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Protein

Probable periplasmic serine endoprotease DegP-like

Gene

degP1

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Might be efficient in the degradation of transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions.By similarity

Catalytic activityi

Acts on substrates that are at least partially unfolded. The cleavage site P1 residue is normally between a pair of hydrophobic residues, such as Val-|-Val.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei140Charge relay systemSequence analysis1
Active sitei170Charge relay systemSequence analysis1
Active sitei244Charge relay systemSequence analysis1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Probable periplasmic serine endoprotease DegP-like (EC:3.4.21.107)
Alternative name(s):
Protease Do
Gene namesi
Name:degP1
Synonyms:degP
Ordered Locus Names:R01021
ORF Names:SMc02365
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000002693327 – 504Probable periplasmic serine endoprotease DegP-likeAdd BLAST478

Interactioni

Protein-protein interaction databases

STRINGi266834.SMc02365.

Structurei

3D structure databases

ProteinModelPortaliQ52894.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini287 – 378PDZ 1PROSITE-ProRule annotationAdd BLAST92
Domaini401 – 491PDZ 2PROSITE-ProRule annotationAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni113 – 286Serine proteaseAdd BLAST174
Regioni242 – 244Substrate bindingBy similarity3
Regioni299 – 303Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the peptidase S1C family.Curated
Contains 2 PDZ (DHR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG4105C0H. Bacteria.
COG0265. LUCA.
HOGENOMiHOG000223640.
KOiK04771.
OMAiVEISLWR.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR001478. PDZ.
IPR011782. Pept_S1C_Do.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
[Graphical view]
PfamiPF13180. PDZ_2. 2 hits.
[Graphical view]
PRINTSiPR00834. PROTEASES2C.
SMARTiSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
SSF50494. SSF50494. 2 hits.
TIGRFAMsiTIGR02037. degP_htrA_DO. 1 hit.
PROSITEiPS50106. PDZ. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q52894-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKTTTVAGL AAVLLTTGLP AEVAQSFAEA VRVQAPAVPS FANVVDAVSP
60 70 80 90 100
AVVSVRVQAR ERVSDDESNF TFDFGGRGFE DLPEDHPLRR FFREFAPREN
110 120 130 140 150
DRADRWRDRR GPRGEGRLRP RAQGSGFFIT EDGYLVTNNH VVSDGSAFTV
160 170 180 190 200
IMNDGTELDA KLVGKDSRTD LAVLKVDDKR KFTYVSFADD EKVRVGDWVV
210 220 230 240 250
AVGNPFGLGG TVTAGIISAR GRDIGSGPYD DYLQVDAAVN RGNSGGPTFN
260 270 280 290 300
LSGEVVGINT AIFSPSGGNV GIAFAIPASV AKDVVDSLIK DGTVSRGWLG
310 320 330 340 350
VQIQPVTKDI AESLGLSEAN GALVVEPQAG SPGEKAGIKN GDVVTALNGE
360 370 380 390 400
PVKDPRDLAR RVAALRPGST AEVTLWRSGK SETVNLEIGT LPSDAKEPAP
410 420 430 440 450
ATGEAQPDEG QAGEEALADL GLTVTPSEDG KGVTIASVDP DSDAGDRGLK
460 470 480 490 500
EGEKIVSVNN QEVKSADDVL KVINNAKKDG RSKALFQIEA QEGSRFVALP

ITQG
Length:504
Mass (Da):53,035
Last modified:May 30, 2000 - v2
Checksum:iD7E82BB9981EA23C
GO

Sequence cautioni

The sequence AAC43669 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14 – 15LL → PV in AAC43669 (PubMed:8550509).Curated2
Sequence conflicti39 – 147PSFAN…SDGSA → AVSPMWSTPFRRRSSPSACR HVNASATMKATSPSISAAAG SRTCRKTIRCGVSSANSLRV KMTVPIVGATAAVRVAKVVS VRGRKAPASSSPKTVTSSPT TTSSPTART in AAC43669 (PubMed:8550509).CuratedAdd BLAST109
Sequence conflicti464 – 504KSADD…PITQG → NRQTTFSR in AAC43669 (PubMed:8550509).CuratedAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31512 Genomic DNA. Translation: AAC43669.1. Different initiation.
AL591688 Genomic DNA. Translation: CAC45593.1.
RefSeqiNP_385127.1. NC_003047.1.
WP_010968991.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC45593; CAC45593; SMc02365.
GeneIDi1232664.
KEGGisme:SMc02365.
PATRICi23631329. VBISinMel96828_2426.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31512 Genomic DNA. Translation: AAC43669.1. Different initiation.
AL591688 Genomic DNA. Translation: CAC45593.1.
RefSeqiNP_385127.1. NC_003047.1.
WP_010968991.1. NC_003047.1.

3D structure databases

ProteinModelPortaliQ52894.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266834.SMc02365.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC45593; CAC45593; SMc02365.
GeneIDi1232664.
KEGGisme:SMc02365.
PATRICi23631329. VBISinMel96828_2426.

Phylogenomic databases

eggNOGiENOG4105C0H. Bacteria.
COG0265. LUCA.
HOGENOMiHOG000223640.
KOiK04771.
OMAiVEISLWR.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR001478. PDZ.
IPR011782. Pept_S1C_Do.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
[Graphical view]
PfamiPF13180. PDZ_2. 2 hits.
[Graphical view]
PRINTSiPR00834. PROTEASES2C.
SMARTiSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
SSF50494. SSF50494. 2 hits.
TIGRFAMsiTIGR02037. degP_htrA_DO. 1 hit.
PROSITEiPS50106. PDZ. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEGPL_RHIME
AccessioniPrimary (citable) accession number: Q52894
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 2, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.