Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative uroporphyrinogen-III C-methyltransferase

Gene

hemX

Organism
Proteus mirabilis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.
S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.

Pathway:iadenosylcobalamin biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes precorrin-2 from uroporphyrinogen III.
Proteins known to be involved in this subpathway in this organism are:
  1. Putative uroporphyrinogen-III C-methyltransferase (hemX)
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes precorrin-2 from uroporphyrinogen III, the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00148; UER00211.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative uroporphyrinogen-III C-methyltransferase (EC:2.1.1.107)
Short name:
Urogen-III methylase
Gene namesi
Name:hemX
OrganismiProteus mirabilis
Taxonomic identifieri584 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei37 – 5721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›170›170Putative uroporphyrinogen-III C-methyltransferasePRO_0000135256Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi529507.PMI0348.

Structurei

3D structure databases

ProteinModelPortaliQ51887.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
SUPFAMiSSF56645. SSF56645. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q51887-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEQKNTNEN DLQNGTSKAD DDIRYQEVKP VNNKRSGLIG SAVAILVILA
60 70 80 90 100
IGGGLYYYTT QQATKLRDPD HLLSDNENPG ITCALIPTDV KGVEIGHRHF
110 120 130 140 150
PLNVPFMNGP TRGKDVFVPI DFIIGGPKMA GQGWRMLVEC LSVGRGITLP
160 170
SNSTGGLKSA AMATGATLEF
Length:170
Mass (Da):18,243
Last modified:November 1, 1997 - v1
Checksum:iDCA77C4EF3E2BE2C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei170 – 1701

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22969 Genomic DNA. Translation: AAC44327.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22969 Genomic DNA. Translation: AAC44327.1.

3D structure databases

ProteinModelPortaliQ51887.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi529507.PMI0348.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00148; UER00211.

Family and domain databases

InterProiIPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
SUPFAMiSSF56645. SSF56645. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Comparative analysis of the cya locus in enterobacteria and related Gram-negative facultative anaerobes."
    Trotot P., Sismeiro O., Vivares C., Glaser P., Bresson-Roy A., Danchin A.
    Biochimie 78:277-287(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHEMX_PROMI
AccessioniPrimary (citable) accession number: Q51887
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 24, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.