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Q51887

- HEMX_PROMI

UniProt

Q51887 - HEMX_PROMI

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Protein

Putative uroporphyrinogen-III C-methyltransferase

Gene

hemX

Organism
Proteus mirabilis
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.
S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.

Pathwayi

GO - Molecular functioni

  1. oxidoreductase activity, acting on the CH-CH group of donors Source: InterPro
  2. uroporphyrin-III C-methyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. cobalamin biosynthetic process Source: UniProtKB-UniPathway
  2. porphyrin-containing compound biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00148; UER00211.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative uroporphyrinogen-III C-methyltransferase (EC:2.1.1.107)
Short name:
Urogen-III methylase
Gene namesi
Name:hemX
OrganismiProteus mirabilis
Taxonomic identifieri584 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus

Subcellular locationi

Cell inner membrane By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›170›170Putative uroporphyrinogen-III C-methyltransferasePRO_0000135256Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ51887.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei37 – 5721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
SUPFAMiSSF56645. SSF56645. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q51887-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEQKNTNEN DLQNGTSKAD DDIRYQEVKP VNNKRSGLIG SAVAILVILA
60 70 80 90 100
IGGGLYYYTT QQATKLRDPD HLLSDNENPG ITCALIPTDV KGVEIGHRHF
110 120 130 140 150
PLNVPFMNGP TRGKDVFVPI DFIIGGPKMA GQGWRMLVEC LSVGRGITLP
160 170
SNSTGGLKSA AMATGATLEF
Length:170
Mass (Da):18,243
Last modified:November 1, 1997 - v1
Checksum:iDCA77C4EF3E2BE2C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei170 – 1701

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U22969 Genomic DNA. Translation: AAC44327.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U22969 Genomic DNA. Translation: AAC44327.1 .

3D structure databases

ProteinModelPortali Q51887.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00148 ; UER00211 .

Family and domain databases

InterProi IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view ]
SUPFAMi SSF56645. SSF56645. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative analysis of the cya locus in enterobacteria and related Gram-negative facultative anaerobes."
    Trotot P., Sismeiro O., Vivares C., Glaser P., Bresson-Roy A., Danchin A.
    Biochimie 78:277-287(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHEMX_PROMI
AccessioniPrimary (citable) accession number: Q51887
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

External Data

Dasty 3