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Protein

Cytosolic phospholipase A2 delta

Gene

Pla2g4d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Compared to its human ortholog, may have no substrate specificity for the fatty acid found at the sn-2 position.1 Publication

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.1 Publication

Enzyme regulationi

Stimulated by cytosolic Ca2+.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei370NucleophileBy similarity1
Active sitei654Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-1482788. Acyl chain remodelling of PC.
R-MMU-1482801. Acyl chain remodelling of PS.
R-MMU-1482839. Acyl chain remodelling of PE.
R-MMU-1482922. Acyl chain remodelling of PI.
R-MMU-1482925. Acyl chain remodelling of PG.
R-MMU-1483115. Hydrolysis of LPC.
R-MMU-1483166. Synthesis of PA.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosolic phospholipase A2 deltaCurated (EC:3.1.1.41 Publication)
Short name:
cPLA2-delta1 Publication
Alternative name(s):
Phospholipase A2 group IVD
Gene namesi
Name:Pla2g4dImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1925640. Pla2g4d.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002470241 – 825Cytosolic phospholipase A2 deltaAdd BLAST825

Proteomic databases

PaxDbiQ50L43.
PRIDEiQ50L43.

PTM databases

iPTMnetiQ50L43.
PhosphoSitePlusiQ50L43.

Expressioni

Tissue specificityi

Weakly or not expressed in most tissues. Detected in placenta of 17.5 dpc embryos.1 Publication

Gene expression databases

BgeeiENSMUSG00000070719.
CleanExiMM_PLA2G4D.
GenevisibleiQ50L43. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092252.

Structurei

3D structure databases

ProteinModelPortaliQ50L43.
SMRiQ50L43.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 129C2PROSITE-ProRule annotationAdd BLAST112
Domaini281 – 825PLA2cPROSITE-ProRule annotationAdd BLAST545

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni339 – 340Substrate bindingBy similarity2

Domaini

The N-terminal C2 domain mediates the association with lipid membranes upon calcium binding. An additional second C2 domain may stand in between the C2 domain and the PLA2c domain.By similarity

Phylogenomic databases

eggNOGiKOG1028. Eukaryota.
KOG1325. Eukaryota.
ENOG410XR72. LUCA.
GeneTreeiENSGT00550000074489.
HOGENOMiHOG000231788.
HOVERGENiHBG080412.
InParanoidiQ50L43.
KOiK16342.
OMAiSHPVWNE.
OrthoDBiEOG091G011T.
TreeFamiTF325228.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiView protein in InterPro
IPR016035. Acyl_Trfase/lysoPLipase.
IPR000008. C2_dom.
IPR002642. LysoPLipase_cat_dom.
PfamiView protein in Pfam
PF00168. C2. 1 hit.
PF01735. PLA2_B. 1 hit.
SMARTiView protein in SMART
SM00239. C2. 1 hit.
SM00022. PLAc. 1 hit.
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF52151. SSF52151. 1 hit.
PROSITEiView protein in PROSITE
PS50004. C2. 1 hit.
PS51210. PLA2C. 1 hit.

Sequencei

Sequence statusi: Complete.

Q50L43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWSGDRRVGM ESLSPERLHG HPYQEEASVF CRLTVKILEA RSLPRADLLS
60 70 80 90 100
QADPYVTVQL PTASGMKFKT QTVTNSSHPV WNETFSFLIQ SQVKNILELT
110 120 130 140 150
IYDEDVITKD DICFKVSYDV SEILPGQLLQ KTFSLNPQGP EELDVELLME
160 170 180 190 200
RTWDPPENLI TNNVLVAREL SHLDVSLDRA GNTAMAAGQD KLELELMLKG
210 220 230 240 250
SYEDTQTFFP DTAFTFSFHY MRGQDTELNG YLRGPRNSGW NSDTSVTPFN
260 270 280 290 300
VPLMSLAAGK EMTIDIPAMK APEGKLQLKT DCCPKELSVR LSYGLCPEEQ
310 320 330 340 350
AFLSRRKKVV AAALKQALQL DEDLNEDEVP VVGINAEGGG MRAMISLYGH
360 370 380 390 400
LLALQKLGLL DCVTYFSGIS GSTWTMAHLY RDPEWSQRDL EGPISHAREH
410 420 430 440 450
VAKTLLKEFL PEHLASYRQT LKLREEQGYT VTVADLWGLV LESKLHGQVT
460 470 480 490 500
DQKLSGQRAA LERGQNPLPL YLSLNVKENH LETLHFKEWV EFSPYEVGFL
510 520 530 540 550
KYGGFVPSEL FGSEFFMGRL MKRLPESQIC FLEGIWSNLF SVNLMDIWYD
560 570 580 590 600
ITYGKDSNNF PVDVRNSEKE FSGSAGTSSG VEAPWLESGT ALAQALKGFL
610 620 630 640 650
TGRPFHQRSA NFLHGLQLHR DYCNQRHFST WADCNLDDTP NQLTPQDPQL
660 670 680 690 700
CLIDAGCFMN SSCPSLFRPG RQVDLIISFN YNQSLPFKGL QQSEKYSRAR
710 720 730 740 750
GLPFPRVEPS PEDHSQPQEC YLFSDPTCPE APVVLHFPLV NDSFRDHSAP
760 770 780 790 800
GVRRSPDELK AGQVNLTGAA SPYFMYNMTY KNEDFDRLLQ LSDYNVQNNQ
810 820
GTILQALRTV LKRRASETRP LGVKT
Length:825
Mass (Da):93,042
Last modified:July 27, 2011 - v3
Checksum:i257668A34FFA841B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti222R → G in BAE39570 (PubMed:16141072).Curated1
Sequence conflicti222R → G in BAE26807 (PubMed:16141072).Curated1
Sequence conflicti482E → G in BAE39570 (PubMed:16141072).Curated1
Sequence conflicti482E → G in BAE26807 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB195276 mRNA. Translation: BAD98152.1.
AK167492 mRNA. Translation: BAE39570.1.
AK145985 mRNA. Translation: BAE26807.1.
AL844608 Genomic DNA. Translation: CAM19514.1.
CCDSiCCDS16617.1.
RefSeqiNP_001019308.1. NM_001024137.1.
UniGeneiMm.330507.

Genome annotation databases

EnsembliENSMUST00000094665; ENSMUSP00000092252; ENSMUSG00000070719.
GeneIDi78390.
KEGGimmu:78390.
UCSCiuc008lvh.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiPA24D_MOUSE
AccessioniPrimary (citable) accession number: Q50L43
Secondary accession number(s): A2AQJ1, Q3TJC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 27, 2011
Last modified: September 27, 2017
This is version 98 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot