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Q51429

- BLO3_PSEAI

UniProt

Q51429 - BLO3_PSEAI

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Protein
Beta-lactamase OXA-3
Gene
bla, oxa3
Organism
Pseudomonas aeruginosa
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This is an oxacillin-hydrolyzing beta-lactamase.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei72 – 721Acyl-ester intermediate By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC
  2. penicillin binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase OXA-3 (EC:3.5.2.6)
Alternative name(s):
Penicillinase
Gene namesi
Name:bla
Synonyms:oxa3
Encoded oniPlasmid pMG250 Publication
OrganismiPseudomonas aeruginosa
Taxonomic identifieri287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 By similarity
Add
BLAST
Chaini22 – 275254Beta-lactamase OXA-3
PRO_0000017027Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei75 – 751N6-carboxylysine By similarity

Structurei

3D structure databases

ProteinModelPortaliQ51429.
SMRiQ51429. Positions 27-265.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni210 – 2123Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q51429-1 [UniParc]FASTAAdd to Basket

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MAIRIFAILF STFVFGTFAH AQEGMRERSD WRKFFSEFQA KGTIVVADER    50
QTDRVILVFD QVRSEKRYSP ASTFKIPHTL FALDAGAARD EFQVFRWDGI 100
KRSFAAHNQD QDLRSAMRNS TVWIYELFAK EIGEDKARRY LKQIDYGNAD 150
PSTSNGDYWI DGNLAIAAQE QIAFLRKLYH NELPFRVEHQ RLVKDLMIVE 200
AGRNWILRAK TGWEGRIGWW VGWVEWPTGP VFFALNIDTP NRMDDLFKRE 250
AIVRAILRSI EALPPNPAVN SDAAR 275
Length:275
Mass (Da):31,879
Last modified:November 1, 1996 - v1
Checksum:i4F9F95D755140146
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L07945 Genomic DNA. Translation: AAC41449.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L07945 Genomic DNA. Translation: AAC41449.1 .

3D structure databases

ProteinModelPortali Q51429.
SMRi Q51429. Positions 27-265.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view ]
Pfami PF00905. Transpeptidase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Primary structure of OXA-3 and phylogeny of oxacillin-hydrolyzing class D beta-lactamases."
    Sanschagrin F., Couture F., Levesque R.C.
    Antimicrob. Agents Chemother. 39:887-893(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiBLO3_PSEAI
AccessioniPrimary (citable) accession number: Q51429
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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