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Protein

Zinc transporter ZIP12

Gene

SLC39A12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a zinc-influx transporter (Potential). May be partly involved in the outbreak of schizophrenia.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Protein family/group databases

TCDBi2.A.5.4.14. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP12
Alternative name(s):
LIV-1 subfamily of ZIP zinc transporter 8
Short name:
LZT-Hs8
Solute carrier family 39 member 12
Zrt- and Irt-like protein 12
Short name:
ZIP-12
Gene namesi
Name:SLC39A12
Synonyms:ZIP12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:20860. SLC39A12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 202202ExtracellularSequence analysisAdd
BLAST
Transmembranei203 – 22321HelicalSequence analysisAdd
BLAST
Topological domaini224 – 369146CytoplasmicSequence analysisAdd
BLAST
Transmembranei370 – 39021HelicalSequence analysisAdd
BLAST
Topological domaini391 – 3988ExtracellularSequence analysis
Transmembranei399 – 41921HelicalSequence analysisAdd
BLAST
Topological domaini420 – 44829CytoplasmicSequence analysisAdd
BLAST
Transmembranei449 – 46921HelicalSequence analysisAdd
BLAST
Topological domaini470 – 53869ExtracellularSequence analysisAdd
BLAST
Transmembranei539 – 55921HelicalSequence analysisAdd
BLAST
Topological domaini560 – 60243CytoplasmicSequence analysisAdd
BLAST
Transmembranei603 – 62321HelicalSequence analysisAdd
BLAST
Topological domaini624 – 6318ExtracellularSequence analysis
Transmembranei632 – 65221HelicalSequence analysisAdd
BLAST
Topological domaini653 – 66311CytoplasmicSequence analysisAdd
BLAST
Transmembranei664 – 68421HelicalSequence analysisAdd
BLAST
Topological domaini685 – 6917ExtracellularSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134956205.

Polymorphism and mutation databases

BioMutaiSLC39A12.
DMDMi313104190.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 691691Zinc transporter ZIP12PRO_0000312497Add
BLAST

Proteomic databases

PaxDbiQ504Y0.
PeptideAtlasiQ504Y0.
PRIDEiQ504Y0.

PTM databases

iPTMnetiQ504Y0.
PhosphoSiteiQ504Y0.

Expressioni

Tissue specificityi

Expressed in brain and eye.2 Publications

Gene expression databases

BgeeiQ504Y0.
CleanExiHS_SLC39A12.
GenevisibleiQ504Y0. HS.

Interactioni

Protein-protein interaction databases

BioGridi128681. 70 interactions.
STRINGi9606.ENSP00000366586.

Structurei

3D structure databases

ProteinModelPortaliQ504Y0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi580 – 5856XEXPHE-motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi116 – 1194Poly-Leu
Compositional biasi564 – 5696Poly-Ser
Compositional biasi677 – 6826Poly-Leu

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOVERGENiHBG108449.
InParanoidiQ504Y0.
KOiK14718.
OMAiHQEEICS.
OrthoDBiEOG7SBNN4.
PhylomeDBiQ504Y0.
TreeFamiTF318470.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q504Y0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCFRTKLSVS WVPLFLLLSR VFSTETDKPS AQDSRSRGSS GQPADLLQVL
60 70 80 90 100
SAGDHPPHNH SRSLIKTLLE KTGCPRRRNG MQGDCNLCFE PDALLLIAGG
110 120 130 140 150
NFEDQLREEV VQRVSLLLLY YIIHQEEICS SKLNMSNKEY KFYLHSLLSL
160 170 180 190 200
RQDEDSSFLS QNETEDILAF TRQYFDTSQS QCMETKTLQK KSGIVSSEGA
210 220 230 240 250
NESTLPQLAA MIITLSLQGV CLGQGNLPSP DYFTEYIFSS LNRTNTLRLS
260 270 280 290 300
ELDQLLNTLW TRSTCIKNEK IHQFQRKQNN IITHDQDYSN FSSSMEKESE
310 320 330 340 350
DGPVSWDQTC FSARQLVEIF LQKGLSLISK EDFKQMSPGI IQQLLSCSCH
360 370 380 390 400
LPKDQQAKLP PTTLEKYGYS TVAVTLLTLG SMLGTALVLF HSCEENYRLI
410 420 430 440 450
LQLFVGLAVG TLSGDALLHL IPQVLGLHKQ EAPEFGHFHE SKGHIWKLMG
460 470 480 490 500
LIGGIHGFFL IEKCFILLVS PNDKQGLSLV NGHVGHSHHL ALNSELSDQA
510 520 530 540 550
GRGKSASTIQ LKSPEDSQAA EMPIGSMTAS NRKCKAISLL AIMILVGDSL
560 570 580 590 600
HNFADGLAIG AAFSSSSESG VTTTIAILCH EIPHEMGDFA VLLSSGLSMK
610 620 630 640 650
TAILMNFISS LTAFMGLYIG LSVSADPCVQ DWIFTVTAGM FLYLSLVEML
660 670 680 690
PEMTHVQTQR PWMMFLLQNF GLILGWLSLL LLAIYEQNIK I
Length:691
Mass (Da):76,666
Last modified:November 30, 2010 - v3
Checksum:iEB5959BDFD229D04
GO
Isoform 2 (identifier: Q504Y0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     343-407: QLLSCSCHLP...RLILQLFVGL → RWSFSIAVRR...SMKAKVIFGN
     408-691: Missing.

