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Protein

Cytochrome c4

Gene

cc4

Organism
Pseudomonas stutzeri (Pseudomonas perfectomarina)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Diheme, high potential cytochrome c believed to be an intermediate electron donor to terminal oxidation systems.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341Heme 1 (covalent)
Binding sitei37 – 371Heme 1 (covalent)
Metal bindingi38 – 381Iron (heme 1 axial ligand)
Metal bindingi86 – 861Iron (heme 1 axial ligand)
Binding sitei139 – 1391Heme 2 (covalent)
Binding sitei142 – 1421Heme 2 (covalent)
Metal bindingi143 – 1431Iron (heme 2 axial ligand)
Metal bindingi187 – 1871Iron (heme 2 axial ligand)

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c4
Gene namesi
Name:cc4
OrganismiPseudomonas stutzeri (Pseudomonas perfectomarina)
Taxonomic identifieri316 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

Pathology & Biotechi

Chemistry

DrugBankiDB03754. Tris.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – 210190Cytochrome c4PRO_0000006509Add
BLAST

Post-translational modificationi

Binds 2 heme groups per subunit.

Interactioni

Protein-protein interaction databases

STRINGi379731.PST_4060.

Structurei

Secondary structure

1
210
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi24 – 285Combined sources
Helixi32 – 343Combined sources
Helixi35 – 384Combined sources
Helixi57 – 7115Combined sources
Helixi84 – 863Combined sources
Turni87 – 926Combined sources
Helixi95 – 10713Combined sources
Helixi117 – 12913Combined sources
Helixi132 – 1343Combined sources
Helixi140 – 1434Combined sources
Helixi151 – 1533Combined sources
Helixi163 – 17412Combined sources
Turni180 – 1845Combined sources
Helixi186 – 1916Combined sources
Helixi196 – 20712Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ETPX-ray2.20A/B21-210[»]
1M6ZX-ray1.35A/B/C/D21-210[»]
1M70X-ray1.25A/B/C/D21-210[»]
ProteinModelPortaliQ52369.
SMRiQ52369. Positions 21-210.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ52369.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4106RE7. Bacteria.
COG2863. LUCA.

Family and domain databases

Gene3Di1.10.760.10. 2 hits.
InterProiIPR009056. Cyt_c-like_dom.
IPR024167. Cytochrome_c4.
[Graphical view]
PfamiPF00034. Cytochrom_C. 2 hits.
[Graphical view]
PIRSFiPIRSF000005. Cytochrome_c4. 1 hit.
SUPFAMiSSF46626. SSF46626. 2 hits.
PROSITEiPS51007. CYTC. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q52369-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKVLVSLLL TLGITGMAHA AGDAEAGQGK VAVCGACHGV DGNSPAPNFP
60 70 80 90 100
KLAGQGERYL LKQLQDIKAG STPGAPEGVG RKVLEMTGML DPLSDQDLED
110 120 130 140 150
IAAYFSSQKG SVGYADPALA KQGEKLFRGG KLDQGMPACT GCHAPNGVGN
160 170 180 190 200
DLAGFPKLGG QHAAYTAKQL TDFREGNRTN DGDTMIMRGV AAKLSNKDIE
210
ALSSYIQGLH
Length:210
Mass (Da):21,742
Last modified:November 1, 1996 - v1
Checksum:iC33CF23A6FAA6F99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05988 Genomic DNA. Translation: AAA20247.1.
RefSeqiWP_014818660.1. NZ_JXJL01000001.1.

Genome annotation databases

GeneIDi13148761.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05988 Genomic DNA. Translation: AAA20247.1.
RefSeqiWP_014818660.1. NZ_JXJL01000001.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ETPX-ray2.20A/B21-210[»]
1M6ZX-ray1.35A/B/C/D21-210[»]
1M70X-ray1.25A/B/C/D21-210[»]
ProteinModelPortaliQ52369.
SMRiQ52369. Positions 21-210.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi379731.PST_4060.

Chemistry

DrugBankiDB03754. Tris.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13148761.

Phylogenomic databases

eggNOGiENOG4106RE7. Bacteria.
COG2863. LUCA.

Miscellaneous databases

EvolutionaryTraceiQ52369.

Family and domain databases

Gene3Di1.10.760.10. 2 hits.
InterProiIPR009056. Cyt_c-like_dom.
IPR024167. Cytochrome_c4.
[Graphical view]
PfamiPF00034. Cytochrom_C. 2 hits.
[Graphical view]
PIRSFiPIRSF000005. Cytochrome_c4. 1 hit.
SUPFAMiSSF46626. SSF46626. 2 hits.
PROSITEiPS51007. CYTC. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterisation of the gene encoding cytochrome c4 from Pseudomonas stutzeri."
    Christensen H.E.M.
    Gene 144:139-140(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 11607 / DSM 50227 / NCIB 9721.
  2. "Crystal structure of the dihaem cytochrome c4 from Pseudomonas stutzeri determined at 2.2-A resolution."
    Kadziola A., Larsen S.
    Structure 5:203-216(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
    Strain: ATCC 11607 / DSM 50227 / NCIB 9721.

Entry informationi

Entry nameiCYC4_PSEST
AccessioniPrimary (citable) accession number: Q52369
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: December 9, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.