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Protein

Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

Gene

Ankrd28

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation (By similarity).By similarity

Enzyme and pathway databases

ReactomeiR-MMU-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
Short name:
PP6-ARS-A
Short name:
Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A
Alternative name(s):
Ankyrin repeat domain-containing protein 28
Phosphatase interactor targeting protein hnRNP K
Short name:
PITK
Gene namesi
Name:Ankrd28
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2145661. Ankrd28.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002445711 – 1053Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit AAdd BLAST1053

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1007PhosphoserineBy similarity1
Modified residuei1011PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ505D1.
MaxQBiQ505D1.
PaxDbiQ505D1.
PeptideAtlasiQ505D1.
PRIDEiQ505D1.

PTM databases

iPTMnetiQ505D1.
PhosphoSitePlusiQ505D1.

Expressioni

Tissue specificityi

Widely expressed (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000014496.
CleanExiMM_ANKRD28.
GenevisibleiQ505D1. MM.

Interactioni

Subunit structurei

Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP1C and HNRPK. Interacts with PPP6C, PPP6R1 and PPP6R3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi222872. 9 interactors.
IntActiQ505D1. 9 interactors.
STRINGi10090.ENSMUSP00000014640.

Structurei

3D structure databases

ProteinModelPortaliQ505D1.
SMRiQ505D1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati40 – 69ANK 1Add BLAST30
Repeati73 – 102ANK 2Add BLAST30
Repeati106 – 135ANK 3Add BLAST30
Repeati139 – 168ANK 4Add BLAST30
Repeati172 – 201ANK 5Add BLAST30
Repeati205 – 234ANK 6Add BLAST30
Repeati238 – 267ANK 7Add BLAST30
Repeati271 – 301ANK 8Add BLAST31
Repeati305 – 334ANK 9Add BLAST30
Repeati338 – 367ANK 10Add BLAST30
Repeati371 – 400ANK 11Add BLAST30
Repeati404 – 433ANK 12Add BLAST30
Repeati437 – 466ANK 13Add BLAST30
Repeati470 – 500ANK 14Add BLAST31
Repeati504 – 534ANK 15Add BLAST31
Repeati549 – 578ANK 16Add BLAST30
Repeati582 – 611ANK 17Add BLAST30
Repeati616 – 645ANK 18Add BLAST30
Repeati652 – 681ANK 19Add BLAST30
Repeati685 – 714ANK 20Add BLAST30
Repeati718 – 747ANK 21Add BLAST30
Repeati755 – 786ANK 22Add BLAST32
Repeati788 – 817ANK 23Add BLAST30
Repeati822 – 851ANK 24Add BLAST30
Repeati855 – 885ANK 25Add BLAST31
Repeati889 – 918ANK 26Add BLAST30
Repeati925 – 954ANK 27Add BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi987 – 990Poly-Ser4

Sequence similaritiesi

Contains 27 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129677.
HOGENOMiHOG000033959.
HOVERGENiHBG067697.
InParanoidiQ505D1.
KOiK15502.
OMAiQKMEGNS.
OrthoDBiEOG091G02S4.
PhylomeDBiQ505D1.
TreeFamiTF312824.

