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Protein

Dihydropteroate synthase

Gene

folP

Organism
Neisseria meningitidis serogroup B (strain MC58)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.By similarity

Catalytic activityi

6-hydroxymethyl-7,8-dihydropterin diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.By similarity

Cofactori

Mg2+By similarity

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Dihydropteroate synthase (folP)
  2. no protein annotated in this organism
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi25MagnesiumBy similarity1
Binding sitei666-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei996-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei1196-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei1906-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei2296-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Folate biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00077; UER00156.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropteroate synthase (EC:2.5.1.15)
Short name:
DHPS
Alternative name(s):
Dihydropteroate pyrophosphorylase
Gene namesi
Name:folP
Synonyms:dhpS
Ordered Locus Names:NMB1691
OrganismiNeisseria meningitidis serogroup B (strain MC58)
Taxonomic identifieri122586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000000425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001682181 – 285Dihydropteroate synthaseAdd BLAST285

Proteomic databases

PaxDbiQ51161.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi122586.NMB1691.

Structurei

3D structure databases

ProteinModelPortaliQ51161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 276Pterin-bindingPROSITE-ProRule annotationAdd BLAST259

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni264 – 2666-hydroxymethyl-7,8-dihydropterin diphosphate bindingBy similarity3

Sequence similaritiesi

Belongs to the DHPS family.Curated
Contains 1 pterin-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105EEI. Bacteria.
COG0294. LUCA.
KOiK00796.
OMAiSIDTYHA.
OrthoDBiPOG091H00BJ.

Family and domain databases

CDDicd00739. DHPS. 1 hit.
Gene3Di3.20.20.20. 1 hit.
InterProiIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding_dom.
[Graphical view]
PfamiPF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMiSSF51717. SSF51717. 1 hit.
TIGRFAMsiTIGR01496. DHPS. 1 hit.
PROSITEiPS00792. DHPS_1. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q51161-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARHVWQAGR FEIGLDKPKI MGIVNLTPDS FSDGGVYSQN AQTALAHAEQ
60 70 80 90 100
LLKEGADILD IGGESTRSGA DYVSPEEEWA RVEPVLAEVA GWGVPISLDT
110 120 130 140 150
RRTVIMEKAL ALGGIDIIND VAALNDEGAV ELLARQADTG ICLMHMQGLP
160 170 180 190 200
KTMQINPKYQ DVVGEVARYL KARSAECIAA GIAPQRIILD PGFGSGFGKP
210 220 230 240 250
LQHNIALMRH LPELMAETGF PLLIGVSRKS TIGELTGEAN AAERVHGSVA
260 270 280
AALASVARGA QIVRVHDVKA TADALKVWEA LGINL
Length:285
Mass (Da):30,313
Last modified:December 8, 2000 - v2
Checksum:iC56518F61CF98A4E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti2 – 4ARH → VGC in strain: 3976 / Serogroup B / Serotype NT. 3
Natural varianti31F → L in strain: 3976 / Serogroup B / Serotype NT. 1
Natural varianti36V → A in strain: BT490 / Serogroup B / Serotype 15, 952 / Serogroup B / Serotype NT and 3976 / Serogroup B / Serotype NT. 1
Natural varianti42Q → R in strain: 3976 / Serogroup B / Serotype NT. 1
Natural varianti50Q → R in strain: BT490 / Serogroup B / Serotype 15, 952 / Serogroup B / Serotype NT and 3976 / Serogroup B / Serotype NT. 1
Natural varianti68S → P in strain: BT490 / Serogroup B / Serotype 15, 952 / Serogroup B / Serotype NT and 3976 / Serogroup B / Serotype NT. 1
Natural varianti69G → C in strain: BT490 / Serogroup B / Serotype 15. 1
Natural varianti84P → S in strain: 3976 / Serogroup B / Serotype NT. 1
Natural varianti96I → V in strain: BT490 / Serogroup B / Serotype 15, 952 / Serogroup B / Serotype NT and 3976 / Serogroup B / Serotype NT. 1
Natural varianti102R → H in strain: 3976 / Serogroup B / Serotype NT. 1
Natural varianti105I → V in strain: 952 / Serogroup B / Serotype NT and 3976 / Serogroup B / Serotype NT. 1
Natural varianti125N → T in strain: BT490 / Serogroup B / Serotype 15, 952 / Serogroup B / Serotype NT and 3976 / Serogroup B / Serotype NT. 1
Natural varianti130V → L in strain: 3976 / Serogroup B / Serotype NT. 1
Natural varianti135R → C in strain: 3976 / Serogroup B / Serotype NT. 1
Natural varianti137A → T in strain: BT490 / Serogroup B / Serotype 15. 1
Natural varianti147Q → R in strain: BT490 / Serogroup B / Serotype 15. 1
Natural varianti151K → E in strain: BT490 / Serogroup B / Serotype 15 and 952 / Serogroup B / Serotype NT. 1
Natural varianti152T → N in strain: BT490 / Serogroup B / Serotype 15, 952 / Serogroup B / Serotype NT and 3976 / Serogroup B / Serotype NT. 1
Natural varianti172A → T in strain: 952 / Serogroup B / Serotype NT. 1
Natural varianti174S → A in strain: BT490 / Serogroup B / Serotype 15 and 3976 / Serogroup B / Serotype NT. 1
Natural varianti175 – 178AECI → ETCV in strain: 952 / Serogroup B / Serotype NT. 4
Natural varianti188I → T in strain: BT490 / Serogroup B / Serotype 15, 952 / Serogroup B / Serotype NT and 3976 / Serogroup B / Serotype NT. 1
Natural varianti194 – 195Missing in strain: BT490 / Serogroup B / Serotype 15, 952 / Serogroup B / Serotype NT and 3976 / Serogroup B / Serotype NT. 2
Natural varianti196G → C in strain: 3976 / Serogroup B / Serotype NT. 1
Natural varianti200P → T in strain: 952 / Serogroup B / Serotype NT and 3976 / Serogroup B / Serotype NT. 1
Natural varianti206A → T in strain: 3976 / Serogroup B / Serotype NT. 1
Natural varianti208M → V in strain: BT490 / Serogroup B / Serotype 15. 1
Natural varianti220F → Y in strain: 3976 / Serogroup B / Serotype NT. 1
Natural varianti230S → R in strain: 952 / Serogroup B / Serotype NT and BT490 / Serogroup B / Serotype 15. 1
Natural varianti231T → M in strain: BT490 / Serogroup B / Serotype 15, 952 / Serogroup B / Serotype NT and 3976 / Serogroup B / Serotype NT. 1
Natural varianti232I → V in strain: BT490 / Serogroup B / Serotype 15. 1
Natural varianti239A → S in strain: BT490 / Serogroup B / Serotype 15. 1
Natural varianti239A → T in strain: 3976 / Serogroup B / Serotype NT. 1
Natural varianti240N → D in strain: BT490 / Serogroup B / Serotype 15, 952 / Serogroup B / Serotype NT and 3976 / Serogroup B / Serotype NT. 1
Natural varianti243E → A in strain: BT490 / Serogroup B / Serotype 15 and 3976 / Serogroup B / Serotype NT. 1
Natural varianti245V → G in strain: 3976 / Serogroup B / Serotype NT. 1
Natural varianti253L → V in strain: BT490 / Serogroup B / Serotype 15. 1
Natural varianti255S → A in strain: BT490 / Serogroup B / Serotype 15 and 3976 / Serogroup B / Serotype NT. 1
Natural varianti261Q → K in strain: 3976 / Serogroup B / Serotype NT. 1
Natural varianti277V → A in strain: 3976 / Serogroup B / Serotype NT. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68062 Genomic DNA. Translation: CAA48199.1.
X68066 Genomic DNA. Translation: CAA48203.1.
X68069 Genomic DNA. Translation: CAA48206.1.
X87405 Genomic DNA. Translation: CAA60855.1.
AE002098 Genomic DNA. Translation: AAF42039.1.
PIRiA57423.
S25611.
S65832.
S65839.
RefSeqiNP_274695.1. NC_003112.2.
WP_002224358.1. NC_003112.2.

