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Q51574

- BLO15_PSEAI

UniProt

Q51574 - BLO15_PSEAI

Protein

Beta-lactamase OXA-15

Gene

bla

Organism
Pseudomonas aeruginosa
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    • Comment

    Functioni

    Hydrolyzes oxacillin, first-generation cephalosporins and ceftazidime. Does not hydrolyze cefotaxime or carbapenems.

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei72 – 721Acyl-ester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC
    2. penicillin binding Source: InterPro

    GO - Biological processi

    1. antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamase OXA-15 (EC:3.5.2.6)
    Gene namesi
    Name:bla
    Synonyms:oxa15
    Encoded oniPlasmid pMLH540 Publication
    OrganismiPseudomonas aeruginosa
    Taxonomic identifieri287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121By similarityAdd
    BLAST
    Chaini22 – 275254Beta-lactamase OXA-15PRO_0000017032Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei75 – 751N6-carboxylysineBy similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ51574.
    SMRiQ51574. Positions 25-265.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni210 – 2123Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class-D beta-lactamase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR002137. Beta-lactam_class-D_AS.
    IPR001460. PCN-bd_Tpept.
    [Graphical view]
    PfamiPF00905. Transpeptidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS00337. BETA_LACTAMASE_D. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q51574-1 [UniParc]FASTAAdd to Basket

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    MAIRIFAILF SIFSLATFAH AQEGTLERSD WRKFFSEFQA KGTIVVADER    50
    QADRAMLVFD PVRSKKRYSP ASTFKIPHTL FALDAGAVRD EFQIFRWDGV 100
    NRGFAGHNQD QDLRSAMRNS TVWVYELFAK EIGDDKARRY LKKIDYGNAG 150
    PSTSNGDYWI EGSLAISAQE QIAFLRKLYR NELPFRVEHQ RLVKDLMIVE 200
    AGRNWILRAK TGWEGRMGWW VGWVEWPTGS VFFALNIDTP NRMDDLFKRE 250
    AIVRAILRSI EALPPNPAVN SDAAR 275
    Length:275
    Mass (Da):31,628
    Last modified:November 1, 1996 - v1
    Checksum:iD3678DFE678C38B5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U63835 Genomic DNA. Translation: AAB05874.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U63835 Genomic DNA. Translation: AAB05874.1 .

    3D structure databases

    ProteinModelPortali Q51574.
    SMRi Q51574. Positions 25-265.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR002137. Beta-lactam_class-D_AS.
    IPR001460. PCN-bd_Tpept.
    [Graphical view ]
    Pfami PF00905. Transpeptidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS00337. BETA_LACTAMASE_D. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "OXA-15, an extended-spectrum variant of OXA-2 beta-lactamase, isolated from a Pseudomonas aeruginosa strain."
      Danel F., Hall L.M.C., Gur D., Livermore D.M.
      Antimicrob. Agents Chemother. 41:785-790(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
      Strain: AH.

    Entry informationi

    Entry nameiBLO15_PSEAI
    AccessioniPrimary (citable) accession number: Q51574
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Plasmid

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3