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Protein

Optic atrophy 3 protein homolog

Gene

Opa3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play some role in mitochondrial processes.By similarity

GO - Biological processi

  • growth Source: MGI
  • mitochondrion morphogenesis Source: MGI
  • neuromuscular process Source: MGI
  • regulation of lipid metabolic process Source: MGI
  • visual perception Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Optic atrophy 3 protein homolog
Gene namesi
Name:Opa3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2686271. Opa3.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi122 – 1221L → P: Homozygous mice have their visual function which is severely reduced, consistent with significant loss of retinal ganglion cells and degeneration of axons in the optic nerve. They also display a severe multi-systemic disease characterized by reduced lifespan (<4 months), decreased weight, dilated cardiomyopathy, extrapyramidal dysfunction and gross neuro-muscular defects. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 179179Optic atrophy 3 protein homologPRO_0000326547Add
BLAST

Proteomic databases

MaxQBiQ505D7.
PaxDbiQ505D7.
PRIDEiQ505D7.

PTM databases

PhosphoSiteiQ505D7.

Expressioni

Gene expression databases

BgeeiQ505D7.
GenevisibleiQ505D7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069965.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili120 – 14324Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the OPA3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG241179.
GeneTreeiENSGT00390000009795.
HOGENOMiHOG000007385.
HOVERGENiHBG019109.
InParanoidiQ505D7.
OMAiHWIEMRT.
OrthoDBiEOG7JMGG7.
PhylomeDBiQ505D7.
TreeFamiTF314653.

Family and domain databases

InterProiIPR010754. OPA3-like.
[Graphical view]
PANTHERiPTHR12499. PTHR12499. 1 hit.
PfamiPF07047. OPA3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q505D7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVGAFPMAK LFYLGIRQVS KPLANRIKDA ARRSEFFKTY ICLPPAQLYH
60 70 80 90 100
WVEMRTKMRI MGFRGTTIKP LNEEAAAELG AELLGEATIF IVGGGCLVLE
110 120 130 140 150
YWRHQTQQRN KEEEQRAAWN ALQDEVGRLA LALEALQAQA QAMPSLSALE
160 170
ELREELQEVR GQVCNAHCTS KCQAASSKK
Length:179
Mass (Da):20,110
Last modified:June 7, 2005 - v1
Checksum:iFF948407D52F742E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561T → A in BAC35141 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052774 mRNA. Translation: BAC35141.1.
AK133480 mRNA. Translation: BAE21678.1.
AK154960 mRNA. Translation: BAE32955.1.
AK164755 mRNA. Translation: BAE37900.1.
AK170977 mRNA. Translation: BAE42155.1.
BC094601 mRNA. Translation: AAH94601.1.
BC132309 mRNA. Translation: AAI32310.1.
BC132311 mRNA. Translation: AAI32312.1.
CCDSiCCDS20894.1.
RefSeqiNP_997408.2. NM_207525.3.
UniGeneiMm.239583.

Genome annotation databases

EnsembliENSMUST00000063976; ENSMUSP00000069965; ENSMUSG00000052214.
GeneIDi403187.
KEGGimmu:403187.
UCSCiuc009flc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052774 mRNA. Translation: BAC35141.1.
AK133480 mRNA. Translation: BAE21678.1.
AK154960 mRNA. Translation: BAE32955.1.
AK164755 mRNA. Translation: BAE37900.1.
AK170977 mRNA. Translation: BAE42155.1.
BC094601 mRNA. Translation: AAH94601.1.
BC132309 mRNA. Translation: AAI32310.1.
BC132311 mRNA. Translation: AAI32312.1.
CCDSiCCDS20894.1.
RefSeqiNP_997408.2. NM_207525.3.
UniGeneiMm.239583.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069965.

PTM databases

PhosphoSiteiQ505D7.

Proteomic databases

MaxQBiQ505D7.
PaxDbiQ505D7.
PRIDEiQ505D7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063976; ENSMUSP00000069965; ENSMUSG00000052214.
GeneIDi403187.
KEGGimmu:403187.
UCSCiuc009flc.1. mouse.

Organism-specific databases

CTDi80207.
MGIiMGI:2686271. Opa3.

Phylogenomic databases

eggNOGiNOG241179.
GeneTreeiENSGT00390000009795.
HOGENOMiHOG000007385.
HOVERGENiHBG019109.
InParanoidiQ505D7.
OMAiHWIEMRT.
OrthoDBiEOG7JMGG7.
PhylomeDBiQ505D7.
TreeFamiTF314653.

Miscellaneous databases

ChiTaRSiOpa3. mouse.
NextBioi406356.
PROiQ505D7.
SOURCEiSearch...

Gene expression databases

BgeeiQ505D7.
GenevisibleiQ505D7. MM.

Family and domain databases

InterProiIPR010754. OPA3-like.
[Graphical view]
PANTHERiPTHR12499. PTHR12499. 1 hit.
PfamiPF07047. OPA3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Kidney and Mammary gland.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. Cited for: MUTAGENESIS OF LEU-122.

Entry informationi

Entry nameiOPA3_MOUSE
AccessioniPrimary (citable) accession number: Q505D7
Secondary accession number(s): Q8C6Z9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 7, 2005
Last modified: July 22, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.