Q505D7 (OPA3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Optic atrophy 3 protein homolog

Gene names

Name:

Opa3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	179 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play some role in mitochondrial processes By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the OPA3 family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	growth Inferred from mutant phenotype Ref.3. Source: MGI mitochondrion morphogenesis Inferred from mutant phenotype PubMed 21613372. Source: MGI neuromuscular process Inferred from mutant phenotype Ref.3. Source: MGI regulation of lipid metabolic process Inferred from mutant phenotype PubMed 22869679. Source: MGI visual perception Inferred from electronic annotation. Source: Compara
Cellular_component	mitochondrion Inferred from direct assay PubMed 18614015PubMed 21613372. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 179	179	Optic atrophy 3 protein homolog		PRO_0000326547
Regions
	Coiled coil	120 – 143	24	Potential
Experimental info
	Mutagenesis	122	1	L → P: Homozygous mice have their visual function which is severely reduced, consistent with significant loss of retinal ganglion cells and degeneration of axons in the optic nerve. They also display a severe multi-systemic disease characterized by reduced lifespan (<4 months), decreased weight, dilated cardiomyopathy, extrapyramidal dysfunction and gross neuro-muscular defects. Ref.3
	Sequence conflict	56	1	T → A in BAC35141. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q505D7 [UniParc]. Last modified June 7, 2005. Version 1. Checksum: FF948407D52F742E	FASTA	179	20,110
	10 20 30 40 50 60 MVVGAFPMAK LFYLGIRQVS KPLANRIKDA ARRSEFFKTY ICLPPAQLYH WVEMRTKMRI 70 80 90 100 110 120 MGFRGTTIKP LNEEAAAELG AELLGEATIF IVGGGCLVLE YWRHQTQQRN KEEEQRAAWN 130 140 150 160 170 ALQDEVGRLA LALEALQAQA QAMPSLSALE ELREELQEVR GQVCNAHCTS KCQAASSKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J and NOD. Tissue: Kidney and Mammary gland.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain.
[3]	"A missense mutation in the murine Opa3 gene models human Costeff syndrome." Davies V.J., Powell K.A., White K.E., Yip W., Hogan V., Hollins A.J., Davies J.R., Piechota M., Brownstein D.G., Moat S.J., Nichols P.P., Wride M.A., Boulton M.E., Votruba M. Brain 131:368-380(2008) [PubMed] [Europe PMC] [Abstract] Cited for: MUTAGENESIS OF LEU-122.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK052774 mRNA. Translation: BAC35141.1. AK133480 mRNA. Translation: BAE21678.1. AK154960 mRNA. Translation: BAE32955.1. AK164755 mRNA. Translation: BAE37900.1. AK170977 mRNA. Translation: BAE42155.1. BC094601 mRNA. Translation: AAH94601.1. BC132309 mRNA. Translation: AAI32310.1. BC132311 mRNA. Translation: AAI32312.1.
IPI	IPI00312507.
RefSeq	NP_997408.2. NM_207525.3.
UniGene	Mm.239583.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000069965.
PTM databases
PhosphoSite	Q505D7.
Proteomic databases
PaxDb	Q505D7.
PRIDE	Q505D7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000063976; ENSMUSP00000069965; ENSMUSG00000052214.
GeneID	403187.
KEGG	mmu:403187.
UCSC	uc009flc.1. mouse.
Organism-specific databases
CTD	80207.
MGI	MGI:2686271. Opa3.
Phylogenomic databases
eggNOG	NOG241179.
GeneTree	ENSGT00390000009795.
HOGENOM	HOG000007385.
HOVERGEN	HBG019109.
InParanoid	Q505D7.
OMA	HWIEMRT.
OrthoDB	EOG470TJS.
Gene expression databases
Bgee	Q505D7.
Genevestigator	Q505D7.
Family and domain databases
InterPro	IPR010754. OPA3-like. [Graphical view]
PANTHER	PTHR12499. PTHR12499. 1 hit.
Pfam	PF07047. OPA3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	406356.
SOURCE	Search...

Entry information

Entry name

OPA3_MOUSE

Accession

Primary (citable) accession number: Q505D7
Secondary accession number(s): Q8C6Z9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	June 7, 2005
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program