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Q51161

- DHPS_NEIMB

UniProt

Q51161 - DHPS_NEIMB

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Protein

Dihydropteroate synthase

Gene

folP

Organism
Neisseria meningitidis serogroup B (strain MC58)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide.

Catalytic activityi

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactori

Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate (By similarity).By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi25 – 251MagnesiumBy similarity
Binding sitei33 – 331SubstrateBy similarity
Binding sitei99 – 991SubstrateBy similarity
Binding sitei119 – 1191SubstrateBy similarity
Binding sitei190 – 1901SubstrateBy similarity
Binding sitei229 – 2291SubstrateBy similarity
Binding sitei264 – 2641SubstrateBy similarity
Binding sitei266 – 2661SubstrateBy similarity

GO - Molecular functioni

  1. dihydropteroate synthase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. response to antibiotic Source: UniProtKB-KW
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Antibiotic resistance, Folate biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciNMEN122586:GHGG-1746-MONOMER.
UniPathwayiUPA00077; UER00156.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropteroate synthase (EC:2.5.1.15)
Short name:
DHPS
Alternative name(s):
Dihydropteroate pyrophosphorylase
Gene namesi
Name:folP
Synonyms:dhpS
Ordered Locus Names:NMB1691
OrganismiNeisseria meningitidis serogroup B (strain MC58)
Taxonomic identifieri122586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000000425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285Dihydropteroate synthasePRO_0000168218Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi122586.NMB1691.

Structurei

3D structure databases

ProteinModelPortaliQ51161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 276259Pterin-bindingPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni66 – 672Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the DHPS family.Curated
Contains 1 pterin-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0294.
KOiK00796.
OMAiDCWISVD.
OrthoDBiEOG67T5P5.

Family and domain databases

Gene3Di3.20.20.20. 1 hit.
InterProiIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view]
PfamiPF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMiSSF51717. SSF51717. 1 hit.
TIGRFAMsiTIGR01496. DHPS. 1 hit.
PROSITEiPS00792. DHPS_1. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q51161-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARHVWQAGR FEIGLDKPKI MGIVNLTPDS FSDGGVYSQN AQTALAHAEQ
60 70 80 90 100
LLKEGADILD IGGESTRSGA DYVSPEEEWA RVEPVLAEVA GWGVPISLDT
110 120 130 140 150
RRTVIMEKAL ALGGIDIIND VAALNDEGAV ELLARQADTG ICLMHMQGLP
160 170 180 190 200
KTMQINPKYQ DVVGEVARYL KARSAECIAA GIAPQRIILD PGFGSGFGKP
210 220 230 240 250
LQHNIALMRH LPELMAETGF PLLIGVSRKS TIGELTGEAN AAERVHGSVA
260 270 280
AALASVARGA QIVRVHDVKA TADALKVWEA LGINL
Length:285
Mass (Da):30,313
Last modified:December 8, 2000 - v2
Checksum:iC56518F61CF98A4E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 43ARH → VGC in strain: 3976 / Serogroup B / Serotype NT.
Natural varianti31 – 311F → L in strain: 3976 / Serogroup B / Serotype NT.
Natural varianti36 – 361V → A in strain: BT490 / Serogroup B / Serotype 15, 952 / Serogroup B / Serotype NT and 3976 / Serogroup B / Serotype NT.
Natural varianti42 – 421Q → R in strain: 3976 / Serogroup B / Serotype NT.
Natural varianti50 – 501Q → R in strain: BT490 / Serogroup B / Serotype 15, 952 / Serogroup B / Serotype NT and 3976 / Serogroup B / Serotype NT.
Natural varianti68 – 681S → P in strain: BT490 / Serogroup B / Serotype 15, 952 / Serogroup B / Serotype NT and 3976 / Serogroup B / Serotype NT.
Natural varianti69 – 691G → C in strain: BT490 / Serogroup B / Serotype 15.
Natural varianti84 – 841P → S in strain: 3976 / Serogroup B / Serotype NT.
Natural varianti96 – 961I → V in strain: BT490 / Serogroup B / Serotype 15, 952 / Serogroup B / Serotype NT and 3976 / Serogroup B / Serotype NT.
Natural varianti102 – 1021R → H in strain: 3976 / Serogroup B / Serotype NT.
Natural varianti105 – 1051I → V in strain: 952 / Serogroup B / Serotype NT and 3976 / Serogroup B / Serotype NT.
Natural varianti125 – 1251N → T in strain: BT490 / Serogroup B / Serotype 15, 952 / Serogroup B / Serotype NT and 3976 / Serogroup B / Serotype NT.
Natural varianti130 – 1301V → L in strain: 3976 / Serogroup B / Serotype NT.
Natural varianti135 – 1351R → C in strain: 3976 / Serogroup B / Serotype NT.
Natural varianti137 – 1371A → T in strain: BT490 / Serogroup B / Serotype 15.
Natural varianti147 – 1471Q → R in strain: BT490 / Serogroup B / Serotype 15.
Natural varianti151 – 1511K → E in strain: BT490 / Serogroup B / Serotype 15 and 952 / Serogroup B / Serotype NT.
Natural varianti152 – 1521T → N in strain: BT490 / Serogroup B / Serotype 15, 952 / Serogroup B / Serotype NT and 3976 / Serogroup B / Serotype NT.
Natural varianti172 – 1721A → T in strain: 952 / Serogroup B / Serotype NT.
Natural varianti174 – 1741S → A in strain: BT490 / Serogroup B / Serotype 15 and 3976 / Serogroup B / Serotype NT.
Natural varianti175 – 1784AECI → ETCV in strain: 952 / Serogroup B / Serotype NT.
Natural varianti188 – 1881I → T in strain: BT490 / Serogroup B / Serotype 15, 952 / Serogroup B / Serotype NT and 3976 / Serogroup B / Serotype NT.
Natural varianti194 – 1952Missing in strain: BT490 / Serogroup B / Serotype 15, 952 / Serogroup B / Serotype NT and 3976 / Serogroup B / Serotype NT.
Natural varianti196 – 1961G → C in strain: 3976 / Serogroup B / Serotype NT.
Natural varianti200 – 2001P → T in strain: 952 / Serogroup B / Serotype NT and 3976 / Serogroup B / Serotype NT.
Natural varianti206 – 2061A → T in strain: 3976 / Serogroup B / Serotype NT.
Natural varianti208 – 2081M → V in strain: BT490 / Serogroup B / Serotype 15.
Natural varianti220 – 2201F → Y in strain: 3976 / Serogroup B / Serotype NT.
Natural varianti230 – 2301S → R in strain: 952 / Serogroup B / Serotype NT and BT490 / Serogroup B / Serotype 15.
Natural varianti231 – 2311T → M in strain: BT490 / Serogroup B / Serotype 15, 952 / Serogroup B / Serotype NT and 3976 / Serogroup B / Serotype NT.
Natural varianti232 – 2321I → V in strain: BT490 / Serogroup B / Serotype 15.
Natural varianti239 – 2391A → S in strain: BT490 / Serogroup B / Serotype 15.
Natural varianti239 – 2391A → T in strain: 3976 / Serogroup B / Serotype NT.
Natural varianti240 – 2401N → D in strain: BT490 / Serogroup B / Serotype 15, 952 / Serogroup B / Serotype NT and 3976 / Serogroup B / Serotype NT.
Natural varianti243 – 2431E → A in strain: BT490 / Serogroup B / Serotype 15 and 3976 / Serogroup B / Serotype NT.
Natural varianti245 – 2451V → G in strain: 3976 / Serogroup B / Serotype NT.
Natural varianti253 – 2531L → V in strain: BT490 / Serogroup B / Serotype 15.
Natural varianti255 – 2551S → A in strain: BT490 / Serogroup B / Serotype 15 and 3976 / Serogroup B / Serotype NT.
Natural varianti261 – 2611Q → K in strain: 3976 / Serogroup B / Serotype NT.
Natural varianti277 – 2771V → A in strain: 3976 / Serogroup B / Serotype NT.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68062 Genomic DNA. Translation: CAA48199.1.
X68066 Genomic DNA. Translation: CAA48203.1.
X68069 Genomic DNA. Translation: CAA48206.1.
X87405 Genomic DNA. Translation: CAA60855.1.
AE002098 Genomic DNA. Translation: AAF42039.1.
PIRiA57423.
S25611.
S65832.
S65839.
RefSeqiNP_274695.1. NC_003112.2.
WP_002224358.1. NC_003112.2.

