNA. Translation: CAA56916.1.
AL591688 Genomic DNA. Translation: CAC45769.1.
PIRiS60684.
RefSeqiNP_385296.1. NC_003047.1.

3D structure databases

ProteinModelPortaliQ52915.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266834.SMc00621.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC45769; CAC45769; SMc00621.
GeneIDi1232834.
KEGGisme:SMc00621.
PATRICi23631681. VBISinMel96828_2601.

Phylogenomic databases

eggNOGiCOG2114.
HOGENOMiHOG000295398.
KOiK01768.
OMAiRYHRPVE.
OrthoDBiEOG6NSGCV.

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-1507-MONOMER.
SMEL266834:GJF6-1216-MONOMER.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 1 hit.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the second adenylate cyclase gene (cya2) from Rhizobium meliloti F34: sequence similarity to eukaryotic cyclases."
    Archdeacon J., Talty J., Boesten B., Danchin A., O'Gara F.
    FEMS Microbiol. Lett. 128:177-184(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: F34.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiCYA2_RHIME
AccessioniPrimary (citable) accession number: Q52915
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: January 7, 2015
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.