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Protein

Holliday junction ATP-dependent DNA helicase RuvA

Gene

ruvA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair, SOS response

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Holliday junction ATP-dependent DNA helicase RuvAUniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:ruvAUniRule annotation
Ordered Locus Names:PA0966
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA0966.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201Holliday junction ATP-dependent DNA helicase RuvAPRO_0000094665Add
BLAST

Proteomic databases

PaxDbiQ51425.
PRIDEiQ51425.

Interactioni

Subunit structurei

Forms a complex with RuvB.UniRule annotation

Protein-protein interaction databases

STRINGi208964.PA0966.

Structurei

3D structure databases

ProteinModelPortaliQ51425.
SMRiQ51425. Positions 1-199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105KA4. Bacteria.
COG0632. LUCA.
HOGENOMiHOG000057116.
InParanoidiQ51425.
KOiK03550.
OMAiVGYQVHC.
PhylomeDBiQ51425.

Family and domain databases

CDDicd14332. UBA_RuvA_C. 1 hit.
Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00031. DNA_helic_RuvA. 1 hit.
InterProiIPR013849. DNA_helicase_Holl-junc_RuvA_I.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR012340. NA-bd_OB-fold.
IPR000085. RuvA.
IPR010994. RuvA_2-like.
IPR011114. RuvA_C.
[Graphical view]
PfamiPF07499. RuvA_C. 1 hit.
PF01330. RuvA_N. 1 hit.
[Graphical view]
SMARTiSM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46929. SSF46929. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00084. ruvA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q51425-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGRLRGTLA EKQPPHLILD VNGVGYEVEV PMTTLYRLPS VGEPVTLHTH
60 70 80 90 100
LVVREDAHLL YGFAEKRERE LFRELIRLNG VGPKLALALM SGLEVDELVR
110 120 130 140 150
CVQAQDTSTL VKIPGVGKKT AERLLVELKD RFKAWENMPT IAPLVMEPRA
160 170 180 190 200
SATVSSAEAD AVSALIALGF KPQEASRAVA AVPGEDLSSE EMIRQALKGM

V
Length:201
Mass (Da):21,960
Last modified:November 1, 1997 - v1
Checksum:i8EB3099077F87F23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83138 Genomic DNA. Translation: BAA11818.1.
AE004091 Genomic DNA. Translation: AAG04355.1.
PIRiJC5476.
RefSeqiNP_249657.1. NC_002516.2.
WP_003086122.1. NZ_ASJY01000132.1.

Genome annotation databases

EnsemblBacteriaiAAG04355; AAG04355; PA0966.
GeneIDi879609.
KEGGipae:PA0966.
PATRICi19836232. VBIPseAer58763_1004.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83138 Genomic DNA. Translation: BAA11818.1.
AE004091 Genomic DNA. Translation: AAG04355.1.
PIRiJC5476.
RefSeqiNP_249657.1. NC_002516.2.
WP_003086122.1. NZ_ASJY01000132.1.

3D structure databases

ProteinModelPortaliQ51425.
SMRiQ51425. Positions 1-199.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA0966.

Proteomic databases

PaxDbiQ51425.
PRIDEiQ51425.

Protocols and materials databases

DNASUi879609.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG04355; AAG04355; PA0966.
GeneIDi879609.
KEGGipae:PA0966.
PATRICi19836232. VBIPseAer58763_1004.

Organism-specific databases

PseudoCAPiPA0966.

Phylogenomic databases

eggNOGiENOG4105KA4. Bacteria.
COG0632. LUCA.
HOGENOMiHOG000057116.
InParanoidiQ51425.
KOiK03550.
OMAiVGYQVHC.
PhylomeDBiQ51425.

Family and domain databases

CDDicd14332. UBA_RuvA_C. 1 hit.
Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00031. DNA_helic_RuvA. 1 hit.
InterProiIPR013849. DNA_helicase_Holl-junc_RuvA_I.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR012340. NA-bd_OB-fold.
IPR000085. RuvA.
IPR010994. RuvA_2-like.
IPR011114. RuvA_C.
[Graphical view]
PfamiPF07499. RuvA_C. 1 hit.
PF01330. RuvA_N. 1 hit.
[Graphical view]
SMARTiSM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46929. SSF46929. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00084. ruvA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRUVA_PSEAE
AccessioniPrimary (citable) accession number: Q51425
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.