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Q51887

- HEMX_PROMI

UniProt

Q51887 - HEMX_PROMI

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Protein

Putative uroporphyrinogen-III C-methyltransferase

Gene
hemX
Organism
Proteus mirabilis
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.
S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.

Pathwayi

GO - Molecular functioni

  1. oxidoreductase activity, acting on the CH-CH group of donors Source: InterPro
  2. uroporphyrin-III C-methyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. cobalamin biosynthetic process Source: UniProtKB-UniPathway
  2. porphyrin-containing compound biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00148; UER00211.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative uroporphyrinogen-III C-methyltransferase (EC:2.1.1.107)
Short name:
Urogen-III methylase
Gene namesi
Name:hemX
OrganismiProteus mirabilis
Taxonomic identifieri584 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus

Subcellular locationi

Cell inner membrane By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei37 – 5721Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›170›170Putative uroporphyrinogen-III C-methyltransferasePRO_0000135256Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ51887.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
SUPFAMiSSF56645. SSF56645. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q51887-1 [UniParc]FASTAAdd to Basket

« Hide

MTEQKNTNEN DLQNGTSKAD DDIRYQEVKP VNNKRSGLIG SAVAILVILA    50
IGGGLYYYTT QQATKLRDPD HLLSDNENPG ITCALIPTDV KGVEIGHRHF 100
PLNVPFMNGP TRGKDVFVPI DFIIGGPKMA GQGWRMLVEC LSVGRGITLP 150
SNSTGGLKSA AMATGATLEF 170
Length:170
Mass (Da):18,243
Last modified:November 1, 1997 - v1
Checksum:iDCA77C4EF3E2BE2C
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei170 – 1701

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U22969 Genomic DNA. Translation: AAC44327.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U22969 Genomic DNA. Translation: AAC44327.1 .

3D structure databases

ProteinModelPortali Q51887.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00148 ; UER00211 .

Family and domain databases

InterProi IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view ]
SUPFAMi SSF56645. SSF56645. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative analysis of the cya locus in enterobacteria and related Gram-negative facultative anaerobes."
    Trotot P., Sismeiro O., Vivares C., Glaser P., Bresson-Roy A., Danchin A.
    Biochimie 78:277-287(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHEMX_PROMI
AccessioniPrimary (citable) accession number: Q51887
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

External Data

Dasty 3