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Protein

Zinc transporter ZIP12

Gene

SLC39A12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a zinc-influx transporter (Potential). May be partly involved in the outbreak of schizophrenia.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Protein family/group databases

TCDBi2.A.5.4.14. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP12
Alternative name(s):
LIV-1 subfamily of ZIP zinc transporter 8
Short name:
LZT-Hs8
Solute carrier family 39 member 12
Zrt- and Irt-like protein 12
Short name:
ZIP-12
Gene namesi
Name:SLC39A12
Synonyms:ZIP12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:20860. SLC39A12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 202ExtracellularSequence analysisAdd BLAST202
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Topological domaini224 – 369CytoplasmicSequence analysisAdd BLAST146
Transmembranei370 – 390HelicalSequence analysisAdd BLAST21
Topological domaini391 – 398ExtracellularSequence analysis8
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Topological domaini420 – 448CytoplasmicSequence analysisAdd BLAST29
Transmembranei449 – 469HelicalSequence analysisAdd BLAST21
Topological domaini470 – 538ExtracellularSequence analysisAdd BLAST69
Transmembranei539 – 559HelicalSequence analysisAdd BLAST21
Topological domaini560 – 602CytoplasmicSequence analysisAdd BLAST43
Transmembranei603 – 623HelicalSequence analysisAdd BLAST21
Topological domaini624 – 631ExtracellularSequence analysis8
Transmembranei632 – 652HelicalSequence analysisAdd BLAST21
Topological domaini653 – 663CytoplasmicSequence analysisAdd BLAST11
Transmembranei664 – 684HelicalSequence analysisAdd BLAST21
Topological domaini685 – 691ExtracellularSequence analysis7

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi221074.
OpenTargetsiENSG00000148482.
PharmGKBiPA134956205.

Polymorphism and mutation databases

BioMutaiSLC39A12.
DMDMi313104190.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003124971 – 691Zinc transporter ZIP12Add BLAST691

Proteomic databases

PaxDbiQ504Y0.
PeptideAtlasiQ504Y0.
PRIDEiQ504Y0.

PTM databases

iPTMnetiQ504Y0.
PhosphoSitePlusiQ504Y0.

Expressioni

Tissue specificityi

Expressed in brain and eye.2 Publications

Gene expression databases

BgeeiENSG00000148482.
CleanExiHS_SLC39A12.
GenevisibleiQ504Y0. HS.

Interactioni

Protein-protein interaction databases

BioGridi128681. 70 interactors.
STRINGi9606.ENSP00000366586.

Structurei

3D structure databases

ProteinModelPortaliQ504Y0.
SMRiQ504Y0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi580 – 585XEXPHE-motif6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi116 – 119Poly-Leu4
Compositional biasi564 – 569Poly-Ser6
Compositional biasi677 – 682Poly-Leu6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOVERGENiHBG108449.
InParanoidiQ504Y0.
KOiK14718.
OMAiHQEEICS.
OrthoDBiEOG091G035V.
PhylomeDBiQ504Y0.
TreeFamiTF318470.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q504Y0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCFRTKLSVS WVPLFLLLSR VFSTETDKPS AQDSRSRGSS GQPADLLQVL
60 70 80 90 100
SAGDHPPHNH SRSLIKTLLE KTGCPRRRNG MQGDCNLCFE PDALLLIAGG
110 120 130 140 150
NFEDQLREEV VQRVSLLLLY YIIHQEEICS SKLNMSNKEY KFYLHSLLSL
160 170 180 190 200
RQDEDSSFLS QNETEDILAF TRQYFDTSQS QCMETKTLQK KSGIVSSEGA
210 220 230 240 250
NESTLPQLAA MIITLSLQGV CLGQGNLPSP DYFTEYIFSS LNRTNTLRLS
260 270 280 290 300
ELDQLLNTLW TRSTCIKNEK IHQFQRKQNN IITHDQDYSN FSSSMEKESE
310 320 330 340 350
DGPVSWDQTC FSARQLVEIF LQKGLSLISK EDFKQMSPGI IQQLLSCSCH
360 370 380 390 400
LPKDQQAKLP PTTLEKYGYS TVAVTLLTLG SMLGTALVLF HSCEENYRLI
410 420 430 440 450
LQLFVGLAVG TLSGDALLHL IPQVLGLHKQ EAPEFGHFHE SKGHIWKLMG
460 470 480 490 500
LIGGIHGFFL IEKCFILLVS PNDKQGLSLV NGHVGHSHHL ALNSELSDQA
510 520 530 540 550
GRGKSASTIQ LKSPEDSQAA EMPIGSMTAS NRKCKAISLL AIMILVGDSL
560 570 580 590 600
HNFADGLAIG AAFSSSSESG VTTTIAILCH EIPHEMGDFA VLLSSGLSMK
610 620 630 640 650
TAILMNFISS LTAFMGLYIG LSVSADPCVQ DWIFTVTAGM FLYLSLVEML
660 670 680 690
PEMTHVQTQR PWMMFLLQNF GLILGWLSLL LLAIYEQNIK I
Length:691
Mass (Da):76,666
Last modified:November 30, 2010 - v3
Checksum:iEB5959BDFD229D04
GO
Isoform 2 (identifier: Q504Y0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     343-407: QLLSCSCHLP...RLILQLFVGL → RWSFSIAVRR...SMKAKVIFGN
     408-691: Missing.

