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Q51701

- NIRE_PARDP

UniProt

Q51701 - NIRE_PARDP

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Protein
Uroporphyrinogen-III C-methyltransferase
Gene
nirE, Pden_2488
Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the methylation of both C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin By similarity. Inactivation of uroporphyrinogen-III methyltransferase results in the loss of nitrite and nitric oxide reductase activities, but not of nitrous oxide reductase activity. Likely involved in heme D1 biosynthesis.

Catalytic activityi

S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.
S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei146 – 1461S-adenosyl-L-methionine By similarity
Binding sitei199 – 1991S-adenosyl-L-methionine; via amide nitrogen By similarity

GO - Molecular functioni

  1. precorrin-2 dehydrogenase activity Source: InterPro
  2. uroporphyrin-III C-methyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. siroheme biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciPDEN318586:GCVQ-2529-MONOMER.
UniPathwayiUPA00262; UER00211.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen-III C-methyltransferase (EC:2.1.1.107)
Short name:
Urogen III methylase
Alternative name(s):
SUMT
Uroporphyrinogen III methylase
Short name:
UROM
Gene namesi
Name:nirE
Ordered Locus Names:Pden_2488
OrganismiParacoccus denitrificans (strain Pd 1222)
Taxonomic identifieri318586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
ProteomesiUP000000361: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287Uroporphyrinogen-III C-methyltransferase
PRO_0000150385Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi318586.Pden_2488.

Structurei

3D structure databases

ProteinModelPortaliQ51701.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni116 – 1183S-adenosyl-L-methionine binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0007.
HOGENOMiHOG000290519.
KOiK02303.
OMAiYAGKEAG.
OrthoDBiEOG6DRPFR.

Family and domain databases

Gene3Di3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
InterProiIPR000878. 4pyrrol_Mease.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR006366. CobA/CysG_C.
IPR003043. Uropor_MeTrfase_CS.
[Graphical view]
PfamiPF00590. TP_methylase. 1 hit.
[Graphical view]
SUPFAMiSSF53790. SSF53790. 1 hit.
TIGRFAMsiTIGR01469. cobA_cysG_Cterm. 1 hit.
PROSITEiPS00839. SUMT_1. 1 hit.
PS00840. SUMT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q51701-1 [UniParc]FASTAAdd to Basket

« Hide

MAGKTVTNGA AQGKAARSGA DGAVRGKAGM GRVDLIGAGP GDPELLTLRA    50
LRLLQQADVV VHDRLVSDEV MACIPAHVRR IPVGKAAGFH PVPQEQINAL 100
LVELGLSGLT VARLKGGDPT IFGRGGEEFE AVTRAGIPCD YVPGITAAQG 150
AAVSARFPLT HRGLATGLRH VTGHRARDAA LDLDWASLAD PQTTLAIYMG 200
AANMAEIARE LIRHGMPADL PVLAVSQAST PQEQRLHATL QDIAAALARK 250
PLPAPVLFIV GHVAAMAEDC ALPQELYRPE WRLVAHG 287
Length:287
Mass (Da):30,029
Last modified:November 1, 1996 - v1
Checksum:iAA319E29BAC6C461
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U05002 Genomic DNA. Translation: AAA93119.1.
CP000489 Genomic DNA. Translation: ABL70575.1.
RefSeqiWP_011748768.1. NC_008686.1.
YP_916271.1. NC_008686.1.

Genome annotation databases

EnsemblBacteriaiABL70575; ABL70575; Pden_2488.
GeneIDi4580126.
KEGGipde:Pden_2488.
PATRICi22856097. VBIParDen97112_2413.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U05002 Genomic DNA. Translation: AAA93119.1 .
CP000489 Genomic DNA. Translation: ABL70575.1 .
RefSeqi WP_011748768.1. NC_008686.1.
YP_916271.1. NC_008686.1.

3D structure databases

ProteinModelPortali Q51701.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 318586.Pden_2488.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL70575 ; ABL70575 ; Pden_2488 .
GeneIDi 4580126.
KEGGi pde:Pden_2488.
PATRICi 22856097. VBIParDen97112_2413.

Phylogenomic databases

eggNOGi COG0007.
HOGENOMi HOG000290519.
KOi K02303.
OMAi YAGKEAG.
OrthoDBi EOG6DRPFR.

Enzyme and pathway databases

UniPathwayi UPA00262 ; UER00211 .
BioCyci PDEN318586:GCVQ-2529-MONOMER.

Family and domain databases

Gene3Di 3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
InterProi IPR000878. 4pyrrol_Mease.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR006366. CobA/CysG_C.
IPR003043. Uropor_MeTrfase_CS.
[Graphical view ]
Pfami PF00590. TP_methylase. 1 hit.
[Graphical view ]
SUPFAMi SSF53790. SSF53790. 1 hit.
TIGRFAMsi TIGR01469. cobA_cysG_Cterm. 1 hit.
PROSITEi PS00839. SUMT_1. 1 hit.
PS00840. SUMT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, sequencing and mutational analysis of a gene cluster involved in nitrite reduction in Paracoccus denitrificans."
    de Boer A.P.N., Reijnders W.N.M., Kuenen J.G., Stouthamer A.H., van Spanning R.J.M.
    Antonie Van Leeuwenhoek 66:111-127(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pd 1222.

Entry informationi

Entry nameiNIRE_PARDP
AccessioniPrimary (citable) accession number: Q51701
Secondary accession number(s): A1B4Y1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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