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Q51429 (BLO3_PSEAI) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase OXA-3

EC=3.5.2.6
Alternative name(s):
Penicillinase
Gene names
Name:bla
Synonyms:oxa3
Encoded onPlasmid pMG25
OrganismPseudomonas aeruginosa
Taxonomic identifier287 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

This is an oxacillin-hydrolyzing beta-lactamase.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Sequence similarities

Belongs to the class-D beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
   Technical termPlasmid
Gene Ontology (GO)
   Biological_processantibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

penicillin binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 By similarity
Chain22 – 275254Beta-lactamase OXA-3
PRO_0000017027

Regions

Region210 – 2123Substrate binding By similarity

Sites

Active site721Acyl-ester intermediate By similarity

Amino acid modifications

Modified residue751N6-carboxylysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q51429 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 4F9F95D755140146

FASTA27531,879
        10         20         30         40         50         60 
MAIRIFAILF STFVFGTFAH AQEGMRERSD WRKFFSEFQA KGTIVVADER QTDRVILVFD 

        70         80         90        100        110        120 
QVRSEKRYSP ASTFKIPHTL FALDAGAARD EFQVFRWDGI KRSFAAHNQD QDLRSAMRNS 

       130        140        150        160        170        180 
TVWIYELFAK EIGEDKARRY LKQIDYGNAD PSTSNGDYWI DGNLAIAAQE QIAFLRKLYH 

       190        200        210        220        230        240 
NELPFRVEHQ RLVKDLMIVE AGRNWILRAK TGWEGRIGWW VGWVEWPTGP VFFALNIDTP 

       250        260        270 
NRMDDLFKRE AIVRAILRSI EALPPNPAVN SDAAR 

« Hide

References

[1]"Primary structure of OXA-3 and phylogeny of oxacillin-hydrolyzing class D beta-lactamases."
Sanschagrin F., Couture F., Levesque R.C.
Antimicrob. Agents Chemother. 39:887-893(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L07945 Genomic DNA. Translation: AAC41449.1.

3D structure databases

ProteinModelPortalQ51429.
SMRQ51429. Positions 27-265.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamPF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLO3_PSEAI
AccessionPrimary (citable) accession number: Q51429
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: October 16, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families