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Protein

Extracellular tyrosine-protein kinase PKDCC

Gene

PKDCC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405). Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405). May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity).By similarity1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei166 – 1661ATPPROSITE-ProRule annotation
Active sitei278 – 2781Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi144 – 1529ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB
  3. protein kinase activity Source: UniProtKB

GO - Biological processi

  1. bone mineralization Source: Ensembl
  2. cell differentiation Source: UniProtKB-KW
  3. embryonic digestive tract development Source: UniProtKB
  4. lung alveolus development Source: UniProtKB
  5. multicellular organism growth Source: Ensembl
  6. negative regulation of Golgi to plasma membrane protein transport Source: UniProtKB
  7. palate development Source: UniProtKB
  8. peptidyl-tyrosine phosphorylation Source: UniProtKB
  9. positive regulation of bone mineralization Source: UniProtKB
  10. positive regulation of chondrocyte differentiation Source: UniProtKB
  11. protein transport Source: UniProtKB-KW
  12. skeletal system development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Differentiation, Osteogenesis, Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ504Y2.

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular tyrosine-protein kinase PKDCCCurated (EC:2.7.10.21 Publication)
Alternative name(s):
Protein kinase domain-containing protein, cytoplasmicImported
Protein kinase-like protein SgK493
Sugen kinase 493
Vertebrate lonesome kinaseBy similarity
Gene namesi
Name:PKDCCImported
Synonyms:SGK493, VLKBy similarity
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:25123. PKDCC.

Subcellular locationi

Secreted 1 Publication. Golgi apparatus By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. Golgi apparatus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165697259.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence AnalysisAdd
BLAST
Chaini33 – 493461Extracellular tyrosine-protein kinase PKDCCPRO_0000263010Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence Analysis
Modified residuei148 – 1481PhosphotyrosineBy similarity
Modified residuei177 – 1771PhosphoserineBy similarity
Glycosylationi320 – 3201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi369 – 3691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi400 – 4001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi460 – 4601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi484 – 4841N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.By similarity
Phosphorylated on tyrosines; probably via autophosphorylation.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ504Y2.
PRIDEiQ504Y2.

PTM databases

PhosphoSiteiQ504Y2.

Expressioni

Tissue specificityi

Highly expressed in platelets.1 Publication

Gene expression databases

BgeeiQ504Y2.
ExpressionAtlasiQ504Y2. baseline and differential.
GenevestigatoriQ504Y2.

Organism-specific databases

HPAiHPA026427.
HPA026442.
HPA026526.

Interactioni

Protein-protein interaction databases

BioGridi124837. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ504Y2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini138 – 493356Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi28 – 128101Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG254379.
GeneTreeiENSGT00390000001205.
HOGENOMiHOG000054185.
HOVERGENiHBG079871.
InParanoidiQ504Y2.
KOiK17548.
OMAiPRLGCAA.
OrthoDBiEOG7034GV.
PhylomeDBiQ504Y2.
TreeFamiTF329248.

Family and domain databases

InterProiIPR022049. FAM69_kinase_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF12260. PIP49_C. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q504Y2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRRRAAVAA GFCASFLLGS VLNVLFAPGS EPPRPGQSPE PSPAPGPGRR
60 70 80 90 100
GGRGELARQI RARYEEVQRY SRGGPGPGAG RPERRRLMDL APGGPGLPRP
110 120 130 140 150
RPPWARPLSD GAPGWPPAPG PGSPGPGPRL GCAALRNVSG AQYMGSGYTK
160 170 180 190 200
AVYRVRLPGG AAVALKAVDF SGHDLGSCVR EFGVRRGCYR LAAHKLLKEM
210 220 230 240 250
VLLERLRHPN VLQLYGYCYQ DSEDIPDTLT TITELGAPVE MIQLLQTSWE
260 270 280 290 300
DRFRICLSLG RLLHHLAHSP LGSVTLLDFR PRQFVLVDGE LKVTDLDDAR
310 320 330 340 350
VEETPCAGST DCILEFPARN FTLPCSAQGW CEGMNEKRNL YNAYRFFFTY
360 370 380 390 400
LLPHSAPPSL RPLLDSIVNA TGELAWGVDE TLAQLEKVLH LYRSGQYLQN
410 420 430 440 450
STASSSTEYQ CIPDSTIPQE DYRCWPSYHH GSCLLSVFNL AEAVDVCESH
460 470 480 490
AQCRAFVVTN QTTWTGRQLV FFKTGWSQVV PDPNKTTYVK ASG
Length:493
Mass (Da):54,132
Last modified:March 23, 2010 - v2
Checksum:i9E6F2AF7BECDA26C
GO

