Q51802 (VORB_PYRFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ketoisovalerate oxidoreductase subunit vorB
Short name=VOR
EC=1.2.7.7

Alternative name(s):
2-oxoisovalerate ferredoxin reductase subunit beta
2-oxoisovalerate oxidoreductase beta chain

Gene names

Name:	vorB
Ordered Locus Names:	PF0968

Organism

Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

Taxonomic identifier

186497 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+.
Subunit structure	Heterotetramer of one alpha, one beta, one delta and one gamma chain.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Molecular function	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity Inferred from electronic annotation. Source: EC thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Ketoisovalerate oxidoreductase subunit vorB		PRO_0000099957

Sequences

	Sequence		Length	Mass (Da)
	Q51802 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 07CC02452E3C6074	FASTA	311	34,766
	10 20 30 40 50 60 MEVPENIKKR VTIPFEEHFY AGHTACQGCG ASLGLRYVLK AYGKKTILVI PACCSTIIAG 70 80 90 100 110 120 PWPYSAIDAN LFHTAFETTG AVISGIEAAL KAMGYKVKGE DGIMVVGWAG DGGTADIGLQ 130 140 150 160 170 180 ALSGFLERGH DAVYIMYDNE AYMNTGIQRS SSTPYGAWTT NTPGGRRHFL EKRHKKKVID 190 200 210 220 230 240 IVIAHRIPYA ATASIAYPED FIRKLKKAQK ISGPSFIQLF APCPTGWRAP TDKSIEIARL 250 260 270 280 290 300 AVQTAYFPLF EYENGKYKIN MPNPKKEPKP IEEFLKLQGR FKYMTKEDIE TLQKWVLEEW 310 ERLKKLAEVF G

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima." Kletzin A., Adams M.W.W. J. Bacteriol. 178:248-257(1996) [PubMed: 8550425] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-7. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
[2]	"Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences." Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T. Genetics 152:1299-1305(1999) [PubMed: 10430560] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X85250 Genomic DNA. Translation: CAA59503.1. AE009950 Genomic DNA. Translation: AAL81092.1.
PIR	T45086.
RefSeq	NP_578697.1. NC_003413.1.
3D structure databases
ProteinModelPortal	Q51802.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000005158; EBPYRP00000005019; EBPYRG00000005157.
GeneID	1468833.
GenomeReviews	Gene locus PF0968 in contig AE009950_GR.
KEGG	pfu:PF0968.
NMPDR	fig|186497.1.peg.1004.
Phylogenomic databases
GeneTree	EBGT00050000022253.
HOGENOM	HBG313203.
OMA	HKKKVID.
ProtClustDB	PRK11864.
Family and domain databases
InterPro	IPR011766. TPP_enzyme-bd_C. [Graphical view]
KO	K00187.
Pfam	PF02775. TPP_enzyme_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VORB_PYRFU

Accession

Primary (citable) accession number: Q51802

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program