Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Fe-regulated protein B

Gene

frpB

Organism
Neisseria meningitidis
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. receptor activity Source: InterPro

GO - Biological processi

  1. siderophore transport Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Fe-regulated protein BImported
Gene namesi
Name:frpBImported
OrganismiNeisseria meningitidisImported
Taxonomic identifieri487 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Subcellular locationi

  1. Cell outer membrane UniRule annotation

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 PotentialImportedAdd
BLAST
Chaini23 – 720698 PotentialImportedPRO_5000146568Add
BLAST

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AIPX-ray2.40A/B/C23-720[»]
ProteinModelPortaliQ51162.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TonB-dependent receptor family.UniRule annotation

Keywords - Domaini

SignalImported, TonB boxUniRule annotationSAAS annotation

Phylogenomic databases

KOiK16087.

Family and domain databases

Gene3Di2.170.130.10. 1 hit.
2.40.170.20. 1 hit.
InterProiIPR012910. Plug.
IPR000531. TonB-dep_rcpt_b-brl.
IPR010917. TonB_rcpt_CS.
IPR010105. TonB_sidphr_rcpt.
[Graphical view]
PfamiPF07715. Plug. 1 hit.
PF00593. TonB_dep_Rec. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01783. TonB-siderophor. 1 hit.
PROSITEiPS01156. TONB_DEPENDENT_REC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q51162-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTPLFRLSL LSLTLAAGFA HAAENNAKVV LDTVTVKGDR QGSKIRTNIV
60 70 80 90 100
TLQQKDESTA TDMRELLKEE PSIDFGGGNG TSQFLTLRGM GQNSVDIKVD
110 120 130 140 150
NAYSDSQILY HQGRFIVDPA LVKVVSVQKG AGSASAGIGA TNGAIIAKTV
160 170 180 190 200
DAQDLLKGLD KNWGVRLNSG FASNEGVSYG ASVFGKEGNF DGLFSYNRND
210 220 230 240 250
EKDYEAGKGF RNVNGGKTVP YSALDKRSYL AKIGTTFGDD DHRIVLSHMK
260 270 280 290 300
DQHRGIRTVR EEFTVGDKSS RINIDRQAPA YRETTQSNTN LAYTGKNLGF
310 320 330 340 350
VEKLDANAYV LEKERYSADD SGTGYAGNVK GPNHTRITTR GANFNFDSRL
360 370 380 390 400
AEQTLLKYGI NYRHQEIKPQ AFLNSKFSIP TTEEKNGQKV DKPMEQQMKD
410 420 430 440 450
RADEDTVHAY KLSNPTKTDT GVYVEAIHDI GDFTLTGGLR YDRFKVKTHD
460 470 480 490 500
GKTVSSSNLN PSFGVIWQPH EHWSFSASHN YASRSPRLYD ALQTHGKRGI
510 520 530 540 550
ISIADGTKAE RARNTEIGFN YNDGTFAANG SYFWQTIKDA LANPQNRHDS
560 570 580 590 600
VAVREAVNAG YIKNHGYELG ASYRTGGLTA KVGVSHSKPR FYDTHKDKLL
610 620 630 640 650
SANPEFGAQV GRTWTASLAY RFQNPNLEIG WRGRYVQKAT GSILAAGQKD
660 670 680 690 700
RKGNLENVVR KGFGVNDVFA NWKPLGKDTL NVNLSVNNVF NKFYYPHSQR
710 720
WTNTLPGVGR DVRLGVNYKF
Length:720
Mass (Da):79,612
Last modified:November 1, 1996 - v1
Checksum:i7F9E540A12A3DB2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89755 Genomic DNA. Translation: CAA61902.1.
PIRiS58133.
RefSeqiYP_005900546.1. NC_017516.1.

Genome annotation databases

KEGGinmh:NMBH4476_1926.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89755 Genomic DNA. Translation: CAA61902.1.
PIRiS58133.
RefSeqiYP_005900546.1. NC_017516.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AIPX-ray2.40A/B/C23-720[»]
ProteinModelPortaliQ51162.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGinmh:NMBH4476_1926.

Phylogenomic databases

KOiK16087.

Family and domain databases

Gene3Di2.170.130.10. 1 hit.
2.40.170.20. 1 hit.
InterProiIPR012910. Plug.
IPR000531. TonB-dep_rcpt_b-brl.
IPR010917. TonB_rcpt_CS.
IPR010105. TonB_sidphr_rcpt.
[Graphical view]
PfamiPF07715. Plug. 1 hit.
PF00593. TonB_dep_Rec. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01783. TonB-siderophor. 1 hit.
PROSITEiPS01156. TONB_DEPENDENT_REC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular characterization of FrpB, the 70-kilodalton iron-regulated outer membrane protein of Neisseria meningitidis."
    Pettersson A.M., Maas, van Wassenaar, van der Ley, Tommassen
    Infect. Immun. 63:4181-4184(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: H44/76Imported.
  2. "Use of a molecular decoy to segregate transport from antigenicity in the FrpB iron transporter from Neisseria meningitidis."
    Saleem M., Prince S.M., Rigby S.E., Imran M., Patel H., Chan H., Sanders H., Maiden M.C., Feavers I.M., Derrick J.P.
    PLoS ONE 8:e56746-e56746(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 23-720.

Entry informationi

Entry nameiQ51162_NEIME
AccessioniPrimary (citable) accession number: Q51162
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 29, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.