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Protein

Phenylalanine--tRNA ligase alpha subunit

Gene

Farsa

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei329L-phenylalanineBy similarity1
Binding sitei435L-phenylalanineBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phenylalanine--tRNA ligase alpha subunit (EC:6.1.1.20By similarity)
Alternative name(s):
Phenylalanyl-tRNA synthetase alpha subunit
Short name:
PheRS
Gene namesi
Name:Farsa
Synonyms:Farsla
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1310314 Farsa

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002804492 – 508Phenylalanine--tRNA ligase alpha subunitAdd BLAST507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei193PhosphoserineBy similarity1
Modified residuei301PhosphoserineBy similarity1
Modified residuei311N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ505J8
PRIDEiQ505J8

PTM databases

iPTMnetiQ505J8
PhosphoSitePlusiQ505J8

Expressioni

Gene expression databases

BgeeiENSRNOG00000003149
GenevisibleiQ505J8 RN

Interactioni

Subunit structurei

Heterotetramer; dimer of two heterodimers formed by FARSA and FARSB.By similarity

Protein-protein interaction databases

IntActiQ505J8, 1 interactor
MINTiQ505J8
STRINGi10116.ENSRNOP00000004370

Structurei

3D structure databases

ProteinModelPortaliQ505J8
SMRiQ505J8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni372 – 374L-phenylalanine bindingBy similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2784 Eukaryota
COG0016 LUCA
GeneTreeiENSGT00390000006387
HOGENOMiHOG000230294
HOVERGENiHBG068046
InParanoidiQ505J8
KOiK01889
OMAiRFKPAFN
OrthoDBiEOG091G04JI
PhylomeDBiQ505J8
TreeFamiTF300647

Family and domain databases

InterProiView protein in InterPro
IPR006195 aa-tRNA-synth_II
IPR013196 HTH_11
IPR004529 Phe-tRNA-synth_IIc_asu
IPR002319 Phenylalanyl-tRNA_Synthase
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF08279 HTH_11, 1 hit
PF01409 tRNA-synt_2d, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
TIGRFAMsiTIGR00468 pheS, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q505J8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADNPVLEQL LRRLEVADGG LDSAELATQL GVEHQAVVGA VKSLQALGEV
60 70 80 90 100
IEAELRSTKC WELTTEGEEI AREGSHEARV FRSIPLEGLV QSELMQLPSG
110 120 130 140 150
KVGFSKAMSN KWIRVDKSAA DGPRVFRVVD SIEDEVQRRL QQVQAGQAEK
160 170 180 190 200
LAEKERNELR KRKLLTEVIL KTYWVSKGKG FSTSVSKQEA ELSPEMISSG
210 220 230 240 250
SWRDRPFKPY NFSARGVLPD SGHLHPLLKV RSQFRQIFLE MGFTEMPTDN
260 270 280 290 300
FIESSFWNFD ALFQPQQHPA RDQHDTFFLR DPAEALQLPM DYVQRVKRTH
310 320 330 340 350
SQGGYGSQGY KYTWKLEEAR KNLLRTHTTA ASARALYRLA QKKPFTPAKY
360 370 380 390 400
FSIDRVFRNE TLDATHLAEF HQIEGVIADH GLTLGHLMGV LREFFTKLGI
410 420 430 440 450
TQLRFKPAYN PYTEPSMEVF SYHQGLKKWV EVGNSGVFRP EMLLPMGLPE
460 470 480 490 500
NVSVIAWGLS LERPTMIKYG INNIRELVGH KVNLQMVYDS PVCRLDIEPR

SSKTQEAA
Length:508
Mass (Da):57,720
Last modified:June 7, 2005 - v1
Checksum:i78CE0B72EC5BF377
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094515 mRNA Translation: AAH94515.1
RefSeqiNP_001019408.1, NM_001024237.1
UniGeneiRn.2972

Genome annotation databases

EnsembliENSRNOT00000004370; ENSRNOP00000004370; ENSRNOG00000003149
GeneIDi288917
KEGGirno:288917

Similar proteinsi

Entry informationi

Entry nameiSYFA_RAT
AccessioniPrimary (citable) accession number: Q505J8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 7, 2005
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
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