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Q50570

- FDHB_METTF

UniProt

Q50570 - FDHB_METTF

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Protein
Formate dehydrogenase subunit beta
Gene
fdhB
Organism
Methanothermobacter thermautotrophicus (Methanobacterium thermoformicicum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidation of formate.

Catalytic activityi

Formate + NAD+ = CO2 + NADH.

Cofactori

Binds 2 4Fe-4S clusters Inferred.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi295 – 2951Iron-sulfur (4Fe-4S) By similarity
Metal bindingi298 – 2981Iron-sulfur (4Fe-4S) By similarity
Metal bindingi301 – 3011Iron-sulfur (4Fe-4S) By similarity
Metal bindingi305 – 3051Iron-sulfur (4Fe-4S) By similarity
Metal bindingi346 – 3461Iron-sulfur (4Fe-4S) By similarity
Metal bindingi349 – 3491Iron-sulfur (4Fe-4S) By similarity
Metal bindingi352 – 3521Iron-sulfur (4Fe-4S) By similarity
Metal bindingi356 – 3561Iron-sulfur (4Fe-4S) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate dehydrogenase subunit beta (EC:1.2.1.2)
    Gene namesi
    Name:fdhB
    OrganismiMethanothermobacter thermautotrophicus (Methanobacterium thermoformicicum)
    Taxonomic identifieri145262 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 394394Formate dehydrogenase subunit beta
    PRO_0000159223Add
    BLAST

    Interactioni

    Subunit structurei

    Dimer of an alpha and a beta subunit.

    Structurei

    3D structure databases

    ProteinModelPortaliQ50570.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini285 – 315314Fe-4S ferredoxin-type 1
    Add
    BLAST
    Domaini337 – 367314Fe-4S ferredoxin-type 2
    Add
    BLAST

    Sequence similaritiesi

    Belongs to the FrhB family.

    Keywords - Domaini

    Repeat

    Family and domain databases

    InterProiIPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR007516. Co_F420_Hydgase/DH_bsu_N.
    IPR007525. FrhB_FdhB_C.
    IPR009051. Helical_ferredxn.
    [Graphical view]
    PfamiPF13183. Fer4_8. 1 hit.
    PF04432. FrhB_FdhB_C. 1 hit.
    PF04422. FrhB_FdhB_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF46548. SSF46548. 1 hit.
    PROSITEiPS00198. 4FE4S_FER_1. 2 hits.
    PS51379. 4FE4S_FER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q50570-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVEVNDMYYA FSKNEEIAEK GEYGGAVTSL LKFLLEEGMV DAVLAVKKGS    50
    DLYDAVPTLI TEPEKVIESA GSLHCGTLNI AKVITRYLNG AKDIKIAVTT 100
    KPCDAMTIVE VAKRGKIDLD NVIMVGVNCG GTLPPVKTRA MIEEVYEMDP 150
    DDVVKEEIAK GKLIIETSDA EKGISVDEVE EMGYGRRTNC RRCEKNIPRM 200
    ADLALGNWGV IGPLAGKATF VEVTSEKGAD LLEKAVSAGV IEIEDPIPKG 250
    IEIREKIDQA MVNLAKKWQK NDFNEETGAE ILMNLDRYMD ELNKCIKCYS 300
    CREACPICYC EECSLETKTP EWIEKGKIPP SPLFHLERML HMVDSCTNCG 350
    QCEELCPAEI PLAKIWHEIN CRVQETFGYK TGFETGQEPP LTHP 394
    Length:394
    Mass (Da):43,683
    Last modified:November 1, 1996 - v1
    Checksum:iF95B3E85B4C44316
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U52681 Genomic DNA. Translation: AAC44821.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U52681 Genomic DNA. Translation: AAC44821.1 .

    3D structure databases

    ProteinModelPortali Q50570.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR007516. Co_F420_Hydgase/DH_bsu_N.
    IPR007525. FrhB_FdhB_C.
    IPR009051. Helical_ferredxn.
    [Graphical view ]
    Pfami PF13183. Fer4_8. 1 hit.
    PF04432. FrhB_FdhB_C. 1 hit.
    PF04422. FrhB_FdhB_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46548. SSF46548. 1 hit.
    PROSITEi PS00198. 4FE4S_FER_1. 2 hits.
    PS51379. 4FE4S_FER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Growth- and substrate-dependent transcription of the formate dehydrogenase (fdhCAB) operon in Methanobacterium thermoformicicum Z-245."
      Noelling J., Reeve J.N.
      J. Bacteriol. 179:899-908(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: DSM 3720 / Z-245.

    Entry informationi

    Entry nameiFDHB_METTF
    AccessioniPrimary (citable) accession number: Q50570
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: November 13, 2013
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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