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Protein

Holliday junction ATP-dependent DNA helicase RuvA

Gene

ruvA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
Biological processDNA damage, DNA recombination, DNA repair, SOS response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-987-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Holliday junction ATP-dependent DNA helicase RuvAUniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:ruvAUniRule annotation
Ordered Locus Names:PA0966
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA0966

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000946651 – 201Holliday junction ATP-dependent DNA helicase RuvAAdd BLAST201

Proteomic databases

PaxDbiQ51425

Interactioni

Subunit structurei

Forms a complex with RuvB.UniRule annotation

Protein-protein interaction databases

STRINGi208964.PA0966

Structurei

3D structure databases

ProteinModelPortaliQ51425
SMRiQ51425
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105KA4 Bacteria
COG0632 LUCA
HOGENOMiHOG000057116
InParanoidiQ51425
KOiK03550
OMAiDCHGVGY
PhylomeDBiQ51425

Family and domain databases

CDDicd14332 UBA_RuvA_C, 1 hit
HAMAPiMF_00031 DNA_helic_RuvA, 1 hit
InterProiView protein in InterPro
IPR013849 DNA_helicase_Holl-junc_RuvA_I
IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif
IPR012340 NA-bd_OB-fold
IPR000085 RuvA
IPR010994 RuvA_2-like
IPR011114 RuvA_C
IPR036267 RuvA_C_sf
PANTHERiPTHR33796 PTHR33796, 1 hit
PfamiView protein in Pfam
PF07499 RuvA_C, 1 hit
PF01330 RuvA_N, 1 hit
SMARTiView protein in SMART
SM00278 HhH1, 2 hits
SUPFAMiSSF46929 SSF46929, 1 hit
SSF47781 SSF47781, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00084 ruvA, 1 hit

Sequencei

Sequence statusi: Complete.

Q51425-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGRLRGTLA EKQPPHLILD VNGVGYEVEV PMTTLYRLPS VGEPVTLHTH
60 70 80 90 100
LVVREDAHLL YGFAEKRERE LFRELIRLNG VGPKLALALM SGLEVDELVR
110 120 130 140 150
CVQAQDTSTL VKIPGVGKKT AERLLVELKD RFKAWENMPT IAPLVMEPRA
160 170 180 190 200
SATVSSAEAD AVSALIALGF KPQEASRAVA AVPGEDLSSE EMIRQALKGM

V
Length:201
Mass (Da):21,960
Last modified:November 1, 1997 - v1
Checksum:i8EB3099077F87F23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83138 Genomic DNA Translation: BAA11818.1
AE004091 Genomic DNA Translation: AAG04355.1
PIRiJC5476
RefSeqiNP_249657.1, NC_002516.2
WP_003086122.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG04355; AAG04355; PA0966
GeneIDi879609
KEGGipae:PA0966
PATRICifig|208964.12.peg.1004

Similar proteinsi

Entry informationi

Entry nameiRUVA_PSEAE
AccessioniPrimary (citable) accession number: Q51425
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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