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Q51P78

- ATG12_MAGO7

UniProt

Q51P78 - ATG12_MAGO7

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Protein

Ubiquitin-like protein ATG12

Gene
ATG12, MGG_00598
Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes By similarity.

GO - Biological processi

  1. autophagic vacuole assembly Source: InterPro
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like protein ATG12
Alternative name(s):
Autophagy-related protein 12
Gene namesi
Name:ATG12
ORF Names:MGG_00598
OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Taxonomic identifieri242507 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
ProteomesiUP000009058: Chromosome 5

Subcellular locationi

GO - Cellular componenti

  1. pre-autophagosomal structure membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Ubiquitin-like protein ATG12PRO_0000212481Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki181 – 181Glycyl lysine isopeptide (Gly-Lys) (interchain with K-162 in ATG5) By similarity

Keywords - PTMi

Isopeptide bond

Interactioni

Subunit structurei

Forms a conjugate with ATG5 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ51P78.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG12 family.

Phylogenomic databases

eggNOGiNOG236266.
KOiK08336.
OrthoDBiEOG7ZSJ5R.

Family and domain databases

InterProiIPR007242. Atg12.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR13385. PTHR13385. 1 hit.
PfamiPF04110. APG12. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.

Sequencei

Sequence statusi: Complete.

Q51P78-1 [UniParc]FASTAAdd to Basket

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MSSPPTRYTR NPQLRRPSLS TPTPPPPSSS STAPASSSAT PIPDDAPDAD    50
DNDGSPPSPD LPLTMSASVM LTQLPRDATA ALATAGEFPA DQKVVVRFKP 100
VGGSAPALRK ELCKISAAQR FEAVVAYLRR TLKVGNGESV FLYINSTFAP 150
ALDEIVGNLH RCFKDSNGQL NVSYSMTPAF G 181
Length:181
Mass (Da):19,118
Last modified:June 7, 2005 - v1
Checksum:i86A3BC56930DE80B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM001235 Genomic DNA. Translation: EHA48856.1.
RefSeqiXP_003718440.1. XM_003718392.1.

Genome annotation databases

EnsemblFungiiMGG_00598T0; MGG_00598T0; MGG_00598.
GeneIDi2674234.
KEGGimgr:MGG_00598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM001235 Genomic DNA. Translation: EHA48856.1 .
RefSeqi XP_003718440.1. XM_003718392.1.

3D structure databases

ProteinModelPortali Q51P78.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii MGG_00598T0 ; MGG_00598T0 ; MGG_00598 .
GeneIDi 2674234.
KEGGi mgr:MGG_00598.

Phylogenomic databases

eggNOGi NOG236266.
KOi K08336.
OrthoDBi EOG7ZSJ5R.

Family and domain databases

InterProi IPR007242. Atg12.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
PANTHERi PTHR13385. PTHR13385. 1 hit.
Pfami PF04110. APG12. 1 hit.
[Graphical view ]
SUPFAMi SSF54236. SSF54236. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.

Entry informationi

Entry nameiATG12_MAGO7
AccessioniPrimary (citable) accession number: Q51P78
Secondary accession number(s): A4REQ6, G4NB95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 7, 2005
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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