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Q51P78

- ATG12_MAGO7

UniProt

Q51P78 - ATG12_MAGO7

Protein

Ubiquitin-like protein ATG12

Gene

ATG12

Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (07 Jun 2005)
      Previous versions | rss
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    Functioni

    Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes By similarity.By similarity

    GO - Biological processi

    1. autophagic vacuole assembly Source: InterPro
    2. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Autophagy, Protein transport, Transport, Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-like protein ATG12
    Alternative name(s):
    Autophagy-related protein 12
    Gene namesi
    Name:ATG12
    ORF Names:MGG_00598
    OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
    Taxonomic identifieri242507 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
    ProteomesiUP000009058: Chromosome 5

    Subcellular locationi

    GO - Cellular componenti

    1. pre-autophagosomal structure membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 181181Ubiquitin-like protein ATG12PRO_0000212481Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki181 – 181Glycyl lysine isopeptide (Gly-Lys) (interchain with K-162 in ATG5)By similarity

    Keywords - PTMi

    Isopeptide bond

    Interactioni

    Subunit structurei

    Forms a conjugate with ATG5.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ51P78.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATG12 family.Curated

    Phylogenomic databases

    eggNOGiNOG236266.
    KOiK08336.
    OrthoDBiEOG7ZSJ5R.

    Family and domain databases

    InterProiIPR007242. Atg12.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PANTHERiPTHR13385. PTHR13385. 1 hit.
    PfamiPF04110. APG12. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q51P78-1 [UniParc]FASTAAdd to Basket

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    MSSPPTRYTR NPQLRRPSLS TPTPPPPSSS STAPASSSAT PIPDDAPDAD    50
    DNDGSPPSPD LPLTMSASVM LTQLPRDATA ALATAGEFPA DQKVVVRFKP 100
    VGGSAPALRK ELCKISAAQR FEAVVAYLRR TLKVGNGESV FLYINSTFAP 150
    ALDEIVGNLH RCFKDSNGQL NVSYSMTPAF G 181
    Length:181
    Mass (Da):19,118
    Last modified:June 7, 2005 - v1
    Checksum:i86A3BC56930DE80B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM001235 Genomic DNA. Translation: EHA48856.1.
    RefSeqiXP_003718440.1. XM_003718392.1.

    Genome annotation databases

    EnsemblFungiiMGG_00598T0; MGG_00598T0; MGG_00598.
    GeneIDi2674234.
    KEGGimgr:MGG_00598.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM001235 Genomic DNA. Translation: EHA48856.1 .
    RefSeqi XP_003718440.1. XM_003718392.1.

    3D structure databases

    ProteinModelPortali Q51P78.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii MGG_00598T0 ; MGG_00598T0 ; MGG_00598 .
    GeneIDi 2674234.
    KEGGi mgr:MGG_00598.

    Phylogenomic databases

    eggNOGi NOG236266.
    KOi K08336.
    OrthoDBi EOG7ZSJ5R.

    Family and domain databases

    InterProi IPR007242. Atg12.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    PANTHERi PTHR13385. PTHR13385. 1 hit.
    Pfami PF04110. APG12. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.

    Entry informationi

    Entry nameiATG12_MAGO7
    AccessioniPrimary (citable) accession number: Q51P78
    Secondary accession number(s): A4REQ6, G4NB95
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3