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Q50566

- DNLI_METTH

UniProt

Q50566 - DNLI_METTH

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Protein
DNA ligase
Gene
lig, MTH_1580
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei249 – 2491ATP By similarity
Active sitei251 – 2511N6-AMP-lysine intermediate By similarity
Binding sitei256 – 2561ATP By similarity
Binding sitei271 – 2711ATP By similarity
Binding sitei301 – 3011ATP By similarity
Binding sitei340 – 3401ATP By similarity
Binding sitei417 – 4171ATP By similarity
Binding sitei423 – 4231ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-1582-MONOMER.
BRENDAi6.5.1.1. 3256.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:lig
Ordered Locus Names:MTH_1580
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000005223: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 561561DNA ligaseUniRule annotation
PRO_0000059609Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH1580.

Structurei

3D structure databases

ProteinModelPortaliQ50566.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1793.
KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q50566-1 [UniParc]FASTAAdd to Basket

« Hide

MKELLYMELA EVYHRLESTT KRLEKTEILA ELLRSVDKEL LPDVTILMLG    50
RVFPIWSEEE LGVGIKLLMK AISLVVGVSM DEIEDEIREQ GDIGLASEKL 100
FSRKTQTTFF SQPLTVEFVY SRLKALASAS GDRAQSKKIN ILVEVLSQAK 150
PLEARYITRT VLEELRVGVA EGIIRDAIAR AFEVDPALVE RAHMLTNDLG 200
MVAAVAREEG EPGLGRLNLE PGRPVKPMLA QLASSIESAI TELGRAFCET 250
KYDGIRVQIH RCGDEISIFT RRLENITAAV PEILEGVEEA LPADDYIVEG 300
EIIVTMDGRP ASFQYILQRV RRKYDVERLT REVPLSLFLF DVLYHREPLI 350
DEPLRHRREV LESILSEIPG RVEASRMVDV GPDNLNDALW LFEESIREGH 400
EGIMIKDTEA PYIPGIRGKK MLKFKAEPET LDLIVVGGTY GRGKRAHLVG 450
SYLLAARDED SGDLVTVAHV ATGLDDETLQ QLSERMEKLA IERKGRKLLV 500
RPEIILEVAY SEIVKSPEYE SGYSLRFPVV KRIRDDLCLD DVDTVGRIES 550
LFQSGQPDQP G 561
Length:561
Mass (Da):63,089
Last modified:November 1, 1996 - v1
Checksum:i0E05CE1E361E5907
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U51624 Genomic DNA. Translation: AAC44812.1.
AE000666 Genomic DNA. Translation: AAB86053.1.
PIRiH69077.
RefSeqiNP_276692.1. NC_000916.1.
WP_010877188.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB86053; AAB86053; MTH_1580.
GeneIDi1471849.
KEGGimth:MTH1580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U51624 Genomic DNA. Translation: AAC44812.1 .
AE000666 Genomic DNA. Translation: AAB86053.1 .
PIRi H69077.
RefSeqi NP_276692.1. NC_000916.1.
WP_010877188.1. NC_000916.1.

3D structure databases

ProteinModelPortali Q50566.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 187420.MTH1580.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB86053 ; AAB86053 ; MTH_1580 .
GeneIDi 1471849.
KEGGi mth:MTH1580.

Phylogenomic databases

eggNOGi COG1793.
KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci MTHE187420:GJNM-1582-MONOMER.
BRENDAi 6.5.1.1. 3256.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Growth- and substrate-dependent transcription of the formate dehydrogenase (fdhCAB) operon in Methanobacterium thermoformicicum Z-245."
    Noelling J., Reeve J.N.
    J. Bacteriol. 179:899-908(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Entry informationi

Entry nameiDNLI_METTH
AccessioniPrimary (citable) accession number: Q50566
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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