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Q504Y2

- PKDCC_HUMAN

UniProt

Q504Y2 - PKDCC_HUMAN

Protein

Protein kinase domain-containing protein, cytoplasmic

Gene

PKDCC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    Protein kinase which is required for longitudinal bone growth through regulation of chondrocyte differentiation. Involved in protein transport from the Golgi apparatus to the plasma membrane By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei166 – 1661ATPPROSITE-ProRule annotation
    Active sitei278 – 2781Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi144 – 1529ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein kinase activity Source: UniProtKB

    GO - Biological processi

    1. bone mineralization Source: Ensembl
    2. cell differentiation Source: UniProtKB-KW
    3. embryonic digestive tract development Source: UniProtKB
    4. lung alveolus development Source: UniProtKB
    5. multicellular organism growth Source: Ensembl
    6. negative regulation of Golgi to plasma membrane protein transport Source: UniProtKB
    7. palate development Source: UniProtKB
    8. positive regulation of bone mineralization Source: UniProtKB
    9. positive regulation of chondrocyte differentiation Source: UniProtKB
    10. protein transport Source: UniProtKB-KW
    11. skeletal system development Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein, Kinase, Transferase

    Keywords - Biological processi

    Differentiation, Osteogenesis, Protein transport, Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ504Y2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein kinase domain-containing protein, cytoplasmic (EC:2.7.-.-)
    Alternative name(s):
    Protein kinase-like protein SgK493
    Sugen kinase 493
    Vertebrate lonesome kinase
    Gene namesi
    Name:PKDCC
    Synonyms:SGK493, VLK
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:25123. PKDCC.

    Subcellular locationi

    Golgi apparatus By similarity

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB

    Keywords - Cellular componenti

    Golgi apparatus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165697259.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 493493Protein kinase domain-containing protein, cytoplasmicPRO_0000263010Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei148 – 1481PhosphotyrosineBy similarity
    Modified residuei177 – 1771PhosphoserineBy similarity
    Glycosylationi320 – 3201N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ504Y2.
    PRIDEiQ504Y2.

    PTM databases

    PhosphoSiteiQ504Y2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ504Y2.
    BgeeiQ504Y2.
    GenevestigatoriQ504Y2.

    Organism-specific databases

    HPAiHPA026427.
    HPA026442.
    HPA026526.

    Structurei

    3D structure databases

    ProteinModelPortaliQ504Y2.
    SMRiQ504Y2. Positions 133-320.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini138 – 493356Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi28 – 128101Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG254379.
    HOGENOMiHOG000054185.
    HOVERGENiHBG079871.
    InParanoidiQ504Y2.
    KOiK17548.
    OMAiYVGSGYT.
    OrthoDBiEOG7034GV.
    PhylomeDBiQ504Y2.
    TreeFamiTF329248.

    Family and domain databases

    InterProiIPR022049. FAM69_kinase_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view]
    PfamiPF12260. PIP49_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q504Y2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRRRRAAVAA GFCASFLLGS VLNVLFAPGS EPPRPGQSPE PSPAPGPGRR    50
    GGRGELARQI RARYEEVQRY SRGGPGPGAG RPERRRLMDL APGGPGLPRP 100
    RPPWARPLSD GAPGWPPAPG PGSPGPGPRL GCAALRNVSG AQYMGSGYTK 150
    AVYRVRLPGG AAVALKAVDF SGHDLGSCVR EFGVRRGCYR LAAHKLLKEM 200
    VLLERLRHPN VLQLYGYCYQ DSEDIPDTLT TITELGAPVE MIQLLQTSWE 250
    DRFRICLSLG RLLHHLAHSP LGSVTLLDFR PRQFVLVDGE LKVTDLDDAR 300
    VEETPCAGST DCILEFPARN FTLPCSAQGW CEGMNEKRNL YNAYRFFFTY 350
    LLPHSAPPSL RPLLDSIVNA TGELAWGVDE TLAQLEKVLH LYRSGQYLQN 400
    STASSSTEYQ CIPDSTIPQE DYRCWPSYHH GSCLLSVFNL AEAVDVCESH 450
    AQCRAFVVTN QTTWTGRQLV FFKTGWSQVV PDPNKTTYVK ASG 493
    Length:493
    Mass (Da):54,132
    Last modified:March 23, 2010 - v2
    Checksum:i9E6F2AF7BECDA26C
    GO

    Sequence cautioni

    The sequence AAH94697.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAI10514.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAI10515.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC013480 Genomic DNA. No translation available.
    CH471053 Genomic DNA. Translation: EAX00325.1.
    CH471053 Genomic DNA. Translation: EAX00326.1.
    BC007901 mRNA. Translation: AAH07901.2.
    BC062988 mRNA. Translation: AAH62988.1.
    BC094697 mRNA. Translation: AAH94697.1. Different initiation.
    BC110513 mRNA. Translation: AAI10514.1. Different initiation.
    BC110514 mRNA. Translation: AAI10515.1. Different initiation.
    CCDSiCCDS33186.2.
    RefSeqiNP_612379.2. NM_138370.2.
    UniGeneiHs.408542.

    Genome annotation databases

    EnsembliENST00000294964; ENSP00000294964; ENSG00000162878.
    GeneIDi91461.
    KEGGihsa:91461.
    UCSCiuc002rsg.3. human.

    Polymorphism databases

    DMDMi292495024.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC013480 Genomic DNA. No translation available.
    CH471053 Genomic DNA. Translation: EAX00325.1 .
    CH471053 Genomic DNA. Translation: EAX00326.1 .
    BC007901 mRNA. Translation: AAH07901.2 .
    BC062988 mRNA. Translation: AAH62988.1 .
    BC094697 mRNA. Translation: AAH94697.1 . Different initiation.
    BC110513 mRNA. Translation: AAI10514.1 . Different initiation.
    BC110514 mRNA. Translation: AAI10515.1 . Different initiation.
    CCDSi CCDS33186.2.
    RefSeqi NP_612379.2. NM_138370.2.
    UniGenei Hs.408542.

    3D structure databases

    ProteinModelPortali Q504Y2.
    SMRi Q504Y2. Positions 133-320.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q504Y2.

    Polymorphism databases

    DMDMi 292495024.

    Proteomic databases

    PaxDbi Q504Y2.
    PRIDEi Q504Y2.

    Protocols and materials databases

    DNASUi 91461.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000294964 ; ENSP00000294964 ; ENSG00000162878 .
    GeneIDi 91461.
    KEGGi hsa:91461.
    UCSCi uc002rsg.3. human.

    Organism-specific databases

    CTDi 91461.
    GeneCardsi GC02P042275.
    H-InvDB HIX0029918.
    HIX0161947.
    HGNCi HGNC:25123. PKDCC.
    HPAi HPA026427.
    HPA026442.
    HPA026526.
    MIMi 614150. gene.
    neXtProti NX_Q504Y2.
    PharmGKBi PA165697259.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG254379.
    HOGENOMi HOG000054185.
    HOVERGENi HBG079871.
    InParanoidi Q504Y2.
    KOi K17548.
    OMAi YVGSGYT.
    OrthoDBi EOG7034GV.
    PhylomeDBi Q504Y2.
    TreeFami TF329248.

    Enzyme and pathway databases

    SignaLinki Q504Y2.

    Miscellaneous databases

    ChiTaRSi PKDCC. human.
    GenomeRNAii 91461.
    NextBioi 77265.
    PROi Q504Y2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q504Y2.
    Bgeei Q504Y2.
    Genevestigatori Q504Y2.

    Family and domain databases

    InterProi IPR022049. FAM69_kinase_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view ]
    Pfami PF12260. PIP49_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 129-493.
      Tissue: Muscle.
    4. Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiPKDCC_HUMAN
    AccessioniPrimary (citable) accession number: Q504Y2
    Secondary accession number(s): D6W5A0, Q96I09
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3