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Q51845 (HAGA2_PORGN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hemagglutinin A
Gene names
Name:hagA
OrganismPorphyromonas gingivalis
Taxonomic identifier837 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Porphyromonas

Protein attributes

Sequence length2628 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Agglutinates erythrocytes.

Sequence similarities

Belongs to the peptidase C25 family.

Ontologies

Keywords
   Biological processVirulence
   DomainRepeat
Signal
   Molecular functionHemagglutinin
Hydrolase
Protease
Thiol protease
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 26282604Hemagglutinin A
PRO_0000026538

Regions

Region25 – 539515Peptidase C25-like 1
Region540 – 995456Peptidase C25-like 2
Region996 – 1451456Peptidase C25-like 3
Region1452 – 1907456Peptidase C25-like 4
Region2074 – 2628555Peptidase C25-like 5

Sequences

Sequence LengthMass (Da)Tools
Q51845 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 61C4DE32540C99DA

FASTA2,628283,325
        10         20         30         40         50         60 
MRKLNSLFSL AVLLSLLCWG QTAAAQGGPK TAPSVTHQAV QKGIRTSKVK DLRDPIPAGM 

        70         80         90        100        110        120 
ARIILEAHDV WEDGTGYQML WDADHNQYGA SIPEESFWFA NGTIPAGLYD PFEYKVPVNA 

       130        140        150        160        170        180 
DASFSPTNFV LDGTASADIP AGTYDYVIIN PNPGIIYIVG EGVSKGNDYV VEAGKTYHFT 

       190        200        210        220        230        240 
VQRQGPGDAA SVVVTGEGGN EFAPVQNLQW SVSGQTVTLT WQAPASDKRT YVLNESFDTQ 

       250        260        270        280        290        300 
TLPNGWTMID ADGDGHNWLS TINVYNTATH TGDGAMFSKS WTASGGAKID LSPDNYLVTP 

       310        320        330        340        350        360 
KVTVPENGKL SYWVSSQVPW TNEHYGVFLS TTGNEAANFT IKLLEETLGS DKPAPMNLVK 

       370        380        390        400        410        420 
SEGVKLPAPY QERTIDLSAY AGQQVYLAFR HFNSTGIFRL YLDDVAVSGE GSSNDYTYTV 

       430        440        450        460        470        480 
YRDNVVIAQN LAATTFNQEN VAPGQYNYCV EVKYTAGVSP KVCKDVTVEG SNEFAHVQNL 

       490        500        510        520        530        540 
TGSAVGQKVT LKWDAPNGTP NPNPGTTTLS ESFENGIPAS WKTIDADGDG NNWTTTPPPG 

       550        560        570        580        590        600 
GTSFAGHNSA ICASSASYIN FEGPQNPDNY LVTPELSLPN GGTLTFWVCA QDANYASEHY 

       610        620        630        640        650        660 
AVYASSTGND ASNFANALLE EVLTAKTVVT APEAIRGTRV QGTWYQKTVQ LPAGTKYVAF 

       670        680        690        700        710        720 
RHFGCTDFFW INLDDVEIKA NGKRADFTET FESSTHGEAP AEWTTIDADG DGQGWLCLSS 

       730        740        750        760        770        780 
GQLDWLTAHG GTNVVASFSW NGMALNPDNY LISKDVTGAT KVKYYYAVND GFPGDHYAVM 

       790        800        810        820        830        840 
ISKTGTNAGD FTVVFEETPN GINKGGARFG LSTEADGAKP QSVWIERTVD LPAGTKYVAF 

       850        860        870        880        890        900 
RHYNCSDLNY ILLDDIQFTM GGSPTPTDYT YTVYRDGTKI KEGLTETTFE EDGVATGNHE 

       910        920        930        940        950        960 
YCVEVKYTAG VSPKECVNVT VDPVQFNPVQ NLTGSAVGQK VTLKWDAPNG TPNPNPNPNP 

       970        980        990       1000       1010       1020 
GTTTLSESFE NGIPASWKTI DADGDGNNWT TTPPPGGTSF AGHNSAICAS SASYINFEGP 

      1030       1040       1050       1060       1070       1080 
QNPDNYLVTP ELSLPNGGTL TFWVCAQDAN YASEHYAVYA SSTGNDASNF ANALLEEVLT 

      1090       1100       1110       1120       1130       1140 
AKTVVTAPEA IRGTRVQGTW YQKTVQLPAG TKYVAFRHFG CTDFFWINLD DVEIKANGKR 

      1150       1160       1170       1180       1190       1200 
ADFTETFESS THGEAPAEWT TIDADGDGQG WLCLSSGQLG WLTAHGGTNV VASFSWNGMA 

      1210       1220       1230       1240       1250       1260 
LNPDNYLISK DVTGATKVKY YYAVNDGFPG DHYAVMISKT GTNAGDFTVV FEETPNGINK 

      1270       1280       1290       1300       1310       1320 
GGARFGLSTE ADGAKPQSVW IERTVDLPAG TKYVAFRHYN CSDLNYILLD DIQFTMGGSP 

