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Protein

Formate dehydrogenase subunit beta

Gene

fdhB

Organism
Methanothermobacter thermautotrophicus (Methanobacterium thermoformicicum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of formate.

Catalytic activityi

Formate + NAD+ = CO2 + NADH.

Cofactori

[4Fe-4S] clusterCuratedNote: Binds 2 [4Fe-4S] clusters.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi295Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi298Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi301Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi305Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi346Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi349Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi352Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi356Iron-sulfur (4Fe-4S)By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Formate dehydrogenase subunit beta (EC:1.2.1.2)
Gene namesi
Name:fdhB
OrganismiMethanothermobacter thermautotrophicus (Methanobacterium thermoformicicum)
Taxonomic identifieri145262 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001592231 – 394Formate dehydrogenase subunit betaAdd BLAST394

Interactioni

Subunit structurei

Dimer of an alpha and a beta subunit.

Structurei

3D structure databases

ProteinModelPortaliQ50570.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini285 – 3154Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST31
Domaini337 – 3674Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST31

Sequence similaritiesi

Belongs to the FrhB family.Curated
Contains 2 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR007516. Co_F420_Hydgase/DH_bsu_N.
IPR007525. FrhB_FdhB_C.
IPR009051. Helical_ferredxn.
[Graphical view]
PfamiPF04432. FrhB_FdhB_C. 1 hit.
PF04422. FrhB_FdhB_N. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 2 hits.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q50570-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEVNDMYYA FSKNEEIAEK GEYGGAVTSL LKFLLEEGMV DAVLAVKKGS
60 70 80 90 100
DLYDAVPTLI TEPEKVIESA GSLHCGTLNI AKVITRYLNG AKDIKIAVTT
110 120 130 140 150
KPCDAMTIVE VAKRGKIDLD NVIMVGVNCG GTLPPVKTRA MIEEVYEMDP
160 170 180 190 200
DDVVKEEIAK GKLIIETSDA EKGISVDEVE EMGYGRRTNC RRCEKNIPRM
210 220 230 240 250
ADLALGNWGV IGPLAGKATF VEVTSEKGAD LLEKAVSAGV IEIEDPIPKG
260 270 280 290 300
IEIREKIDQA MVNLAKKWQK NDFNEETGAE ILMNLDRYMD ELNKCIKCYS
310 320 330 340 350
CREACPICYC EECSLETKTP EWIEKGKIPP SPLFHLERML HMVDSCTNCG
360 370 380 390
QCEELCPAEI PLAKIWHEIN CRVQETFGYK TGFETGQEPP LTHP
Length:394
Mass (Da):43,683
Last modified:November 1, 1996 - v1
Checksum:iF95B3E85B4C44316
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52681 Genomic DNA. Translation: AAC44821.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52681 Genomic DNA. Translation: AAC44821.1.

3D structure databases

ProteinModelPortaliQ50570.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR007516. Co_F420_Hydgase/DH_bsu_N.
IPR007525. FrhB_FdhB_C.
IPR009051. Helical_ferredxn.
[Graphical view]
PfamiPF04432. FrhB_FdhB_C. 1 hit.
PF04422. FrhB_FdhB_N. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 2 hits.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFDHB_METTF
AccessioniPrimary (citable) accession number: Q50570
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 16, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.