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Protein

Mitochondrial glutamate carrier 2

Gene

Slc25a18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H+ (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glutamate carrier 2
Short name:
GC-2
Alternative name(s):
Glutamate/H(+) symporter 2
Solute carrier family 25 member 18
Gene namesi
Name:Slc25a18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1590470. Slc25a18.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei66 – 8621Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei111 – 13121Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei190 – 21021Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei230 – 25021Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei293 – 31321Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Mitochondrial glutamate carrier 2PRO_0000090623Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei150 – 1501PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ505J6.
PRIDEiQ505J6.

PTM databases

iPTMnetiQ505J6.

Expressioni

Gene expression databases

GenevisibleiQ505J6. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015561.

Structurei

3D structure databases

ProteinModelPortaliQ505J6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 9787Solcar 1Add
BLAST
Repeati105 – 215111Solcar 2Add
BLAST
Repeati224 – 31390Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0750. Eukaryota.
ENOG410Y240. LUCA.
GeneTreeiENSGT00530000062944.
HOGENOMiHOG000168308.
HOVERGENiHBG039469.
InParanoidiQ505J6.
KOiK15107.
OMAiVMVASIR.
OrthoDBiEOG7KM5TK.
PhylomeDBiQ505J6.
TreeFamiTF313209.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q505J6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIACRMSSQD LSITAKLING GIAGLVGVTC VFPIDLAKTR LQNQQGKDVY
60 70 80 90 100
KGMTDCLVKT ARAEGFLGMY RGAAVNLTLV TPEKAIKLAA NDFLRQLLMQ
110 120 130 140 150
DGTQRNLKME MLAGCGAGIC QVVITCPMEM LKIQLQDAGR LAVCQQASAS
160 170 180 190 200
ATPTSRPYST GSTSTHRRPS ATLIAWELLR TQGLSGLYRG LGATLLRDIP
210 220 230 240 250
FSIIYFPLFA NLNQLGVSEL TGKASFTHSF VAGCAAGSVS AVAVTPLDVL
260 270 280 290 300
KTRIQTLKKG LGEDTYRGVT DCARKLWTQE GAAAFMKGAG CRALVIAPLF
310 320
GIAQGVYFIG IGERILKCFE
Length:320
Mass (Da):34,170
Last modified:April 8, 2008 - v2
Checksum:i658DCFBF6B5AB51C
GO

Sequence cautioni

The sequence AAH94517.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094517 mRNA. Translation: AAH94517.1. Different initiation.
RefSeqiNP_001037745.2. NM_001044280.2.
UniGeneiRn.42043.

Genome annotation databases

EnsembliENSRNOT00000015560; ENSRNOP00000015561; ENSRNOG00000042731.
GeneIDi681896.
KEGGirno:681896.
UCSCiRGD:1590470. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094517 mRNA. Translation: AAH94517.1. Different initiation.
RefSeqiNP_001037745.2. NM_001044280.2.
UniGeneiRn.42043.

3D structure databases

ProteinModelPortaliQ505J6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015561.

PTM databases

iPTMnetiQ505J6.

Proteomic databases

PaxDbiQ505J6.
PRIDEiQ505J6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015560; ENSRNOP00000015561; ENSRNOG00000042731.
GeneIDi681896.
KEGGirno:681896.
UCSCiRGD:1590470. rat.

Organism-specific databases

CTDi83733.
RGDi1590470. Slc25a18.

Phylogenomic databases

eggNOGiKOG0750. Eukaryota.
ENOG410Y240. LUCA.
GeneTreeiENSGT00530000062944.
HOGENOMiHOG000168308.
HOVERGENiHBG039469.
InParanoidiQ505J6.
KOiK15107.
OMAiVMVASIR.
OrthoDBiEOG7KM5TK.
PhylomeDBiQ505J6.
TreeFamiTF313209.

Miscellaneous databases

NextBioi721845.
PROiQ505J6.

Gene expression databases

GenevisibleiQ505J6. RN.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiGHC2_RAT
AccessioniPrimary (citable) accession number: Q505J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: April 8, 2008
Last modified: May 11, 2016
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.