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Q504Y2

- PKDCC_HUMAN

UniProt

Q504Y2 - PKDCC_HUMAN

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Protein

Protein kinase domain-containing protein, cytoplasmic

Gene
PKDCC, SGK493, VLK
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Protein kinase which is required for longitudinal bone growth through regulation of chondrocyte differentiation. Involved in protein transport from the Golgi apparatus to the plasma membrane By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei166 – 1661ATP By similarity
Active sitei278 – 2781Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi144 – 1529ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein kinase activity Source: UniProtKB

GO - Biological processi

  1. bone mineralization Source: Ensembl
  2. cell differentiation Source: UniProtKB-KW
  3. embryonic digestive tract development Source: UniProtKB
  4. lung alveolus development Source: UniProtKB
  5. multicellular organism growth Source: Ensembl
  6. negative regulation of Golgi to plasma membrane protein transport Source: UniProtKB
  7. palate development Source: UniProtKB
  8. positive regulation of bone mineralization Source: UniProtKB
  9. positive regulation of chondrocyte differentiation Source: UniProtKB
  10. protein transport Source: UniProtKB-KW
  11. skeletal system development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Transferase

Keywords - Biological processi

Differentiation, Osteogenesis, Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ504Y2.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase domain-containing protein, cytoplasmic (EC:2.7.-.-)
Alternative name(s):
Protein kinase-like protein SgK493
Sugen kinase 493
Vertebrate lonesome kinase
Gene namesi
Name:PKDCC
Synonyms:SGK493, VLK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:25123. PKDCC.

Subcellular locationi

Golgi apparatus By similarity

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165697259.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493Protein kinase domain-containing protein, cytoplasmicPRO_0000263010Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei148 – 1481Phosphotyrosine By similarity
Modified residuei177 – 1771Phosphoserine By similarity
Glycosylationi320 – 3201N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ504Y2.
PRIDEiQ504Y2.

PTM databases

PhosphoSiteiQ504Y2.

Expressioni

Gene expression databases

ArrayExpressiQ504Y2.
BgeeiQ504Y2.
GenevestigatoriQ504Y2.

Organism-specific databases

HPAiHPA026427.
HPA026442.
HPA026526.

Structurei

3D structure databases

ProteinModelPortaliQ504Y2.
SMRiQ504Y2. Positions 133-320.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini138 – 493356Protein kinaseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi28 – 128101Pro-richAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG254379.
HOGENOMiHOG000054185.
HOVERGENiHBG079871.
InParanoidiQ504Y2.
KOiK17548.
OMAiYVGSGYT.
OrthoDBiEOG7034GV.
PhylomeDBiQ504Y2.
TreeFamiTF329248.

Family and domain databases

InterProiIPR022049. FAM69_kinase_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF12260. PIP49_C. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q504Y2-1 [UniParc]FASTAAdd to Basket

« Hide

MRRRRAAVAA GFCASFLLGS VLNVLFAPGS EPPRPGQSPE PSPAPGPGRR    50
GGRGELARQI RARYEEVQRY SRGGPGPGAG RPERRRLMDL APGGPGLPRP 100
RPPWARPLSD GAPGWPPAPG PGSPGPGPRL GCAALRNVSG AQYMGSGYTK 150
AVYRVRLPGG AAVALKAVDF SGHDLGSCVR EFGVRRGCYR LAAHKLLKEM 200
VLLERLRHPN VLQLYGYCYQ DSEDIPDTLT TITELGAPVE MIQLLQTSWE 250
DRFRICLSLG RLLHHLAHSP LGSVTLLDFR PRQFVLVDGE LKVTDLDDAR 300
VEETPCAGST DCILEFPARN FTLPCSAQGW CEGMNEKRNL YNAYRFFFTY 350
LLPHSAPPSL RPLLDSIVNA TGELAWGVDE TLAQLEKVLH LYRSGQYLQN 400
STASSSTEYQ CIPDSTIPQE DYRCWPSYHH GSCLLSVFNL AEAVDVCESH 450
AQCRAFVVTN QTTWTGRQLV FFKTGWSQVV PDPNKTTYVK ASG 493
Length:493
Mass (Da):54,132
Last modified:March 23, 2010 - v2
Checksum:i9E6F2AF7BECDA26C
GO

Sequence cautioni

The sequence AAH94697.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAI10514.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAI10515.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC013480 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00325.1.
CH471053 Genomic DNA. Translation: EAX00326.1.
BC007901 mRNA. Translation: AAH07901.2.
BC062988 mRNA. Translation: AAH62988.1.
BC094697 mRNA. Translation: AAH94697.1. Different initiation.
BC110513 mRNA. Translation: AAI10514.1. Different initiation.
BC110514 mRNA. Translation: AAI10515.1. Different initiation.
CCDSiCCDS33186.2.
RefSeqiNP_612379.2. NM_138370.2.
UniGeneiHs.408542.

Genome annotation databases

EnsembliENST00000294964; ENSP00000294964; ENSG00000162878.
GeneIDi91461.
KEGGihsa:91461.
UCSCiuc002rsg.3. human.

Polymorphism databases

DMDMi292495024.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC013480 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00325.1 .
CH471053 Genomic DNA. Translation: EAX00326.1 .
BC007901 mRNA. Translation: AAH07901.2 .
BC062988 mRNA. Translation: AAH62988.1 .
BC094697 mRNA. Translation: AAH94697.1 . Different initiation.
BC110513 mRNA. Translation: AAI10514.1 . Different initiation.
BC110514 mRNA. Translation: AAI10515.1 . Different initiation.
CCDSi CCDS33186.2.
RefSeqi NP_612379.2. NM_138370.2.
UniGenei Hs.408542.

3D structure databases

ProteinModelPortali Q504Y2.
SMRi Q504Y2. Positions 133-320.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q504Y2.

Polymorphism databases

DMDMi 292495024.

Proteomic databases

PaxDbi Q504Y2.
PRIDEi Q504Y2.

Protocols and materials databases

DNASUi 91461.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000294964 ; ENSP00000294964 ; ENSG00000162878 .
GeneIDi 91461.
KEGGi hsa:91461.
UCSCi uc002rsg.3. human.

Organism-specific databases

CTDi 91461.
GeneCardsi GC02P042275.
H-InvDB HIX0029918.
HIX0161947.
HGNCi HGNC:25123. PKDCC.
HPAi HPA026427.
HPA026442.
HPA026526.
MIMi 614150. gene.
neXtProti NX_Q504Y2.
PharmGKBi PA165697259.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG254379.
HOGENOMi HOG000054185.
HOVERGENi HBG079871.
InParanoidi Q504Y2.
KOi K17548.
OMAi YVGSGYT.
OrthoDBi EOG7034GV.
PhylomeDBi Q504Y2.
TreeFami TF329248.

Enzyme and pathway databases

SignaLinki Q504Y2.

Miscellaneous databases

ChiTaRSi PKDCC. human.
GenomeRNAii 91461.
NextBioi 77265.
PROi Q504Y2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q504Y2.
Bgeei Q504Y2.
Genevestigatori Q504Y2.

Family and domain databases

InterProi IPR022049. FAM69_kinase_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view ]
Pfami PF12260. PIP49_C. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 129-493.
    Tissue: Muscle.
  4. Cited for: IDENTIFICATION.

Entry informationi

Entry nameiPKDCC_HUMAN
AccessioniPrimary (citable) accession number: Q504Y2
Secondary accession number(s): D6W5A0, Q96I09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 23, 2010
Last modified: July 9, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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