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Protein

Cbb3-type cytochrome c oxidase subunit CcoP

Gene

ccoP

Organism
Rhodobacter capsulatus (Rhodopseudomonas capsulata)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex. CcoP subunit is required for transferring electrons from donor cytochrome c via its heme groups to CcoO subunit. From there, electrons are shuttled to the catalytic binuclear center of CcoN subunit where oxygen reduction takes place. The complex also functions as a proton pump.2 PublicationsBy similarity2 Publications

Cofactori

heme cBy similarityNote: Binds 2 heme C groups per subunit.By similarity

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.2 Publications
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei121 – 1211Heme C 1 (covalent)By similarity
Binding sitei124 – 1241Heme C 1 (covalent)By similarity
Metal bindingi125 – 1251Iron (heme C 1 axial ligand)By similarity
Metal bindingi174 – 1741Iron (heme C 2 axial ligand)By similarity
Binding sitei219 – 2191Heme C 2 (covalent)By similarity
Binding sitei222 – 2221Heme C 2 (covalent)By similarity
Metal bindingi223 – 2231Iron (heme C 2 axial ligand)By similarity
Metal bindingi264 – 2641Iron (heme C 1 axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cbb3-type cytochrome c oxidase subunit CcoP2 Publications
Short name:
Cbb3-Cox subunit CcoP1 Publication
Alternative name(s):
C-type cytochrome CcoP2 Publications
Short name:
Cyt c(P)By similarity
Cytochrome c oxidase subunit IIIBy similarity
Gene namesi
Name:ccoPImported
OrganismiRhodobacter capsulatus (Rhodopseudomonas capsulata)
Taxonomic identifieri1061 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Subcellular locationi

  • Cell inner membrane Sequence analysisBy similarity; Single-pass membrane protein Sequence analysisBy similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535CytoplasmicSequence analysisBy similarityAdd
BLAST
Transmembranei36 – 5621HelicalSequence analysisAdd
BLAST
Topological domaini57 – 297241PeriplasmicSequence analysisBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Cbb3-type cytochrome c oxidase subunit CcoPPRO_0000412291Add
BLAST

Interactioni

Subunit structurei

Component of the cbb3-type cytochrome c oxidase at least composed of CcoN, CcoO, CcoQ and CcoP. Interacts with CcoQ.2 Publications

Protein-protein interaction databases

IntActiQ52689. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ52689.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini108 – 19992Cytochrome c 1PROSITE-ProRule annotationAdd
BLAST
Domaini206 – 29489Cytochrome c 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CcoP / FixP family.Curated
Contains 2 cytochrome c domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.760.10. 3 hits.
InterProiIPR032858. CcoP_N.
IPR009056. Cyt_c-like_dom.
IPR004678. Cyt_c_oxidase_cbb3_su3.
[Graphical view]
PfamiPF13442. Cytochrome_CBB3. 2 hits.
PF14715. FixP_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000006. Cbb3-Cox_fixP. 1 hit.
SUPFAMiSSF46626. SSF46626. 3 hits.
TIGRFAMsiTIGR00782. ccoP. 1 hit.
PROSITEiPS51007. CYTC. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q52689-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKPTTKKE VQTTGHQWDG IEELNTPLPR WWLWTFYATI IWGVAYSIAM
60 70 80 90 100
PAWPIFSDKA TPGLLGSSTR ADVEKDIAKF AEMNKAVEEK LVATDLTAIA
110 120 130 140 150
ADPELVTYTR NAGAAVFRTW CAQCHGAGAG GNTGFPSLLD GDWLHGGAIE
160 170 180 190 200
TIYTNVKHGI RDPLDPDTLL VANMPAHLTD ELLEPAQIDE VVQYVLQISG
210 220 230 240 250
QPADEVKATA GQQIFAENCA SCHGEDAKGL VEMGAPNLTD GIWLYGGDVA
260 270 280 290
TLTSTIQYGR GGVMPSWSWA ADGAKPRLSE AQIRAVASYV HSLGGGQ
Length:297
Mass (Da):31,899
Last modified:November 1, 1996 - v1
Checksum:iD0FF60591E6FA869
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80134 Genomic DNA. Translation: CAA56436.1.
PIRiS65861. S49348.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80134 Genomic DNA. Translation: CAA56436.1.
PIRiS65861. S49348.

3D structure databases

ProteinModelPortaliQ52689.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ52689. 2 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

Gene3Di1.10.760.10. 3 hits.
InterProiIPR032858. CcoP_N.
IPR009056. Cyt_c-like_dom.
IPR004678. Cyt_c_oxidase_cbb3_su3.
[Graphical view]
PfamiPF13442. Cytochrome_CBB3. 2 hits.
PF14715. FixP_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000006. Cbb3-Cox_fixP. 1 hit.
SUPFAMiSSF46626. SSF46626. 3 hits.
TIGRFAMsiTIGR00782. ccoP. 1 hit.
PROSITEiPS51007. CYTC. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The ccoNOQP gene cluster codes for a cb-type cytochrome oxidase that functions in aerobic respiration of Rhodobacter capsulatus."
    Thony-Meyer L., Beck C., Preisig O., Hennecke H.
    Mol. Microbiol. 14:705-716(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DSM 938 / 37b4Imported.
  2. "Multi-step assembly pathway of the cbb3-type cytochrome c oxidase complex."
    Kulajta C., Thumfart J.O., Haid S., Daldal F., Koch H.G.
    J. Mol. Biol. 355:989-1004(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY OF THE CYTOCHROME C OXIDASE COMPLEX, SUBUNIT, IDENTIFICATION BY MASS SPECTROMETRY.
  3. "Stability of the cbb3-type cytochrome oxidase requires specific CcoQ-CcoP interactions."
    Peters A., Kulajta C., Pawlik G., Daldal F., Koch H.G.
    J. Bacteriol. 190:5576-5586(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY OF THE CYTOCHROME C OXIDASE COMPLEX, INTERACTION WITH CCOQ.

Entry informationi

Entry nameiCCOP_RHOCA
AccessioniPrimary (citable) accession number: Q52689
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: November 1, 1996
Last modified: January 20, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.