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Protein

Zinc finger CW-type PWWP domain protein 2

Gene

ZCWPW2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri24 – 7956CW-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CW-type PWWP domain protein 2
Gene namesi
Name:ZCWPW2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:23574. ZCWPW2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134888742.

Polymorphism and mutation databases

BioMutaiZCWPW2.
DMDMi74740233.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Zinc finger CW-type PWWP domain protein 2PRO_0000286348Add
BLAST

Proteomic databases

PaxDbiQ504Y3.
PRIDEiQ504Y3.

Expressioni

Gene expression databases

BgeeiQ504Y3.
CleanExiHS_ZCWPW2.
ExpressionAtlasiQ504Y3. baseline and differential.
GenevisibleiQ504Y3. HS.

Organism-specific databases

HPAiHPA035035.

Interactioni

Protein-protein interaction databases

BioGridi127425. 1 interaction.
STRINGi9606.ENSP00000373278.

Structurei

Secondary structure

1
356
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi28 – 325Combined sources
Turni36 – 383Combined sources
Beta strandi41 – 455Combined sources
Helixi46 – 505Combined sources
Helixi60 – 623Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4O62X-ray1.78A/B/C21-78[»]
4Z0OX-ray1.57A21-78[»]
4Z0RX-ray1.75A/B/C21-78[»]
ProteinModelPortaliQ504Y3.
SMRiQ504Y3. Positions 23-77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini98 – 16265PWWPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CW-type zinc finger.PROSITE-ProRule annotation
Contains 1 PWWP domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri24 – 7956CW-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IIVB. Eukaryota.
ENOG41124DG. LUCA.
GeneTreeiENSGT00560000077278.
HOGENOMiHOG000155771.
InParanoidiQ504Y3.
OMAiNVCSDDA.
PhylomeDBiQ504Y3.
TreeFamiTF318885.

Family and domain databases

InterProiIPR000313. PWWP_dom.
IPR011124. Znf_CW.
[Graphical view]
PfamiPF00855. PWWP. 1 hit.
PF07496. zf-CW. 1 hit.
[Graphical view]
PROSITEiPS50812. PWWP. 1 hit.
PS51050. ZF_CW. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q504Y3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKEKLDVKI EYCNYAMDSS VENMYVNKVW VQCENENCLK WRLLSSEDSA
60 70 80 90 100
KVDHDEPWYC FMNTDSRYNN CSISEEDFPE ESQLHQCGFK IVYSQLPLGS
110 120 130 140 150
LVLVKLQNWP SWPGILCPDR FKGKYVTYDP DGNVEEYHIE FLGDPHSRSW
160 170 180 190 200
IKATFVGHYS ITLKPEKCKN KKKWYKSALQ EACLLYGYSH EQRLEMCCLS
210 220 230 240 250
KLQDKSETHD KVAALVKKRK QTSKNNIEKK KPKFRKRKRK AILKCSFENV
260 270 280 290 300
YSDDALSKEN RVVCETEVLL KELEQMLQQA LQPTATPDES EEGHGEEINM
310 320 330 340 350
GEKLSKCSPE APAGSLFENH YEEDYLVIDG IKLKAGECIE DITNKFKEID

ALMSEF
Length:356
Mass (Da):41,376
Last modified:June 7, 2005 - v1
Checksum:i90CB5558C9801B1F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti202 – 2021L → Q.
Corresponds to variant rs1563656 [ dbSNP | Ensembl ].
VAR_051499

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094696 mRNA. Translation: AAH94696.1.
CCDSiCCDS33723.1.
RefSeqiNP_001035522.1. NM_001040432.2.
UniGeneiHs.510635.
Hs.539824.
Hs.659030.

Genome annotation databases

EnsembliENST00000383768; ENSP00000373278; ENSG00000206559.
GeneIDi152098.
KEGGihsa:152098.
UCSCiuc003ceh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094696 mRNA. Translation: AAH94696.1.
CCDSiCCDS33723.1.
RefSeqiNP_001035522.1. NM_001040432.2.
UniGeneiHs.510635.
Hs.539824.
Hs.659030.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4O62X-ray1.78A/B/C21-78[»]
4Z0OX-ray1.57A21-78[»]
4Z0RX-ray1.75A/B/C21-78[»]
ProteinModelPortaliQ504Y3.
SMRiQ504Y3. Positions 23-77.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127425. 1 interaction.
STRINGi9606.ENSP00000373278.

Polymorphism and mutation databases

BioMutaiZCWPW2.
DMDMi74740233.

Proteomic databases

PaxDbiQ504Y3.
PRIDEiQ504Y3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383768; ENSP00000373278; ENSG00000206559.
GeneIDi152098.
KEGGihsa:152098.
UCSCiuc003ceh.4. human.

Organism-specific databases

CTDi152098.
GeneCardsiZCWPW2.
HGNCiHGNC:23574. ZCWPW2.
HPAiHPA035035.
neXtProtiNX_Q504Y3.
PharmGKBiPA134888742.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIVB. Eukaryota.
ENOG41124DG. LUCA.
GeneTreeiENSGT00560000077278.
HOGENOMiHOG000155771.
InParanoidiQ504Y3.
OMAiNVCSDDA.
PhylomeDBiQ504Y3.
TreeFamiTF318885.

Miscellaneous databases

GenomeRNAii152098.
PROiQ504Y3.

Gene expression databases

BgeeiQ504Y3.
CleanExiHS_ZCWPW2.
ExpressionAtlasiQ504Y3. baseline and differential.
GenevisibleiQ504Y3. HS.

Family and domain databases

InterProiIPR000313. PWWP_dom.
IPR011124. Znf_CW.
[Graphical view]
PfamiPF00855. PWWP. 1 hit.
PF07496. zf-CW. 1 hit.
[Graphical view]
PROSITEiPS50812. PWWP. 1 hit.
PS51050. ZF_CW. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Cw-type zinc finger of ZCWPW2 in complex with the amino terminus of histone H3."
    Structural genomics consortium (SGC)
    Submitted (MAR-2014) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.78 ANGSTROMS) OF 21-78.

Entry informationi

Entry nameiZCPW2_HUMAN
AccessioniPrimary (citable) accession number: Q504Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: June 7, 2005
Last modified: June 8, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.