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Reviewed, UniProtKB/Swiss-Prot Q505I0 (P4K2A_XENTR)

Last modified November 3, 2009. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Phosphatidylinositol 4-kinase type 2-alpha
    EC=2.7.1.67
Alternative name(s):
    Phosphatidylinositol 4-kinase type II-alpha
Gene names
Name: pi4k2a
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraMesobatrachiaPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length471 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) By similarity.

Catalytic activity

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.

Subcellular location

Cytoplasm By similarity. Membrane By similarity.

Sequence similarities

Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.

Contains 1 PI3K/PI4K domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Membrane
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function1-phosphatidylinositol 4-kinase activity

Inferred from electronic annotation. Source: EC

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 471471Phosphatidylinositol 4-kinase type 2-alpha
PRO_0000285163

Regions

Domain126 – 430305PI3K/PI4K

Sequences

Sequence LengthMass (Da)Tools
Q505I0-1 [UniParc].

Last modified May 1, 2007. Version 2.
Checksum: 1209E79DDA3CB8E7

FASTA47153,484
        10         20         30         40         50         60 
MDETSPLVSP DRDQTDYSYQ SQCSPGVPVC LSPNGRFSAV PGVVVRIPGS ATSPIRGSAA 

        70         80         90        100        110        120 
SGPSPPGSPC DRERQPLLER SQTRGAAAQA ERERNKFPDD PEFAEVVKKA EKAIVRDILP 

       130        140        150        160        170        180 
ERISQGSSGS YFVKNEQGEI IAVFKPKNEE PYGQLNPKWT KWLQKLCCPC CFGRDCLVLN 

       190        200        210        220        230        240 
QGYLSEAGAS LVDQKLELNI VPRTKVVFLA SETFNYSAID RVKSRGKRLA LEKVPKVGQR 

       250        260        270        280        290        300 
FNRIGLPPKV GSFQLFVKGY KDADYWLRRF EADPLPENTN RQLQLQFERL VVLDYIIRNT 

       310        320        330        340        350        360 
DRGNDNWLIK YDCPMDSASA RDDWVMVKEP VIKIAAIDNG LAFPLKHPDS WRAYPFYWAW 

       370        380        390        400        410        420 
LPQAKIQFSQ EIKDLILPKI SDPNFVKDLE EDLYELFKRD PGFDRGQFRK QIAVMRGQIL 

       430        440        450        460        470 
NLTQALKDGK SPLQLVQTPP VIVETARSHQ KSTSESYTQS FQSRKPFFSW W 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

BC094534 mRNA. Translation: AAH94534.1. Different initiation.
UniGeneStr.37157

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSXETT00000029616; ENSXETP00000029616; ENSXETG00000013516; Xenopus tropicalis. [Genome view]

Organism-specific databases

XenbaseXB-FEAT-491467. pi4k2a.

Phylogenomic databases

HOVERGENQ505I0.
OMAIIKLAAI.

Enzyme and pathway databases

BRENDA2.7.1.67. 279072.

Gene expression databases

BgeeQ505I0.

Family and domain databases

InterProIPR000403. PI3/4_kinase_cat.
IPR018936. PI3/4_kinase_CS.
[Graphical view]
PfamPF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
PROSITEPS00915. PI3_4_KINASE_1. False negative.
PS00916. PI3_4_KINASE_2. False negative.
PS50290. PI3_4_KINASE_3. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameP4K2A_XENTR
AccessionPrimary (citable) accession number: Q505I0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: November 3, 2009
This is version 24 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectXenopus annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents