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Q51701

- NIRE_PARDP

UniProt

Q51701 - NIRE_PARDP

Protein

Uroporphyrinogen-III C-methyltransferase

Gene

nirE

Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the methylation of both C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin By similarity. Inactivation of uroporphyrinogen-III methyltransferase results in the loss of nitrite and nitric oxide reductase activities, but not of nitrous oxide reductase activity. Likely involved in heme D1 biosynthesis.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.
    S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei40 – 401S-adenosyl-L-methionine; via carbonyl oxygenBy similarity
    Binding sitei146 – 1461S-adenosyl-L-methionineBy similarity
    Binding sitei199 – 1991S-adenosyl-L-methionine; via amide nitrogenBy similarity

    GO - Molecular functioni

    1. precorrin-2 dehydrogenase activity Source: InterPro
    2. uroporphyrin-III C-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. siroheme biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciPDEN318586:GCVQ-2529-MONOMER.
    UniPathwayiUPA00262; UER00211.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uroporphyrinogen-III C-methyltransferase (EC:2.1.1.107)
    Short name:
    Urogen III methylase
    Alternative name(s):
    SUMT
    Uroporphyrinogen III methylase
    Short name:
    UROM
    Gene namesi
    Name:nirE
    Ordered Locus Names:Pden_2488
    OrganismiParacoccus denitrificans (strain Pd 1222)
    Taxonomic identifieri318586 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
    ProteomesiUP000000361: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 287287Uroporphyrinogen-III C-methyltransferasePRO_0000150385Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi318586.Pden_2488.

    Structurei

    3D structure databases

    ProteinModelPortaliQ51701.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni116 – 1183S-adenosyl-L-methionine bindingBy similarity

    Sequence similaritiesi

    Belongs to the precorrin methyltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG0007.
    HOGENOMiHOG000290519.
    KOiK02303.
    OMAiYAGKEAG.
    OrthoDBiEOG6DRPFR.

    Family and domain databases

    Gene3Di3.30.950.10. 1 hit.
    3.40.1010.10. 1 hit.
    InterProiIPR000878. 4pyrrol_Mease.
    IPR014777. 4pyrrole_Mease_sub1.
    IPR014776. 4pyrrole_Mease_sub2.
    IPR006366. CobA/CysG_C.
    IPR003043. Uropor_MeTrfase_CS.
    [Graphical view]
    PfamiPF00590. TP_methylase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53790. SSF53790. 1 hit.
    TIGRFAMsiTIGR01469. cobA_cysG_Cterm. 1 hit.
    PROSITEiPS00839. SUMT_1. 1 hit.
    PS00840. SUMT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q51701-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGKTVTNGA AQGKAARSGA DGAVRGKAGM GRVDLIGAGP GDPELLTLRA    50
    LRLLQQADVV VHDRLVSDEV MACIPAHVRR IPVGKAAGFH PVPQEQINAL 100
    LVELGLSGLT VARLKGGDPT IFGRGGEEFE AVTRAGIPCD YVPGITAAQG 150
    AAVSARFPLT HRGLATGLRH VTGHRARDAA LDLDWASLAD PQTTLAIYMG 200
    AANMAEIARE LIRHGMPADL PVLAVSQAST PQEQRLHATL QDIAAALARK 250
    PLPAPVLFIV GHVAAMAEDC ALPQELYRPE WRLVAHG 287
    Length:287
    Mass (Da):30,029
    Last modified:November 1, 1996 - v1
    Checksum:iAA319E29BAC6C461
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U05002 Genomic DNA. Translation: AAA93119.1.
    CP000489 Genomic DNA. Translation: ABL70575.1.
    RefSeqiWP_011748768.1. NC_008686.1.
    YP_916271.1. NC_008686.1.

    Genome annotation databases

    EnsemblBacteriaiABL70575; ABL70575; Pden_2488.
    GeneIDi4580126.
    KEGGipde:Pden_2488.
    PATRICi22856097. VBIParDen97112_2413.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U05002 Genomic DNA. Translation: AAA93119.1 .
    CP000489 Genomic DNA. Translation: ABL70575.1 .
    RefSeqi WP_011748768.1. NC_008686.1.
    YP_916271.1. NC_008686.1.

    3D structure databases

    ProteinModelPortali Q51701.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 318586.Pden_2488.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL70575 ; ABL70575 ; Pden_2488 .
    GeneIDi 4580126.
    KEGGi pde:Pden_2488.
    PATRICi 22856097. VBIParDen97112_2413.

    Phylogenomic databases

    eggNOGi COG0007.
    HOGENOMi HOG000290519.
    KOi K02303.
    OMAi YAGKEAG.
    OrthoDBi EOG6DRPFR.

    Enzyme and pathway databases

    UniPathwayi UPA00262 ; UER00211 .
    BioCyci PDEN318586:GCVQ-2529-MONOMER.

    Family and domain databases

    Gene3Di 3.30.950.10. 1 hit.
    3.40.1010.10. 1 hit.
    InterProi IPR000878. 4pyrrol_Mease.
    IPR014777. 4pyrrole_Mease_sub1.
    IPR014776. 4pyrrole_Mease_sub2.
    IPR006366. CobA/CysG_C.
    IPR003043. Uropor_MeTrfase_CS.
    [Graphical view ]
    Pfami PF00590. TP_methylase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53790. SSF53790. 1 hit.
    TIGRFAMsi TIGR01469. cobA_cysG_Cterm. 1 hit.
    PROSITEi PS00839. SUMT_1. 1 hit.
    PS00840. SUMT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation, sequencing and mutational analysis of a gene cluster involved in nitrite reduction in Paracoccus denitrificans."
      de Boer A.P.N., Reijnders W.N.M., Kuenen J.G., Stouthamer A.H., van Spanning R.J.M.
      Antonie Van Leeuwenhoek 66:111-127(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pd 1222.

    Entry informationi

    Entry nameiNIRE_PARDP
    AccessioniPrimary (citable) accession number: Q51701
    Secondary accession number(s): A1B4Y1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3