Genome annotation databases

EnsemblBacteriaiAAF42039; AAF42039; NMB1691.
GeneIDi903415.
KEGGinme:NMB1691.
PATRICi20359335. VBINeiMen85645_2174.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68062 Genomic DNA. Translation: CAA48199.1 .
X68066 Genomic DNA. Translation: CAA48203.1 .
X68069 Genomic DNA. Translation: CAA48206.1 .
X87405 Genomic DNA. Translation: CAA60855.1 .
AE002098 Genomic DNA. Translation: AAF42039.1 .
PIRi A57423.
S25611.
S65832.
S65839.
RefSeqi NP_274695.1. NC_003112.2.
WP_002224358.1. NC_003112.2.

3D structure databases

ProteinModelPortali Q51161.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 122586.NMB1691.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF42039 ; AAF42039 ; NMB1691 .
GeneIDi 903415.
KEGGi nme:NMB1691.
PATRICi 20359335. VBINeiMen85645_2174.

Phylogenomic databases

eggNOGi COG0294.
KOi K00796.
OMAi DCWISVD.
OrthoDBi EOG67T5P5.

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00156 .
BioCyci NMEN122586:GHGG-1746-MONOMER.

Family and domain databases

Gene3Di 3.20.20.20. 1 hit.
InterProi IPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view ]
Pfami PF00809. Pterin_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF51717. SSF51717. 1 hit.
TIGRFAMsi TIGR01496. DHPS. 1 hit.
PROSITEi PS00792. DHPS_1. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Transformational exchanges in the dihydropteroate synthase gene of Neisseria meningitidis: a novel mechanism for acquisition of sulfonamide resistance."
    Raadstroem P., Fermer C., Kristiansen B.-E., Jenkins A., Skoeld O., Swedberg G.
    J. Bacteriol. 174:6386-6393(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 952 / Serogroup B / Serotype NT, BT490 / Serogroup B / Serotype 15 and MO035 / Serogroup B / Serotype 15.
  2. "Sulfonamide resistance in Neisseria meningitidis as defined by site-directed mutagenesis could have its origin in other species."
    Fermer C., Kristiansen B.E., Skoeld O., Swedberg G.
    J. Bacteriol. 177:4669-4675(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 3976 / Serogroup B / Serotype NT.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MC58.

Entry informationi

Entry nameiDHPS_NEIMB
AccessioniPrimary (citable) accession number: Q51161
Secondary accession number(s): Q51157
, Q51158, Q51159, Q51160, Q57214, Q60395
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 8, 2000
Last modified: October 1, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3