Note: No experimental confirmation available.
Show »
Length:404
Mass (Da):45,813
Checksum:i4B36E204882F93B2
GO
Isoform 3 (identifier: Q504Y0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     475-511: Missing.

Note: No experimental confirmation available.
Show »
Length:654
Mass (Da):72,864
Checksum:i13C4765D5F82A708
GO
Isoform 4 (identifier: Q504Y0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     475-475: Missing.

Note: No experimental confirmation available.
Show »
Length:690
Mass (Da):76,538
Checksum:iEBFE5BE2E8F4C877
GO
Isoform 5 (identifier: Q504Y0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: Missing.

Show »
Length:557
Mass (Da):61,643
Checksum:iE3C90A4E5412F2F3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti287 – 2871D → G in BAB70848 (PubMed:14702039).Curated
Sequence conflicti316 – 3161L → R in AAH47635 (PubMed:15489334).Curated
Sequence conflicti423 – 4231Q → R in BAH12025 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti36 – 361S → G.2 Publications
Corresponds to variant rs10764176 [ dbSNP | Ensembl ].
VAR_037516
Natural varianti244 – 2441T → M.
Corresponds to variant rs7899328 [ dbSNP | Ensembl ].
VAR_037517
Natural varianti304 – 3041V → I.1 Publication
Corresponds to variant rs2478568 [ dbSNP | Ensembl ].
VAR_037518
Natural varianti435 – 4351F → L.
Corresponds to variant rs11011935 [ dbSNP | Ensembl ].
VAR_037519
Natural varianti471 – 4711P → T in a breast cancer sample; somatic mutation. 1 Publication
VAR_037520

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 134134Missing in isoform 5. VSP_057594Add
BLAST
Alternative sequencei343 – 40765QLLSC…LFVGL → RWSFSIAVRRTTGLSYSCLW AWPSGHCLGTLCSTLSLRFL VYISRKPQNLGISMKAKVIF GN in isoform 2. 1 PublicationVSP_029847Add
BLAST
Alternative sequencei408 – 691284Missing in isoform 2. 1 PublicationVSP_029848Add
BLAST
Alternative sequencei475 – 51137Missing in isoform 3. 1 PublicationVSP_029849Add
BLAST
Alternative sequencei475 – 4751Missing in isoform 4. CuratedVSP_029850

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055061 mRNA. Translation: BAB70848.1.
AK295294 mRNA. Translation: BAH12025.1.
AL360231, AC069023, AL590111 Genomic DNA. Translation: CAH70123.1.
AL360231, AC069023, AL590111 Genomic DNA. Translation: CAH70124.1.
AL590111, AC069023, AL360231 Genomic DNA. Translation: CAI15903.1.
AL590111, AC069023, AL360231 Genomic DNA. Translation: CAI15904.1.
BC035118 mRNA. Translation: AAH35118.1.
BC047635 mRNA. Translation: AAH47635.1.
BC065917 mRNA. Translation: AAH65917.1.
BC094700 mRNA. Translation: AAH94700.1.
BC117323 mRNA. Translation: AAI17324.1.
BC143551 mRNA. Translation: AAI43552.1.
CCDSiCCDS44362.1. [Q504Y0-1]
CCDS60493.1. [Q504Y0-4]
CCDS60494.1. [Q504Y0-5]
CCDS7124.1. [Q504Y0-3]
RefSeqiNP_001138667.1. NM_001145195.1. [Q504Y0-1]
NP_001269662.1. NM_001282733.1. [Q504Y0-4]
NP_001269663.1. NM_001282734.1. [Q504Y0-5]
NP_689938.2. NM_152725.3. [Q504Y0-3]
UniGeneiHs.350895.

