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Protein

Glutaredoxin domain-containing cysteine-rich protein 1

Gene

Grxcr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in actin filament architecture in developing stereocilia of sensory cells.1 Publication

GO - Molecular functioni

GO - Biological processi

  • auditory receptor cell differentiation Source: MGI
  • cell redox homeostasis Source: InterPro
  • inner ear development Source: MGI
  • inner ear receptor cell development Source: UniProtKB
  • inner ear receptor stereocilium organization Source: UniProtKB
  • negative regulation of phosphatase activity Source: UniProtKB
  • post-embryonic animal organ morphogenesis Source: MGI
  • sensory perception of sound Source: UniProtKB
  • vestibular receptor cell development Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Hearing

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaredoxin domain-containing cysteine-rich protein 1
Gene namesi
Name:Grxcr1
Synonyms:pi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3577767. Grxcr1.

Subcellular locationi

GO - Cellular componenti

  • kinocilium Source: UniProtKB
  • microvillus Source: UniProtKB-SubCell
  • stereocilium Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Involvement in diseasei

Defects in Grxcr1 are the cause of the pirouette (pi) phenotype which is characterized by vestibular defects and profound deafness with affected mice displaying abnormally thin and slightly shortened sterocilia.

Keywords - Diseasei

Deafness

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003491901 – 290Glutaredoxin domain-containing cysteine-rich protein 1Add BLAST290

Proteomic databases

PaxDbiQ50H32.
PRIDEiQ50H32.

PTM databases

PhosphoSitePlusiQ50H32.

Expressioni

Tissue specificityi

In the inner ear, expressed predominantly in sensory hair cells and their stereocilia bundles with higher levels in outer hair cells (OHC) at P1 and in inner hair cells (IHC) at P5. At P1, expression is prominent in each row of stereocilia within bundles including immature shorter stereocilia. Expression is also observed in apical microvilli of sensory cells at P1 and in kinocilia at P1 and P5. In the adult, expression is localized throughout the length of the stereocilia of both OHC and IHC (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000068082.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092305.

Structurei

3D structure databases

ProteinModelPortaliQ50H32.
SMRiQ50H32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini127 – 234GlutaredoxinPROSITE-ProRule annotationAdd BLAST108

Sequence similaritiesi

Belongs to the GRXCR1 family.Curated
Contains 1 glutaredoxin domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2824. Eukaryota.
ENOG4111HAI. LUCA.
HOGENOMiHOG000112811.
HOVERGENiHBG095477.
InParanoidiQ50H32.
KOiK17479.
PhylomeDBiQ50H32.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR002109. Glutaredoxin.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00462. Glutaredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q50H32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRRETKPES DRPRKVRFRI ASSHSGRVLK EVYEDGQAPG SLDSECASIC
60 70 80 90 100
AIDGLSDSEG QQNGHIGSED NEQEKDQDNL LVLARTASEK AFGTRRVNIL
110 120 130 140 150
SKNGTVRGVK YKVSAGQALF NNLTKVLQQP SADLEFDRVV IYTTCLRVVR
160 170 180 190 200
TTFERCELVR KIFQNHRVKF EEKNIALNGD YGKELDERCR RVSEAPSLPV
210 220 230 240 250
VFIDGHYLGG AEKILSMNES GELQDLLTKI ERVQHPHECP SCGGFGFLPC
260 270 280 290
SVCHGSKMSV FRNCFTDAFK ALKCTACNEN GLQRCKNCTC
Length:290
Mass (Da):32,402
Last modified:June 7, 2005 - v1
Checksum:i410ABE24FA7D27B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY616753 mRNA. Translation: AAU84851.1.
BC147268 mRNA. Translation: AAI47269.1.
BC147269 mRNA. Translation: AAI47270.1.
RefSeqiNP_001018019.2. NM_001018019.2.
UniGeneiMm.332422.

Genome annotation databases

GeneIDi433899.
KEGGimmu:433899.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY616753 mRNA. Translation: AAU84851.1.
BC147268 mRNA. Translation: AAI47269.1.
BC147269 mRNA. Translation: AAI47270.1.
RefSeqiNP_001018019.2. NM_001018019.2.
UniGeneiMm.332422.

3D structure databases

ProteinModelPortaliQ50H32.
SMRiQ50H32.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092305.

PTM databases

PhosphoSitePlusiQ50H32.

Proteomic databases

PaxDbiQ50H32.
PRIDEiQ50H32.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi433899.
KEGGimmu:433899.

Organism-specific databases

CTDi389207.
MGIiMGI:3577767. Grxcr1.

Phylogenomic databases

eggNOGiKOG2824. Eukaryota.
ENOG4111HAI. LUCA.
HOGENOMiHOG000112811.
HOVERGENiHBG095477.
InParanoidiQ50H32.
KOiK17479.
PhylomeDBiQ50H32.

Miscellaneous databases

PROiQ50H32.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068082.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR002109. Glutaredoxin.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00462. Glutaredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRCR1_MOUSE
AccessioniPrimary (citable) accession number: Q50H32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: June 7, 2005
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.