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Q505D7

- OPA3_MOUSE

UniProt

Q505D7 - OPA3_MOUSE

Protein

Optic atrophy 3 protein homolog

Gene

Opa3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (07 Jun 2005)
      Previous versions | rss
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    Functioni

    May play some role in mitochondrial processes.By similarity

    GO - Biological processi

    1. growth Source: MGI
    2. mitochondrion morphogenesis Source: MGI
    3. neuromuscular process Source: MGI
    4. regulation of lipid metabolic process Source: MGI
    5. visual perception Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Optic atrophy 3 protein homolog
    Gene namesi
    Name:Opa3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:2686271. Opa3.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi122 – 1221L → P: Homozygous mice have their visual function which is severely reduced, consistent with significant loss of retinal ganglion cells and degeneration of axons in the optic nerve. They also display a severe multi-systemic disease characterized by reduced lifespan (<4 months), decreased weight, dilated cardiomyopathy, extrapyramidal dysfunction and gross neuro-muscular defects. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 179179Optic atrophy 3 protein homologPRO_0000326547Add
    BLAST

    Proteomic databases

    MaxQBiQ505D7.
    PaxDbiQ505D7.
    PRIDEiQ505D7.

    PTM databases

    PhosphoSiteiQ505D7.

    Expressioni

    Gene expression databases

    BgeeiQ505D7.
    GenevestigatoriQ505D7.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000069965.

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili120 – 14324Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the OPA3 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG241179.
    GeneTreeiENSGT00390000009795.
    HOGENOMiHOG000007385.
    HOVERGENiHBG019109.
    InParanoidiQ505D7.
    OMAiESNDIMH.
    OrthoDBiEOG7JMGG7.
    PhylomeDBiQ505D7.
    TreeFamiTF314653.

    Family and domain databases

    InterProiIPR010754. OPA3-like.
    [Graphical view]
    PANTHERiPTHR12499. PTHR12499. 1 hit.
    PfamiPF07047. OPA3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q505D7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVVGAFPMAK LFYLGIRQVS KPLANRIKDA ARRSEFFKTY ICLPPAQLYH    50
    WVEMRTKMRI MGFRGTTIKP LNEEAAAELG AELLGEATIF IVGGGCLVLE 100
    YWRHQTQQRN KEEEQRAAWN ALQDEVGRLA LALEALQAQA QAMPSLSALE 150
    ELREELQEVR GQVCNAHCTS KCQAASSKK 179
    Length:179
    Mass (Da):20,110
    Last modified:June 7, 2005 - v1
    Checksum:iFF948407D52F742E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti56 – 561T → A in BAC35141. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK052774 mRNA. Translation: BAC35141.1.
    AK133480 mRNA. Translation: BAE21678.1.
    AK154960 mRNA. Translation: BAE32955.1.
    AK164755 mRNA. Translation: BAE37900.1.
    AK170977 mRNA. Translation: BAE42155.1.
    BC094601 mRNA. Translation: AAH94601.1.
    BC132309 mRNA. Translation: AAI32310.1.
    BC132311 mRNA. Translation: AAI32312.1.
    CCDSiCCDS20894.1.
    RefSeqiNP_997408.2. NM_207525.3.
    UniGeneiMm.239583.

    Genome annotation databases

    EnsembliENSMUST00000063976; ENSMUSP00000069965; ENSMUSG00000052214.
    GeneIDi403187.
    KEGGimmu:403187.
    UCSCiuc009flc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK052774 mRNA. Translation: BAC35141.1 .
    AK133480 mRNA. Translation: BAE21678.1 .
    AK154960 mRNA. Translation: BAE32955.1 .
    AK164755 mRNA. Translation: BAE37900.1 .
    AK170977 mRNA. Translation: BAE42155.1 .
    BC094601 mRNA. Translation: AAH94601.1 .
    BC132309 mRNA. Translation: AAI32310.1 .
    BC132311 mRNA. Translation: AAI32312.1 .
    CCDSi CCDS20894.1.
    RefSeqi NP_997408.2. NM_207525.3.
    UniGenei Mm.239583.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000069965.

    PTM databases

    PhosphoSitei Q505D7.

    Proteomic databases

    MaxQBi Q505D7.
    PaxDbi Q505D7.
    PRIDEi Q505D7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000063976 ; ENSMUSP00000069965 ; ENSMUSG00000052214 .
    GeneIDi 403187.
    KEGGi mmu:403187.
    UCSCi uc009flc.1. mouse.

    Organism-specific databases

    CTDi 80207.
    MGIi MGI:2686271. Opa3.

    Phylogenomic databases

    eggNOGi NOG241179.
    GeneTreei ENSGT00390000009795.
    HOGENOMi HOG000007385.
    HOVERGENi HBG019109.
    InParanoidi Q505D7.
    OMAi ESNDIMH.
    OrthoDBi EOG7JMGG7.
    PhylomeDBi Q505D7.
    TreeFami TF314653.

    Miscellaneous databases

    NextBioi 406356.
    PROi Q505D7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q505D7.
    Genevestigatori Q505D7.

    Family and domain databases

    InterProi IPR010754. OPA3-like.
    [Graphical view ]
    PANTHERi PTHR12499. PTHR12499. 1 hit.
    Pfami PF07047. OPA3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Kidney and Mammary gland.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    3. Cited for: MUTAGENESIS OF LEU-122.

    Entry informationi

    Entry nameiOPA3_MOUSE
    AccessioniPrimary (citable) accession number: Q505D7
    Secondary accession number(s): Q8C6Z9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3