Genome annotation databases

EnsembliENST00000377369; ENSP00000366586; ENSG00000148482. [Q504Y0-1]
ENST00000377371; ENSP00000366588; ENSG00000148482. [Q504Y0-4]
ENST00000377374; ENSP00000366591; ENSG00000148482. [Q504Y0-3]
ENST00000539911; ENSP00000440445; ENSG00000148482. [Q504Y0-5]
GeneIDi221074.
KEGGihsa:221074.
UCSCiuc001ipn.3. human. [Q504Y0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055061 mRNA. Translation: BAB70848.1.
AK295294 mRNA. Translation: BAH12025.1.
AL360231, AC069023, AL590111 Genomic DNA. Translation: CAH70123.1.
AL360231, AC069023, AL590111 Genomic DNA. Translation: CAH70124.1.
AL590111, AC069023, AL360231 Genomic DNA. Translation: CAI15903.1.
AL590111, AC069023, AL360231 Genomic DNA. Translation: CAI15904.1.
BC035118 mRNA. Translation: AAH35118.1.
BC047635 mRNA. Translation: AAH47635.1.
BC065917 mRNA. Translation: AAH65917.1.
BC094700 mRNA. Translation: AAH94700.1.
BC117323 mRNA. Translation: AAI17324.1.
BC143551 mRNA. Translation: AAI43552.1.
CCDSiCCDS44362.1. [Q504Y0-1]
CCDS60493.1. [Q504Y0-4]
CCDS60494.1. [Q504Y0-5]
CCDS7124.1. [Q504Y0-3]
RefSeqiNP_001138667.1. NM_001145195.1. [Q504Y0-1]
NP_001269662.1. NM_001282733.1. [Q504Y0-4]
NP_001269663.1. NM_001282734.1. [Q504Y0-5]
NP_689938.2. NM_152725.3. [Q504Y0-3]
UniGeneiHs.350895.

3D structure databases

ProteinModelPortaliQ504Y0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128681. 70 interactions.
STRINGi9606.ENSP00000366586.

Protein family/group databases

TCDBi2.A.5.4.14. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

PTM databases

iPTMnetiQ504Y0.
PhosphoSiteiQ504Y0.

Polymorphism and mutation databases

BioMutaiSLC39A12.
DMDMi313104190.

Proteomic databases

PaxDbiQ504Y0.
PeptideAtlasiQ504Y0.
PRIDEiQ504Y0.

Protocols and materials databases

DNASUi221074.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377369; ENSP00000366586; ENSG00000148482. [Q504Y0-1]
ENST00000377371; ENSP00000366588; ENSG00000148482. [Q504Y0-4]
ENST00000377374; ENSP00000366591; ENSG00000148482. [Q504Y0-3]
ENST00000539911; ENSP00000440445; ENSG00000148482. [Q504Y0-5]
GeneIDi221074.
KEGGihsa:221074.
UCSCiuc001ipn.3. human. [Q504Y0-1]

Organism-specific databases

CTDi221074.
GeneCardsiSLC39A12.
H-InvDBHIX0008685.
HIX0019390.
HGNCiHGNC:20860. SLC39A12.
MIMi608734. gene.
neXtProtiNX_Q504Y0.
PharmGKBiPA134956205.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOVERGENiHBG108449.
InParanoidiQ504Y0.
KOiK14718.
OMAiHQEEICS.
OrthoDBiEOG7SBNN4.
PhylomeDBiQ504Y0.
TreeFamiTF318470.

Miscellaneous databases

GenomeRNAii221074.
PROiQ504Y0.
SOURCEiSearch...

Gene expression databases

BgeeiQ504Y0.
CleanExiHS_SLC39A12.
GenevisibleiQ504Y0. HS.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5), VARIANT ILE-304.
    Tissue: Brain and Caudate nucleus.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS GLY-36 AND ILE-304.
    Tissue: Brain and Lung.
  4. "Expressed sequence tag analysis of human RPE/choroid for the NEIBank project: over 6000 non-redundant transcripts, novel genes and splice variants."
    Wistow G., Bernstein S.L., Wyatt M.K., Fariss R.N., Behal A., Touchman J.W., Bouffard G., Smith D., Peterson K.
    Mol. Vis. 8:205-220(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions."
    Suzuki Y., Yamashita R., Shirota M., Sakakibara Y., Chiba J., Mizushima-Sugano J., Nakai K., Sugano S.
    Genome Res. 14:1711-1718(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "Examination of the zinc transporter gene, SLC39A12."
    Bly M.
    Schizophr. Res. 81:321-322(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROBABLE INVOLVEMENT IN SCHIZOPHRENIA, VARIANT GLY-36.
  7. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-471.

Entry informationi

Entry nameiS39AC_HUMAN
AccessioniPrimary (citable) accession number: Q504Y0
Secondary accession number(s): B7Z2Y9
, B7ZL35, C9JJL4, F5GX72, Q49AN8, Q4G0L3, Q5VWV8, Q5VWV9, Q6NZY5, Q96NN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: November 30, 2010
Last modified: July 6, 2016
This is version 85 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.