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Q51826

- FIMA3_PORGN

UniProt

Q51826 - FIMA3_PORGN

Protein

Major fimbrial subunit protein type-3

Gene

fimA

Organism
Porphyromonas gingivalis
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Fimbrillin is the structural subunit of the fimbriae, that are filamentous appendages on the cell surface. Fimbriae of P.gingivalis are recognized as a major virulence factor as they mediate cell adhesion and play an important role in invasion of periodontal tissues.1 Publication

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. pathogenesis Source: UniProtKB-KW

    Keywords - Biological processi

    Cell adhesion, Virulence

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Major fimbrial subunit protein type-3
    Alternative name(s):
    Fimbrillin
    Short name:
    Fimbrilin
    Major fimbrial subunit protein type III
    Gene namesi
    Name:fimA
    OrganismiPorphyromonas gingivalis
    Taxonomic identifieri837 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas

    Subcellular locationi

    GO - Cellular componenti

    1. pilus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Fimbrium

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 1010By similarityPRO_0000009164
    Chaini11 – 353343Major fimbrial subunit protein type-3PRO_0000009165Add
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the P.gingivalis fimbrillin family.Curated

    Family and domain databases

    InterProiIPR029141. FimA_N.
    IPR008110. Fimbrillin.
    [Graphical view]
    PfamiPF06321. P_gingi_FimA. 1 hit.
    [Graphical view]
    PRINTSiPR01737. FIMBRILLIN.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q51826-1 [UniParc]FASTAAdd to Basket

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    MVLKTSNPNR AFGNAGDEAK VAKLTVMVYK GEQQEAIKSV ENAIKVENIK    50
    CGAGQRTLVV MANTGGMELA GKTLAEVKAL TTELTEGNQE AAGLIMTAEP 100
    VEVTLVAGNN YYGYDGSQGG NQISQGTPLE IKRVHARIAF TKIEVTMSQS 150
    YANKYNFAPE NIYALVAKKK SNLFGASLAN SDDAYLTGSL TTFNGAYSPA 200
    NYTHVDWLGR DYTEIGAATV NTPKGFYVLE STYAQNAGLR PTILCVKGKL 250
    TKHDGTALSS EEMTAAFNAG WIVANNDPTT YYPVLVNFES NNYTYTGEAV 300
    EKGKIVRNHK FDINLTITGP GTNNPENPIT ESANLNVNCV VAAWKGVVQN 350
    VIW 353
    Length:353
    Mass (Da):38,024
    Last modified:November 1, 1996 - v1
    Checksum:i7FBE4FBF427EA2AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D17801 Genomic DNA. Translation: BAA04627.1.
    PIRiD60275.
    JN0920.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D17801 Genomic DNA. Translation: BAA04627.1 .
    PIRi D60275.
    JN0920.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR029141. FimA_N.
    IPR008110. Fimbrillin.
    [Graphical view ]
    Pfami PF06321. P_gingi_FimA. 1 hit.
    [Graphical view ]
    PRINTSi PR01737. FIMBRILLIN.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and sequencing of the fimbrilin gene of Porphyromonas gingivalis strains and characterization of recombinant proteins."
      Fujiwara T., Morishima S., Takahashi I., Hamada S.
      Biochem. Biophys. Res. Commun. 197:241-247(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 6/26.
    2. "Functional differences among FimA variants of Porphyromonas gingivalis and their effects on adhesion to and invasion of human epithelial cells."
      Nakagawa I., Amano A., Kuboniwa M., Nakamura T., Kawabata S., Hamada S.
      Infect. Immun. 70:277-285(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CLASSIFICATION INTO TYPES.

    Entry informationi

    Entry nameiFIMA3_PORGN
    AccessioniPrimary (citable) accession number: Q51826
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3