Q505I0 (P4K2A_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidylinositol 4-kinase type 2-alpha
EC=2.7.1.67

Alternative name(s):
Phosphatidylinositol 4-kinase type II-alpha

Gene names

Name:

pi4k2a

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	471 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) By similarity.
Catalytic activity	ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.
Subcellular location	Cytoplasm By similarity. Membrane By similarity.
Sequence similarities	Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily. Contains 1 PI3K/PI4K domain.
Sequence caution	The sequence AAH94534.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	1-phosphatidylinositol 4-kinase activity Inferred from electronic annotation. Source: EC ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 471	471	Phosphatidylinositol 4-kinase type 2-alpha		PRO_0000285163
Regions
	Domain	126 – 430	305	PI3K/PI4K

Sequences

	Sequence		Length	Mass (Da)
	Q505I0 [UniParc]. Last modified May 1, 2007. Version 2. Checksum: 1209E79DDA3CB8E7	FASTA	471	53,484
	10 20 30 40 50 60 MDETSPLVSP DRDQTDYSYQ SQCSPGVPVC LSPNGRFSAV PGVVVRIPGS ATSPIRGSAA 70 80 90 100 110 120 SGPSPPGSPC DRERQPLLER SQTRGAAAQA ERERNKFPDD PEFAEVVKKA EKAIVRDILP 130 140 150 160 170 180 ERISQGSSGS YFVKNEQGEI IAVFKPKNEE PYGQLNPKWT KWLQKLCCPC CFGRDCLVLN 190 200 210 220 230 240 QGYLSEAGAS LVDQKLELNI VPRTKVVFLA SETFNYSAID RVKSRGKRLA LEKVPKVGQR 250 260 270 280 290 300 FNRIGLPPKV GSFQLFVKGY KDADYWLRRF EADPLPENTN RQLQLQFERL VVLDYIIRNT 310 320 330 340 350 360 DRGNDNWLIK YDCPMDSASA RDDWVMVKEP VIKIAAIDNG LAFPLKHPDS WRAYPFYWAW 370 380 390 400 410 420 LPQAKIQFSQ EIKDLILPKI SDPNFVKDLE EDLYELFKRD PGFDRGQFRK QIAVMRGQIL 430 440 450 460 470 NLTQALKDGK SPLQLVQTPP VIVETARSHQ KSTSESYTQS FQSRKPFFSW W

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC094534 mRNA. Translation: AAH94534.1. Different initiation.
RefSeq	XP_002936479.1. XM_002936433.1.
UniGene	Str.37157.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q505I0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSXETT00000029616; ENSXETP00000029616; ENSXETG00000013516.
GeneID	594904.
KEGG	xtr:594904.
Organism-specific databases
CTD	55361.
Xenbase	XB-GENE-491468. pi4k2a.
Phylogenomic databases
eggNOG	veNOG07167.
GeneTree	ENSGT00390000010434.
HOGENOM	HBG714361.
HOVERGEN	HBG059542.
InParanoid	Q505I0.
OMA	QRFHRIG.
OrthoDB	EOG4VT5X4.
Gene expression databases
Bgee	Q505I0.
Family and domain databases
InterPro	IPR000403. PI3/4_kinase_cat. [Graphical view]
KO	K13711.
Pfam	PF00454. PI3_PI4_kinase. 1 hit. [Graphical view]
PROSITE	PS00915. PI3_4_KINASE_1. False negative. PS00916. PI3_4_KINASE_2. False negative. PS50290. PI3_4_KINASE_3. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P4K2A_XENTR

Accession

Primary (citable) accession number: Q505I0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	May 1, 2007
Last modified:	December 14, 2011
This is version 41 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program