ID   Q51592_BURCE            Unreviewed;       467 AA.
AC   Q51592;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1996, sequence version 1.
DT   27-MAR-2024, entry version 91.
DE   SubName: Full=2,4,5-trichlorophenoxyacetic acid oxygenase 1 {ECO:0000313|EMBL:AAB39767.1};
GN   Name=tftA {ECO:0000313|EMBL:AAB39767.1};
OS   Burkholderia cepacia (Pseudomonas cepacia).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=292 {ECO:0000313|EMBL:AAB39767.1};
RN   [1] {ECO:0000313|EMBL:AAB39767.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=AC1100 {ECO:0000313|EMBL:AAB39767.1};
RX   PubMed=7527626;
RA   Danganan C.E., Ye R.W., Daubaras D.L., Xun L., Chakrabarty A.M.;
RT   "Nucleotide sequence and functional analysis of the genes encoding 2,4,5-
RT   trichlorophenoxyacetic acid oxygenase in Pseudomonas cepacia AC1100.";
RL   Appl. Environ. Microbiol. 60:4100-4106(1994).
CC   -!- SIMILARITY: Belongs to the bacterial ring-hydroxylating dioxygenase
CC       alpha subunit family. {ECO:0000256|ARBA:ARBA00008751}.
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DR   EMBL; U11420; AAB39767.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q51592; -.
DR   KEGG; ag:AAB39767; -.
DR   BioCyc; MetaCyc:MONOMER-14671; -.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd08879; RHO_alpha_C_AntDO-like; 1.
DR   Gene3D; 2.102.10.10; Rieske [2Fe-2S] iron-sulphur domain; 1.
DR   InterPro; IPR017941; Rieske_2Fe-2S.
DR   InterPro; IPR036922; Rieske_2Fe-2S_sf.
DR   InterPro; IPR015881; Ring-hydroxy_dOase_2Fe2S_BS.
DR   InterPro; IPR015879; Ring_hydroxy_dOase_asu_C_dom.
DR   InterPro; IPR001663; Rng_hydr_dOase-A.
DR   PANTHER; PTHR43756:SF1; 3-PHENYLPROPIONATE_CINNAMIC ACID DIOXYGENASE SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR43756; CHOLINE MONOOXYGENASE, CHLOROPLASTIC; 1.
DR   Pfam; PF00355; Rieske; 1.
DR   Pfam; PF00848; Ring_hydroxyl_A; 1.
DR   PRINTS; PR00090; RNGDIOXGNASE.
DR   SUPFAM; SSF55961; Bet v1-like; 1.
DR   SUPFAM; SSF50022; ISP domain; 1.
DR   PROSITE; PS51296; RIESKE; 1.
DR   PROSITE; PS00570; RING_HYDROXYL_ALPHA; 1.
PE   3: Inferred from homology;
KW   2Fe-2S {ECO:0000256|ARBA:ARBA00022714};
KW   Aromatic hydrocarbons catabolism {ECO:0000256|ARBA:ARBA00022797};
KW   Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          56..156
FT                   /note="Rieske"
FT                   /evidence="ECO:0000259|PROSITE:PS51296"
SQ   SEQUENCE   467 AA;  52636 MW;  B05FAD22D974175E CRC64;
     MNTTMNTPVP SYVNDVSHRG LVDDRATDGI FRVHREAFLD PRIFELEMSR IFESTWVFIG
     LESQVAKPHD FITADIGRQP VILTRNAEGK LACFLNSCRH RGALLCPFSK GNQKFHVCRY
     HGWSYDSSGR NIAITDQKDG QYPSAFDKEN HDLVSVARLE SYRGFVFASL SPDVPTLQEH
     LGGASVFLDL VADQAPNGLE YVSGTVDYTF DANWKLQFEN GLDFYHFGST HSSYVDILKL
     RAQRAVAPDA TQTGVKLASE PNEQGQGTFS FPRGHSVMWS TFQPGQEQRL SDGKGLQMNA
     KARAGEVRWK WMMRQRNLTI FPNLQIIDLQ SMQLSLQLRT WQPLAVDKTR MLSHCLAPIG
     ESFDERRSRI RRYEDFFNPS GLATSDDNVM YEFCQSGYRA IAAGATQGYV RGLGKPTENQ
     RDYAGELGLD NCESVYGSMA FGNETCFHAG YREWQRLLLA SDTTSSV
//