Family and domain databases

Gene3Di1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 2 hits.
PF12796. Ank_2. 7 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 28 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 4 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 24 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q505D1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFLKLRDQP SLVQAIFNGD PDEVRALIFK KEDVNFQDNE KRTPLHAAAY
60 70 80 90 100
LGDAEIIELL ILSGARVNAK DSKWLTPLHR AVASCSEEAV QILLKHSADV
110 120 130 140 150
NARDKNWQTP LHIAAANKAV KCAESLVPLL SNVNVSDRAG RTALHHAAFS
160 170 180 190 200
GHGEMVKLLL SRGANINAFD KKDRRAIHWA AYMGHIEVVK LLVSHGAEVT
210 220 230 240 250
CKDKKSYTPL HAAASSGMIS VVKYLLDLGV DMNEPNAYGN TPLHVACYNG
260 270 280 290 300
QDVVVNELID CGANVNQKNE KGFTPLHFAA ASTHGALCLE LLVGNGADVN
310 320 330 340 350
MKSKDGKTPL HMTALHGRFS RSQTIIQSGA VIDCEDKNGN TPLHIAARYG
360 370 380 390 400
HELLINTLIT SGADTAKRGI HGMFPLHLAA LSGFSDCCRK LLSSGFDIDT
410 420 430 440 450
PDDFGRTCLH AAAAGGNLEC LNLLLNTGAD FNKKDKFGRS PLHYAAANCN
460 470 480 490 500
YQCLFALVGS GASVNDLDER GCTPLHYAAT SDTDGKCLEY LLRNDANPGI
510 520 530 540 550
RDKQGYNAVH YSAAYGHRLC LQLIASETPL DVLMETSGTD MLSDSDNRAT
560 570 580 590 600
ISPLHLAAYH GHHQALEVLV QSLLDLDVRN SSGRTPLDLA AFKGHVECVD
610 620 630 640 650
VLINQGASIL VKDYVLKRTP IHAAATNGHS ECLRLLIGNA EPQNAVDIQD
660 670 680 690 700
GNGQTPLMLS VLNGHTDCVY SLLNKGANVD AKDKWGRTAL HRGAVTGHEE
710 720 730 740 750
CVDALLQHGA KCLLRDSRGR TPIHLSAACG HIGVLGALLQ SATSVDANPA
760 770 780 790 800
VVDNHGYTAL HWACYNGHET CVELLLEQDV FQKIDGNAFS PLHCAVINDN
810 820 830 840 850
EGAAEMLIDS LGASIVNATD SKGRTPLHAA AFTDHVECLQ LLLSQNAQVN
860 870 880 890 900
SADSTGKTPL MMAAENGQTN TVEMLVSSAS ADLTLQDKSK NTALHLACGK
910 920 930 940 950
GHETSALLIL EKITDRNLIN ATNAALQTPL HVAARNGLTM VVQELLGKGA
960 970 980 990 1000
SVLAVDENGY TPALACAPNK DVADCLALIL ATMMPVSSSS PLTSLTFNAI
1010 1020 1030 1040 1050
NRYTNTSKTV SFEALPIMRN EASSYCSFNN IGGEQEYLYT DVDELNDSDS

ETY
Length:1,053
Mass (Da):112,898
Last modified:June 7, 2005 - v1
Checksum:iD7649AF1D1F22F62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094609 mRNA. Translation: AAH94609.1.
BC051456 mRNA. Translation: AAH51456.1.
CCDSiCCDS36858.1.
RefSeqiNP_001019775.1. NM_001024604.2.
UniGeneiMm.37660.

Genome annotation databases

EnsembliENSMUST00000014640; ENSMUSP00000014640; ENSMUSG00000014496.
GeneIDi105522.
KEGGimmu:105522.
UCSCiuc007sxz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094609 mRNA. Translation: AAH94609.1.
BC051456 mRNA. Translation: AAH51456.1.
CCDSiCCDS36858.1.
RefSeqiNP_001019775.1. NM_001024604.2.
UniGeneiMm.37660.

3D structure databases

ProteinModelPortaliQ505D1.
SMRiQ505D1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222872. 9 interactors.
IntActiQ505D1. 9 interactors.
STRINGi10090.ENSMUSP00000014640.

PTM databases

iPTMnetiQ505D1.
PhosphoSitePlusiQ505D1.

Proteomic databases

EPDiQ505D1.
MaxQBiQ505D1.
PaxDbiQ505D1.
PeptideAtlasiQ505D1.
PRIDEiQ505D1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000014640; ENSMUSP00000014640; ENSMUSG00000014496.
GeneIDi105522.
KEGGimmu:105522.
UCSCiuc007sxz.1. mouse.

Organism-specific databases

CTDi23243.
MGIiMGI:2145661. Ankrd28.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129677.
HOGENOMiHOG000033959.
HOVERGENiHBG067697.
InParanoidiQ505D1.
KOiK15502.
OMAiQKMEGNS.
OrthoDBiEOG091G02S4.
PhylomeDBiQ505D1.
TreeFamiTF312824.

Enzyme and pathway databases

ReactomeiR-MMU-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Miscellaneous databases

PROiQ505D1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000014496.
CleanExiMM_ANKRD28.
GenevisibleiQ505D1. MM.

Family and domain databases

Gene3Di1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 2 hits.
PF12796. Ank_2. 7 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 28 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 4 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 24 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANR28_MOUSE
AccessioniPrimary (citable) accession number: Q505D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 7, 2005
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.