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Q50KB1 (SEP2_EMIHU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein disulfide-isomerase-like protein EhSep2
Gene names
Name:SEP2
OrganismEmiliania huxleyi (Pontosphaera huxleyi)
Taxonomic identifier2903 [NCBI]
Taxonomic lineageEukaryotaHaptophyceaeIsochrysidalesNoelaerhabdaceaeEmiliania

Protein attributes

Sequence length223 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Endoplasmic reticulum lumen Potential.

Sequence similarities

Belongs to the protein disulfide isomerase family.

Contains 1 thioredoxin domain.

Caution

Contains a selenocysteine rather than a cysteine at one of the conserved active site positions so does not form the disulfide bond normally required for protein disulfide isomerase activity.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   Coding sequence diversitySelenocysteine
   DomainCoiled coil
Signal
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processcell redox homeostasis

Inferred from electronic annotation. Source: InterPro

protein folding

Non-traceable author statement Ref.1. Source: GOC

   Cellular_componentendoplasmic reticulum

Non-traceable author statement Ref.1. Source: UniProtKB

endoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein disulfide isomerase activity

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Ref.1
Chain18 – 223206Protein disulfide-isomerase-like protein EhSep2 Ref.1
PRO_0000248266

Regions

Domain18 – 125108Thioredoxin
Coiled coil155 – 20147 Potential
Motif220 – 2234Prevents secretion from ER Potential

Amino acid modifications

Non-standard residue471Selenocysteine

Experimental info

Sequence conflict1031D → V AA sequence Ref.1
Sequence conflict107 – 1082ED → GA AA sequence Ref.1
Sequence conflict111 – 1122GG → AL AA sequence Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q50KB1 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: 9744C1A547A86F4C

FASTA22324,564
        10         20         30         40         50         60 
MALRSLTLLC AAAGASAGAI ELTPDNFDEL VLKSGKAAFI KFLAPWUGHC KKMKPDWDSL 

        70         80         90        100        110        120 
ASTFEDSKKV LIADVDCTTG GKPLCEKYGV RGYPTIKYFN PPDEEGEDYK GGRSLDELKK 

       130        140        150        160        170        180 
FAENELGPGC SVDLMDNCSE EQKGKLKEYI DMAPEKRTEM LETLKKELAD AESTHEALLK 

       190        200        210        220 
ELQATYKESM DKLEKLKEES APKIKLLKAA TPAPKAEGAK DEV 

« Hide

References

[1]"A novel eukaryotic selenoprotein in the haptophyte alga Emiliania huxleyi."
Obata T., Shiraiwa Y.
J. Biol. Chem. 280:18462-18468(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 18-38 AND 98-112.
Strain: NIES-873.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB205027 mRNA. Translation: BAD98262.1.

3D structure databases

ProteinModelPortalQ50KB1.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR005788. Disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
TIGRFAMsTIGR01126. pdi_dom. 1 hit.
PROSITEPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSEP2_EMIHU
AccessionPrimary (citable) accession number: Q50KB1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: February 26, 2008
Last modified: April 16, 2014
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families