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Protein

Leucine-rich repeat-containing protein 24

Gene

LRRC24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 24
Gene namesi
Name:LRRC24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:28947. LRRC24.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei406 – 426HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000254402.
PharmGKBiPA142671520.

Polymorphism and mutation databases

BioMutaiLRRC24.
DMDMi296434571.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000023159621 – 513Leucine-rich repeat-containing protein 24Add BLAST493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi281 ↔ 345PROSITE-ProRule annotation
Glycosylationi334N-linked (GlcNAc...)Sequence analysis1
Glycosylationi363N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ50LG9.
PeptideAtlasiQ50LG9.
PRIDEiQ50LG9.

PTM databases

iPTMnetiQ50LG9.
PhosphoSitePlusiQ50LG9.

Expressioni

Gene expression databases

BgeeiENSG00000254402.
CleanExiHS_LRRC24.
ExpressionAtlasiQ50LG9. baseline and differential.

Organism-specific databases

HPAiHPA052250.

Interactioni

Protein-protein interaction databases

BioGridi137417. 2 interactors.
STRINGi9606.ENSP00000434849.

Structurei

3D structure databases

ProteinModelPortaliQ50LG9.
SMRiQ50LG9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 50LRRNTAdd BLAST30
Repeati51 – 72LRR 1Add BLAST22
Repeati75 – 96LRR 2Add BLAST22
Repeati99 – 120LRR 3Add BLAST22
Repeati123 – 144LRR 4Add BLAST22
Repeati147 – 168LRR 5Add BLAST22
Repeati171 – 192LRR 6Add BLAST22
Domaini204 – 259LRRCTAdd BLAST56
Domaini260 – 361Ig-like C2-typeAdd BLAST102

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi375 – 378Poly-Pro4
Compositional biasi427 – 432Poly-Arg6

Sequence similaritiesi

Contains 6 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00850000132257.
HOGENOMiHOG000234857.
HOVERGENiHBG079563.
InParanoidiQ50LG9.
OMAiECEASNA.
OrthoDBiEOG091G03RV.
PhylomeDBiQ50LG9.
TreeFamiTF320455.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 6 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q50LG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRAPALLP LLLLLLPLRA AGCPAACRCY SATVECGALR LRVVPLGIPP
60 70 80 90 100
GTQTLFLQDN NIARLEPGAL APLAALRRLY LHNNSLRALE AGAFRAQPRL
110 120 130 140 150
LELALTSNRL RGLRSGAFVG LAQLRVLYLA GNQLARLLDF TFLHLPRLQE
160 170 180 190 200
LHLQENSIEL LEDQALAGLS SLALLDLSRN QLGTISREAL QPLASLQVLR
210 220 230 240 250
LTENPWRCDC ALHWLGAWIK EGGQRLLTSR DRKIMCAEPP RLALQSLLDV
260 270 280 290 300
SHSSLICIPP SVHVQPLELT ANLGEDLRVA CQASGYPQPL VTWRKVPQPR
310 320 330 340 350
EGRPRAQAQL EGGLLGLGGH SASDTGSGML FLSNITLAHA GKYECEASNA
360 370 380 390 400
GGAARVPFRL LVNASRQQPQ QPAQPPPPAA RPAGSEPRPE AGSMAFRALG
410 420 430 440 450
VATQTAIAAA IALLALTALL LVAMICRRRR RRKKARGPPG EGALFVNDYL
460 470 480 490 500
DGPCTFAQLE ELRDERGHEM FVINRSKPLF AEGPAEAPAD CGPEQGAGPG
510
LRVPPPVAYE IHC
Length:513
Mass (Da):55,257
Last modified:May 18, 2010 - v2
Checksum:i3770FA87B4B9C1DE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti494E → A in BAD97811 (Ref. 1) Curated1
Sequence conflicti494E → A in AAI11068 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB178281 mRNA. Translation: BAD97811.1.
AC084125 Genomic DNA. No translation available.
BC111067 mRNA. Translation: AAI11068.1.
CCDSiCCDS34969.1.
RefSeqiNP_001019849.2. NM_001024678.3.
UniGeneiHs.740859.

Genome annotation databases

EnsembliENST00000529415; ENSP00000434849; ENSG00000254402.
GeneIDi441381.
KEGGihsa:441381.
UCSCiuc003zdm.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB178281 mRNA. Translation: BAD97811.1.
AC084125 Genomic DNA. No translation available.
BC111067 mRNA. Translation: AAI11068.1.
CCDSiCCDS34969.1.
RefSeqiNP_001019849.2. NM_001024678.3.
UniGeneiHs.740859.

3D structure databases

ProteinModelPortaliQ50LG9.
SMRiQ50LG9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi137417. 2 interactors.
STRINGi9606.ENSP00000434849.

PTM databases

iPTMnetiQ50LG9.
PhosphoSitePlusiQ50LG9.

Polymorphism and mutation databases

BioMutaiLRRC24.
DMDMi296434571.

Proteomic databases

PaxDbiQ50LG9.
PeptideAtlasiQ50LG9.
PRIDEiQ50LG9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000529415; ENSP00000434849; ENSG00000254402.
GeneIDi441381.
KEGGihsa:441381.
UCSCiuc003zdm.4. human.

Organism-specific databases

CTDi441381.
GeneCardsiLRRC24.
HGNCiHGNC:28947. LRRC24.
HPAiHPA052250.
neXtProtiNX_Q50LG9.
OpenTargetsiENSG00000254402.
PharmGKBiPA142671520.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00850000132257.
HOGENOMiHOG000234857.
HOVERGENiHBG079563.
InParanoidiQ50LG9.
OMAiECEASNA.
OrthoDBiEOG091G03RV.
PhylomeDBiQ50LG9.
TreeFamiTF320455.

Miscellaneous databases

ChiTaRSiLRRC24. human.
GenomeRNAii441381.
PROiQ50LG9.

Gene expression databases

BgeeiENSG00000254402.
CleanExiHS_LRRC24.
ExpressionAtlasiQ50LG9. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 6 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRC24_HUMAN
AccessioniPrimary (citable) accession number: Q50LG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.