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Protein

Polyferredoxin protein MvhB

Gene

mvhB

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

[4Fe-4S] clusterCuratedNote: Binds 10 [4Fe-4S] clusters.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi9 – 91Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi12 – 121Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi15 – 151Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi19 – 191Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi76 – 761Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi79 – 791Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi82 – 821Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi86 – 861Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi107 – 1071Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi110 – 1101Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi113 – 1131Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi117 – 1171Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi146 – 1461Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi149 – 1491Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi152 – 1521Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi156 – 1561Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi177 – 1771Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi180 – 1801Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi183 – 1831Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi187 – 1871Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi216 – 2161Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi219 – 2191Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi222 – 2221Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi226 – 2261Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi246 – 2461Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi249 – 2491Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi252 – 2521Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi256 – 2561Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi325 – 3251Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi328 – 3281Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi331 – 3311Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi335 – 3351Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi366 – 3661Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi369 – 3691Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi372 – 3721Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi376 – 3761Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi394 – 3941Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi397 – 3971Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi400 – 4001Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi404 – 4041Iron-sulfur (4Fe-4S)Sequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-1135-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyferredoxin protein MvhB
Gene namesi
Name:mvhB
Ordered Locus Names:MTH_1133
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 412412Polyferredoxin protein MvhBPRO_0000159143Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH1133.

Structurei

3D structure databases

ProteinModelPortaliQ50784.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 29284Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini30 – 57284Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd
BLAST
Domaini67 – 96304Fe-4S ferredoxin-type 3PROSITE-ProRule annotationAdd
BLAST
Domaini97 – 127314Fe-4S ferredoxin-type 4PROSITE-ProRule annotationAdd
BLAST
Domaini138 – 166294Fe-4S ferredoxin-type 5PROSITE-ProRule annotationAdd
BLAST
Domaini168 – 197304Fe-4S ferredoxin-type 6PROSITE-ProRule annotationAdd
BLAST
Domaini207 – 236304Fe-4S ferredoxin-type 7PROSITE-ProRule annotationAdd
BLAST
Domaini238 – 266294Fe-4S ferredoxin-type 8PROSITE-ProRule annotationAdd
BLAST
Domaini276 – 305304Fe-4S ferredoxin-type 9PROSITE-ProRule annotationAdd
BLAST
Domaini314 – 345324Fe-4S ferredoxin-type 10PROSITE-ProRule annotationAdd
BLAST
Domaini357 – 386304Fe-4S ferredoxin-type 11PROSITE-ProRule annotationAdd
BLAST
Domaini385 – 412284Fe-4S ferredoxin-type 12PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiarCOG02181. Archaea.
COG1145. LUCA.
OMAiECIGCEK.

Family and domain databases

InterProiIPR001080. 3Fe4S_ferredoxin.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
[Graphical view]
PfamiPF00037. Fer4. 2 hits.
PF12798. Fer4_3. 1 hit.
PF12800. Fer4_4. 1 hit.
PF12838. Fer4_7. 3 hits.
PF13187. Fer4_9. 1 hit.
[Graphical view]
PRINTSiPR00352. 3FE4SFRDOXIN.
PROSITEiPS00198. 4FE4S_FER_1. 10 hits.
PS51379. 4FE4S_FER_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q50784-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIVNKEDCI RCGACQGTCP TAAIEVTPED VIYCDICGGE PKCVDICPTG
60 70 80 90 100
ALKLEDLVVD EAGNTQGRIV FNPDKCNECG DCVEVCPPQI LKLDEGKVKK
110 120 130 140 150
VPLQGFCVMC QKCVDICPVG VIGVEGIKEP AKVELEIEGP IFIADCVGCG
160 170 180 190 200
MCVPECPVDA ITLDKVGGVI EIDEDTCIKC GVCAQTCPWN AVYISGRKPE
210 220 230 240 250
KRAKEIKKFE LDEDACIGCN TCVEACPGDF IVPRTSNLTV ELPAICTACG
260 270 280 290 300
LCEQLCPVDA IDLEVELGPA KPASEEGLVW DEEKCDFIGA CANICPNDAI
310 320 330 340 350
RVVTKEGMKV PDNEKVDEEP SFAMCTRCGA CTVACPKGAL SLVDMDKVVD
360 370 380 390 400
GEVVKRKRVQ YNPALCDQCG DCIEACPYDM LKLTDEKVPL KGFCILCDQC
410
IPACPKGALS LK
Length:412
Mass (Da):44,103
Last modified:January 16, 2004 - v2
Checksum:i845D8F4D55EB3DED
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961G → A in AAB02352 (PubMed:2654933).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04540 Genomic DNA. Translation: AAB02352.1.
AE000666 Genomic DNA. Translation: AAB85622.1.
PIRiG30315.
RefSeqiWP_010876757.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB85622; AAB85622; MTH_1133.
GeneIDi1471541.
KEGGimth:MTH_1133.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04540 Genomic DNA. Translation: AAB02352.1.
AE000666 Genomic DNA. Translation: AAB85622.1.
PIRiG30315.
RefSeqiWP_010876757.1. NC_000916.1.

3D structure databases

ProteinModelPortaliQ50784.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187420.MTH1133.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB85622; AAB85622; MTH_1133.
GeneIDi1471541.
KEGGimth:MTH_1133.

Phylogenomic databases

eggNOGiarCOG02181. Archaea.
COG1145. LUCA.
OMAiECIGCEK.

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-1135-MONOMER.

Family and domain databases

InterProiIPR001080. 3Fe4S_ferredoxin.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
[Graphical view]
PfamiPF00037. Fer4. 2 hits.
PF12798. Fer4_3. 1 hit.
PF12800. Fer4_4. 1 hit.
PF12838. Fer4_7. 3 hits.
PF13187. Fer4_9. 1 hit.
[Graphical view]
PRINTSiPR00352. 3FE4SFRDOXIN.
PROSITEiPS00198. 4FE4S_FER_1. 10 hits.
PS51379. 4FE4S_FER_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A hydrogenase-linked gene in Methanobacterium thermoautotrophicum strain delta H encodes a polyferredoxin."
    Reeve J.N., Beckler G.S., Cram D.S., Hamilton P.T., Brown J.W., Krzycki J.A., Kolodziej A.F., Alex L., Orme-Johnson W.H., Walsh C.T.
    Proc. Natl. Acad. Sci. U.S.A. 86:3031-3035(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Entry informationi

Entry nameiMVHB_METTH
AccessioniPrimary (citable) accession number: Q50784
Secondary accession number(s): O27205
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: June 8, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.