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Q50KB1

- SEP2_EMIHU

UniProt

Q50KB1 - SEP2_EMIHU

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Protein

Protein disulfide-isomerase-like protein EhSep2

Gene

SEP2

Organism
Emiliania huxleyi (Pontosphaera huxleyi)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein disulfide isomerase activity Source: UniProtKB

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
  2. protein folding Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase-like protein EhSep2
Gene namesi
Name:SEP2
OrganismiEmiliania huxleyi (Pontosphaera huxleyi)
Taxonomic identifieri2903 [NCBI]
Taxonomic lineageiEukaryotaHaptophyceaeIsochrysidalesNoelaerhabdaceaeEmiliania

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 17171 PublicationAdd
BLAST
Chaini18 – 223206Protein disulfide-isomerase-like protein EhSep21 PublicationPRO_0000248266Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ50KB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 125108ThioredoxinPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili155 – 20147Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi220 – 2234Prevents secretion from ERSequence Analysis

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Sequence Analysis
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005788. Disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01126. pdi_dom. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q50KB1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALRSLTLLC AAAGASAGAI ELTPDNFDEL VLKSGKAAFI KFLAPWUGHC
60 70 80 90 100
KKMKPDWDSL ASTFEDSKKV LIADVDCTTG GKPLCEKYGV RGYPTIKYFN
110 120 130 140 150
PPDEEGEDYK GGRSLDELKK FAENELGPGC SVDLMDNCSE EQKGKLKEYI
160 170 180 190 200
DMAPEKRTEM LETLKKELAD AESTHEALLK ELQATYKESM DKLEKLKEES
210 220
APKIKLLKAA TPAPKAEGAK DEV
Length:223
Mass (Da):24,564
Last modified:February 26, 2008 - v2
Checksum:i9744C1A547A86F4C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031D → V AA sequence (PubMed:15743763)Curated
Sequence conflicti107 – 1082ED → GA AA sequence (PubMed:15743763)Curated
Sequence conflicti111 – 1122GG → AL AA sequence (PubMed:15743763)Curated

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei47 – 471SelenocysteineImported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB205027 mRNA. Translation: BAD98262.1.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB205027 mRNA. Translation: BAD98262.1 .

3D structure databases

ProteinModelPortali Q50KB1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR005788. Disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF00085. Thioredoxin. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
TIGRFAMsi TIGR01126. pdi_dom. 1 hit.
PROSITEi PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel eukaryotic selenoprotein in the haptophyte alga Emiliania huxleyi."
    Obata T., Shiraiwa Y.
    J. Biol. Chem. 280:18462-18468(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 18-38 AND 98-112.
    Strain: NIES-873.

Entry informationi

Entry nameiSEP2_EMIHU
AccessioniPrimary (citable) accession number: Q50KB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: February 26, 2008
Last modified: October 29, 2014
This is version 51 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Caution

Contains a selenocysteine rather than a cysteine at one of the conserved active site positions so does not form the disulfide bond normally required for protein disulfide isomerase activity.Curated

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3