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Protein

Mitochondrial glutamate carrier 2

Gene

Slc25a18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H+ (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSymport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-428643 Organic anion transporters

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glutamate carrier 2
Short name:
GC-2
Alternative name(s):
Glutamate/H(+) symporter 2
Solute carrier family 25 member 18
Gene namesi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1590470 Slc25a18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 37Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei66 – 86Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei111 – 131Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei190 – 210Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei230 – 250Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei293 – 313Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906231 – 320Mitochondrial glutamate carrier 2Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei150PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ505J6
PRIDEiQ505J6

PTM databases

iPTMnetiQ505J6
PhosphoSitePlusiQ505J6

Expressioni

Gene expression databases

BgeeiENSRNOG00000042731
GenevisibleiQ505J6 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015561

Structurei

3D structure databases

ProteinModelPortaliQ505J6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 97Solcar 1Add BLAST87
Repeati105 – 215Solcar 2Add BLAST111
Repeati224 – 313Solcar 3Add BLAST90

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0750 Eukaryota
ENOG410Y240 LUCA
GeneTreeiENSGT00530000062944
HOGENOMiHOG000168308
HOVERGENiHBG039469
InParanoidiQ505J6
KOiK15107
OMAiMTHQDLS
OrthoDBiEOG091G08GT
PhylomeDBiQ505J6
TreeFamiTF313209

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q505J6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIACRMSSQD LSITAKLING GIAGLVGVTC VFPIDLAKTR LQNQQGKDVY
60 70 80 90 100
KGMTDCLVKT ARAEGFLGMY RGAAVNLTLV TPEKAIKLAA NDFLRQLLMQ
110 120 130 140 150
DGTQRNLKME MLAGCGAGIC QVVITCPMEM LKIQLQDAGR LAVCQQASAS
160 170 180 190 200
ATPTSRPYST GSTSTHRRPS ATLIAWELLR TQGLSGLYRG LGATLLRDIP
210 220 230 240 250
FSIIYFPLFA NLNQLGVSEL TGKASFTHSF VAGCAAGSVS AVAVTPLDVL
260 270 280 290 300
KTRIQTLKKG LGEDTYRGVT DCARKLWTQE GAAAFMKGAG CRALVIAPLF
310 320
GIAQGVYFIG IGERILKCFE
Length:320
Mass (Da):34,170
Last modified:April 8, 2008 - v2
Checksum:i658DCFBF6B5AB51C
GO

Sequence cautioni

The sequence AAH94517 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094517 mRNA Translation: AAH94517.1 Different initiation.
RefSeqiNP_001037745.2, NM_001044280.2
UniGeneiRn.42043

Genome annotation databases

EnsembliENSRNOT00000015560; ENSRNOP00000015561; ENSRNOG00000042731
GeneIDi681896
KEGGirno:681896
UCSCiRGD:1590470 rat

Similar proteinsi

Entry informationi

Entry nameiGHC2_RAT
AccessioniPrimary (citable) accession number: Q505J6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: April 8, 2008
Last modified: May 23, 2018
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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