Reviewed,
UniProtKB/Swiss-Prot Q50648 (PANE_MYCTU)
Last modified
February 9, 2010.
Version 70.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Putative 2-dehydropantoate 2-reductase EC=1.1.1.169 Alternative name(s): Ketopantoate reductase Short name=KPA reductase Short name=KPR | ||||
| Gene names |
| ||||
| Organism | Mycobacterium tuberculosis [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 1773 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex |
Protein attributes
| Sequence length | 295 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid By similarity. |
| Catalytic activity | (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH. |
| Pathway | |
| Subcellular location | Cytoplasm Potential. |
| Miscellaneous | Was identified as a high-confidence drug target. |
| Sequence similarities | Belongs to the ketopantoate reductase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Pantothenate biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pantothenate biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | 2-dehydropantoate 2-reductase activity Inferred from electronic annotation. Source: EC NADP or NADPH bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 295 | 295 | Putative 2-dehydropantoate 2-reductase | PRO_0000157316 | |||||
Regions | |||||||||
| Nucleotide binding | 9 – 14 | 6 | NADP By similarity | ||||||
Sites | |||||||||
| Active site | 177 | 1 | Proton donor By similarity | ||||||
| Binding site | 100 | 1 | NADP; via amide nitrogen By similarity | ||||||
| Binding site | 100 | 1 | Substrate By similarity | ||||||
| Binding site | 181 | 1 | Substrate By similarity | ||||||
| Binding site | 246 | 1 | Substrate By similarity | ||||||
| Binding site | 258 | 1 | NADP By similarity | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BX842580 Genomic DNA. Translation: CAB01270.1. Different initiation. AE000516 Genomic DNA. Translation: AAK46962.1. Different initiation. |
| PIR | D70724. |
| RefSeq | NP_217089.2. NP_337148.1. |
3D structure databases | |
| SMR | Q50648. Positions 4-288. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 888188. 925668. |
| GenomeReviews | Gene locus MT2649 in contig AE000516_GR. |
| KEGG | mtc:MT2649. mtu:Rv2573. |
| TIGR | MT2649. |
Organism-specific databases | |
| TubercuList | Rv2573. |
Phylogenomic databases | |
| HOGENOM | HBG668370. |
| OMA | DASVWLR. |
Enzyme and pathway databases | |
| BRENDA | 1.1.1.169. 809. |
Family and domain databases | |
| InterPro | IPR008927. 6-PGluconate_DH_C-like. IPR003710. ApbA. IPR013752. ApbA_C. IPR013332. ApbA_N. IPR013328. DH_multihelical. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit. |
| PANTHER | PTHR21708:SF21. ApbA. 1 hit. |
| Pfam | PF02558. ApbA. 1 hit. PF08546. ApbA_C. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00745. apbA_panE. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | PANE_MYCTU | ||||||||
| Accession | Primary (citable) accession number: Q50648 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


