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Protein

Extracellular tyrosine-protein kinase PKDCC

Gene

PKDCC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405). Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405). May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity).By similarity1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei166ATPPROSITE-ProRule annotation1
Active sitei278Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi144 – 152ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Kinase, Transferase, Tyrosine-protein kinase
Biological processDifferentiation, Osteogenesis, Protein transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ504Y2

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular tyrosine-protein kinase PKDCCCurated (EC:2.7.10.21 Publication)
Alternative name(s):
Protein kinase domain-containing protein, cytoplasmicImported
Protein kinase-like protein SgK493
Sugen kinase 493
Vertebrate lonesome kinaseBy similarity
Gene namesi
Name:PKDCCImported
Synonyms:SGK493, VLKBy similarity
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000162878.12
HGNCiHGNC:25123 PKDCC
MIMi614150 gene
neXtProtiNX_Q504Y2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi91461
OpenTargetsiENSG00000162878
PharmGKBiPA165697259

Polymorphism and mutation databases

BioMutaiPKDCC
DMDMi292495024

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000026301033 – 493Extracellular tyrosine-protein kinase PKDCCAdd BLAST461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei148PhosphotyrosineBy similarity1
Modified residuei177PhosphoserineBy similarity1
Glycosylationi320N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi369N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi400N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi460N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi484N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity
Phosphorylated on tyrosines; probably via autophosphorylation.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ504Y2
PeptideAtlasiQ504Y2
PRIDEiQ504Y2

PTM databases

iPTMnetiQ504Y2
PhosphoSitePlusiQ504Y2

Expressioni

Tissue specificityi

Highly expressed in platelets.1 Publication

Gene expression databases

BgeeiENSG00000162878
ExpressionAtlasiQ504Y2 baseline and differential
GenevisibleiQ504Y2 HS

Organism-specific databases

HPAiHPA026427
HPA026442
HPA026526

Interactioni

Protein-protein interaction databases

BioGridi124837, 2 interactors
STRINGi9606.ENSP00000294964

Structurei

3D structure databases

ProteinModelPortaliQ504Y2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini138 – 493Protein kinasePROSITE-ProRule annotationAdd BLAST356

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 128Pro-richAdd BLAST101

Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1187 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00390000001205
HOGENOMiHOG000054185
HOVERGENiHBG079871
InParanoidiQ504Y2
KOiK17548
OMAiYLQNSTA
OrthoDBiEOG091G0JWN
PhylomeDBiQ504Y2
TreeFamiTF329248

Family and domain databases

InterProiView protein in InterPro
IPR022049 FAM69_kinase_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
PfamiView protein in Pfam
PF12260 PIP49_C, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q504Y2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRRRAAVAA GFCASFLLGS VLNVLFAPGS EPPRPGQSPE PSPAPGPGRR
60 70 80 90 100
GGRGELARQI RARYEEVQRY SRGGPGPGAG RPERRRLMDL APGGPGLPRP
110 120 130 140 150
RPPWARPLSD GAPGWPPAPG PGSPGPGPRL GCAALRNVSG AQYMGSGYTK
160 170 180 190 200
AVYRVRLPGG AAVALKAVDF SGHDLGSCVR EFGVRRGCYR LAAHKLLKEM
210 220 230 240 250
VLLERLRHPN VLQLYGYCYQ DSEDIPDTLT TITELGAPVE MIQLLQTSWE
260 270 280 290 300
DRFRICLSLG RLLHHLAHSP LGSVTLLDFR PRQFVLVDGE LKVTDLDDAR
310 320 330 340 350
VEETPCAGST DCILEFPARN FTLPCSAQGW CEGMNEKRNL YNAYRFFFTY
360 370 380 390 400
LLPHSAPPSL RPLLDSIVNA TGELAWGVDE TLAQLEKVLH LYRSGQYLQN
410 420 430 440 450
STASSSTEYQ CIPDSTIPQE DYRCWPSYHH GSCLLSVFNL AEAVDVCESH
460 470 480 490
AQCRAFVVTN QTTWTGRQLV FFKTGWSQVV PDPNKTTYVK ASG
Length:493
Mass (Da):54,132
Last modified:March 23, 2010 - v2
Checksum:i9E6F2AF7BECDA26C
GO

Sequence cautioni

The sequence AAH94697 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI10514 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI10515 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013480 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00325.1
CH471053 Genomic DNA Translation: EAX00326.1
BC007901 mRNA Translation: AAH07901.2
BC062988 mRNA Translation: AAH62988.1
BC094697 mRNA Translation: AAH94697.1 Different initiation.
BC110513 mRNA Translation: AAI10514.1 Different initiation.
BC110514 mRNA Translation: AAI10515.1 Different initiation.
CCDSiCCDS33186.2
RefSeqiNP_612379.2, NM_138370.2
UniGeneiHs.408542

Genome annotation databases

EnsembliENST00000294964; ENSP00000294964; ENSG00000162878
GeneIDi91461
KEGGihsa:91461
UCSCiuc002rsg.4 human

Similar proteinsi

Entry informationi

Entry nameiPKDCC_HUMAN
AccessioniPrimary (citable) accession number: Q504Y2
Secondary accession number(s): D6W5A0, Q96I09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 23, 2010
Last modified: May 23, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families

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