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Protein

Ketoisovalerate oxidoreductase subunit VorD

Gene

vorD

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+.

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 2 [4Fe-4S] clusters.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53Iron-sulfur 1 (4Fe-4S)Sequence analysis1
Metal bindingi56Iron-sulfur 1 (4Fe-4S)Sequence analysis1
Metal bindingi59Iron-sulfur 1 (4Fe-4S)Sequence analysis1
Metal bindingi63Iron-sulfur 2 (4Fe-4S)Sequence analysis1
Metal bindingi83Iron-sulfur 2 (4Fe-4S)Sequence analysis1
Metal bindingi86Iron-sulfur 2 (4Fe-4S)Sequence analysis1
Metal bindingi89Iron-sulfur 2 (4Fe-4S)Sequence analysis1
Metal bindingi93Iron-sulfur 1 (4Fe-4S)Sequence analysis1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ketoisovalerate oxidoreductase subunit VorD (EC:1.2.7.7)
Short name:
VOR
Alternative name(s):
2-oxoisovalerate ferredoxin reductase subunit delta
2-oxoisovalerate oxidoreductase delta chain
Gene namesi
Name:vorD
Ordered Locus Names:PF0970
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000999621 – 105Ketoisovalerate oxidoreductase subunit VorDAdd BLAST105

Proteomic databases

PRIDEiQ51800.

Interactioni

Subunit structurei

Heterotetramer of one alpha, one beta, one delta and one gamma chain.

Protein-protein interaction databases

STRINGi186497.PF0970.

Structurei

3D structure databases

ProteinModelPortaliQ51800.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 734Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST30
Domaini74 – 1034Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST30

Sequence similaritiesi

Contains 2 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiarCOG01605. Archaea.
COG1144. LUCA.
HOGENOMiHOG000044614.
KOiK00188.
OMAiKSVDEYP.

Family and domain databases

InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR011898. PorD_KorD.
[Graphical view]
TIGRFAMsiTIGR02179. PorD_KorD. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 2 hits.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q51800-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTLFGKTKE EAKPIVLKSV DEYPEAPISL GTTLVNPTGD WRTFKPVVNE
60 70 80 90 100
EKCVKCYICW KYCPEPAIYI KPDGYVAIDY DYCKGCGICA NECPTKAITM

IKEEK
Length:105
Mass (Da):11,851
Last modified:November 1, 1996 - v1
Checksum:iF609078E069DB899
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85250 Genomic DNA. Translation: CAA59501.1.
AE009950 Genomic DNA. Translation: AAL81094.1.
PIRiT45084.
RefSeqiWP_011012107.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL81094; AAL81094; PF0970.
GeneIDi1468835.
KEGGipfu:PF0970.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85250 Genomic DNA. Translation: CAA59501.1.
AE009950 Genomic DNA. Translation: AAL81094.1.
PIRiT45084.
RefSeqiWP_011012107.1. NC_003413.1.

3D structure databases

ProteinModelPortaliQ51800.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi186497.PF0970.

Proteomic databases

PRIDEiQ51800.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL81094; AAL81094; PF0970.
GeneIDi1468835.
KEGGipfu:PF0970.

Phylogenomic databases

eggNOGiarCOG01605. Archaea.
COG1144. LUCA.
HOGENOMiHOG000044614.
KOiK00188.
OMAiKSVDEYP.

Family and domain databases

InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR011898. PorD_KorD.
[Graphical view]
TIGRFAMsiTIGR02179. PorD_KorD. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 2 hits.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVORD_PYRFU
AccessioniPrimary (citable) accession number: Q51800
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 11, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.