Note: No experimental confirmation available.
Show »
Length:404
Mass (Da):45,813
Checksum:i4B36E204882F93B2
GO
Isoform 3 (identifier: Q504Y0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     475-511: Missing.

Note: No experimental confirmation available.
Show »
Length:654
Mass (Da):72,864
Checksum:i13C4765D5F82A708
GO
Isoform 4 (identifier: Q504Y0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     475-475: Missing.

Note: No experimental confirmation available.
Show »
Length:690
Mass (Da):76,538
Checksum:iEBFE5BE2E8F4C877
GO
Isoform 5 (identifier: Q504Y0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: Missing.

Show »
Length:557
Mass (Da):61,643
Checksum:iE3C90A4E5412F2F3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti287D → G in BAB70848 (PubMed:14702039).Curated1
Sequence conflicti316L → R in AAH47635 (PubMed:15489334).Curated1
Sequence conflicti423Q → R in BAH12025 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03751636S → G.2 PublicationsCorresponds to variant rs10764176dbSNPEnsembl.1
Natural variantiVAR_037517244T → M.Corresponds to variant rs7899328dbSNPEnsembl.1
Natural variantiVAR_037518304V → I.1 PublicationCorresponds to variant rs2478568dbSNPEnsembl.1
Natural variantiVAR_037519435F → L.Corresponds to variant rs11011935dbSNPEnsembl.1
Natural variantiVAR_037520471P → T in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0575941 – 134Missing in isoform 5. Add BLAST134
Alternative sequenceiVSP_029847343 – 407QLLSC…LFVGL → RWSFSIAVRRTTGLSYSCLW AWPSGHCLGTLCSTLSLRFL VYISRKPQNLGISMKAKVIF GN in isoform 2. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_029848408 – 691Missing in isoform 2. 1 PublicationAdd BLAST284
Alternative sequenceiVSP_029849475 – 511Missing in isoform 3. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_029850475Missing in isoform 4. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055061 mRNA. Translation: BAB70848.1.
AK295294 mRNA. Translation: BAH12025.1.
AL360231, AC069023, AL590111 Genomic DNA. Translation: CAH70123.1.
AL360231, AC069023, AL590111 Genomic DNA. Translation: CAH70124.1.
AL590111, AC069023, AL360231 Genomic DNA. Translation: CAI15903.1.
AL590111, AC069023, AL360231 Genomic DNA. Translation: CAI15904.1.
BC035118 mRNA. Translation: AAH35118.1.
BC047635 mRNA. Translation: AAH47635.1.
BC065917 mRNA. Translation: AAH65917.1.
BC094700 mRNA. Translation: AAH94700.1.
BC117323 mRNA. Translation: AAI17324.1.
BC143551 mRNA. Translation: AAI43552.1.
CCDSiCCDS44362.1. [Q504Y0-1]
CCDS60493.1. [Q504Y0-4]
CCDS60494.1. [Q504Y0-5]
CCDS7124.1. [Q504Y0-3]
RefSeqiNP_001138667.1. NM_001145195.1. [Q504Y0-1]
NP_001269662.1. NM_001282733.1. [Q504Y0-4]
NP_001269663.1. NM_001282734.1. [Q504Y0-5]
NP_689938.2. NM_152725.3. [Q504Y0-3]
UniGeneiHs.350895.

Genome annotation databases

EnsembliENST00000377369; ENSP00000366586; ENSG00000148482. [Q504Y0-1]
ENST00000377371; ENSP00000366588; ENSG00000148482. [Q504Y0-4]
ENST00000377374; ENSP00000366591; ENSG00000148482. [Q504Y0-3]
ENST00000539911; ENSP00000440445; ENSG00000148482. [Q504Y0-5]
GeneIDi221074.
KEGGihsa:221074.
UCSCiuc001ipn.3. human. [Q504Y0-1]
uc010qck.1. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055061 mRNA. Translation: BAB70848.1.
AK295294 mRNA. Translation: BAH12025.1.
AL360231, AC069023, AL590111 Genomic DNA. Translation: CAH70123.1.
AL360231, AC069023, AL590111 Genomic DNA. Translation: CAH70124.1.
AL590111, AC069023, AL360231 Genomic DNA. Translation: CAI15903.1.
AL590111, AC069023, AL360231 Genomic DNA. Translation: CAI15904.1.
BC035118 mRNA. Translation: AAH35118.1.
BC047635 mRNA. Translation: AAH47635.1.
BC065917 mRNA. Translation: AAH65917.1.
BC094700 mRNA. Translation: AAH94700.1.
BC117323 mRNA. Translation: AAI17324.1.
BC143551 mRNA. Translation: AAI43552.1.
CCDSiCCDS44362.1. [Q504Y0-1]
CCDS60493.1. [Q504Y0-4]
CCDS60494.1. [Q504Y0-5]
CCDS7124.1. [Q504Y0-3]
RefSeqiNP_001138667.1. NM_001145195.1. [Q504Y0-1]
NP_001269662.1. NM_001282733.1. [Q504Y0-4]
NP_001269663.1. NM_001282734.1. [Q504Y0-5]
NP_689938.2. NM_152725.3. [Q504Y0-3]
UniGeneiHs.350895.

3D structure databases

ProteinModelPortaliQ504Y0.
SMRiQ504Y0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128681. 70 interactors.
STRINGi9606.ENSP00000366586.

Protein family/group databases

TCDBi2.A.5.4.14. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

PTM databases

iPTMnetiQ504Y0.
PhosphoSitePlusiQ504Y0.

Polymorphism and mutation databases

BioMutaiSLC39A12.
DMDMi313104190.

Proteomic databases

PaxDbiQ504Y0.
PeptideAtlasiQ504Y0.
PRIDEiQ504Y0.

Protocols and materials databases

DNASUi221074.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377369; ENSP00000366586; ENSG00000148482. [Q504Y0-1]
ENST00000377371; ENSP00000366588; ENSG00000148482. [Q504Y0-4]
ENST00000377374; ENSP00000366591; ENSG00000148482. [Q504Y0-3]
ENST00000539911; ENSP00000440445; ENSG00000148482. [Q504Y0-5]
GeneIDi221074.
KEGGihsa:221074.
UCSCiuc001ipn.3. human. [Q504Y0-1]
uc010qck.1. human.

Organism-specific databases

CTDi221074.
DisGeNETi221074.
GeneCardsiSLC39A12.
H-InvDBHIX0008685.
HIX0019390.
HGNCiHGNC:20860. SLC39A12.
MIMi608734. gene.
neXtProtiNX_Q504Y0.
OpenTargetsiENSG00000148482.
PharmGKBiPA134956205.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOVERGENiHBG108449.
InParanoidiQ504Y0.
KOiK14718.
OMAiHQEEICS.
OrthoDBiEOG091G035V.
PhylomeDBiQ504Y0.
TreeFamiTF318470.

Miscellaneous databases

GenomeRNAii221074.
PROiQ504Y0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148482.
CleanExiHS_SLC39A12.
GenevisibleiQ504Y0. HS.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS39AC_HUMAN
AccessioniPrimary (citable) accession number: Q504Y0
Secondary accession number(s): B7Z2Y9
, B7ZL35, C9JJL4, F5GX72, Q49AN8, Q4G0L3, Q5VWV8, Q5VWV9, Q6NZY5, Q96NN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: November 30, 2010
Last modified: November 2, 2016
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.