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Protein

Alcohol dehydrogenase

Gene

Adh

Organism
Drosophila ananassae (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.PROSITE-ProRule annotationCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei140SubstrateBy similarity1
Active sitei153Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 41NADBy similarityAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenaseBy similarity (EC:1.1.1.1)
Gene namesi
Name:AdhImported
ORF Names:GF14888
OrganismiDrosophila ananassae (Fruit fly)
Taxonomic identifieri7217 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000007801 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0012113. Dana\Adh.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003527522 – 256Alcohol dehydrogenaseBy similarityAdd BLAST255

Expressioni

Gene expression databases

BgeeiFBgn0012113.

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi7217.FBpp0118080.

Structurei

3D structure databases

ProteinModelPortaliQ50L96.
SMRiQ50L96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4169. Eukaryota.
COG1028. LUCA.
InParanoidiQ50L96.
KOiK00001.
OMAiWSKHWDS.
OrthoDBiEOG091G0OC9.
PhylomeDBiQ50L96.

Family and domain databases

InterProiView protein in InterPro
IPR002425. ADH_Drosophila-type.
IPR002424. ADH_insect.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR01168. ALCDHDRGNASE.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q50L96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSLTNKNV VFVAGLGGIG LDTTKELLKR DLKNLVILDR IDNPVVIAEL
60 70 80 90 100
KTINPKVTVT FIPYDVTVPI TETKKLLKTI FDKLKTVDIL INGAGILDDH
110 120 130 140 150
QIERTIAVNY TGLVNTTTAI LDFWDKRKGG PGGIICNIGS VTGFNAIYQV
160 170 180 190 200
PVYSGTKAAV VNFTSSLAKL APITGVTAYT VNPGITRTTL VHKFNSWLDV
210 220 230 240 250
EPQVAEKLLA HPTQSSQACG ENFVKAIELN QNGAIWKLDR GTLEAIQWSK

HWDSGI
Length:256
Mass (Da):27,854
Last modified:June 7, 2005 - v1
Checksum:iD9702C0DA79765E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB194426 Genomic DNA. Translation: BAD98197.1.
EU877943 Genomic DNA. Translation: ACF95828.1.
CH902620 Genomic DNA. Translation: EDV30743.1.
AF459754 Genomic DNA. Translation: AAM28691.1.
RefSeqiXP_001961522.1. XM_001961486.2.

Genome annotation databases

EnsemblMetazoaiFBtr0119588; FBpp0118080; FBgn0012113.
GeneIDi6492907.
KEGGidan:Dana_GF14888.

Similar proteinsi

Entry informationi

Entry nameiADH_DROAN
AccessioniPrimary (citable) accession number: Q50L96
Secondary accession number(s): Q8N0A0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: June 7, 2005
Last modified: August 30, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families