Sequence cautioni

The sequence AAH94697.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI10514.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI10515.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013480 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00325.1.
CH471053 Genomic DNA. Translation: EAX00326.1.
BC007901 mRNA. Translation: AAH07901.2.
BC062988 mRNA. Translation: AAH62988.1.
BC094697 mRNA. Translation: AAH94697.1. Different initiation.
BC110513 mRNA. Translation: AAI10514.1. Different initiation.
BC110514 mRNA. Translation: AAI10515.1. Different initiation.
CCDSiCCDS33186.2.
RefSeqiNP_612379.2. NM_138370.2.
UniGeneiHs.408542.

Genome annotation databases

EnsembliENST00000294964; ENSP00000294964; ENSG00000162878.
GeneIDi91461.
KEGGihsa:91461.
UCSCiuc002rsg.3. human.

Polymorphism databases

DMDMi292495024.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013480 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00325.1.
CH471053 Genomic DNA. Translation: EAX00326.1.
BC007901 mRNA. Translation: AAH07901.2.
BC062988 mRNA. Translation: AAH62988.1.
BC094697 mRNA. Translation: AAH94697.1. Different initiation.
BC110513 mRNA. Translation: AAI10514.1. Different initiation.
BC110514 mRNA. Translation: AAI10515.1. Different initiation.
CCDSiCCDS33186.2.
RefSeqiNP_612379.2. NM_138370.2.
UniGeneiHs.408542.

3D structure databases

ProteinModelPortaliQ504Y2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124837. 1 interaction.

PTM databases

PhosphoSiteiQ504Y2.

Polymorphism databases

DMDMi292495024.

Proteomic databases

PaxDbiQ504Y2.
PRIDEiQ504Y2.

Protocols and materials databases

DNASUi91461.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294964; ENSP00000294964; ENSG00000162878.
GeneIDi91461.
KEGGihsa:91461.
UCSCiuc002rsg.3. human.

Organism-specific databases

CTDi91461.
GeneCardsiGC02P042275.
H-InvDBHIX0029918.
HIX0161947.
HGNCiHGNC:25123. PKDCC.
HPAiHPA026427.
HPA026442.
HPA026526.
MIMi614150. gene.
neXtProtiNX_Q504Y2.
PharmGKBiPA165697259.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG254379.
GeneTreeiENSGT00390000001205.
HOGENOMiHOG000054185.
HOVERGENiHBG079871.
InParanoidiQ504Y2.
KOiK17548.
OMAiPRLGCAA.
OrthoDBiEOG7034GV.
PhylomeDBiQ504Y2.
TreeFamiTF329248.

Enzyme and pathway databases

SignaLinkiQ504Y2.

Miscellaneous databases

ChiTaRSiPKDCC. human.
GenomeRNAii91461.
NextBioi77265.
PROiQ504Y2.
SOURCEiSearch...

Gene expression databases

BgeeiQ504Y2.
ExpressionAtlasiQ504Y2. baseline and differential.
GenevestigatoriQ504Y2.

Family and domain databases

InterProiIPR022049. FAM69_kinase_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF12260. PIP49_C. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 129-493.
    Tissue: Muscle.
  4. Cited for: IDENTIFICATION.
  5. Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiPKDCC_HUMAN
AccessioniPrimary (citable) accession number: Q504Y2
Secondary accession number(s): D6W5A0, Q96I09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 23, 2010
Last modified: January 7, 2015
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.