Reviewed, UniProtKB/Swiss-Prot Q51802 (VORB_PYRFU)

Names and origin

Protein names

Recommended name:
    Ketoisovalerate oxidoreductase subunit vorB
      Short name=VOR
    EC=1.2.7.7
Alternative name(s):
    2-oxoisovalerate oxidoreductase beta chain
    2-oxoisovalerate ferredoxin reductase subunit beta

Gene names

Name:	vorB
Ordered Locus Names:	PF0968

Organism

Pyrococcus furiosus [Complete proteome] [HAMAP]

Taxonomic identifier

2261 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+.
Subunit structure	Heterotetramer of one alpha, one beta, one delta and one gamma chain.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity Inferred from electronic annotation. Source: EC thiamin pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Ketoisovalerate oxidoreductase subunit vorB		PRO_0000099957

Sequences

	Sequence		Length	Mass (Da)
	Q51802-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 07CC02452E3C6074	FASTA	311	34,766
	10 20 30 40 50 60 MEVPENIKKR VTIPFEEHFY AGHTACQGCG ASLGLRYVLK AYGKKTILVI PACCSTIIAG 70 80 90 100 110 120 PWPYSAIDAN LFHTAFETTG AVISGIEAAL KAMGYKVKGE DGIMVVGWAG DGGTADIGLQ 130 140 150 160 170 180 ALSGFLERGH DAVYIMYDNE AYMNTGIQRS SSTPYGAWTT NTPGGRRHFL EKRHKKKVID 190 200 210 220 230 240 IVIAHRIPYA ATASIAYPED FIRKLKKAQK ISGPSFIQLF APCPTGWRAP TDKSIEIARL 250 260 270 280 290 300 AVQTAYFPLF EYENGKYKIN MPNPKKEPKP IEEFLKLQGR FKYMTKEDIE TLQKWVLEEW 310 ERLKKLAEVF G

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima." Kletzin A., Adams M.W.W. J. Bacteriol. 178:248-257(1996) [PubMed: 8550425] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-7. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
[2]	"The complete sequence of the Pyrococcus furiosus genome." Weiss R.B., Dunn D.M., Robb F.T., Brown J.R. Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X85250 Genomic DNA. Translation: CAA59503.1. AE009950 Genomic DNA. Translation: AAL81092.1.
PIR	T45086.
RefSeq	NP_578697.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1468833.
GenomeReviews	Gene locus PF0968 in contig AE009950_GR.
KEGG	pfu:PF0968.
NMPDR	fig|186497.1.peg.1004.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG313203.
OMA	PACCSTI.
Enzyme and pathway databases
BRENDA	1.2.7.7. 321.
Family and domain databases
InterPro	IPR011766. TPP_enzyme_bd_C. [Graphical view]
Pfam	PF02775. TPP_enzyme_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VORB_PYRFU

Accession

Primary (citable) accession number: Q51802

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	December 15, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)