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Q51841

- NADK_PORGI

UniProt

Q51841 - NADK_PORGI

Protein

NAD kinase

Gene

nadK

Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (03 Oct 2003)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei73 – 731Proton acceptorUniRule annotation
    Binding sitei78 – 781NADUniRule annotation
    Binding sitei174 – 1741NADUniRule annotation
    Binding sitei209 – 2091NAD; via carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi73 – 742NADUniRule annotation
    Nucleotide bindingi144 – 1452NADUniRule annotation
    Nucleotide bindingi185 – 1906NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPGIN242619:GHX8-576-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Synonyms:put
    Ordered Locus Names:PG_0629
    OrganismiPorphyromonas gingivalis (strain ATCC BAA-308 / W83)
    Taxonomic identifieri242619 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
    ProteomesiUP000000588: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288NAD kinasePRO_0000120645Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi242619.PG0629.

    Structurei

    3D structure databases

    ProteinModelPortaliQ51841.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    KOiK00858.
    OMAiSAYRADG.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q51841-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKIAIFGSR HKSEQGASIK ALILKLEEAG TPLYIERKFL SFLKQDLDFH    50
    PAICGVIDTL PEHIDYVICM GGDGTFLRTA HQIGVSQIPV LGVNTGRLGF 100
    LTDVDCHEAS ELITRLLDGD FTIETRSLLE VTEDNGSSPS YALNEAAILK 150
    RETGSMIRVN ACLNDDYLAA YDADGLVVAT PSGSTAYSLS GNGPIIMPAC 200
    RNFVLTPIAP HSLNMRPLVV PDDTVIRLEV DSRSRNYLLV LDGRTRTLPC 250
    DTSILLKRAP HTLRMIRLRP HSFAETLRRK LMWGAAVR 288
    Length:288
    Mass (Da):31,731
    Last modified:October 3, 2003 - v2
    Checksum:i49C6D0570B5AE8B7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti81 – 9212HQIGV…IPVLG → IKSAFRRSLSWA in CAA65865. 1 PublicationCuratedAdd
    BLAST
    Sequence conflicti269 – 2691R → G in CAA65865. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X97228 Genomic DNA. Translation: CAA65865.1.
    AE015924 Genomic DNA. Translation: AAQ65813.1.
    RefSeqiNP_904914.1. NC_002950.2.
    WP_005874508.1. NC_002950.2.

    Genome annotation databases

    EnsemblBacteriaiAAQ65813; AAQ65813; PG_0629.
    GeneIDi2552505.
    KEGGipgi:PG0629.
    PATRICi22978338. VBIPorGin134034_0575.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X97228 Genomic DNA. Translation: CAA65865.1 .
    AE015924 Genomic DNA. Translation: AAQ65813.1 .
    RefSeqi NP_904914.1. NC_002950.2.
    WP_005874508.1. NC_002950.2.

    3D structure databases

    ProteinModelPortali Q51841.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 242619.PG0629.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAQ65813 ; AAQ65813 ; PG_0629 .
    GeneIDi 2552505.
    KEGGi pgi:PG0629.
    PATRICi 22978338. VBIPorGin134034_0575.

    Phylogenomic databases

    eggNOGi COG0061.
    KOi K00858.
    OMAi SAYRADG.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci PGIN242619:GHX8-576-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of pyridoxal phosphate from P.gingivalis."
      Wallace A.M., Roberts I.S.
      Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC BAA-308 / W83.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-308 / W83.

    Entry informationi

    Entry nameiNADK_PORGI
    AccessioniPrimary (citable) accession number: Q51841
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 4, 2001
    Last sequence update: October 3, 2003
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3