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Q51887 (HEMX_PROMI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative uroporphyrinogen-III C-methyltransferase

Short name=Urogen-III methylase
EC=2.1.1.107
Gene names
Name:hemX
OrganismProteus mirabilis
Taxonomic identifier584 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus

Protein attributes

Sequence length170 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.

S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.

Pathway

Cofactor biosynthesis; adenosylcobalamin biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1.

Subcellular location

Cell inner membrane By similarity.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›170›170Putative uroporphyrinogen-III C-methyltransferase
PRO_0000135256

Regions

Transmembrane37 – 5721Helical; Potential

Experimental info

Non-terminal residue1701

Sequences

Sequence LengthMass (Da)Tools
Q51887 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: DCA77C4EF3E2BE2C

FASTA17018,243
        10         20         30         40         50         60 
MTEQKNTNEN DLQNGTSKAD DDIRYQEVKP VNNKRSGLIG SAVAILVILA IGGGLYYYTT 

        70         80         90        100        110        120 
QQATKLRDPD HLLSDNENPG ITCALIPTDV KGVEIGHRHF PLNVPFMNGP TRGKDVFVPI 

       130        140        150        160        170 
DFIIGGPKMA GQGWRMLVEC LSVGRGITLP SNSTGGLKSA AMATGATLEF 

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References

[1]"Comparative analysis of the cya locus in enterobacteria and related Gram-negative facultative anaerobes."
Trotot P., Sismeiro O., Vivares C., Glaser P., Bresson-Roy A., Danchin A.
Biochimie 78:277-287(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U22969 Genomic DNA. Translation: AAC44327.1.

3D structure databases

ProteinModelPortalQ51887.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00148; UER00211.

Family and domain databases

InterProIPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
SUPFAMSSF56645. SSF56645. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHEMX_PROMI
AccessionPrimary (citable) accession number: Q51887
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways