Q50857 (Q50857_MYXXA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Saframycin Mx1 synthetase B EMBL AAC44128.1

Gene names

Name:

safB EMBL AAC44128.1

Organism

Myxococcus xanthus EMBL AAC44128.1

Taxonomic identifier

34 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Myxococcus

Protein attributes

Sequence length	1770 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Ligand	Phosphopantetheine RuleBase RU000721
Gene Ontology (GO)
Molecular_function	catalytic activity Inferred from electronic annotation. Source: InterPro phosphopantetheine binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q50857 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 545AC943B6A1CF1E	FASTA	1,770	192,497
	10 20 30 40 50 60 MACRPDSLHA SAVTSRRRMR HTLVELLQER ALSEPRHEAF TFLGEAGVPA VRVDYSSMDV 70 80 90 100 110 120 LARAIAARLQ ADGRVGERAL LLYAPGPEYV AAFFGCLYAG VVAVPVYPPD TARLERSLLR 130 140 150 160 170 180 LRTVARDSRA SVVLTTSFLQ GLAGAMFELA PELGELSWVA TDGIALEEAG AWKPPGLSGD 190 200 210 220 230 240 SVAFLQYTSG STADPKGVVL THRNLMHNLS VIHERFQLNR GSRGVIWLPP YHDMGLIGGV 250 260 270 280 290 300 LTPIFGGLPV DLMSPLSFLQ EPLRWLKTLS ERRGTCSGGP NFAYELCVRK ISDEQKAGLD 310 320 330 340 350 360 LSSWELAFCG AEPIRPDTLE AFSKAFEPCG FRREAFYPCY GLAEGTLIVT GVSKGRAARV 370 380 390 400 410 420 EHFQREALEA HRAVAASSPG EAARDTVRHV SCGTVVPDEQ ILVVDPETRT ALPPGHIGEI 430 440 450 460 470 480 WVRGPSVAQG YWLRPEETAR TFQARLAGGT EAPWLRTGDL GFLHDGELFV SGRRKDLLVI 490 500 510 520 530 540 RGRNYYPQDL ELTVERSHPA LRPGCAAVFS VSVGASEEVV VVQEVDRRYP GGDWPDVIAA 550 560 570 580 590 600 IRRDISEQHA LRVHAVVLIK SGSLLKTSSG KVQRGATREA YLEGQLDTVS ADAAQEPVGE 610 620 630 640 650 660 FSLSRASLLE RSEAERLPAL VAYLASAATR AGSLPRAILT GEVRLPDLGL DSLALVELKH 670 680 690 700 710 720 RIEQDLEVAL ELRLLLEGPT LGALAVHLLE AAGREARPVS APTPGTGERL PVPPGQRALW 730 740 750 760 770 780 FLHQLAPDSP GYTIARAICL QGALDVEALR RAFQSLVTRH PALRATFPMV GEEPVQQVHA 790 800 810 820 830 840 HVPASFLVVD ASGDDEAALR RRLLREAYRP FDLGRGPLLR THLFSRAAQE HVLLLSVHHI 850 860 870 880 890 900 VVDFWSLAVL VDELRRLYEA GGDGVVLPPV GQPADAIRWQ AEYMAGPSHE EDWGYWRQRL 910 920 930 940 950 960 AGPLPRLELP APALSSSGAA PSEPYHRFML GGALRQRVAA FSRKRGLTPY VTLLAGFQAL 970 980 990 1000 1010 1020 LHRLTGQDDI VVGSPVATRN WKGASRLVGY YVNTLPLRVG LSGEPSFSLL VDRVGEAVRG 1030 1040 1050 1060 1070 1080 ALKHQGFPFP LMVERLQPER LGDRTPIFQS LFVYQRAPLS EQPELAGFAV GDGSARLPLG 1090 1100 1110 1120 1130 1140 EASMSLLPLP PGAAQFELTL AVAPVGDGLV CTLEYDTARF DAGTAARLGA QYERLLSAAL 1150 1160 1170 1180 1190 1200 DAEDTPVSRL PLLPEAQHEQ LLRHWNATTR PYPEDARLHH LVAAQAARTP EGIALVCGAE 1210 1220 1230 1240 1250 1260 RLTYAGLMER VRKLAARLRR NGVGPEVRVG VFSLRTADLV VGLLAVLEAG GAYVPLDPNY 1270 1280 1290 1300 1310 1320 PRQRLDFIMR DAEMPVLLTQ RALASRLSPH GARLLFLEEP DTQEGPLPTP APVQPEQLAY 1330 1340 1350 1360 1370 1380 VLYTSGSTGQ PKGVAISHRS AATFVQWAGE TFSKEELTGV LAATSICFDL SVFELFVPLS 1390 1400 1410 1420 1430 1440 YGGRVILADT ALHLLELPAA SEVTLINTVP SAITELLNAS GIPSSVRTIN LAGEALTSDL 1450 1460 1470 1480 1490 1500 VARLYAETPA ARVVNLYGPS ETTTYSTYTP LPAQAVEPVS IGRPVANTQV YVLDRHLAPV 1510 1520 1530 1540 1550 1560 PVGVRGELFI GGAGVARGYL GRPRMTAERF LPDPFREAPG ARMYRTGDIV RYRAEGSLEF 1570 1580 1590 1600 1610 1620 LGRADHQVKV RGFRIEFEEI ETALRNHPAV REAVVVARGT GAERHLVAYV VLSARGESLV 1630 1640 1650 1660 1670 1680 TELREHLRGR LPDYMVPGVF VMMEVLPLTP NGKVDRAALP EPRASSLDPG QDYLAPRNEL 1690 1700 1710 1720 1730 1740 EARIAAIWEG LLRRERVGVH DSFFDLGGNS LLATRLATRL AATLQVQAGV RTVFEHRTVA 1750 1760 1770 AQAAHFTQAT KTHQAHSPIV AQPRVPYRGR

References

[1]	"A new Myxococcus xanthus gene cluster for the biosynthesis of the antibiotic saframycin Mx1 encoding a peptide synthetase." Pospiech A., Cluzel B., Bietenhader J., Schupp T. Microbiology 141:1793-1803(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: DM504-15 EMBL AAC44128.1.
[2]	"Two multifunctional peptide synthetases and an O-methyltransferase are involved in the biosynthesis of the DNA-binding antibiotic and antitumour agent saframycin Mx1 from Myxococcus xanthus." Pospiech A., Bietenhader J., Schupp T. Microbiology 142:741-746(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: DM504-15 EMBL AAC44128.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U24657 Genomic DNA. Translation: AAC44128.1.
PIR	T18551.
3D structure databases
HSSP	HSSP built from PDB template 1AMU based on UniProtKB P14687.
ProteinModelPortal	Q50857.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.10.1200.10. 2 hits.
InterPro	IPR010071. AA_adenyl_domain. IPR009081. Acyl_carrier_prot-like. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. IPR001242. Condensatn. IPR020806. PKS_PP-bd. IPR006162. PPantetheine_attach_site. [Graphical view]
Pfam	PF00501. AMP-binding. 2 hits. PF00668. Condensation. 1 hit. PF00550. PP-binding. 2 hits. [Graphical view]
SMART	SM00823. PKS_PP. 2 hits. [Graphical view]
SUPFAM	SSF47336. ACP_like. 2 hits.
TIGRFAMs	TIGR01733. AA-adenyl-dom. 1 hit.
PROSITE	PS50075. ACP_DOMAIN. 2 hits. PS00455. AMP_BINDING. 1 hit. PS00012. PHOSPHOPANTETHEINE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q50857_MYXXA

Accession

Primary (citable) accession number: Q50857

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)