Q51799 (PORC_PYRFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyruvate/ketoisovalerate oxidoreductases common subunit gamma

Including the following 2 domains:

1. Pyruvate synthase subunit porC
   EC=1.2.7.1
   Alternative name(s):
   Pyruvate oxidoreductase gamma chain
   Short name=POR
   Pyruvic-ferredoxin oxidoreductase subunit gamma
2. Ketoisovalerate oxidoreductase subunit vorC
   Short name=VOR
   EC=1.2.7.7
   Alternative name(s):
   2-oxoisovalerate ferredoxin reductase subunit gamma
   2-oxoisovalerate oxidoreductase gamma chain

Gene names

Name:	porG
Ordered Locus Names:	PF0971

Organism

Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

Taxonomic identifier

186497 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+. 3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+.
Subunit structure	Heterotetramer of one alpha, one beta, one delta and one gamma chain.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Molecular function	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity Inferred from electronic annotation. Source: EC pyruvate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Pyruvate/ketoisovalerate oxidoreductases common subunit gamma		PRO_0000099914

Sequences

	Sequence		Length	Mass (Da)
	Q51799 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: E58743586CE87C13	FASTA	185	20,021
	10 20 30 40 50 60 MIEVRFHGRG GQGAVTAANI LAEAAFLEGK YVQAFPFFGV ERRGAPVTAF TRIDNKPIRI 70 80 90 100 110 120 KTQIYEPDVV VVLDPSLLDA VDVTAGLKDE GIVIVNTEKS KEEVLEKLKK KPKKLAIVDA 130 140 150 160 170 180 TTIALEILGL PITNTAILGA VAKATGLVKI ESIEEAIKDT FSGELGEKNA RAAREAYEKT EVFEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima." Kletzin A., Adams M.W.W. J. Bacteriol. 178:248-257(1996) [PubMed: 8550425] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-28. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
[2]	"Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences." Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T. Genetics 152:1299-1305(1999) [PubMed: 10430560] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
[3]	"Purification and characterization of pyruvate ferredoxin oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus." Blamey J.M., Adams M.W.W. Biochim. Biophys. Acta 1161:19-27(1993) [PubMed: 8380721] [Abstract] Cited for: CHARACTERIZATION. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X85250 Genomic DNA. Translation: CAA59500.1. AE009950 Genomic DNA. Translation: AAL81095.1.
PIR	T45083.
RefSeq	NP_578700.1. NC_003413.1.
3D structure databases
ProteinModelPortal	Q51799.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000005358; EBPYRP00000005219; EBPYRG00000005357.
GeneID	1468836.
GenomeReviews	Gene locus PF0971 in contig AE009950_GR.
KEGG	pfu:PF0971.
NMPDR	fig|186497.1.peg.1007.
Phylogenomic databases
GeneTree	EBGT00050000022250.
HOGENOM	HBG553299.
OMA	DYVIVQD.
ProtClustDB	PRK14029.
Family and domain databases
InterPro	IPR011894. PorC_KorC. IPR019752. Pyrv/ketoisovalerate_OxRed_cat. IPR002869. Pyrv_flavodox_OxRed_cen. [Graphical view]
Gene3D	G3DSA:3.40.920.10. Pyrv_Fd/Flavodoxin_OxRdtase. 1 hit.
KO	K00189.
Pfam	PF01558. POR. 1 hit. [Graphical view]
SUPFAM	SSF53323. Pyrv_Fd/Flavodoxin_OxRdtase. 1 hit.
TIGRFAMs	TIGR02175. PorC_KorC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PORC_PYRFU

Accession

Primary (citable) accession number: Q51799

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program