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Q505D7

- OPA3_MOUSE

UniProt

Q505D7 - OPA3_MOUSE

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Protein

Optic atrophy 3 protein homolog

Gene
Opa3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May play some role in mitochondrial processes By similarity.

GO - Biological processi

  1. growth Source: MGI
  2. mitochondrion morphogenesis Source: MGI
  3. neuromuscular process Source: MGI
  4. regulation of lipid metabolic process Source: MGI
  5. visual perception Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Optic atrophy 3 protein homolog
Gene namesi
Name:Opa3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:2686271. Opa3.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi122 – 1221L → P: Homozygous mice have their visual function which is severely reduced, consistent with significant loss of retinal ganglion cells and degeneration of axons in the optic nerve. They also display a severe multi-systemic disease characterized by reduced lifespan (<4 months), decreased weight, dilated cardiomyopathy, extrapyramidal dysfunction and gross neuro-muscular defects. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 179179Optic atrophy 3 protein homologPRO_0000326547Add
BLAST

Proteomic databases

MaxQBiQ505D7.
PaxDbiQ505D7.
PRIDEiQ505D7.

PTM databases

PhosphoSiteiQ505D7.

Expressioni

Gene expression databases

BgeeiQ505D7.
GenevestigatoriQ505D7.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069965.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili120 – 14324 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the OPA3 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG241179.
GeneTreeiENSGT00390000009795.
HOGENOMiHOG000007385.
HOVERGENiHBG019109.
InParanoidiQ505D7.
OMAiESNDIMH.
OrthoDBiEOG7JMGG7.
PhylomeDBiQ505D7.
TreeFamiTF314653.

Family and domain databases

InterProiIPR010754. OPA3-like.
[Graphical view]
PANTHERiPTHR12499. PTHR12499. 1 hit.
PfamiPF07047. OPA3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q505D7-1 [UniParc]FASTAAdd to Basket

« Hide

MVVGAFPMAK LFYLGIRQVS KPLANRIKDA ARRSEFFKTY ICLPPAQLYH    50
WVEMRTKMRI MGFRGTTIKP LNEEAAAELG AELLGEATIF IVGGGCLVLE 100
YWRHQTQQRN KEEEQRAAWN ALQDEVGRLA LALEALQAQA QAMPSLSALE 150
ELREELQEVR GQVCNAHCTS KCQAASSKK 179
Length:179
Mass (Da):20,110
Last modified:June 7, 2005 - v1
Checksum:iFF948407D52F742E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561T → A in BAC35141. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK052774 mRNA. Translation: BAC35141.1.
AK133480 mRNA. Translation: BAE21678.1.
AK154960 mRNA. Translation: BAE32955.1.
AK164755 mRNA. Translation: BAE37900.1.
AK170977 mRNA. Translation: BAE42155.1.
BC094601 mRNA. Translation: AAH94601.1.
BC132309 mRNA. Translation: AAI32310.1.
BC132311 mRNA. Translation: AAI32312.1.
CCDSiCCDS20894.1.
RefSeqiNP_997408.2. NM_207525.3.
UniGeneiMm.239583.

Genome annotation databases

EnsembliENSMUST00000063976; ENSMUSP00000069965; ENSMUSG00000052214.
GeneIDi403187.
KEGGimmu:403187.
UCSCiuc009flc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK052774 mRNA. Translation: BAC35141.1 .
AK133480 mRNA. Translation: BAE21678.1 .
AK154960 mRNA. Translation: BAE32955.1 .
AK164755 mRNA. Translation: BAE37900.1 .
AK170977 mRNA. Translation: BAE42155.1 .
BC094601 mRNA. Translation: AAH94601.1 .
BC132309 mRNA. Translation: AAI32310.1 .
BC132311 mRNA. Translation: AAI32312.1 .
CCDSi CCDS20894.1.
RefSeqi NP_997408.2. NM_207525.3.
UniGenei Mm.239583.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000069965.

PTM databases

PhosphoSitei Q505D7.

Proteomic databases

MaxQBi Q505D7.
PaxDbi Q505D7.
PRIDEi Q505D7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000063976 ; ENSMUSP00000069965 ; ENSMUSG00000052214 .
GeneIDi 403187.
KEGGi mmu:403187.
UCSCi uc009flc.1. mouse.

Organism-specific databases

CTDi 80207.
MGIi MGI:2686271. Opa3.

Phylogenomic databases

eggNOGi NOG241179.
GeneTreei ENSGT00390000009795.
HOGENOMi HOG000007385.
HOVERGENi HBG019109.
InParanoidi Q505D7.
OMAi ESNDIMH.
OrthoDBi EOG7JMGG7.
PhylomeDBi Q505D7.
TreeFami TF314653.

Miscellaneous databases

NextBioi 406356.
PROi Q505D7.
SOURCEi Search...

Gene expression databases

Bgeei Q505D7.
Genevestigatori Q505D7.

Family and domain databases

InterProi IPR010754. OPA3-like.
[Graphical view ]
PANTHERi PTHR12499. PTHR12499. 1 hit.
Pfami PF07047. OPA3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Kidney and Mammary gland.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. Cited for: MUTAGENESIS OF LEU-122.

Entry informationi

Entry nameiOPA3_MOUSE
AccessioniPrimary (citable) accession number: Q505D7
Secondary accession number(s): Q8C6Z9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 7, 2005
Last modified: July 9, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi