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Reviewed, UniProtKB/Swiss-Prot Q51800 (VORD_PYRFU)

Last modified February 9, 2010. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Ketoisovalerate oxidoreductase subunit vorD
      Short name=VOR
    EC=1.2.7.7
Alternative name(s):
    2-oxoisovalerate oxidoreductase delta chain
    2-oxoisovalerate ferredoxin reductase subunit delta
Gene names
Name: vorD
Ordered Locus Names: PF0970
OrganismPyrococcus furiosus [Complete proteome] [HAMAP]
Taxonomic identifier2261 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus

Protein attributes

Sequence length105 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+.

Cofactor

Binds 2 4Fe-4S clusters By similarity.

Subunit structure

Heterotetramer of one alpha, one beta, one delta and one gamma chain.

Sequence similarities

Contains 2 4Fe-4S ferredoxin-type domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 105105Ketoisovalerate oxidoreductase subunit vorD
PRO_0000099962

Regions

Domain44 – 73304Fe-4S ferredoxin-type 1
Domain74 – 103304Fe-4S ferredoxin-type 2

Sites

Metal binding531Iron-sulfur 1 (4Fe-4S) Potential
Metal binding561Iron-sulfur 1 (4Fe-4S) Potential
Metal binding591Iron-sulfur 1 (4Fe-4S) Potential
Metal binding631Iron-sulfur 2 (4Fe-4S) Potential
Metal binding831Iron-sulfur 2 (4Fe-4S) Potential
Metal binding861Iron-sulfur 2 (4Fe-4S) Potential
Metal binding891Iron-sulfur 2 (4Fe-4S) Potential
Metal binding931Iron-sulfur 1 (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
Q51800-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: F609078E069DB899

FASTA10511,851
        10         20         30         40         50         60 
MNTLFGKTKE EAKPIVLKSV DEYPEAPISL GTTLVNPTGD WRTFKPVVNE EKCVKCYICW 

        70         80         90        100 
KYCPEPAIYI KPDGYVAIDY DYCKGCGICA NECPTKAITM IKEEK 

« Hide

References

« Hide 'large scale' references
[1]"Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima."
Kletzin A., Adams M.W.W.
J. Bacteriol. 178:248-257(1996) [PubMed: 8550425] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-15.
Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
[2]"The complete sequence of the Pyrococcus furiosus genome."
Weiss R.B., Dunn D.M., Robb F.T., Brown J.R.
Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X85250 Genomic DNA. Translation: CAA59501.1.
AE009950 Genomic DNA. Translation: AAL81094.1.
PIRT45084.
RefSeqNP_578699.1.

3D structure databases

SMRQ51800. Positions 40-102.
ModBaseSearch...

Genome annotation databases

GeneID1468835.
GenomeReviewsGene locus PF0970 in contig AE009950_GR.
KEGGpfu:PF0970.
NMPDRfig|186497.1.peg.1006.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG734156.
OMAVDYEYCK.

Enzyme and pathway databases

BRENDA1.2.7.7. 321.

Family and domain databases

InterProIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR011898. PorD_KorD.
[Graphical view]
TIGRFAMsTIGR02179. PorD_KorD. 1 hit.
PROSITEPS00198. 4FE4S_FER_1. 2 hits.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVORD_PYRFU
AccessionPrimary (citable) accession number: Q51800
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: February 9, 2010
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents