Reviewed, UniProtKB/Swiss-Prot Q51799 (PORC_PYRFU)

Names and origin

Protein names

Recommended name:
    Pyruvate/ketoisovalerate oxidoreductases common subunit gamma
Including the following 2 domains:
    1- Recommended name:
            Pyruvate synthase subunit porC
              EC=1.2.7.1
        Alternative name(s):
            Pyruvate oxidoreductase gamma chain
              Short name=POR
            Pyruvic-ferredoxin oxidoreductase subunit gamma
    2- Recommended name:
            Ketoisovalerate oxidoreductase subunit vorC
                Short name=VOR
              EC=1.2.7.7
        Alternative name(s):
            2-oxoisovalerate oxidoreductase gamma chain
            2-oxoisovalerate ferredoxin reductase subunit gamma

Gene names

Name:	porG
Ordered Locus Names:	PF0971

Organism

Pyrococcus furiosus [Complete proteome] [HAMAP]

Taxonomic identifier

2261 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+. 3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+.
Subunit structure	Heterotetramer of one alpha, one beta, one delta and one gamma chain.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity Inferred from electronic annotation. Source: EC pyruvate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Pyruvate/ketoisovalerate oxidoreductases common subunit gamma		PRO_0000099914

Sequences

	Sequence		Length	Mass (Da)
	Q51799-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: E58743586CE87C13	FASTA	185	20,021
	10 20 30 40 50 60 MIEVRFHGRG GQGAVTAANI LAEAAFLEGK YVQAFPFFGV ERRGAPVTAF TRIDNKPIRI 70 80 90 100 110 120 KTQIYEPDVV VVLDPSLLDA VDVTAGLKDE GIVIVNTEKS KEEVLEKLKK KPKKLAIVDA 130 140 150 160 170 180 TTIALEILGL PITNTAILGA VAKATGLVKI ESIEEAIKDT FSGELGEKNA RAAREAYEKT EVFEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima." Kletzin A., Adams M.W.W. J. Bacteriol. 178:248-257(1996) [PubMed: 8550425] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-28. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
[2]	"The complete sequence of the Pyrococcus furiosus genome." Weiss R.B., Dunn D.M., Robb F.T., Brown J.R. Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
[3]	"Purification and characterization of pyruvate ferredoxin oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus." Blamey J.M., Adams M.W.W. Biochim. Biophys. Acta 1161:19-27(1993) [PubMed: 8380721] [Abstract] Cited for: CHARACTERIZATION. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X85250 Genomic DNA. Translation: CAA59500.1. AE009950 Genomic DNA. Translation: AAL81095.1.
PIR	T45083.
RefSeq	NP_578700.1.
3D structure databases
SMR	Q51799. Positions 1-184.
ModBase	Search...
Genome annotation databases
GeneID	1468836.
GenomeReviews	Gene locus PF0971 in contig AE009950_GR.
KEGG	pfu:PF0971.
NMPDR	fig|186497.1.peg.1007.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG553299.
OMA	KEIRIHG.
Enzyme and pathway databases
BRENDA	1.2.7.1. 321. 1.2.7.7. 321.
Family and domain databases
InterPro	IPR011894. PorC_KorC. IPR019752. Pyrv/ketoisovalerate_OxRed_cat. IPR002869. Pyrv_flavodox_OxRed_cen. [Graphical view]
Gene3D	G3DSA:3.40.920.10. Pyrv_Fd/Flavodoxin_OxRdtase. 1 hit.
Pfam	PF01558. POR. 1 hit. [Graphical view]
TIGRFAMs	TIGR02175. PorC_KorC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PORC_PYRFU

Accession

Primary (citable) accession number: Q51799

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	February 9, 2010
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)