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Q50KB1

- SEP2_EMIHU

UniProt

Q50KB1 - SEP2_EMIHU

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Protein
Protein disulfide-isomerase-like protein EhSep2
Gene
SEP2
Organism
Emiliania huxleyi (Pontosphaera huxleyi)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein disulfide isomerase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
  2. protein folding Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase-like protein EhSep2
Gene namesi
Name:SEP2
OrganismiEmiliania huxleyi (Pontosphaera huxleyi)
Taxonomic identifieri2903 [NCBI]
Taxonomic lineageiEukaryotaHaptophyceaeIsochrysidalesNoelaerhabdaceaeEmiliania

Subcellular locationi

Endoplasmic reticulum lumen Reviewed prediction

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 17171 Publication
Add
BLAST
Chaini18 – 223206Protein disulfide-isomerase-like protein EhSep21 Publication
PRO_0000248266Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ50KB1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 125108Thioredoxin
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili155 – 20147 Reviewed prediction
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi220 – 2234Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Contains 1 thioredoxin domain.

Keywords - Domaini

Coiled coil, Signal

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005788. Disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01126. pdi_dom. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q50KB1-1 [UniParc]FASTAAdd to Basket

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MALRSLTLLC AAAGASAGAI ELTPDNFDEL VLKSGKAAFI KFLAPWUGHC    50
KKMKPDWDSL ASTFEDSKKV LIADVDCTTG GKPLCEKYGV RGYPTIKYFN 100
PPDEEGEDYK GGRSLDELKK FAENELGPGC SVDLMDNCSE EQKGKLKEYI 150
DMAPEKRTEM LETLKKELAD AESTHEALLK ELQATYKESM DKLEKLKEES 200
APKIKLLKAA TPAPKAEGAK DEV 223
Length:223
Mass (Da):24,564
Last modified:February 26, 2008 - v2
Checksum:i9744C1A547A86F4C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031D → V AA sequence 1 Publication
Sequence conflicti107 – 1082ED → GA AA sequence 1 Publication
Sequence conflicti111 – 1122GG → AL AA sequence 1 Publication

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei47 – 471Selenocysteine

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB205027 mRNA. Translation: BAD98262.1.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB205027 mRNA. Translation: BAD98262.1 .

3D structure databases

ProteinModelPortali Q50KB1.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR005788. Disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF00085. Thioredoxin. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
TIGRFAMsi TIGR01126. pdi_dom. 1 hit.
PROSITEi PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel eukaryotic selenoprotein in the haptophyte alga Emiliania huxleyi."
    Obata T., Shiraiwa Y.
    J. Biol. Chem. 280:18462-18468(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 18-38 AND 98-112.
    Strain: NIES-873.

Entry informationi

Entry nameiSEP2_EMIHU
AccessioniPrimary (citable) accession number: Q50KB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: February 26, 2008
Last modified: April 16, 2014
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Caution

Contains a selenocysteine rather than a cysteine at one of the conserved active site positions so does not form the disulfide bond normally required for protein disulfide isomerase activity.

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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