Q50L96 (ADH_DROAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alcohol dehydrogenase
EC=1.1.1.1

Gene names

Name:	Adh
ORF Names:	GF14888

Organism

Drosophila ananassae (Fruit fly) [Complete proteome]

Taxonomic identifier

7217 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	An alcohol + NAD+ = an aldehyde or ketone + NADH.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	alcohol catabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	alcohol dehydrogenase (NAD) activity Inferred from sequence or structural similarity. Source: UniProtKB nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity UniProtKB P00334
	Chain	2 – 256	255	Alcohol dehydrogenase UniProtKB P00334		PRO_0000352752
Regions
	Nucleotide binding	12 – 41	30	NAD By similarity UniProtKB P00334
Sites
	Active site	153	1	Proton acceptor By similarity UniProtKB P00334
	Binding site	140	1	Substrate By similarity UniProtKB P00334

Sequences

	Sequence		Length	Mass (Da)
	Q50L96 [UniParc]. Last modified June 7, 2005. Version 1. Checksum: D9702C0DA79765E0	FASTA	256	27,854
	10 20 30 40 50 60 MALSLTNKNV VFVAGLGGIG LDTTKELLKR DLKNLVILDR IDNPVVIAEL KTINPKVTVT 70 80 90 100 110 120 FIPYDVTVPI TETKKLLKTI FDKLKTVDIL INGAGILDDH QIERTIAVNY TGLVNTTTAI 130 140 150 160 170 180 LDFWDKRKGG PGGIICNIGS VTGFNAIYQV PVYSGTKAAV VNFTSSLAKL APITGVTAYT 190 200 210 220 230 240 VNPGITRTTL VHKFNSWLDV EPQVAEKLLA HPTQSSQACG ENFVKAIELN QNGAIWKLDR 250 GTLEAIQWSK HWDSGI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel chimeric gene, siren, with retroposed promoter sequence in the Drosophila bipectinata complex." Nozawa M., Aotsuka T., Tamura K. Genetics 171:1719-1727(2005) [PubMed: 16143626] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Patterns of amino acid evolution in Drosophila ananassae chimeric gene, siren, parallel those of other Adh derived chimeras." Jones C.D., Shih H.-J. Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Evolution of genes and genomes on the Drosophila phylogeny." Drosophila 12 genomes consortium Nature 450:203-218(2007) [PubMed: 17994087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tucson 14024-0371.13.
[4]	"Phylogeny of a paradigm lineage: the Drosophila melanogaster species group (Diptera: Drosophilidae)." Schawaroch V.A. Biol. J. Linn. Soc. Lond. 76:21-37(2002) [Agricola: IND23292123] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 50-145.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB194426 Genomic DNA. Translation: BAD98197.1. EU877943 Genomic DNA. Translation: ACF95828.1. CH902620 Genomic DNA. Translation: EDV30743.1. AF459754 Genomic DNA. Translation: AAM28691.1.
RefSeq	XP_001961522.1. XM_001961486.1.
3D structure databases
HSSP	HSSP built from PDB template 1SBY based on UniProtKB P10807.
ProteinModelPortal	Q50L96.
SMR	Q50L96. Positions 2-256.
ModBase	Search...
Protein-protein interaction databases
STRING	Q50L96.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0119588; FBpp0118080; FBgn0012113.
GeneID	6492907.
KEGG	dan:Dana_GF14888.
Organism-specific databases
FlyBase	FBgn0012113. Dana\Adh.
Phylogenomic databases
GeneTree	EMGT00050000006799.
InParanoid	Q50L96.
OrthoDB	EOG40K6FN.
PhylomeDB	Q50L96.
Family and domain databases
InterPro	IPR002425. ADH_Drosophila-type. IPR002424. ADH_insect. IPR002198. DH_sc/Rdtase_SDR. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00001.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR01168. ALCDHDRGNASE. PR01167. INSADHFAMILY. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH_DROAN

Accession

Primary (citable) accession number: Q50L96
Secondary accession number(s): Q8N0A0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	June 7, 2005
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project