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Q51700

- NIRS_PARDP

UniProt

Q51700 - NIRS_PARDP

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Protein
Nitrite reductase
Gene
nirS, Pden_2487
Organism
Paracoccus denitrificans (strain Pd 1222)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Inactivation of this cytochrome oxidase results in the loss of nitrite and nitric oxide reductase activities, but not of nitrous oxide reductase activity.

Catalytic activityi

Nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+.
NH3 + H2O + acceptor = hydroxylamine + reduced acceptor.

Cofactori

Binds 2 heme groups per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi46 – 461Iron (heme axial ligand) By similarity
Binding sitei94 – 941Heme (covalent) By similarity
Binding sitei97 – 971Heme (covalent) By similarity
Metal bindingi98 – 981Iron (heme axial ligand) By similarity
Metal bindingi229 – 2291Iron (heme D1 proximal ligand) By similarity

GO - Molecular functioni

  1. electron carrier activity Source: InterPro
  2. heme binding Source: InterPro
  3. hydroxylamine reductase activity Source: UniProtKB-EC
  4. metal ion binding Source: UniProtKB-KW
  5. nitrite reductase (NO-forming) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciPDEN318586:GCVQ-2528-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nitrite reductase (EC:1.7.2.1)
Alternative name(s):
Cytochrome cd1
Cytochrome oxidase
Hydroxylamine reductase (EC:1.7.99.1)
Gene namesi
Name:nirS
Ordered Locus Names:Pden_2487
OrganismiParacoccus denitrificans (strain Pd 1222)
Taxonomic identifieri318586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus
ProteomesiUP000000361: Chromosome 1

Subcellular locationi

Periplasm By similarity

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 By similarity
Add
BLAST
Chaini30 – 596567Nitrite reductase
PRO_0000006574Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi318586.Pden_2487.

Structurei

3D structure databases

ProteinModelPortaliQ51700.
SMRiQ51700. Positions 38-596.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini77 – 16286Cytochrome c
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni30 – 7647N-terminal tail
Add
BLAST
Regioni163 – 596434D1-heme domain
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2010.
HOGENOMiHOG000225986.
KOiK15864.
OMAiWPPQFVI.
OrthoDBiEOG6RC3M0.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
2.130.10.10. 1 hit.
2.140.10.20. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR003143. Cyt_cd1_C.
IPR011048. Haem_d1.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF13442. Cytochrome_CBB3. 1 hit.
[Graphical view]
SUPFAMiSSF46626. SSF46626. 2 hits.
SSF51004. SSF51004. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q51700-1 [UniParc]FASTAAdd to Basket

« Hide

MRQRTPFARP GLLASAALAL VLGPLAVAAQ EQAAPPKDPA AALEDHKTKT    50
DNRYEPSLDN LAQQDVAALG APEGIPALSD AQYNEANKIY FERCAGCHGV 100
LRKGATGKAL TPDLTRDLGF DYLQSFITYG SPAGMPNWGT SGELTAEQVD 150
LMANYLLLDP AAPPEFGMKE MRESWQVHVA PEDRPTQQEN DWDLENLFSV 200
TLRDAGQIAL IDGTTYEIKS VLDTGYAVHI SRMSASGRYL FVIGRDGKVN 250
MIDLWMKEPA TVAEIKIGSE ARSIETSKME GWEDKYAIAG AYWPPQYVIM 300
DGETLEPMKI QSTRGMIYDE QEYHPEPRVA AILASHYRPE FIVNVKETGK 350
ILLVDYTDLK NLKTTEIEAE RFLHDGGLDG SHRYFITAAN ARNKLVVIDT 400
KEGKLVAIED TGGQTPHPGR GANFVHPTFG PVWATSHMGD DSVALIGTDP 450
EGHPDNAWKI LDSFPALGGG SLFIKTHPNS QYLYVDATLN PEAEISGSVA 500
VFDTKAMTGD GSDPEFKTLP IAEWAGIAEG QPRVVQGEFN KDGTEVWFSV 550
WNGKDQESAL VVVDDKTLEL KHVIKDERLV TPTGKFNVYN TMTDTY 596
Length:596
Mass (Da):65,440
Last modified:November 1, 1996 - v1
Checksum:i90C981B688A74BD3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U05002 Genomic DNA. Translation: AAA93118.1.
CP000489 Genomic DNA. Translation: ABL70574.1.
RefSeqiWP_011748767.1. NC_008686.1.
YP_916270.1. NC_008686.1.

Genome annotation databases

EnsemblBacteriaiABL70574; ABL70574; Pden_2487.
GeneIDi4580125.
KEGGipde:Pden_2487.
PATRICi22856095. VBIParDen97112_2412.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U05002 Genomic DNA. Translation: AAA93118.1 .
CP000489 Genomic DNA. Translation: ABL70574.1 .
RefSeqi WP_011748767.1. NC_008686.1.
YP_916270.1. NC_008686.1.

3D structure databases

ProteinModelPortali Q51700.
SMRi Q51700. Positions 38-596.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 318586.Pden_2487.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL70574 ; ABL70574 ; Pden_2487 .
GeneIDi 4580125.
KEGGi pde:Pden_2487.
PATRICi 22856095. VBIParDen97112_2412.

Phylogenomic databases

eggNOGi COG2010.
HOGENOMi HOG000225986.
KOi K15864.
OMAi WPPQFVI.
OrthoDBi EOG6RC3M0.

Enzyme and pathway databases

BioCyci PDEN318586:GCVQ-2528-MONOMER.

Family and domain databases

Gene3Di 1.10.760.10. 1 hit.
2.130.10.10. 1 hit.
2.140.10.20. 1 hit.
InterProi IPR009056. Cyt_c-like_dom.
IPR003143. Cyt_cd1_C.
IPR011048. Haem_d1.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
Pfami PF13442. Cytochrome_CBB3. 1 hit.
[Graphical view ]
SUPFAMi SSF46626. SSF46626. 2 hits.
SSF51004. SSF51004. 1 hit.
PROSITEi PS51007. CYTC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, sequencing and mutational analysis of a gene cluster involved in nitrite reduction in Paracoccus denitrificans."
    de Boer A.P.N., Reijnders W.N.M., Kuenen J.G., Stouthamer A.H., van Spanning R.J.M.
    Antonie Van Leeuwenhoek 66:111-127(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pd 1222.

Entry informationi

Entry nameiNIRS_PARDP
AccessioniPrimary (citable) accession number: Q51700
Secondary accession number(s): A1B4Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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