Genome annotation databases

EnsemblBacteriaiAAF42039; AAF42039; NMB1691.
GeneIDi903415.
KEGGinme:NMB1691.
PATRICi20359335. VBINeiMen85645_2174.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68062 Genomic DNA. Translation: CAA48199.1.
X68066 Genomic DNA. Translation: CAA48203.1.
X68069 Genomic DNA. Translation: CAA48206.1.
X87405 Genomic DNA. Translation: CAA60855.1.
AE002098 Genomic DNA. Translation: AAF42039.1.
PIRiA57423.
S25611.
S65832.
S65839.
RefSeqiNP_274695.1. NC_003112.2.
WP_002224358.1. NC_003112.2.

3D structure databases

ProteinModelPortaliQ51161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi122586.NMB1691.

Proteomic databases

PaxDbiQ51161.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF42039; AAF42039; NMB1691.
GeneIDi903415.
KEGGinme:NMB1691.
PATRICi20359335. VBINeiMen85645_2174.

Phylogenomic databases

eggNOGiENOG4105EEI. Bacteria.
COG0294. LUCA.
KOiK00796.
OMAiSIDTYHA.
OrthoDBiPOG091H00BJ.

Enzyme and pathway databases

UniPathwayiUPA00077; UER00156.

Family and domain databases

CDDicd00739. DHPS. 1 hit.
Gene3Di3.20.20.20. 1 hit.
InterProiIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding_dom.
[Graphical view]
PfamiPF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMiSSF51717. SSF51717. 1 hit.
TIGRFAMsiTIGR01496. DHPS. 1 hit.
PROSITEiPS00792. DHPS_1. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDHPS_NEIMB
AccessioniPrimary (citable) accession number: Q51161
Secondary accession number(s): Q51157
, Q51158, Q51159, Q51160, Q57214, Q60395
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 8, 2000
Last modified: November 30, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.