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Q50570

- FDHB_METTF

UniProt

Q50570 - FDHB_METTF

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Protein

Formate dehydrogenase subunit beta

Gene

fdhB

Organism
Methanothermobacter thermautotrophicus (Methanobacterium thermoformicicum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidation of formate.

Catalytic activityi

Formate + NAD+ = CO2 + NADH.

Cofactori

Binds 2 4Fe-4S clusters.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi295 – 2951Iron-sulfur (4Fe-4S)By similarity
Metal bindingi298 – 2981Iron-sulfur (4Fe-4S)By similarity
Metal bindingi301 – 3011Iron-sulfur (4Fe-4S)By similarity
Metal bindingi305 – 3051Iron-sulfur (4Fe-4S)By similarity
Metal bindingi346 – 3461Iron-sulfur (4Fe-4S)By similarity
Metal bindingi349 – 3491Iron-sulfur (4Fe-4S)By similarity
Metal bindingi352 – 3521Iron-sulfur (4Fe-4S)By similarity
Metal bindingi356 – 3561Iron-sulfur (4Fe-4S)By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Formate dehydrogenase subunit beta (EC:1.2.1.2)
Gene namesi
Name:fdhB
OrganismiMethanothermobacter thermautotrophicus (Methanobacterium thermoformicicum)
Taxonomic identifieri145262 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Formate dehydrogenase subunit betaPRO_0000159223Add
BLAST

Interactioni

Subunit structurei

Dimer of an alpha and a beta subunit.

Structurei

3D structure databases

ProteinModelPortaliQ50570.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini285 – 315314Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini337 – 367314Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FrhB family.Curated
Contains 2 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR007516. Co_F420_Hydgase/DH_bsu_N.
IPR007525. FrhB_FdhB_C.
IPR009051. Helical_ferredxn.
[Graphical view]
PfamiPF13183. Fer4_8. 1 hit.
PF04432. FrhB_FdhB_C. 1 hit.
PF04422. FrhB_FdhB_N. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 2 hits.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q50570-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVEVNDMYYA FSKNEEIAEK GEYGGAVTSL LKFLLEEGMV DAVLAVKKGS
60 70 80 90 100
DLYDAVPTLI TEPEKVIESA GSLHCGTLNI AKVITRYLNG AKDIKIAVTT
110 120 130 140 150
KPCDAMTIVE VAKRGKIDLD NVIMVGVNCG GTLPPVKTRA MIEEVYEMDP
160 170 180 190 200
DDVVKEEIAK GKLIIETSDA EKGISVDEVE EMGYGRRTNC RRCEKNIPRM
210 220 230 240 250
ADLALGNWGV IGPLAGKATF VEVTSEKGAD LLEKAVSAGV IEIEDPIPKG
260 270 280 290 300
IEIREKIDQA MVNLAKKWQK NDFNEETGAE ILMNLDRYMD ELNKCIKCYS
310 320 330 340 350
CREACPICYC EECSLETKTP EWIEKGKIPP SPLFHLERML HMVDSCTNCG
360 370 380 390
QCEELCPAEI PLAKIWHEIN CRVQETFGYK TGFETGQEPP LTHP
Length:394
Mass (Da):43,683
Last modified:November 1, 1996 - v1
Checksum:iF95B3E85B4C44316
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U52681 Genomic DNA. Translation: AAC44821.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U52681 Genomic DNA. Translation: AAC44821.1 .

3D structure databases

ProteinModelPortali Q50570.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR007516. Co_F420_Hydgase/DH_bsu_N.
IPR007525. FrhB_FdhB_C.
IPR009051. Helical_ferredxn.
[Graphical view ]
Pfami PF13183. Fer4_8. 1 hit.
PF04432. FrhB_FdhB_C. 1 hit.
PF04422. FrhB_FdhB_N. 1 hit.
[Graphical view ]
SUPFAMi SSF46548. SSF46548. 1 hit.
PROSITEi PS00198. 4FE4S_FER_1. 2 hits.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Growth- and substrate-dependent transcription of the formate dehydrogenase (fdhCAB) operon in Methanobacterium thermoformicicum Z-245."
    Noelling J., Reeve J.N.
    J. Bacteriol. 179:899-908(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DSM 3720 / Z-245.

Entry informationi

Entry nameiFDHB_METTF
AccessioniPrimary (citable) accession number: Q50570
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3