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Q51887

- HEMX_PROMI

UniProt

Q51887 - HEMX_PROMI

Protein

Putative uroporphyrinogen-III C-methyltransferase

Gene

hemX

Organism
Proteus mirabilis
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.
    S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.

    Pathwayi

    GO - Molecular functioni

    1. oxidoreductase activity, acting on the CH-CH group of donors Source: InterPro
    2. uroporphyrin-III C-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cobalamin biosynthetic process Source: UniProtKB-UniPathway
    2. porphyrin-containing compound biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    UniPathwayiUPA00148; UER00211.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative uroporphyrinogen-III C-methyltransferase (EC:2.1.1.107)
    Short name:
    Urogen-III methylase
    Gene namesi
    Name:hemX
    OrganismiProteus mirabilis
    Taxonomic identifieri584 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus

    Subcellular locationi

    Cell inner membrane By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›170›170Putative uroporphyrinogen-III C-methyltransferasePRO_0000135256Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ51887.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei37 – 5721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR009100. AcylCoA_DH/oxidase_NM_dom.
    [Graphical view]
    SUPFAMiSSF56645. SSF56645. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Q51887-1 [UniParc]FASTAAdd to Basket

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    MTEQKNTNEN DLQNGTSKAD DDIRYQEVKP VNNKRSGLIG SAVAILVILA    50
    IGGGLYYYTT QQATKLRDPD HLLSDNENPG ITCALIPTDV KGVEIGHRHF 100
    PLNVPFMNGP TRGKDVFVPI DFIIGGPKMA GQGWRMLVEC LSVGRGITLP 150
    SNSTGGLKSA AMATGATLEF 170
    Length:170
    Mass (Da):18,243
    Last modified:November 1, 1997 - v1
    Checksum:iDCA77C4EF3E2BE2C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei170 – 1701

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U22969 Genomic DNA. Translation: AAC44327.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U22969 Genomic DNA. Translation: AAC44327.1 .

    3D structure databases

    ProteinModelPortali Q51887.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00148 ; UER00211 .

    Family and domain databases

    InterProi IPR009100. AcylCoA_DH/oxidase_NM_dom.
    [Graphical view ]
    SUPFAMi SSF56645. SSF56645. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative analysis of the cya locus in enterobacteria and related Gram-negative facultative anaerobes."
      Trotot P., Sismeiro O., Vivares C., Glaser P., Bresson-Roy A., Danchin A.
      Biochimie 78:277-287(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiHEMX_PROMI
    AccessioniPrimary (citable) accession number: Q51887
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways

    External Data

    Dasty 3