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Q504Y2 (PKDCC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein kinase domain-containing protein, cytoplasmic

EC=2.7.-.-
Alternative name(s):
Protein kinase-like protein SgK493
Sugen kinase 493
Vertebrate lonesome kinase
Gene names
Name:PKDCC
Synonyms:SGK493, VLK
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length493 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protein kinase which is required for longitudinal bone growth through regulation of chondrocyte differentiation. Involved in protein transport from the Golgi apparatus to the plasma membrane By similarity.

Subcellular location

Golgi apparatus By similarity.

Sequence similarities

Belongs to the protein kinase superfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence AAH94697.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAI10514.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAI10515.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processDifferentiation
Osteogenesis
Protein transport
Transport
   Cellular componentGolgi apparatus
   LigandATP-binding
Nucleotide-binding
   Molecular functionDevelopmental protein
Kinase
Transferase
   PTMGlycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbone mineralization

Inferred from electronic annotation. Source: Ensembl

cell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

embryonic digestive tract development

Inferred from sequence or structural similarity. Source: UniProtKB

lung alveolus development

Inferred from sequence or structural similarity. Source: UniProtKB

multicellular organism growth

Inferred from electronic annotation. Source: Ensembl

negative regulation of Golgi to plasma membrane protein transport

Inferred from sequence or structural similarity. Source: UniProtKB

palate development

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of bone mineralization

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of chondrocyte differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

protein transport

Inferred from electronic annotation. Source: UniProtKB-KW

skeletal system development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentGolgi apparatus

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein kinase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 493493Protein kinase domain-containing protein, cytoplasmic
PRO_0000263010

Regions

Domain138 – 493356Protein kinase
Nucleotide binding144 – 1529ATP By similarity
Compositional bias28 – 128101Pro-rich

Sites

Active site2781Proton acceptor By similarity
Binding site1661ATP By similarity

Amino acid modifications

Modified residue1481Phosphotyrosine By similarity
Modified residue1771Phosphoserine By similarity
Glycosylation3201N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q504Y2 [UniParc].

Last modified March 23, 2010. Version 2.
Checksum: 9E6F2AF7BECDA26C

FASTA49354,132
        10         20         30         40         50         60 
MRRRRAAVAA GFCASFLLGS VLNVLFAPGS EPPRPGQSPE PSPAPGPGRR GGRGELARQI 

        70         80         90        100        110        120 
RARYEEVQRY SRGGPGPGAG RPERRRLMDL APGGPGLPRP RPPWARPLSD GAPGWPPAPG 

       130        140        150        160        170        180 
PGSPGPGPRL GCAALRNVSG AQYMGSGYTK AVYRVRLPGG AAVALKAVDF SGHDLGSCVR 

       190        200        210        220        230        240 
EFGVRRGCYR LAAHKLLKEM VLLERLRHPN VLQLYGYCYQ DSEDIPDTLT TITELGAPVE 

       250        260        270        280        290        300 
MIQLLQTSWE DRFRICLSLG RLLHHLAHSP LGSVTLLDFR PRQFVLVDGE LKVTDLDDAR 

       310        320        330        340        350        360 
VEETPCAGST DCILEFPARN FTLPCSAQGW CEGMNEKRNL YNAYRFFFTY LLPHSAPPSL 

       370        380        390        400        410        420 
RPLLDSIVNA TGELAWGVDE TLAQLEKVLH LYRSGQYLQN STASSSTEYQ CIPDSTIPQE 

       430        440        450        460        470        480 
DYRCWPSYHH GSCLLSVFNL AEAVDVCESH AQCRAFVVTN QTTWTGRQLV FFKTGWSQVV 

       490 
PDPNKTTYVK ASG 

« Hide

References

« Hide 'large scale' references
[1]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 129-493.
Tissue: Muscle.
[4]"The protein kinase complement of the human genome."
Manning G., Whyte D.B., Martinez R., Hunter T., Sudarsanam S.
Science 298:1912-1934(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC013480 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00325.1.
CH471053 Genomic DNA. Translation: EAX00326.1.
BC007901 mRNA. Translation: AAH07901.2.
BC062988 mRNA. Translation: AAH62988.1.
BC094697 mRNA. Translation: AAH94697.1. Different initiation.
BC110513 mRNA. Translation: AAI10514.1. Different initiation.
BC110514 mRNA. Translation: AAI10515.1. Different initiation.
CCDSCCDS33186.2.
RefSeqNP_612379.2. NM_138370.2.
UniGeneHs.408542.

3D structure databases

ProteinModelPortalQ504Y2.
SMRQ504Y2. Positions 133-320.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ504Y2.

Polymorphism databases

DMDM292495024.

Proteomic databases

PaxDbQ504Y2.
PRIDEQ504Y2.

Protocols and materials databases

DNASU91461.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000294964; ENSP00000294964; ENSG00000162878.
GeneID91461.
KEGGhsa:91461.
UCSCuc002rsg.3. human.

Organism-specific databases

CTD91461.
GeneCardsGC02P042275.
H-InvDBHIX0029918.
HIX0161947.
HGNCHGNC:25123. PKDCC.
HPAHPA026427.
HPA026442.
HPA026526.
MIM614150. gene.
neXtProtNX_Q504Y2.
PharmGKBPA165697259.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG254379.
HOGENOMHOG000054185.
HOVERGENHBG079871.
InParanoidQ504Y2.
KOK17548.
OMAYVGSGYT.
OrthoDBEOG7034GV.
PhylomeDBQ504Y2.
TreeFamTF329248.

Enzyme and pathway databases

SignaLinkQ504Y2.

Gene expression databases

ArrayExpressQ504Y2.
BgeeQ504Y2.
GenevestigatorQ504Y2.

Family and domain databases

InterProIPR022049. FAM69_kinase_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamPF12260. PIP49_C. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPKDCC. human.
GenomeRNAi91461.
NextBio77265.
PROQ504Y2.
SOURCESearch...

Entry information

Entry namePKDCC_HUMAN
AccessionPrimary (citable) accession number: Q504Y2
Secondary accession number(s): D6W5A0, Q96I09
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 23, 2010
Last modified: July 9, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM