Unreviewed, UniProtKB/TrEMBL Q504U3 (Q504U3_HUMAN)

Names and origin

Protein names

Recommended name:
    Pyruvate kinase RuleBase RU000504V4
    EC=2.7.1.40 RuleBase RU000504V4

Gene names

Name:

PKM2 EMBL AAH94767.1

Organism

Homo sapiens (Human) EMBL AAH94767.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + pyruvate = ADP + phosphoenolpyruvate. RuleBase RU000504V4
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5. RuleBase RU000504V4
Sequence similarities	Belongs to the pyruvate kinase family.

Ontologies

Keywords
Biological process	Glycolysis RuleBase RU000504V4
Ligand	Magnesium RuleBase RU000504V4
Molecular function	Kinase RuleBase RU000504V4 Transferase
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW potassium ion binding Inferred from electronic annotation. Source: InterPro pyruvate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q504U3-1 [UniParc]. Last modified June 7, 2005. Version 1. Checksum: 0B938BE87B8DBE80	FASTA	366	40,164
	10 20 30 40 50 60 MSKPHSEAGT AFIQTQQLHA AMADTFLEHM CRLDIDSPPS KKGVNLPGAA VDLPAVSEKD 70 80 90 100 110 120 IQDLKFGVEQ DVDMVFASFI RKASDVHEVR KVLGEKGKNI KIISKIENHE GVRRFDEILE 130 140 150 160 170 180 ASDGIMVARG DLGIEIPAEK VFLAQKMMIG RCNRAGKPVI CATQMLESMI KKPRPTRAEG 190 200 210 220 230 240 SDVANAVLDG ADCIMLSGET AKGDYPLEAV RMQHLIAREA EAAMFHRKLF EELVRASSHS 250 260 270 280 290 300 TDLMEAMAMG SVEASYKCLA AALIVLTESG RSAHQVARYR PRAPIIAVTR NPQTARQAHL 310 320 330 340 350 360 YRGIFPVLCK DPVQEAWAED VDLRVNFAMN VGKARGFFKK GDVVIVLTGW RPGSGFTNTM RVVPVP

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis EMBL AAH94767.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC094767 mRNA. Translation: AAH94767.1.
IPI	IPI00604528.
UniGene	Hs.534770
3D structure databases
SMR	Q504U3. Positions 2-366.
ModBase	Search...
Protein-protein interaction databases
STRING	Q504U3.
Proteomic databases
PRIDE	Q504U3.
Genome annotation databases
Ensembl	ENST00000327974; ENSP00000369278; ENSG00000067225; Homo sapiens. [Genome view]
Organism-specific databases
HGNC	HGNC:9021. PKM2.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q504U3.
PhylomeDB	Q504U3.
Gene expression databases
ArrayExpress	Q504U3.
Bgee	Q504U3.
Family and domain databases
InterPro	IPR001697. Pyr_Knase. IPR015813. Pyrv/PenolPyrv_Kinase_cat. IPR015794. Pyrv_Knase_a/b. IPR018209. Pyrv_Knase_AS. IPR015793. Pyrv_Knase_brl. IPR015795. Pyrv_Knase_C-like. [Graphical view]
Gene3D	G3DSA:3.20.20.60. Pyrv/PenolPyrv_Kinase_cat. 1 hit. G3DSA:3.40.1380.20. Pyrv_Knase_a/b. 1 hit.
PANTHER	PTHR11817. Pyruvate_kinase. 1 hit.
Pfam	PF00224. PK. 1 hit. PF02887. PK_C. 1 hit. [Graphical view]
PRINTS	PR01050. PYRUVTKNASE.
TIGRFAMs	TIGR01064. pyruv_kin. 1 hit.
PROSITE	PS00110. PYRUVATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q504U3_HUMAN

Accession

Primary (citable) accession number: Q504U3

Entry history

Integrated into UniProtKB/TrEMBL:	June 7, 2005
Last sequence update:	June 7, 2005
Last modified:	January 19, 2010
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.