Reviewed,
UniProtKB/Swiss-Prot Q50L96 (ADH_DROAN)
Last modified
June 16, 2009.
Version 32.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Alcohol dehydrogenase EC=1.1.1.1 | ||||
| Gene names |
| ||||
| Organism | Drosophila ananassae (Fruit fly) | ||||
| Taxonomic identifier | 7217 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 256 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | An alcohol + NAD+ = an aldehyde or ketone + NADH. |
| Subunit structure | Homodimer. |
| Sequence similarities | Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | alcohol catabolic process Inferred from sequence or structural similarity. Source: UniProtKB oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | alcohol dehydrogenase activity Inferred from sequence or structural similarity. Source: UniProtKB bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity UniProtKB P00334 | ||||||
| Chain | 2 – 256 | 255 | Alcohol dehydrogenase UniProtKB P00334 | PRO_0000352752 | |||||
Regions | |||||||||
| Nucleotide binding | 12 – 41 | 30 | NAD By similarity UniProtKB P00334 | ||||||
Sites | |||||||||
| Active site | 153 | 1 | Proton acceptor By similarity UniProtKB P00334 | ||||||
| Binding site | 140 | 1 | Substrate By similarity UniProtKB P00334 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A novel chimeric gene, siren, with retroposed promoter sequence in the Drosophila bipectinata complex." Nozawa M., Aotsuka T., Tamura K. Genetics 171:1719-1727(2005) [PubMed: 16143626] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Patterns of amino acid evolution in Drosophila ananassae chimeric gene, siren, parallel those of other Adh derived chimeras." Jones C.D., Shih H.-J. Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Evolution of genes and genomes on the Drosophila phylogeny." Drosophila 12 genomes consortium Nature 450:203-218(2007) [PubMed: 17994087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tucson 14024-0371.13. |
| [4] | "Phylogeny of a paradigm lineage: the Drosophila melanogaster species group (Diptera: Drosophilidae)." Schawaroch V.A. Biol. J. Linn. Soc. Lond. 76:21-37(2002) [Agricola: IND23292123] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 50-145. |
Cross-references
Sequence databases | |
|---|---|
| AB194426 Genomic DNA. Translation: BAD98197.1. EU877943 Genomic DNA. Translation: ACF95828.1. CH902620 Genomic DNA. Translation: EDV30743.1. AF459754 Genomic DNA. Translation: AAM28691.1. | |
| RefSeq | XP_001961522.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1MG5 based on UniProtKB P00334. |
| SMR | Q50L96. Positions 2-256. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 6492907. |
| KEGG | dan:Dana_GF14888. |
Organism-specific databases | |
| FlyBase | FBgn0012113. Dana\Adh. |
Family and domain databases | |
| InterPro | IPR002198. DH_sc/Rdtase_SDR. IPR002425. Insect_ADH. IPR002424. Insect_AlcDH_fam. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| PANTHER | PTHR19410. ADH_short_C2. 1 hit. |
| Pfam | PF00106. adh_short. 1 hit. [Graphical view] |
| PRINTS | PR01168. ALCDHDRGNASE. PR01167. INSADHFAMILY. PR00080. SDRFAMILY. |
| PROSITE | PS00061. ADH_SHORT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ADH_DROAN | ||||||||
| Accession | Primary (citable) accession number: Q50L96 Secondary accession number(s): Q8N0A0 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| SIMILARITY comments Index of protein domains and families |

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