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Protein

Efflux pump membrane transporter

Gene

MtrD

Organism
Neisseria gonorrhoeae
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Biological processTransportUniRule annotation

Protein family/group databases

TCDBi2.A.6.2.5. the resistance-nodulation-cell division (rnd) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Efflux pump membrane transporterUniRule annotation
Gene namesi
Name:MtrDImported
OrganismiNeisseria gonorrhoeaeImported
Taxonomic identifieri485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 27HelicalUniRule annotationAdd BLAST18
Transmembranei338 – 357HelicalUniRule annotationAdd BLAST20
Transmembranei364 – 384HelicalUniRule annotationAdd BLAST21
Transmembranei390 – 411HelicalUniRule annotationAdd BLAST22
Transmembranei432 – 456HelicalUniRule annotationAdd BLAST25
Transmembranei468 – 491HelicalUniRule annotationAdd BLAST24
Transmembranei536 – 554HelicalUniRule annotationAdd BLAST19
Transmembranei871 – 889HelicalUniRule annotationAdd BLAST19
Transmembranei896 – 913HelicalUniRule annotationAdd BLAST18
Transmembranei933 – 957HelicalUniRule annotationAdd BLAST25
Transmembranei982 – 1002HelicalUniRule annotationAdd BLAST21
Transmembranei1014 – 1036HelicalUniRule annotationAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, Membrane

Structurei

3D structure databases

ProteinModelPortaliQ51073.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini368 – 493SSD (sterol-sensing)InterPro annotationAdd BLAST126

Sequence similaritiesi

Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiCOG0841. LUCA.

Family and domain databases

Gene3Di3.30.2090.10. 2 hits.
InterProiView protein in InterPro
IPR027463. AcrB_DN_DC_subdom.
IPR001036. Acrflvin-R.
IPR004764. HAE1.
IPR000731. SSD.
PANTHERiPTHR32063. PTHR32063. 1 hit.
PfamiView protein in Pfam
PF00873. ACR_tran. 1 hit.
PRINTSiPR00702. ACRIFLAVINRP.
SUPFAMiSSF82714. SSF82714. 2 hits.
TIGRFAMsiTIGR00915. 2A0602. 1 hit.
PROSITEiView protein in PROSITE
PS50156. SSD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q51073-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKFFIDRPI FAWVISIFII AAGIFGIKSL PVSQYPSVAA PTITLHAIYP
60 70 80 90 100
GASAQVMEGS VLSVIERNMN GVEGLDYMST SADSSGSGSV SLTFTPDTDE
110 120 130 140 150
NLAQVEVQNK LSEVLRTLPA TVQQYGVTVS KARSNFLMIV MLSSDVQSTE
160 170 180 190 200
EMNDYAQRNV VPELQRIEGV GQVRLFGAQR AMRIWVDPKK LQNYNLSFAD
210 220 230 240 250
VGSALSAQNI QISAGSIGSL PAVRGQTVTA TVTAQGQLGT AEEFGNVILR
260 270 280 290 300
ANTDGSNIYL KDVAKVGLGM EDYSSSTRLN GVNTTGMAVM LSNSGNAMAT
310 320 330 340 350
AKAVKERLAV LEKYFPQGMS WKTPYDTSKF VEISIEKVIH TLIEAMVLVF
360 370 380 390 400
VVMYLFLQNI RYTLIPTIVV PISLLGGFAF ISYMGMSINV LTMFAMILVI
410 420 430 440 450
GIVVDDAIVV VENVERIMAG EGLPPKEATK KAMGQISGAV IGITAVLISV
460 470 480 490 500
FVPLAMFSGA AGNIYKQFAL TMASSIAFSA FLALTLTPAL CATMLKTIPK
510 520 530 540 550
GHHEEKKGFF GWFNKKFDSW THGYEGRVAK VLRKTFRMMV VYIGLAVVGV
560 570 580 590 600
FLFMRLPTSF LPTEDQGFVM VSVQLPAGAT KERTDATLAQ VTQLAKSIPE
610 620 630 640 650
IENIITVSGF SFSGSGQNMA MGFAIFKDWN ERTASGSDAV AVAGKLTGMM
660 670 680 690 700
MGTLKDGFGI AVVPPPILEL GNGSGLSINL QDRNNTGHTG IAGEGNELIQ
710 720 730 740 750
KMRASGLFDP STVRAGGLED SPQLKIDINR AAAAAQGISF ADIRTALASA
760 770 780 790 800
LSSSYVSDFP NQGRLQRVMV QADEDARMQP ADILNLTVPN KSGVAVPLST
810 820 830 840 850
IATVSWENGT EQSVRFNGYP SMKLSASPAT GVSTGQAMEA VQKMVDELGG
860 870 880 890 900
GYSFEWGGQS SEEAKGGSQT LILYGLAVAA VFLVLAALYE SWSIPLAVIL
910 920 930 940 950
VIPLGLIGAA AGVTGRNLFE GLLGSVPSFA NDIYFQVGFV TVMGLSAKNA
960 970 980 990 1000
ILIIEFAKDL QAQGKSAVEA ALEAARLRFR PIIMTSFAFI LGVVPLYIAA
1010 1020 1030 1040 1050
GASSASQRAI GTTVFWGMLV GTLLSVFLVP LFYVVVRKFF KETAHEHEMA
1060
VRHASKAGIT GSDDKQY
Length:1,067
Mass (Da):113,905
Last modified:November 1, 1996 - v1
Checksum:iC6286EF224841CB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60099 Genomic DNA. Translation: AAC45560.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ51073_NEIGO
AccessioniPrimary (citable) accession number: Q51073
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)