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Q51504 (Q51504_PSEAI) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Penicillin-binding protein 3 EMBL CAA58872.1
Gene names
Name:pbpB EMBL CAA58872.1
OrganismPseudomonas aeruginosa EMBL CAA58872.1
Taxonomic identifier287 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas ›

Protein attributes

Sequence length579 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Ontologies

Keywords
   Technical term3D-structure PDB 3OC2 PDB 3OCL PDB 3OCN PDB 3PBN PDB 3PBO PDB 3PBQ PDB 3PBS PDB 4FSF
Gene Ontology (GO)
   Molecular_functionpenicillin binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q51504 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 983D0F43C66A7218

FASTA57962,856
        10         20         30         40         50         60 
MKLNYFQGAL YPWRFCVIVG LLLAMVGAIV WRIVDLHVID HDFLKGQGDA RSVRHIAIPA 

        70         80         90        100        110        120 
HRGLITDRNG EPLAVSTPVT TLWANPKELM TAKERWPQLA AALGQDTKLF ADRIEQNAER 

       130        140        150        160        170        180 
EFIYLVRGLT PEQGEGVIAL KVPGVYSIEE FRRFYPAGEV VAHAVGFTDV DDRGREGIEL 

       190        200        210        220        230        240 
AFDEWLAGVP GKRQVLKDRR GRVIKDVQVT KNAKPGKTLA LSIDLRLQYL AHRELRNALL 

       250        260        270        280        290        300 
ENGAKAGSLV IMDVKTGEIL AMTNQPTYNP NNRRNLQPAA MRNRAMIDVF EPGSTVKPFS 

       310        320        330        340        350        360 
MSAALASGRW KPSDIVDVYP GTLQIGRYTI RDVSRNSRQL DLTGILIKSS NVGISKIAFD 

       370        380        390        400        410        420 
IGAESIYSVM QQVGLGQDTG LGFPGERVGN LPNHRKWPKA ETATLAYGYG LSVTAIQLAH 

       430        440        450        460        470        480 
AYAALANDGK SVPLSMTRVD RVPDGVQVIS PEVASTVQGM LQQVVEAQGG VFRAQVPGYH 

       490        500        510        520        530        540 
AAGKSGTARK VSVGTKGYRE NAYRSLFAGF APATDPRIAM VVVIDEPSKA GYFGGLVSAP 

       550        560        570 
VFSKVMAGAL RLMNVPPDNL PTATEQQQVN AAPAKGGRG

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References

[1]"Cloning and characterization of the Pseudomonas aeruginosa pbpB gene encoding penicillin-binding protein 3."
Liao X., Hancock R.E.W.
Antimicrob. Agents Chemother. 39:1871-1874(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: PAO1 EMBL CAA58872.1.
[2]"Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa."
Han S., Zaniewski R.P., Marr E.S., Lacey B.M., Tomaras A.P., Evdokimov A., Miller J.R., Shanmugasundaram V.
Proc. Natl. Acad. Sci. U.S.A. 107:22002-22007(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 50-579.
[3]"Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms."
Sainsbury S., Bird L., Rao V., Shepherd S.M., Stuart D.I., Hunter W.N., Owens R.J., Ren J.
J. Mol. Biol. 405:173-184(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.97 ANGSTROMS) OF 35-579.
[4]"Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections."
Mitton-Fry M.J., Arcari J.T., Brown M.F., Casavant J.M., Finegan S.M., Flanagan M.E., Gao H., George D.M., Gerstenberger B.S., Han S., Hardink J.R., Harris T.M., Hoang T., Huband M.D., Irvine R., Lall M.S., Megan Lemmon M., Li C. expand/collapse author list , Lin J., McCurdy S.P., Mueller J.P., Mullins L., Niosi M., Noe M.C., Pattavina D., Penzien J., Plummer M.S., Risley H., Schuff B.P., Shanmugasundaram V., Starr J.T., Sun J., Winton J., Young J.A.
Bioorg. Med. Chem. Lett. 22:5989-5994(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 50-579.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X84053 Genomic DNA. Translation: CAA58872.1.
PIRS54872.
RefSeqNP_253108.1. NC_002516.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3OC2X-ray1.97A35-579[»]
3OCLX-ray2.30A35-579[»]
3OCNX-ray2.61A35-579[»]
3PBNX-ray2.00A50-579[»]
3PBOX-ray1.74A50-579[»]
3PBQX-ray1.70A50-579[»]
3PBSX-ray2.00A50-579[»]
4FSFX-ray2.20A50-579[»]
ProteinModelPortalQ51504.
SMRQ51504. Positions 53-563.
ModBaseSearch...

Protein-protein interaction databases

STRING208964.PA4418.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID881247.
KEGGpae:PA4418.
PATRIC19843561. VBIPseAer58763_4627.

Organism-specific databases

PseudoCAPPA4418.

Phylogenomic databases

HOGENOMHOG000049554.
KOK03587.
ProtClustDBCLSK868643.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamPF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMSSF56519. PBP_dimer. 1 hit.
SSF56601. PBP_transp_fold. 1 hit.
ProtoNetSearch...

Other

ChEMBLCHEMBL5225.
EvolutionaryTraceQ51504.

Entry information

Entry nameQ51504_PSEAI
AccessionPrimary (citable) accession number: Q51504
Secondary accession number(s): Q7DC71
Entry history
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 29, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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