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Q50570 (FDHB_METTF) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Formate dehydrogenase subunit beta

EC=1.2.1.2
Gene names
Name:fdhB
OrganismMethanothermobacter thermautotrophicus (Methanobacterium thermoformicicum)
Taxonomic identifier145262 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter

Protein attributes

Sequence length394 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of formate.

Catalytic activity

Formate + NAD+ = CO2 + NADH.

Cofactor

Binds 2 4Fe-4S clusters Probable.

Subunit structure

Dimer of an alpha and a beta subunit.

Sequence similarities

Belongs to the FrhB family.

Contains 2 4Fe-4S ferredoxin-type domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 394394Formate dehydrogenase subunit beta
PRO_0000159223

Regions

Domain285 – 315314Fe-4S ferredoxin-type 1
Domain337 – 367314Fe-4S ferredoxin-type 2

Sites

Metal binding2951Iron-sulfur (4Fe-4S) By similarity
Metal binding2981Iron-sulfur (4Fe-4S) By similarity
Metal binding3011Iron-sulfur (4Fe-4S) By similarity
Metal binding3051Iron-sulfur (4Fe-4S) By similarity
Metal binding3461Iron-sulfur (4Fe-4S) By similarity
Metal binding3491Iron-sulfur (4Fe-4S) By similarity
Metal binding3521Iron-sulfur (4Fe-4S) By similarity
Metal binding3561Iron-sulfur (4Fe-4S) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q50570 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: F95B3E85B4C44316

FASTA39443,683
        10         20         30         40         50         60 
MVEVNDMYYA FSKNEEIAEK GEYGGAVTSL LKFLLEEGMV DAVLAVKKGS DLYDAVPTLI 

        70         80         90        100        110        120 
TEPEKVIESA GSLHCGTLNI AKVITRYLNG AKDIKIAVTT KPCDAMTIVE VAKRGKIDLD 

       130        140        150        160        170        180 
NVIMVGVNCG GTLPPVKTRA MIEEVYEMDP DDVVKEEIAK GKLIIETSDA EKGISVDEVE 

       190        200        210        220        230        240 
EMGYGRRTNC RRCEKNIPRM ADLALGNWGV IGPLAGKATF VEVTSEKGAD LLEKAVSAGV 

       250        260        270        280        290        300 
IEIEDPIPKG IEIREKIDQA MVNLAKKWQK NDFNEETGAE ILMNLDRYMD ELNKCIKCYS 

       310        320        330        340        350        360 
CREACPICYC EECSLETKTP EWIEKGKIPP SPLFHLERML HMVDSCTNCG QCEELCPAEI 

       370        380        390 
PLAKIWHEIN CRVQETFGYK TGFETGQEPP LTHP 

« Hide

References

[1]"Growth- and substrate-dependent transcription of the formate dehydrogenase (fdhCAB) operon in Methanobacterium thermoformicicum Z-245."
Noelling J., Reeve J.N.
J. Bacteriol. 179:899-908(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DSM 3720 / Z-245.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U52681 Genomic DNA. Translation: AAC44821.1.

3D structure databases

ProteinModelPortalQ50570.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR007516. Co_F420_Hydgase/DH_bsu_N.
IPR007525. FrhB_FdhB_C.
IPR009051. Helical_ferredxn.
[Graphical view]
PfamPF13183. Fer4_8. 1 hit.
PF04432. FrhB_FdhB_C. 1 hit.
PF04422. FrhB_FdhB_N. 1 hit.
[Graphical view]
SUPFAMSSF46548. SSF46548. 1 hit.
PROSITEPS00198. 4FE4S_FER_1. 2 hits.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFDHB_METTF
AccessionPrimary (citable) accession number: Q50570
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 13, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families