Q51805 (PORB_PYRFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyruvate synthase subunit porB
EC=1.2.7.1

Alternative name(s):
Pyruvate oxidoreductase beta chain
Short name=POR
Pyruvic-ferredoxin oxidoreductase subunit beta

Gene names

Name:	porB
Ordered Locus Names:	PF0965

Organism

Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

Taxonomic identifier

186497 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+.
Subunit structure	Heterotetramer of one alpha, one beta, one delta and one gamma chain.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Molecular function	pyruvate synthase activity Inferred from electronic annotation. Source: EC thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.1
	Chain	2 – 331	330	Pyruvate synthase subunit porB		PRO_0000099907

Sequences

	Sequence		Length	Mass (Da)
	Q51805 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 1523640D21AB7D12	FASTA	331	36,261
	10 20 30 40 50 60 MAVRKPPITT REYWAPGHAA CAGCGCATAL RLATKALSEA MEEKYGDPNA FAIAHATGCM 70 80 90 100 110 120 EVVSAVFPYT AWKAPWIHVA FENAAAVASG IEAAWKKLGR KGKILAIGGD GGTADIGLQA 130 140 150 160 170 180 LSGMLERWHN VLYLMYDNEA YMNTGIQRSS STPYGAWTTT SPPGKYSVGE DKPKKWVALI 190 200 210 220 230 240 AAAHQIPYVA TASIGNPLDF VRKIKKAGKI DGPAFVQVLC TCPTGWRSPL EKGVEIARLA 250 260 270 280 290 300 IETGIWPLFE IENGDIWNIK IQPPGGGAKV YKEGNRVVRI EFKKPIEEYL KLQGRFKHLF 310 320 330 KRPEAIEELR NQVKAMWKVL GVEAILPRPE E

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima." Kletzin A., Adams M.W.W. J. Bacteriol. 178:248-257(1996) [PubMed: 8550425] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-24. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
[2]	"Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences." Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T. Genetics 152:1299-1305(1999) [PubMed: 10430560] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
[3]	"Purification and characterization of pyruvate ferredoxin oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus." Blamey J.M., Adams M.W.W. Biochim. Biophys. Acta 1161:19-27(1993) [PubMed: 8380721] [Abstract] Cited for: CHARACTERIZATION. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X85250 Genomic DNA. Translation: CAA59506.1. AE009950 Genomic DNA. Translation: AAL81089.1.
PIR	T45089.
RefSeq	NP_578694.1. NC_003413.1.
3D structure databases
ProteinModelPortal	Q51805.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000005899; EBPYRP00000005760; EBPYRG00000005898.
GeneID	1468830.
GenomeReviews	Gene locus PF0965 in contig AE009950_GR.
KEGG	pfu:PF0965.
NMPDR	fig|186497.1.peg.1001.
Phylogenomic databases
GeneTree	EBGT00050000022253.
HOGENOM	HBG313203.
OMA	SPCTTEW.
ProtClustDB	PRK11865.
Family and domain databases
InterPro	IPR011766. TPP_enzyme-bd_C. [Graphical view]
KO	K00170.
Pfam	PF02775. TPP_enzyme_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PORB_PYRFU

Accession

Primary (citable) accession number: Q51805

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 23, 2007
Last modified:	November 16, 2011
This is version 70 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program