Reviewed, UniProtKB/Swiss-Prot Q51789 (PHZC_PSEFL)

Names and origin

Protein names

Recommended name:
    Probable phospho-2-dehydro-3-deoxyheptonate aldolase
    EC=2.5.1.54
Alternative name(s):
    Phospho-2-keto-3-deoxyheptonate aldolase
    3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
    DAHP synthetase

Gene names

Name:

phzC

Organism

Pseudomonas fluorescens

Taxonomic identifier

294 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	400 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.
Pathway	Antibiotic biosynthesis; phenazine biosynthesis.
Sequence similarities	Belongs to the class-II DAHP synthetase family.

Ontologies

Keywords
Biological process	Antibiotic biosynthesis Virulence
Molecular function	Transferase
Gene Ontology (GO)
Biological process	antibiotic biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: InterPro pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-deoxy-7-phosphoheptulonate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 400	400	Probable phospho-2-dehydro-3-deoxyheptonate aldolase		PRO_0000140858

Sequences

	Sequence		Length	Mass (Da)
	Q51789-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 2787F91861253BA8	FASTA	400	44,005
	10 20 30 40 50 60 MEDLLKRVLK CEALQQPQWS EPSQLHDAQA YLRDSASLIR VEDILVLRAT LARVAAGEAM 70 80 90 100 110 120 IIQCGDCAED MDESAADHVT RKAALLDMLA GTFRLVTQQP VVRVGRIAGQ FAKPRSNHSE 130 140 150 160 170 180 RIGDVELPVY RGDMVNGRDA VLGHRQHDAQ RLVRGYRAAQ DIMQHLGWKE PSGQEQLTGS 190 200 210 220 230 240 PAWTSHEMLV LDYELPQVRR DEQGRTFLGS THWPWIGERT RQLTGAHVAL LSEVLNPVAC 250 260 270 280 290 300 KVGPDITQDQ LLSLCERLDP RREPGRLTLI ARMGAHKVAD RLPPLVEAVR RAGHKIIWLS 310 320 330 340 350 360 DPMHGNTIVA PCGNKTRMVQ TITDEITAFK HAVVSAGGVA GGLHLETTPD DVSECASDAA 370 380 390 400 GLGQVGSHYK SLCDPRLNPW QAITAVMAWK ACPPPSFVSL

References

[1]

"A seven-gene locus for synthesis of phenazine-1-carboxylic acid by Pseudomonas fluorescens 2-79." Mavrodi D.V., Ksenzenko V.N., Bonsall R.F., Cook R.J., Boronin A.M., Thomashow L.S. J. Bacteriol. 180:2541-2548(1998) [PubMed: 9573209] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: NRRL B-15132 / 2-79.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L48616 Genomic DNA. Translation: AAC18902.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.5.1.54. 329.
Family and domain databases
InterPro	IPR002480. DAHP_synth_2. [Graphical view]
PANTHER	PTHR21337. DAHP_synth_2. 1 hit.
Pfam	PF01474. DAHP_synth_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PHZC_PSEFL

Accession

Primary (citable) accession number: Q51789

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)