Q51801 (VORA_PYRFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ketoisovalerate oxidoreductase subunit vorA
Short name=VOR
EC=1.2.7.7

Alternative name(s):
2-oxoisovalerate ferredoxin reductase subunit alpha
2-oxoisovalerate oxidoreductase alpha chain

Gene names

Name:	vorA
Ordered Locus Names:	PF0969

Organism

Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

Taxonomic identifier

186497 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+.
Subunit structure	Heterotetramer of one alpha, one beta, one delta and one gamma chain.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Molecular function	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	Ketoisovalerate oxidoreductase subunit vorA		PRO_0000099952

Sequences

	Sequence		Length	Mass (Da)
	Q51801 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: D8E580E790CEBB2B	FASTA	394	43,960
	10 20 30 40 50 60 MEYKPIRKVV SGNYAAAYAA LHARVQVVAA YPITPQTSII EKIAEFIANG EADIQYIPVE 70 80 90 100 110 120 SEHSAMAACI GASATGARTF TATSAQGLAL MHEMLHWAAG ARLPIVMVDV NRAMAPPWSV 130 140 150 160 170 180 WDDQTDSLSQ RDTGWMQFYA ENNQEVYDGV LMAYKVAETV NVPAMVVESA FILSHTYDVV 190 200 210 220 230 240 EMIPQELVDE FLPPRKPLYS LANFDEPIAV GALATPNDYY EFRYKLAKAH EEAKKVIKEV 250 260 270 280 290 300 GKEFGERFGR DYSQMIETGY IDDADFVFMG MGSLMGTVKE AVDLLRKEGY KVGYAKVRWF 310 320 330 340 350 360 RPFPKEELVE IAESVKGIAV LDRNFSFGQE GILFTESKGA LYNSSAHPLM KNYIVGLGGR 370 380 390 DVTVKDIKAI ADDMKKVIES GKVDKEVVWY HLKR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima." Kletzin A., Adams M.W.W. J. Bacteriol. 178:248-257(1996) [PubMed: 8550425] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-22. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
[2]	"Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences." Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T. Genetics 152:1299-1305(1999) [PubMed: 10430560] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X85250 Genomic DNA. Translation: CAA59502.1. AE009950 Genomic DNA. Translation: AAL81093.1.
PIR	T45085.
RefSeq	NP_578698.1. NC_003413.1.
3D structure databases
ProteinModelPortal	Q51801.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q51801. 1 interaction.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000004757; EBPYRP00000004618; EBPYRG00000004757.
GeneID	1468834.
GenomeReviews	Gene locus PF0969 in contig AE009950_GR.
KEGG	pfu:PF0969.
NMPDR	fig|186497.1.peg.1005.
Phylogenomic databases
GeneTree	EBGT00050000022252.
HOGENOM	HBG313202.
OMA	EADIQYI.
ProtClustDB	PRK08366.
Family and domain databases
InterPro	IPR002880. Pyrv_Fd/Flavodoxin_OxRdtase_N. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K00186.
Pfam	PF01855. POR_N. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

VORA_PYRFU

Accession

Primary (citable) accession number: Q51801

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program