Reviewed, UniProtKB/Swiss-Prot Q51805 (PORB_PYRFU)

Names and origin

Protein names

Recommended name:
    Pyruvate synthase subunit porB
    EC=1.2.7.1
Alternative name(s):
    Pyruvate oxidoreductase beta chain
      Short name=POR
    Pyruvic-ferredoxin oxidoreductase subunit beta

Gene names

Name:	porB
Ordered Locus Names:	PF0965

Organism

Pyrococcus furiosus [Complete proteome] [HAMAP]

Taxonomic identifier

2261 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+.
Subunit structure	Heterotetramer of one alpha, one beta, one delta and one gamma chain.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	pyruvate synthase activity Inferred from electronic annotation. Source: EC thiamin pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.1
	Chain	2 – 331	330	Pyruvate synthase subunit porB		PRO_0000099907

Sequences

	Sequence		Length	Mass (Da)
	Q51805-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 1523640D21AB7D12	FASTA	331	36,261
	10 20 30 40 50 60 MAVRKPPITT REYWAPGHAA CAGCGCATAL RLATKALSEA MEEKYGDPNA FAIAHATGCM 70 80 90 100 110 120 EVVSAVFPYT AWKAPWIHVA FENAAAVASG IEAAWKKLGR KGKILAIGGD GGTADIGLQA 130 140 150 160 170 180 LSGMLERWHN VLYLMYDNEA YMNTGIQRSS STPYGAWTTT SPPGKYSVGE DKPKKWVALI 190 200 210 220 230 240 AAAHQIPYVA TASIGNPLDF VRKIKKAGKI DGPAFVQVLC TCPTGWRSPL EKGVEIARLA 250 260 270 280 290 300 IETGIWPLFE IENGDIWNIK IQPPGGGAKV YKEGNRVVRI EFKKPIEEYL KLQGRFKHLF 310 320 330 KRPEAIEELR NQVKAMWKVL GVEAILPRPE E

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima." Kletzin A., Adams M.W.W. J. Bacteriol. 178:248-257(1996) [PubMed: 8550425] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-24. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
[2]	"The complete sequence of the Pyrococcus furiosus genome." Weiss R.B., Dunn D.M., Robb F.T., Brown J.R. Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
[3]	"Purification and characterization of pyruvate ferredoxin oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus." Blamey J.M., Adams M.W.W. Biochim. Biophys. Acta 1161:19-27(1993) [PubMed: 8380721] [Abstract] Cited for: CHARACTERIZATION. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X85250 Genomic DNA. Translation: CAA59506.1. AE009950 Genomic DNA. Translation: AAL81089.1.
PIR	T45089.
RefSeq	NP_578694.1.
3D structure databases
HSSP	HSSP built from PDB template 1KEK based on UniProtKB P94692.
ModBase	Search...
Genome annotation databases
GeneID	1468830.
GenomeReviews	Gene locus PF0965 in contig AE009950_GR.
KEGG	pfu:PF0965.
NMPDR	fig|186497.1.peg.1001.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q51805.
OMA	YICLDNE.
Enzyme and pathway databases
BRENDA	1.2.7.1. 321.
Family and domain databases
InterPro	IPR011766. TPP_enzyme_bd_C. [Graphical view]
Pfam	PF02775. TPP_enzyme_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PORB_PYRFU

Accession

Primary (citable) accession number: Q51805

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 23, 2007
Last modified:	November 3, 2009
This is version 58 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)