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Q50H32

- GRCR1_MOUSE

UniProt

Q50H32 - GRCR1_MOUSE

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Protein

Glutaredoxin domain-containing cysteine-rich protein 1

Gene

Grxcr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in actin filament architecture in developing stereocilia of sensory cells.1 Publication

GO - Molecular functioni

  1. electron carrier activity Source: InterPro
  2. protein disulfide oxidoreductase activity Source: InterPro

GO - Biological processi

  1. auditory receptor cell differentiation Source: MGI
  2. cell redox homeostasis Source: InterPro
  3. inner ear development Source: MGI
  4. inner ear receptor cell development Source: UniProtKB
  5. inner ear receptor stereocilium organization Source: UniProtKB
  6. negative regulation of phosphatase activity Source: UniProtKB
  7. post-embryonic organ morphogenesis Source: MGI
  8. sensory perception of sound Source: UniProtKB
  9. vestibular receptor cell development Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Hearing

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaredoxin domain-containing cysteine-rich protein 1
Gene namesi
Name:Grxcr1
Synonyms:pi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:3577767. Grxcr1.

Subcellular locationi

Cell projectionstereocilium 1 Publication. Cell projectionmicrovillus 1 Publication. Cell projectionkinocilium 1 Publication
Note: In the inner ear, localized to stereocilia, apical microvilli of sensory cells and kinocilia.

GO - Cellular componenti

  1. kinocilium Source: UniProtKB
  2. stereocilium Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Involvement in diseasei

Defects in Grxcr1 are the cause of the pirouette (pi) phenotype which is characterized by vestibular defects and profound deafness with affected mice displaying abnormally thin and slightly shortened sterocilia.2 Publications

Keywords - Diseasei

Deafness

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Glutaredoxin domain-containing cysteine-rich protein 1PRO_0000349190Add
BLAST

Proteomic databases

PRIDEiQ50H32.

PTM databases

PhosphoSiteiQ50H32.

Expressioni

Tissue specificityi

In the inner ear, expressed predominantly in sensory hair cells and their stereocilia bundles with higher levels in outer hair cells (OHC) at P1 and in inner hair cells (IHC) at P5. At P1, expression is prominent in each row of stereocilia within bundles including immature shorter stereocilia. Expression is also observed in apical microvilli of sensory cells at P1 and in kinocilia at P1 and P5. In the adult, expression is localized throughout the length of the stereocilia of both OHC and IHC (at protein level).1 Publication

Gene expression databases

BgeeiQ50H32.
GenevestigatoriQ50H32.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092305.

Structurei

3D structure databases

ProteinModelPortaliQ50H32.
SMRiQ50H32. Positions 138-228.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini127 – 234108GlutaredoxinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the GRXCR1 family.Curated
Contains 1 glutaredoxin domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG114644.
HOGENOMiHOG000112811.
HOVERGENiHBG095477.
InParanoidiQ50H32.
KOiK17479.
PhylomeDBiQ50H32.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR002109. Glutaredoxin.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00462. Glutaredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q50H32-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRRETKPES DRPRKVRFRI ASSHSGRVLK EVYEDGQAPG SLDSECASIC
60 70 80 90 100
AIDGLSDSEG QQNGHIGSED NEQEKDQDNL LVLARTASEK AFGTRRVNIL
110 120 130 140 150
SKNGTVRGVK YKVSAGQALF NNLTKVLQQP SADLEFDRVV IYTTCLRVVR
160 170 180 190 200
TTFERCELVR KIFQNHRVKF EEKNIALNGD YGKELDERCR RVSEAPSLPV
210 220 230 240 250
VFIDGHYLGG AEKILSMNES GELQDLLTKI ERVQHPHECP SCGGFGFLPC
260 270 280 290
SVCHGSKMSV FRNCFTDAFK ALKCTACNEN GLQRCKNCTC
Length:290
Mass (Da):32,402
Last modified:June 7, 2005 - v1
Checksum:i410ABE24FA7D27B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY616753 mRNA. Translation: AAU84851.1.
BC147268 mRNA. Translation: AAI47269.1.
BC147269 mRNA. Translation: AAI47270.1.
RefSeqiNP_001018019.2. NM_001018019.2.
UniGeneiMm.332422.

Genome annotation databases

GeneIDi433899.
KEGGimmu:433899.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY616753 mRNA. Translation: AAU84851.1 .
BC147268 mRNA. Translation: AAI47269.1 .
BC147269 mRNA. Translation: AAI47270.1 .
RefSeqi NP_001018019.2. NM_001018019.2.
UniGenei Mm.332422.

3D structure databases

ProteinModelPortali Q50H32.
SMRi Q50H32. Positions 138-228.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000092305.

PTM databases

PhosphoSitei Q50H32.

Proteomic databases

PRIDEi Q50H32.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 433899.
KEGGi mmu:433899.

Organism-specific databases

CTDi 389207.
MGIi MGI:3577767. Grxcr1.

Phylogenomic databases

eggNOGi NOG114644.
HOGENOMi HOG000112811.
HOVERGENi HBG095477.
InParanoidi Q50H32.
KOi K17479.
PhylomeDBi Q50H32.

Miscellaneous databases

NextBioi 409091.
PROi Q50H32.
SOURCEi Search...

Gene expression databases

Bgeei Q50H32.
Genevestigatori Q50H32.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR002109. Glutaredoxin.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00462. Glutaredoxin. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
PROSITEi PS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISEASE.
    Strain: C57BL/6.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Hair cells in the inner ear of the pirouette and shaker 2 mutant mice."
    Beyer L.A., Odeh H., Probst F.J., Lambert E.H., Dolan D.F., Camper S.A., Kohrman D.C., Raphael Y.
    J. Neurocytol. 29:227-240(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISEASE.

Entry informationi

Entry nameiGRCR1_MOUSE
AccessioniPrimary (citable) accession number: Q50H32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: June 7, 2005
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3