Q51551 (PYRX_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dihydroorotase-like protein

Alternative name(s):
Aspartate carbamoyltransferase 44 kDa Non-catalytic chain

Gene names

Name:	pyrC'
Synonyms:	pyrX
Ordered Locus Names:	PA0401

Organism

Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

Taxonomic identifier

208964 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	423 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Non-functional DHOase By similarity. HAMAP MF_00220_B
Subunit structure	Heterododecamer of 6 active pyrB subunits and 6 non-catalytic pyrC' subunits By similarity.
Sequence similarities	Belongs to the DHOase family. PyrC' subfamily.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 423	423	Dihydroorotase-like protein HAMAP MF_00220_B		PRO_0000147284
Regions
	Compositional bias	81 – 84	4	Poly-Ala HAMAP MF_00220_B
Experimental info
	Sequence conflict	55	1	P → A in AAA25977. Ref.1
	Sequence conflict	296	1	K → N in AAA25977. Ref.1
	Sequence conflict	312	1	A → P in AAA25977. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q51551 [UniParc]. Last modified December 8, 2000. Version 2. Checksum: AD950F9EE4556F21	FASTA	423	44,150
	10 20 30 40 50 60 MTISIRGARV IDPASDLDQV GDLHIEAGKI VAIGAAPAGF SAQKTLDGAG LVAAPGLVDL 70 80 90 100 110 120 SVALREPGYG RKGNVESETR AAAAGGTTSL CCPPYTRPVL DTPAVAELIL DRAREAGNAK 130 140 150 160 170 180 VYPIGALTRG FGGEQLSELV ALRDTGCVAF TNGLHGFASN RILRRALEYA ATFDLTVIFT 190 200 210 220 230 240 SQDTDLAEGG LAHEGPTASF LGLAGIPETA ETVALARNLL LVEQSGVRAH FSQLTSARGI 250 260 270 280 290 300 ELVAQAQARG LPVTCDVALY QLILTDEALV GFSSLYHVQP PLRTRADREA LREAVKNGVV 310 320 330 340 350 360 QAIASHHQPH EADAKNAPFA ATEPGISGAE LLLPLAMTLV QDGLLDLPTL LARLSHGPAQ 370 380 390 400 410 420 ALRLPAGRLA VGQAADLVLF DPQGSTLAGE SWYSKGQNSP FVGHCLPGRV RYTLVDGHLT HEG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of the gene coding for dihydroorotase-like polypeptide from Pseudomonas aeruginosa." Vickrey J.F., Schurr M.J., Benjamin R.C., Cunin R., Shanley M.S., O'Donovan G.A. Submitted (JUN-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
[2]	"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen." Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R. , Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V. Nature 406:959-964(2000) [PubMed: 10984043] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L19649 Genomic DNA. Translation: AAA25977.1. AE004091 Genomic DNA. Translation: AAG03790.1.
PIR	G83595.
RefSeq	NP_249092.1. NC_002516.2.
3D structure databases
ProteinModelPortal	Q51551.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	878275.
GenomeReviews	Gene locus PA0401 in contig AE004091_GR.
KEGG	pae:PA0401.
NMPDR	fig|208964.1.peg.402.
PATRIC	19835042. VBIPseAer58763_0422.
Organism-specific databases
PseudoCAP	PA0401.
Phylogenomic databases
HOGENOM	HBG724623.
OMA	SHHQPHE.
ProtClustDB	PRK09357.
Enzyme and pathway databases
BioCyc	PAER208964:PA0401-MONOMER.
Family and domain databases
HAMAP	MF_00220_B. PyrC_type2_B. Divergent sequence. [Tree]
InterPro	IPR006680. Amidohydro_1. IPR004722. DHOase. IPR011059. Metal-dep_hydrolase_composite. [Graphical view]
KO	K01465.
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
SUPFAM	SSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMs	TIGR00857. PyrC_multi. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PYRX_PSEAE

Accession

Primary (citable) accession number: Q51551

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	December 8, 2000
Last modified:	January 25, 2012
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program