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Unreviewed, UniProtKB/TrEMBL Q504U3 (Q504U3_HUMAN)

Last modified January 19, 2010. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesRecommended name:
    Pyruvate kinase RuleBase RU000504V4
    EC=2.7.1.40 RuleBase RU000504V4
Gene names
Name: PKM2 EMBL AAH94767.1
OrganismHomo sapiens (Human) EMBL AAH94767.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

ATP + pyruvate = ADP + phosphoenolpyruvate. RuleBase RU000504V4

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5. RuleBase RU000504V4

Sequence similarities

Belongs to the pyruvate kinase family.

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Sequences

Sequence LengthMass (Da)Tools
Q504U3-1 [UniParc].

Last modified June 7, 2005. Version 1.
Checksum: 0B938BE87B8DBE80

FASTA36640,164
        10         20         30         40         50         60 
MSKPHSEAGT AFIQTQQLHA AMADTFLEHM CRLDIDSPPS KKGVNLPGAA VDLPAVSEKD 

        70         80         90        100        110        120 
IQDLKFGVEQ DVDMVFASFI RKASDVHEVR KVLGEKGKNI KIISKIENHE GVRRFDEILE 

       130        140        150        160        170        180 
ASDGIMVARG DLGIEIPAEK VFLAQKMMIG RCNRAGKPVI CATQMLESMI KKPRPTRAEG 

       190        200        210        220        230        240 
SDVANAVLDG ADCIMLSGET AKGDYPLEAV RMQHLIAREA EAAMFHRKLF EELVRASSHS 

       250        260        270        280        290        300 
TDLMEAMAMG SVEASYKCLA AALIVLTESG RSAHQVARYR PRAPIIAVTR NPQTARQAHL 

       310        320        330        340        350        360 
YRGIFPVLCK DPVQEAWAED VDLRVNFAMN VGKARGFFKK GDVVIVLTGW RPGSGFTNTM 


RVVPVP

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References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis EMBL AAH94767.1.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC094767 mRNA. Translation: AAH94767.1.
IPIIPI00604528.
UniGeneHs.534770

3D structure databases

SMRQ504U3. Positions 2-366.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ504U3.

Proteomic databases

PRIDEQ504U3.

Genome annotation databases

EnsemblENST00000327974; ENSP00000369278; ENSG00000067225; Homo sapiens. [Genome view]

Organism-specific databases

HGNCHGNC:9021. PKM2.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ504U3.
PhylomeDBQ504U3.

Gene expression databases

ArrayExpressQ504U3.
BgeeQ504U3.

Family and domain databases

InterProIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase_cat.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C-like.
[Graphical view]
Gene3DG3DSA:3.20.20.60. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
G3DSA:3.40.1380.20. Pyrv_Knase_a/b. 1 hit.
PANTHERPTHR11817. Pyruvate_kinase. 1 hit.
PfamPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSPR01050. PYRUVTKNASE.
TIGRFAMsTIGR01064. pyruv_kin. 1 hit.
PROSITEPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameQ504U3_HUMAN
AccessionPrimary (citable) accession number: Q504U3
Entry history
Integrated into UniProtKB/TrEMBL: June 7, 2005
Last sequence update: June 7, 2005
Last modified: January 19, 2010
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information