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Protein

Synaptonemal complex central element protein 2

Gene

Syce2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination.1 Publication

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • synaptonemal complex assembly Source: MGI

Keywordsi

Biological processCell cycle, Cell division, Meiosis

Enzyme and pathway databases

ReactomeiR-MMU-1221633. Meiotic Synapsis.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptonemal complex central element protein 2
Gene namesi
Name:Syce2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1919096. Syce2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002625631 – 171Synaptonemal complex central element protein 2Add BLAST171

Proteomic databases

EPDiQ505B8.
PaxDbiQ505B8.
PRIDEiQ505B8.

2D gel databases

REPRODUCTION-2DPAGEiIPI00321051.

PTM databases

iPTMnetiQ505B8.
PhosphoSitePlusiQ505B8.

Expressioni

Tissue specificityi

Meiotic cells (at protein level). Expressed in the ovary and testis.1 Publication

Developmental stagei

Expressed in ovary, embryo, spleen, thymus, brain, kidney, epididymis, heart and liver at 14 dpc and in oocytes at 18 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000003824.
CleanExiMM_SYCE2.
ExpressionAtlasiQ505B8. baseline and differential.
GenevisibleiQ505B8. MM.

Interactioni

Subunit structurei

Homodimer. Found in a complex with SYCP1 and SYCE1. Interacts with SYCP1, SYCE1 and SYCE3.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Syce3B5KM662EBI-6131573,EBI-6128737

Protein-protein interaction databases

BioGridi214975. 6 interactors.
CORUMiQ505B8.
IntActiQ505B8. 5 interactors.
STRINGi10090.ENSMUSP00000131438.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili52 – 83Sequence analysisAdd BLAST32
Coiled coili118 – 146Sequence analysisAdd BLAST29

Sequence similaritiesi

Belongs to the SYCE family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J5YK. Eukaryota.
ENOG410XUQ9. LUCA.
GeneTreeiENSGT00390000004872.
HOVERGENiHBG080707.
InParanoidiQ505B8.
KOiK19535.
PhylomeDBiQ505B8.
TreeFamiTF333776.

Family and domain databases

InterProiView protein in InterPro
IPR034609. Syce2.
PANTHERiPTHR28398. PTHR28398. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q505B8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERHGVAAPP VELKDQEPPA IVESGEHRQS ENHEETPGSV APSASCQLPG
60 70 80 90 100
PFSSLDSSIE TLKKKAQELI ENINESRQKD HALMTNFRDS LKMKVSDLTE
110 120 130 140 150
KLEERMYQVY SHHSKIIQER LQEFTQKMAK INHLEMELKQ VCQTVETVYK
160 170
DLCVQSEVPT CEEQNYKDGE C
Length:171
Mass (Da):19,558
Last modified:June 7, 2005 - v1
Checksum:iB0517F1D9B8BF9F6
GO
Isoform 2 (identifier: Q505B8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Show »
Length:88
Mass (Da):10,537
Checksum:iB132A5D46FB5DDDE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26E → K in BAB24337 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0217881 – 83Missing in isoform 2. 1 PublicationAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005954 mRNA. Translation: BAB24337.1.
AK167332 mRNA. Translation: BAE39434.1.
BC094628 mRNA. Translation: AAH94628.1.
CCDSiCCDS22481.1. [Q505B8-1]
RefSeqiNP_001161716.1. NM_001168244.1. [Q505B8-2]
NP_082230.2. NM_027954.3. [Q505B8-1]
UniGeneiMm.229128.

Genome annotation databases

EnsembliENSMUST00000136026; ENSMUSP00000122159; ENSMUSG00000003824. [Q505B8-1]
GeneIDi71846.
KEGGimmu:71846.
UCSCiuc009mnv.2. mouse. [Q505B8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSYCE2_MOUSE
AccessioniPrimary (citable) accession number: Q505B8
Secondary accession number(s): Q3TJR1, Q9DAC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: June 7, 2005
Last modified: November 22, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families