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Q51P78 (ATG12_MAGO7) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-like protein ATG12
Alternative name(s):
Autophagy-related protein 12
Gene names
Name:ATG12
ORF Names:MGG_00598
OrganismMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) [Complete proteome]
Taxonomic identifier242507 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe

Protein attributes

Sequence length181 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes By similarity.

Subunit structure

Forms a conjugate with ATG5 By similarity.

Subcellular location

Preautophagosomal structure membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the ATG12 family.

Ontologies

Keywords
   Biological processAutophagy
Protein transport
Transport
Ubl conjugation pathway
   Cellular componentMembrane
   PTMIsopeptide bond
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processautophagic vacuole assembly

Inferred from electronic annotation. Source: InterPro

protein transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentpre-autophagosomal structure membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 181181Ubiquitin-like protein ATG12
PRO_0000212481

Amino acid modifications

Cross-link181Glycyl lysine isopeptide (Gly-Lys) (interchain with K-162 in ATG5) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q51P78 [UniParc].

Last modified June 7, 2005. Version 1.
Checksum: 86A3BC56930DE80B

FASTA18119,118
        10         20         30         40         50         60 
MSSPPTRYTR NPQLRRPSLS TPTPPPPSSS STAPASSSAT PIPDDAPDAD DNDGSPPSPD 

        70         80         90        100        110        120 
LPLTMSASVM LTQLPRDATA ALATAGEFPA DQKVVVRFKP VGGSAPALRK ELCKISAAQR 

       130        140        150        160        170        180 
FEAVVAYLRR TLKVGNGESV FLYINSTFAP ALDEIVGNLH RCFKDSNGQL NVSYSMTPAF 


G 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM001235 Genomic DNA. Translation: EHA48856.1.
RefSeqXP_003718440.1. XM_003718392.1.

3D structure databases

ProteinModelPortalQ51P78.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiMGG_00598T0; MGG_00598T0; MGG_00598.
GeneID2674234.
KEGGmgr:MGG_00598.

Phylogenomic databases

eggNOGNOG236266.
KOK08336.
OrthoDBEOG7ZSJ5R.

Family and domain databases

InterProIPR007242. Atg12.
[Graphical view]
PANTHERPTHR13385. PTHR13385. 1 hit.
PfamPF04110. APG12. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameATG12_MAGO7
AccessionPrimary (citable) accession number: Q51P78
Secondary accession number(s): A4REQ6, G4NB95
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 7, 2005
Last modified: March 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families