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Q50KB1

- SEP2_EMIHU

UniProt

Q50KB1 - SEP2_EMIHU

Protein

Protein disulfide-isomerase-like protein EhSep2

Gene

SEP2

Organism
Emiliania huxleyi (Pontosphaera huxleyi)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 2 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein disulfide isomerase activity Source: UniProtKB

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro
    2. protein folding Source: GOC

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein disulfide-isomerase-like protein EhSep2
    Gene namesi
    Name:SEP2
    OrganismiEmiliania huxleyi (Pontosphaera huxleyi)
    Taxonomic identifieri2903 [NCBI]
    Taxonomic lineageiEukaryotaHaptophyceaeIsochrysidalesNoelaerhabdaceaeEmiliania

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB
    2. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 17171 PublicationAdd
    BLAST
    Chaini18 – 223206Protein disulfide-isomerase-like protein EhSep21 PublicationPRO_0000248266Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ50KB1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 125108ThioredoxinPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili155 – 20147Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi220 – 2234Prevents secretion from ERSequence Analysis

    Sequence similaritiesi

    Belongs to the protein disulfide isomerase family.Sequence Analysis
    Contains 1 thioredoxin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Signal

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR005788. Disulphide_isomerase.
    IPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF00085. Thioredoxin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    TIGRFAMsiTIGR01126. pdi_dom. 1 hit.
    PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q50KB1-1 [UniParc]FASTAAdd to Basket

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    MALRSLTLLC AAAGASAGAI ELTPDNFDEL VLKSGKAAFI KFLAPWUGHC    50
    KKMKPDWDSL ASTFEDSKKV LIADVDCTTG GKPLCEKYGV RGYPTIKYFN 100
    PPDEEGEDYK GGRSLDELKK FAENELGPGC SVDLMDNCSE EQKGKLKEYI 150
    DMAPEKRTEM LETLKKELAD AESTHEALLK ELQATYKESM DKLEKLKEES 200
    APKIKLLKAA TPAPKAEGAK DEV 223
    Length:223
    Mass (Da):24,564
    Last modified:February 26, 2008 - v2
    Checksum:i9744C1A547A86F4C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti103 – 1031D → V AA sequence (PubMed:15743763)Curated
    Sequence conflicti107 – 1082ED → GA AA sequence (PubMed:15743763)Curated
    Sequence conflicti111 – 1122GG → AL AA sequence (PubMed:15743763)Curated

    Non-standard residue

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-standard residuei47 – 471SelenocysteineImported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB205027 mRNA. Translation: BAD98262.1.

    Keywords - Coding sequence diversityi

    Selenocysteine

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB205027 mRNA. Translation: BAD98262.1 .

    3D structure databases

    ProteinModelPortali Q50KB1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR005788. Disulphide_isomerase.
    IPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF00085. Thioredoxin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    TIGRFAMsi TIGR01126. pdi_dom. 1 hit.
    PROSITEi PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel eukaryotic selenoprotein in the haptophyte alga Emiliania huxleyi."
      Obata T., Shiraiwa Y.
      J. Biol. Chem. 280:18462-18468(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 18-38 AND 98-112.
      Strain: NIES-873.

    Entry informationi

    Entry nameiSEP2_EMIHU
    AccessioniPrimary (citable) accession number: Q50KB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Caution

    Contains a selenocysteine rather than a cysteine at one of the conserved active site positions so does not form the disulfide bond normally required for protein disulfide isomerase activity.Curated

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3