Q504Y2 (PKDCC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein kinase domain-containing protein, cytoplasmic
EC=2.7.-.-

Alternative name(s):
Protein kinase-like protein SgK493
Sugen kinase 493
Vertebrate lonesome kinase

Gene names

Name:	PKDCC
Synonyms:	SGK493, VLK

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protein kinase which is required for longitudinal bone growth through regulation of chondrocyte differentiation. Involved in protein transport from the Golgi apparatus to the plasma membrane By similarity.
Subcellular location	Golgi apparatus By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Contains 1 protein kinase domain.
Sequence caution	The sequence AAH94697.1 differs from that shown. Reason: Erroneous initiation. The sequence AAI10514.1 differs from that shown. Reason: Erroneous initiation. The sequence AAI10515.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Differentiation Osteogenesis Protein transport Transport
Cellular component	Golgi apparatus
Ligand	ATP-binding Nucleotide-binding
Molecular function	Developmental protein Kinase Transferase
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW embryonic digestive tract development Inferred from sequence or structural similarity. Source: UniProtKB lung alveolus development Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of Golgi to plasma membrane protein transport Inferred from sequence or structural similarity. Source: UniProtKB ossification Inferred from electronic annotation. Source: UniProtKB-KW palate development Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of bone mineralization Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of chondrocyte differentiation Inferred from sequence or structural similarity. Source: UniProtKB protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	Golgi apparatus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein kinase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 493	493	Protein kinase domain-containing protein, cytoplasmic		PRO_0000263010
Regions
	Domain	138 – 493	356	Protein kinase
	Nucleotide binding	144 – 152	9	ATP By similarity
	Compositional bias	28 – 128	101	Pro-rich
Sites
	Active site	278	1	Proton acceptor By similarity
	Binding site	166	1	ATP By similarity
Amino acid modifications
	Modified residue	148	1	Phosphotyrosine By similarity
	Modified residue	177	1	Phosphoserine By similarity
	Glycosylation	320	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q504Y2 [UniParc]. Last modified March 23, 2010. Version 2. Checksum: 9E6F2AF7BECDA26C	FASTA	493	54,132
	10 20 30 40 50 60 MRRRRAAVAA GFCASFLLGS VLNVLFAPGS EPPRPGQSPE PSPAPGPGRR GGRGELARQI 70 80 90 100 110 120 RARYEEVQRY SRGGPGPGAG RPERRRLMDL APGGPGLPRP RPPWARPLSD GAPGWPPAPG 130 140 150 160 170 180 PGSPGPGPRL GCAALRNVSG AQYMGSGYTK AVYRVRLPGG AAVALKAVDF SGHDLGSCVR 190 200 210 220 230 240 EFGVRRGCYR LAAHKLLKEM VLLERLRHPN VLQLYGYCYQ DSEDIPDTLT TITELGAPVE 250 260 270 280 290 300 MIQLLQTSWE DRFRICLSLG RLLHHLAHSP LGSVTLLDFR PRQFVLVDGE LKVTDLDDAR 310 320 330 340 350 360 VEETPCAGST DCILEFPARN FTLPCSAQGW CEGMNEKRNL YNAYRFFFTY LLPHSAPPSL 370 380 390 400 410 420 RPLLDSIVNA TGELAWGVDE TLAQLEKVLH LYRSGQYLQN STASSSTEYQ CIPDSTIPQE 430 440 450 460 470 480 DYRCWPSYHH GSCLLSVFNL AEAVDVCESH AQCRAFVVTN QTTWTGRQLV FFKTGWSQVV 490 PDPNKTTYVK ASG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 129-493. Tissue: Muscle.
[4]	"The protein kinase complement of the human genome." Manning G., Whyte D.B., Martinez R., Hunter T., Sudarsanam S. Science 298:1912-1934(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC013480 Genomic DNA. No translation available. CH471053 Genomic DNA. Translation: EAX00325.1. CH471053 Genomic DNA. Translation: EAX00326.1. BC007901 mRNA. Translation: AAH07901.2. BC062988 mRNA. Translation: AAH62988.1. BC094697 mRNA. Translation: AAH94697.1. Different initiation. BC110513 mRNA. Translation: AAI10514.1. Different initiation. BC110514 mRNA. Translation: AAI10515.1. Different initiation.
IPI	IPI00014629.
RefSeq	NP_612379.2. NM_138370.2.
UniGene	Hs.408542.
3D structure databases
ProteinModelPortal	Q504Y2.
ModBase	Search...
PTM databases
PhosphoSite	Q504Y2.
Polymorphism databases
DMDM	292495024.
Proteomic databases
PaxDb	Q504Y2.
PRIDE	Q504Y2.
Protocols and materials databases
DNASU	91461.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000294964; ENSP00000294964; ENSG00000162878.
GeneID	91461.
KEGG	hsa:91461.
UCSC	uc002rsg.3. human.
Organism-specific databases
CTD	91461.
GeneCards	GC02P042275.
H-InvDB	HIX0029918. HIX0161947.
HGNC	HGNC:25123. PKDCC.
HPA	HPA026427. HPA026442. HPA026526.
MIM	614150. gene.
neXtProt	NX_Q504Y2.
PharmGKB	PA165697259.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG254379.
HOGENOM	HOG000054185.
HOVERGEN	HBG079871.
InParanoid	Q504Y2.
OMA	PRLGCAA.
OrthoDB	EOG4WQ13D.
Gene expression databases
ArrayExpress	Q504Y2.
Bgee	Q504Y2.
Genevestigator	Q504Y2.
GermOnline	ENSG00000162878. Homo sapiens.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PKDCC. human.
GenomeRNAi	91461.
NextBio	77265.
SOURCE	Search...

Entry information

Entry name

PKDCC_HUMAN

Accession

Primary (citable) accession number: Q504Y2
Secondary accession number(s): D6W5A0, Q96I09

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	March 23, 2010
Last modified:	May 1, 2013
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.