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Protein

Probable periplasmic serine endoprotease DegP-like

Gene

degP1

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Might be efficient in the degradation of transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions.By similarity

Catalytic activityi

Acts on substrates that are at least partially unfolded. The cleavage site P1 residue is normally between a pair of hydrophobic residues, such as Val-|-Val.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei140Charge relay systemSequence analysis1
Active sitei170Charge relay systemSequence analysis1
Active sitei244Charge relay systemSequence analysis1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
Probable periplasmic serine endoprotease DegP-like (EC:3.4.21.107)
Alternative name(s):
Protease Do
Gene namesi
Name:degP1
Synonyms:degP
Ordered Locus Names:R01021
ORF Names:SMc02365
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000002693327 – 504Probable periplasmic serine endoprotease DegP-likeAdd BLAST478

Interactioni

Protein-protein interaction databases

STRINGi266834.SMc02365

Structurei

3D structure databases

ProteinModelPortaliQ52894
SMRiQ52894
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini287 – 378PDZ 1PROSITE-ProRule annotationAdd BLAST92
Domaini401 – 491PDZ 2PROSITE-ProRule annotationAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni113 – 286Serine proteaseAdd BLAST174
Regioni242 – 244Substrate bindingBy similarity3
Regioni299 – 303Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the peptidase S1C family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG4105C0H Bacteria
COG0265 LUCA
HOGENOMiHOG000223640
KOiK04771
OMAiQAQPFEG

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011782 Pept_S1C_Do
IPR009003 Peptidase_S1_PA
IPR001940 Peptidase_S1C
PfamiView protein in Pfam
PF13180 PDZ_2, 2 hits
PRINTSiPR00834 PROTEASES2C
SMARTiView protein in SMART
SM00228 PDZ, 2 hits
SUPFAMiSSF50156 SSF50156, 2 hits
SSF50494 SSF50494, 2 hits
TIGRFAMsiTIGR02037 degP_htrA_DO, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q52894-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKTTTVAGL AAVLLTTGLP AEVAQSFAEA VRVQAPAVPS FANVVDAVSP
60 70 80 90 100
AVVSVRVQAR ERVSDDESNF TFDFGGRGFE DLPEDHPLRR FFREFAPREN
110 120 130 140 150
DRADRWRDRR GPRGEGRLRP RAQGSGFFIT EDGYLVTNNH VVSDGSAFTV
160 170 180 190 200
IMNDGTELDA KLVGKDSRTD LAVLKVDDKR KFTYVSFADD EKVRVGDWVV
210 220 230 240 250
AVGNPFGLGG TVTAGIISAR GRDIGSGPYD DYLQVDAAVN RGNSGGPTFN
260 270 280 290 300
LSGEVVGINT AIFSPSGGNV GIAFAIPASV AKDVVDSLIK DGTVSRGWLG
310 320 330 340 350
VQIQPVTKDI AESLGLSEAN GALVVEPQAG SPGEKAGIKN GDVVTALNGE
360 370 380 390 400
PVKDPRDLAR RVAALRPGST AEVTLWRSGK SETVNLEIGT LPSDAKEPAP
410 420 430 440 450
ATGEAQPDEG QAGEEALADL GLTVTPSEDG KGVTIASVDP DSDAGDRGLK
460 470 480 490 500
EGEKIVSVNN QEVKSADDVL KVINNAKKDG RSKALFQIEA QEGSRFVALP

ITQG
Length:504
Mass (Da):53,035
Last modified:May 30, 2000 - v2
Checksum:iD7E82BB9981EA23C
GO

Sequence cautioni

The sequence AAC43669 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14 – 15LL → PV in AAC43669 (PubMed:8550509).Curated2
Sequence conflicti39 – 147PSFAN…SDGSA → AVSPMWSTPFRRRSSPSACR HVNASATMKATSPSISAAAG SRTCRKTIRCGVSSANSLRV KMTVPIVGATAAVRVAKVVS VRGRKAPASSSPKTVTSSPT TTSSPTART in AAC43669 (PubMed:8550509).CuratedAdd BLAST109
Sequence conflicti464 – 504KSADD…PITQG → NRQTTFSR in AAC43669 (PubMed:8550509).CuratedAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31512 Genomic DNA Translation: AAC43669.1 Different initiation.
AL591688 Genomic DNA Translation: CAC45593.1
RefSeqiNP_385127.1, NC_003047.1
WP_010968991.1, NC_003047.1

Genome annotation databases

EnsemblBacteriaiCAC45593; CAC45593; SMc02365
GeneIDi1232664
KEGGisme:SMc02365
PATRICifig|266834.11.peg.2426

Similar proteinsi

Entry informationi

Entry nameiDEGPL_RHIME
AccessioniPrimary (citable) accession number: Q52894
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: March 28, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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