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Protein

DNA ligase

Gene

lig

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei249ATPUniRule annotation1
Active sitei251N6-AMP-lysine intermediateUniRule annotation1
Binding sitei256ATPUniRule annotation1
Binding sitei271ATPUniRule annotation1
Binding sitei301ATPUniRule annotation1
Binding sitei340ATPUniRule annotation1
Binding sitei417ATPUniRule annotation1
Binding sitei423ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.5.1.1 3256

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:MTH_1580
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000596091 – 561DNA ligaseAdd BLAST561

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH1580

Structurei

3D structure databases

ProteinModelPortaliQ50566
SMRiQ50566
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
KOiK10747
OMAiWLFEESY
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

Q50566-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKELLYMELA EVYHRLESTT KRLEKTEILA ELLRSVDKEL LPDVTILMLG
60 70 80 90 100
RVFPIWSEEE LGVGIKLLMK AISLVVGVSM DEIEDEIREQ GDIGLASEKL
110 120 130 140 150
FSRKTQTTFF SQPLTVEFVY SRLKALASAS GDRAQSKKIN ILVEVLSQAK
160 170 180 190 200
PLEARYITRT VLEELRVGVA EGIIRDAIAR AFEVDPALVE RAHMLTNDLG
210 220 230 240 250
MVAAVAREEG EPGLGRLNLE PGRPVKPMLA QLASSIESAI TELGRAFCET
260 270 280 290 300
KYDGIRVQIH RCGDEISIFT RRLENITAAV PEILEGVEEA LPADDYIVEG
310 320 330 340 350
EIIVTMDGRP ASFQYILQRV RRKYDVERLT REVPLSLFLF DVLYHREPLI
360 370 380 390 400
DEPLRHRREV LESILSEIPG RVEASRMVDV GPDNLNDALW LFEESIREGH
410 420 430 440 450
EGIMIKDTEA PYIPGIRGKK MLKFKAEPET LDLIVVGGTY GRGKRAHLVG
460 470 480 490 500
SYLLAARDED SGDLVTVAHV ATGLDDETLQ QLSERMEKLA IERKGRKLLV
510 520 530 540 550
RPEIILEVAY SEIVKSPEYE SGYSLRFPVV KRIRDDLCLD DVDTVGRIES
560
LFQSGQPDQP G
Length:561
Mass (Da):63,089
Last modified:November 1, 1996 - v1
Checksum:i0E05CE1E361E5907
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51624 Genomic DNA Translation: AAC44812.1
AE000666 Genomic DNA Translation: AAB86053.1
PIRiH69077

Genome annotation databases

EnsemblBacteriaiAAB86053; AAB86053; MTH_1580
KEGGimth:MTH_1580
PATRICifig|187420.15.peg.1543

Similar proteinsi

Entry informationi

Entry nameiDNLI_METTH
AccessioniPrimary (citable) accession number: Q50566
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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