Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q50H32 (GRCR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutaredoxin domain-containing cysteine-rich protein 1
Gene names
Name:Grxcr1
Synonyms:pi
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in actin filament architecture in developing stereocilia of sensory cells. Ref.1

Subcellular location

Cell projectionstereocilium. Cell projectionmicrovillus. Cell projectionkinocilium. Note: In the inner ear, localized to stereocilia, apical microvilli of sensory cells and kinocilia. Ref.1

Tissue specificity

In the inner ear, expressed predominantly in sensory hair cells and their stereocilia bundles with higher levels in outer hair cells (OHC) at P1 and in inner hair cells (IHC) at P5. At P1, expression is prominent in each row of stereocilia within bundles including immature shorter stereocilia. Expression is also observed in apical microvilli of sensory cells at P1 and in kinocilia at P1 and P5. In the adult, expression is localized throughout the length of the stereocilia of both OHC and IHC (at protein level). Ref.1

Involvement in disease

Defects in Grxcr1 are the cause of the pirouette (pi) phenotype which is characterized by vestibular defects and profound deafness with affected mice displaying abnormally thin and slightly shortened sterocilia. Ref.1 Ref.3

Sequence similarities

Belongs to the GRXCR1 family.

Contains 1 glutaredoxin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290Glutaredoxin domain-containing cysteine-rich protein 1
PRO_0000349190

Regions

Domain127 – 234108Glutaredoxin

Sequences

Sequence LengthMass (Da)Tools
Q50H32 [UniParc].

Last modified June 7, 2005. Version 1.
Checksum: 410ABE24FA7D27B9

FASTA29032,402
        10         20         30         40         50         60 
MLRRETKPES DRPRKVRFRI ASSHSGRVLK EVYEDGQAPG SLDSECASIC AIDGLSDSEG 

        70         80         90        100        110        120 
QQNGHIGSED NEQEKDQDNL LVLARTASEK AFGTRRVNIL SKNGTVRGVK YKVSAGQALF 

       130        140        150        160        170        180 
NNLTKVLQQP SADLEFDRVV IYTTCLRVVR TTFERCELVR KIFQNHRVKF EEKNIALNGD 

       190        200        210        220        230        240 
YGKELDERCR RVSEAPSLPV VFIDGHYLGG AEKILSMNES GELQDLLTKI ERVQHPHECP 

       250        260        270        280        290 
SCGGFGFLPC SVCHGSKMSV FRNCFTDAFK ALKCTACNEN GLQRCKNCTC 

« Hide

References

« Hide 'large scale' references
[1]"Mutations in Grxcr1 are the basis for inner ear dysfunction in the pirouette mouse."
Odeh H., Hunker K.L., Belyantseva I.A., Azaiez H., Avenarius M.R., Zheng L., Peters L.M., Gagnon L.H., Hagiwara N., Skynner M.J., Brilliant M.H., Allen N.D., Riazuddin S., Johnson K.R., Raphael Y., Najmabadi H., Friedman T.B., Bartles J.R., Smith R.J., Kohrman D.C.
Am. J. Hum. Genet. 86:148-160(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISEASE.
Strain: C57BL/6.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"Hair cells in the inner ear of the pirouette and shaker 2 mutant mice."
Beyer L.A., Odeh H., Probst F.J., Lambert E.H., Dolan D.F., Camper S.A., Kohrman D.C., Raphael Y.
J. Neurocytol. 29:227-240(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: DISEASE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY616753 mRNA. Translation: AAU84851.1.
BC147268 mRNA. Translation: AAI47269.1.
BC147269 mRNA. Translation: AAI47270.1.
RefSeqNP_001018019.2. NM_001018019.2.
UniGeneMm.332422.

3D structure databases

ProteinModelPortalQ50H32.
SMRQ50H32. Positions 137-230.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000092305.

PTM databases

PhosphoSiteQ50H32.

Proteomic databases

PRIDEQ50H32.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID433899.
KEGGmmu:433899.

Organism-specific databases

CTD389207.
MGIMGI:3577767. Grxcr1.

Phylogenomic databases

eggNOGNOG114644.
HOGENOMHOG000112811.
HOVERGENHBG095477.
InParanoidQ50H32.
KOK17479.
PhylomeDBQ50H32.

Gene expression databases

BgeeQ50H32.
GenevestigatorQ50H32.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR002109. Glutaredoxin.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00462. Glutaredoxin. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
PROSITEPS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio409091.
PROQ50H32.
SOURCESearch...

Entry information

Entry nameGRCR1_MOUSE
AccessionPrimary (citable) accession number: Q50H32
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: June 7, 2005
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot