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Q51841

- NADK_PORGI

UniProt

Q51841 - NADK_PORGI

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Protein

NAD kinase

Gene

nadK

Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei73 – 731Proton acceptorUniRule annotation
Binding sitei78 – 781NADUniRule annotation
Binding sitei174 – 1741NADUniRule annotation
Binding sitei209 – 2091NAD; via carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi73 – 742NADUniRule annotation
Nucleotide bindingi144 – 1452NADUniRule annotation
Nucleotide bindingi185 – 1906NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciPGIN242619:GHX8-576-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Synonyms:put
Ordered Locus Names:PG_0629
OrganismiPorphyromonas gingivalis (strain ATCC BAA-308 / W83)
Taxonomic identifieri242619 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
ProteomesiUP000000588: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288NAD kinasePRO_0000120645Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi242619.PG0629.

Structurei

3D structure databases

ProteinModelPortaliQ51841.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.
OMAiSAYRADG.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q51841-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKIAIFGSR HKSEQGASIK ALILKLEEAG TPLYIERKFL SFLKQDLDFH
60 70 80 90 100
PAICGVIDTL PEHIDYVICM GGDGTFLRTA HQIGVSQIPV LGVNTGRLGF
110 120 130 140 150
LTDVDCHEAS ELITRLLDGD FTIETRSLLE VTEDNGSSPS YALNEAAILK
160 170 180 190 200
RETGSMIRVN ACLNDDYLAA YDADGLVVAT PSGSTAYSLS GNGPIIMPAC
210 220 230 240 250
RNFVLTPIAP HSLNMRPLVV PDDTVIRLEV DSRSRNYLLV LDGRTRTLPC
260 270 280
DTSILLKRAP HTLRMIRLRP HSFAETLRRK LMWGAAVR
Length:288
Mass (Da):31,731
Last modified:October 3, 2003 - v2
Checksum:i49C6D0570B5AE8B7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 9212HQIGV…IPVLG → IKSAFRRSLSWA in CAA65865. 1 PublicationCuratedAdd
BLAST
Sequence conflicti269 – 2691R → G in CAA65865. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97228 Genomic DNA. Translation: CAA65865.1.
AE015924 Genomic DNA. Translation: AAQ65813.1.
RefSeqiNP_904914.1. NC_002950.2.

Genome annotation databases

EnsemblBacteriaiAAQ65813; AAQ65813; PG_0629.
GeneIDi2552505.
KEGGipgi:PG0629.
PATRICi22978338. VBIPorGin134034_0575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97228 Genomic DNA. Translation: CAA65865.1 .
AE015924 Genomic DNA. Translation: AAQ65813.1 .
RefSeqi NP_904914.1. NC_002950.2.

3D structure databases

ProteinModelPortali Q51841.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 242619.PG0629.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAQ65813 ; AAQ65813 ; PG_0629 .
GeneIDi 2552505.
KEGGi pgi:PG0629.
PATRICi 22978338. VBIPorGin134034_0575.

Phylogenomic databases

eggNOGi COG0061.
KOi K00858.
OMAi SAYRADG.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci PGIN242619:GHX8-576-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of pyridoxal phosphate from P.gingivalis."
    Wallace A.M., Roberts I.S.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC BAA-308 / W83.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-308 / W83.

Entry informationi

Entry nameiNADK_PORGI
AccessioniPrimary (citable) accession number: Q51841
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: October 3, 2003
Last modified: November 26, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3