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Protein

Protein disulfide-isomerase-like protein EhSep2

Gene

SEP2

Organism
Emiliania huxleyi (Pontosphaera huxleyi)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein disulfide isomerase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase-like protein EhSep2
Gene namesi
Name:SEP2
OrganismiEmiliania huxleyi (Pontosphaera huxleyi)
Taxonomic identifieri2903 [NCBI]
Taxonomic lineageiEukaryotaHaptophyceaeIsochrysidalesNoelaerhabdaceaeEmiliania
Proteomesi
  • UP000013827 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 171 PublicationAdd BLAST17
ChainiPRO_000024826618 – 223Protein disulfide-isomerase-like protein EhSep21 PublicationAdd BLAST206

Structurei

3D structure databases

ProteinModelPortaliQ50KB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 125ThioredoxinPROSITE-ProRule annotationAdd BLAST108

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili155 – 201Sequence analysisAdd BLAST47

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi220 – 223Prevents secretion from ERSequence analysis4

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Sequence analysis
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005788. Disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01126. pdi_dom. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q50KB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRSLTLLC AAAGASAGAI ELTPDNFDEL VLKSGKAAFI KFLAPWUGHC
60 70 80 90 100
KKMKPDWDSL ASTFEDSKKV LIADVDCTTG GKPLCEKYGV RGYPTIKYFN
110 120 130 140 150
PPDEEGEDYK GGRSLDELKK FAENELGPGC SVDLMDNCSE EQKGKLKEYI
160 170 180 190 200
DMAPEKRTEM LETLKKELAD AESTHEALLK ELQATYKESM DKLEKLKEES
210 220
APKIKLLKAA TPAPKAEGAK DEV
Length:223
Mass (Da):24,564
Last modified:February 26, 2008 - v2
Checksum:i9744C1A547A86F4C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103D → V AA sequence (PubMed:15743763).Curated1
Sequence conflicti107 – 108ED → GA AA sequence (PubMed:15743763).Curated2
Sequence conflicti111 – 112GG → AL AA sequence (PubMed:15743763).Curated2

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei47SelenocysteineImported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB205027 mRNA. Translation: BAD98262.1.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB205027 mRNA. Translation: BAD98262.1.

3D structure databases

ProteinModelPortaliQ50KB1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005788. Disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01126. pdi_dom. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEP2_EMIHU
AccessioniPrimary (citable) accession number: Q50KB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: February 26, 2008
Last modified: July 6, 2016
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Caution

Contains a selenocysteine rather than a cysteine at one of the conserved active site positions so does not form the disulfide bond normally required for protein disulfide isomerase activity.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.