      1330       1340       1350       1360       1370       1380 
TPTDYTYTVY RDGTKIKEGL TETTFEEDGV ATGNHEYCVE VKYTAGVSPK ECVNVTVDPV 

      1390       1400       1410       1420       1430       1440 
QFNPVQNLTG SAVGQKVTLK WDAPNGTPNP NPNPNPGTTT LSESFENGIP ASWKTIDADG 

      1450       1460       1470       1480       1490       1500 
DGNNWTTTPP PGGTSFAGHN SAICASSASY INFEGPQNPD NYLVTPELSL PNGGTLTFWV 

      1510       1520       1530       1540       1550       1560 
CAQDANYASE HYAVYASSTG NDASNFANAL LEEVLTAKTV VTAPEAIRGT RVQGTWYQKT 

      1570       1580       1590       1600       1610       1620 
VQLPAGTKYV AFRHFGCTDF FWINLDDVEI KANGKRADFT ETFESSTHGE APAEWTTIDA 

      1630       1640       1650       1660       1670       1680 
DGDGQGWLCL SSGQLGWLTA HGGTNVVASF SWNGMALNPD NYLISKDVTG ATKVKYYYAV 

      1690       1700       1710       1720       1730       1740 
NDGFPGDHYA VMISKTGTNA GDFTVVFEET PNGINKGGAR FGLSTEADGA KPQSVWIERT 

      1750       1760       1770       1780       1790       1800 
VDLPAGTKYV AFRHYNCSDL NYILLDDIQF TMGGSPTPTD YTYTVYRDGT KIKEGLTETT 

      1810       1820       1830       1840       1850       1860 
FEEDGVATGN HEYCVEVKYT AGVSPKECVN VTVDPVQFNP VQNLTGSAVG QKVTLKWDAP 

      1870       1880       1890       1900       1910       1920 
NGTPNPNPNP NPGTTTLSES FENGIPASWK TIDADGDGNN WTTTPPPGGT SFAGHNSAIC 

      1930       1940       1950       1960       1970       1980 
VSSASYINFE GPQNPDNYLV TPELSLPGGG TLTFWVCAQD ANYASEHYAV YASSTGNDAS 

      1990       2000       2010       2020       2030       2040 
NFANALLEEV LTAKTVVTAP EAIRGTRVQG TWYQKTVQLP AGTKYVAFRH FGCTDFFWIN 

      2050       2060       2070       2080       2090       2100 
LDEVEIKANG KRADFTETFE SSTHGEAPAE WTTIDADGDG QGWLCLSSGQ LDWLTAHGGT 

      2110       2120       2130       2140       2150       2160 
NVVASFSWNG MALNPDNYLI SKDVTGATKV KYYYAVNDGF PGDHYAVMIS KTGTNAGDFT 

      2170       2180       2190       2200       2210       2220 
VVFEETPNGI NKGGARFGLS TEADGAKPQS VWIERTVDLP AGTKYVAFRH YNCSDLNYIL 

      2230       2240       2250       2260       2270       2280 
LDDIQFTMGG SPTPTDYTYT VYRDGTKIKE GLTETTFEED GVATGNHEYC VEVKYTAGVS 

      2290       2300       2310       2320       2330       2340 
PKVCVNVTIN PTQFNPVQNL TAEQAPNSMD AILKWNAPAS KRAEVLNEDF ENGIPSSWKT 

      2350       2360       2370       2380       2390       2400 
IDADGDGNNW TTTPPPGGSS FAGHNSAICV SSASYINFEG PQNPDNYLVT PELSLPGGGT 

      2410       2420       2430       2440       2450       2460 
LTFWVCAQDA NYASEHYAVY ASSTGNDASN FANALLEEVL TAKTVVTAPE AIRGTRVQGT 

      2470       2480       2490       2500       2510       2520 
WYQKTVQLPA GTKYVAFRHF GCTDFFWINL DDVVITSGNA PSYTYTIYRN NTQIASGVTE 

      2530       2540       2550       2560       2570       2580 
TTYRDPDLAT GFYTYGVKVV YPNGESAIET ATLNITSLAD VTAQKPYTLT VVGKTITVTC 

      2590       2600       2610       2620 
QGEAMIYDMN GRRLAAGRNT VVYTAQGGHY AVMVVVDGKS YVEKLAVK

« Hide

References

[1]"The hemagglutinin gene A (hagA) of Porphyromonas gingivalis 381 contains four large, contiguous, direct repeats."
Han N., Whitlock J., Progulske-Fox A.
Infect. Immun. 64:4000-4007(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 381.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U41807 Genomic DNA. Translation: AAB17128.1.
PIRT28651.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG12793.

Family and domain databases

InterProIPR011628. Cleaved_adhesin.
IPR003961. Fibronectin_type3.
IPR018832. Pept_C25_gingipain_C.
[Graphical view]
PfamPF07675. Cleaved_Adhesin. 10 hits.
PF10365. DUF2436. 1 hit.
[Graphical view]
SMARTSM00060. FN3. 6 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHAGA2_PORGN
AccessionPrimary (citable) accession number: Q51845
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: April 3, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

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