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Q50H32

- GRCR1_MOUSE

UniProt

Q50H32 - GRCR1_MOUSE

Protein

Glutaredoxin domain-containing cysteine-rich protein 1

Gene

Grxcr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (07 Jun 2005)
      Previous versions | rss
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    Functioni

    May play a role in actin filament architecture in developing stereocilia of sensory cells.1 Publication

    GO - Molecular functioni

    1. electron carrier activity Source: InterPro
    2. protein disulfide oxidoreductase activity Source: InterPro

    GO - Biological processi

    1. auditory receptor cell differentiation Source: MGI
    2. cell redox homeostasis Source: InterPro
    3. inner ear development Source: MGI
    4. inner ear receptor cell development Source: UniProtKB
    5. inner ear receptor stereocilium organization Source: UniProtKB
    6. negative regulation of phosphatase activity Source: UniProtKB
    7. post-embryonic organ morphogenesis Source: MGI
    8. sensory perception of sound Source: UniProtKB
    9. vestibular receptor cell development Source: UniProtKB

    Keywords - Biological processi

    Hearing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutaredoxin domain-containing cysteine-rich protein 1
    Gene namesi
    Name:Grxcr1
    Synonyms:pi
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:3577767. Grxcr1.

    Subcellular locationi

    Cell projectionstereocilium 1 Publication. Cell projectionmicrovillus 1 Publication. Cell projectionkinocilium 1 Publication
    Note: In the inner ear, localized to stereocilia, apical microvilli of sensory cells and kinocilia.

    GO - Cellular componenti

    1. kinocilium Source: UniProtKB
    2. stereocilium Source: UniProtKB

    Keywords - Cellular componenti

    Cell projection, Cilium

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Grxcr1 are the cause of the pirouette (pi) phenotype which is characterized by vestibular defects and profound deafness with affected mice displaying abnormally thin and slightly shortened sterocilia.2 Publications

    Keywords - Diseasei

    Deafness

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 290290Glutaredoxin domain-containing cysteine-rich protein 1PRO_0000349190Add
    BLAST

    Proteomic databases

    PRIDEiQ50H32.

    PTM databases

    PhosphoSiteiQ50H32.

    Expressioni

    Tissue specificityi

    In the inner ear, expressed predominantly in sensory hair cells and their stereocilia bundles with higher levels in outer hair cells (OHC) at P1 and in inner hair cells (IHC) at P5. At P1, expression is prominent in each row of stereocilia within bundles including immature shorter stereocilia. Expression is also observed in apical microvilli of sensory cells at P1 and in kinocilia at P1 and P5. In the adult, expression is localized throughout the length of the stereocilia of both OHC and IHC (at protein level).1 Publication

    Gene expression databases

    BgeeiQ50H32.
    GenevestigatoriQ50H32.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000092305.

    Structurei

    3D structure databases

    ProteinModelPortaliQ50H32.
    SMRiQ50H32. Positions 137-228.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini127 – 234108GlutaredoxinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GRXCR1 family.Curated
    Contains 1 glutaredoxin domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG114644.
    HOGENOMiHOG000112811.
    HOVERGENiHBG095477.
    InParanoidiQ50H32.
    KOiK17479.
    PhylomeDBiQ50H32.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR002109. Glutaredoxin.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00462. Glutaredoxin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    PROSITEiPS51354. GLUTAREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q50H32-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRRETKPES DRPRKVRFRI ASSHSGRVLK EVYEDGQAPG SLDSECASIC    50
    AIDGLSDSEG QQNGHIGSED NEQEKDQDNL LVLARTASEK AFGTRRVNIL 100
    SKNGTVRGVK YKVSAGQALF NNLTKVLQQP SADLEFDRVV IYTTCLRVVR 150
    TTFERCELVR KIFQNHRVKF EEKNIALNGD YGKELDERCR RVSEAPSLPV 200
    VFIDGHYLGG AEKILSMNES GELQDLLTKI ERVQHPHECP SCGGFGFLPC 250
    SVCHGSKMSV FRNCFTDAFK ALKCTACNEN GLQRCKNCTC 290
    Length:290
    Mass (Da):32,402
    Last modified:June 7, 2005 - v1
    Checksum:i410ABE24FA7D27B9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY616753 mRNA. Translation: AAU84851.1.
    BC147268 mRNA. Translation: AAI47269.1.
    BC147269 mRNA. Translation: AAI47270.1.
    RefSeqiNP_001018019.2. NM_001018019.2.
    UniGeneiMm.332422.

    Genome annotation databases

    GeneIDi433899.
    KEGGimmu:433899.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY616753 mRNA. Translation: AAU84851.1 .
    BC147268 mRNA. Translation: AAI47269.1 .
    BC147269 mRNA. Translation: AAI47270.1 .
    RefSeqi NP_001018019.2. NM_001018019.2.
    UniGenei Mm.332422.

    3D structure databases

    ProteinModelPortali Q50H32.
    SMRi Q50H32. Positions 137-228.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000092305.

    PTM databases

    PhosphoSitei Q50H32.

    Proteomic databases

    PRIDEi Q50H32.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 433899.
    KEGGi mmu:433899.

    Organism-specific databases

    CTDi 389207.
    MGIi MGI:3577767. Grxcr1.

    Phylogenomic databases

    eggNOGi NOG114644.
    HOGENOMi HOG000112811.
    HOVERGENi HBG095477.
    InParanoidi Q50H32.
    KOi K17479.
    PhylomeDBi Q50H32.

    Miscellaneous databases

    NextBioi 409091.
    PROi Q50H32.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q50H32.
    Genevestigatori Q50H32.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR002109. Glutaredoxin.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00462. Glutaredoxin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    PROSITEi PS51354. GLUTAREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISEASE.
      Strain: C57BL/6.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Hair cells in the inner ear of the pirouette and shaker 2 mutant mice."
      Beyer L.A., Odeh H., Probst F.J., Lambert E.H., Dolan D.F., Camper S.A., Kohrman D.C., Raphael Y.
      J. Neurocytol. 29:227-240(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISEASE.

    Entry informationi

    Entry nameiGRCR1_MOUSE
    AccessioniPrimary (citable) accession number: Q50H32
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3