Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

L-aspartate oxidase

Gene

nadB

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the oxidation of L-aspartate to iminoaspartate.

Catalytic activityi

L-aspartate + O2 = iminosuccinate + H2O2.

Cofactori

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes iminoaspartate from L-aspartate (oxidase route).
Proteins known to be involved in this subpathway in this organism are:
  1. L-aspartate oxidase (nadB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes iminoaspartate from L-aspartate (oxidase route), the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei244By similarity1
Active sitei263By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 24FADSequence analysisAdd BLAST15

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPyridine nucleotide biosynthesis
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-774-MONOMER
UniPathwayiUPA00253; UER00326

Names & Taxonomyi

Protein namesi
Recommended name:
L-aspartate oxidase (EC:1.4.3.16)
Short name:
LASPO
Alternative name(s):
Quinolinate synthase B
Gene namesi
Name:nadB
Ordered Locus Names:PA0761
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA0761

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001843931 – 538L-aspartate oxidaseAdd BLAST538

Proteomic databases

PaxDbiQ51363

Interactioni

Protein-protein interaction databases

STRINGi208964.PA0761

Structurei

3D structure databases

ProteinModelPortaliQ51363
SMRiQ51363
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108IYU Bacteria
COG0029 LUCA
InParanoidiQ51363
KOiK00278
OMAiHCVQWLI
PhylomeDBiQ51363

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR005288 NadB
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
PANTHERiPTHR42716:SF2 PTHR42716:SF2, 1 hit
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR00551 nadB, 1 hit

Sequencei

Sequence statusi: Complete.

Q51363-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQHYQHDVL VIGSGAAGLS LALTLPEHLR IAVLSKGELS QGSTYWAQGG
60 70 80 90 100
VAAVLDDTDT VESHVEDTLV AGGGLCREDA VRFTVEHSRE AIQWLIEQGV
110 120 130 140 150
PFTRDEQHNH EEGSFEYHLT REGGHSHRRI IHAADATGAA IFNTLLAQAR
160 170 180 190 200
RRPNIELLSQ RVAVDLITER KLGLPSKRCL GAYVLNRESG EVDTFRARFS
210 220 230 240 250
VLASGGASKV YLYTSNPDGN SGDGIAMAWR AGCRVGNLEF NQFHPTCLYH
260 270 280 290 300
PQAKSFLITE ALRGEGALLR LPNGERFMPR FDPRGELAPR DIVARAIDHE
310 320 330 340 350
MKRLGIDCVY LDISHKPAEF IKAHFPTVYE RCLDFGIDIT QQPIPVVPAA
360 370 380 390 400
HYTCGGVLVD QHGHTDVPGL YAIGETTFTG LHGANRMASN SLLECFVYAR
410 420 430 440 450
SAAADMLQRL PGTPVPESLP SWDASQVTDS DEDVIIAHNW DELRRFMWDY
460 470 480 490 500
VGIVRTNKRL QRAQHRVRLL LSEIDEFYSN YKVSRDLIEL RNLALVAELI
510 520 530
IRSAMQRRES RGLHYTLDYP DLLPEARDTI LVPPIYGD
Length:538
Mass (Da):60,005
Last modified:November 1, 1997 - v1
Checksum:iF2B76A500DA814A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17232 Genomic DNA Translation: AAA92356.1
AE004091 Genomic DNA Translation: AAG04150.1
L36379 Genomic DNA Translation: AAA64438.1
PIRiT46863
RefSeqiNP_249452.1, NC_002516.2
WP_003114182.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG04150; AAG04150; PA0761
GeneIDi882067
KEGGipae:PA0761
PATRICifig|208964.12.peg.791

Similar proteinsi

Entry informationi

Entry nameiNADB_PSEAE
AccessioniPrimary (citable) accession number: Q51363
Secondary accession number(s): Q51412
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health